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| 1 | Clinical Observation of Transepithelial Corneal Collagen Cross-linking by Iontophoresis of Riboflavin in Treatment of Keratoconus显示文摘Purpose: To evaluate the efficacy and safety of transepithelial collagen cross-linking by iontophoretic delivery of riboflavin in treatment of progressive keratoconus.Methods:.Eleven patients(15 eyes) with progressive keratoconus were enrolled. After 0.1% riboflavin-distilled water solution was deliveried via transepithelial iontophpresis for 5 min with 1 m A current, and ultraviolet radiation(370 nm,.3 m W /cm2) was performed at a 1.5 cm distance for 30 min. The follow up were 6 months in all eyes. The uncorrected visual acuity, corrected visual acuity,endothelial cell counting, corneal thickness,.intraocular pressure, corneal curvature, corneal topography,.OCT and corneal opacity before and 6-month after surgery were analyzed.Results: At 6 month postoperatively, mean uncorrected visual acuity and corrected visual acuity changed from 0.36 to 0.30 and from 0.42 to 0.57 without statistical significance..The mean value of each index of corneal curvature declined without statistical significance.Kmax value dereased from 60.91 to59.91, and the astigmatism declined from 3.86 to 3.19. Central corneal thickness decreased from 460.93 μm to 455.40μm,.and thinnest corneal thickness declined from 450.87 μm to 440.60 μm with no statistical significance..Intraocular pressure was significantly elevated from 10.85 mm Hg to 12.62 mm Hg. Endothelial cell count did not change significantly. No corneal haze occurred. Mean depth of corneal demarcation line was 288.46 μm at 1 month postoperatively..Conclusion:.Transepithelial corneal collagen cross-linking by iontophoresis is effective and safe in the treatment of progressive keratoconus, and yields stable clinical outcomes during 6-month follow up..However,.long-term follow up is urgently required. | Na Li Zhengjun Fan Xiujun Peng Xu Pang Chunyu Tian | 2014 | Eye Science2014，29，3： | 15 |
| 2 | Iontophoretic Delivery of Riboflavin into the Rabbit Cornea:a Primary Study显示文摘Purpose: To determine the penetrability of riboflavin into the corneal stroma by iontophoresis and to compare the permeability effects of different solvents.Methods: Twenty rabbits were randomly divided into four groups: a group that received 0.1% riboflavin-balanced salt solution(BSS) by iontophoresis, a group that received 0.1%riboflavin-saline solution by iontophoresis, a group that received 0.1% riboflavin-distilled water solution by iontophoresis, and a control group that received classical riboflavin instillation after corneal de-epithelialization. The degree of yellowing of the de-epithelialized corneal stromal button from each rabbit was compared.Results: The yellow color scores for the corneal stromal buttons in the three iontophoresis groups were compared with those of control group. Iontophoretic delivery of a 0.1% riboflavin-distilled water solution yielded similar yellow changes in the corneal stromal button when compared with classical riboflavin instillation after de-epithelialization. However, the other two solvents did not sufficiently enhance the permeability of riboflavin.Conclusion: Riboflavin can effectively penetrate into the corneal stroma to saturation levels by iontophoresis. Using distilled water as the solvent can promote penetrability. | Na Li Xiujun Peng Zhengjun Fan Yu Xia | 2014 | Eye Science2014，29，1： | 9 |
| 3 | Corneal refractive surgery and phakic intraocular lens for treatment of amblyopia caused by high myopia or anisometropia in children显示文摘 | Tian Chunyu Peng Xiujun Fan Zhengjun Yin Zhengqin | 2014 | Chinese Medical Journal2014，，11： | 6 |
| 4 | Clinical Evaluation of Pranoprofen Combined with Fluorometholone Eye Drops on Postoperative Reaction of Corneal Cross-linking显示文摘Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery. | Xu Pang Zhengjun Fan Xiujun Peng Hongzhen Jia Tengfei Wu | 2012 | Eye Science2012，27，4： | 4 |
| 5 | STUDIES ON MICROYIELD BEHAVIOR OF A SiCp/2024Al COMPOSITE显示文摘1INTRODUCTIONDuetotheexcelentcomprehensivepropertiessuchashighspecificstrengthandYoung’smodulus,lowerthermalconductivityandt... | Zhang, Fan Li, Xiaocui Jin, Chen Hu, Zhengjun | 1998 | 中国有色金属学会会刊:英文版1998，8，3： | 4 |
| 6 | QNE1 is a key flowering regulator determining the length of the vegetative period in soybean cultivars显示文摘The soybean E1 gene is a major regulator that plays an important role in flowering time and maturity.However,it remains unclear how cultivars carrying the dominant E1 allele adapt to the higher latitudinal areas of northern China.We mapped the novel quantitative trait locus QNE1(QTL near E1) for flowering time to the region proximal to E1 on chromosome 6 in two mapping populations.Positional cloning revealed Glyma.06G204300,encoding a TCP-type transcription factor,as a strong candidate gene for QNE1.Association analysis further confirmed that functional single nucleotide polymorphisms(SNPs) at nucleotides 686 and 1,063 in the coding region of Glyma.06G204300 were significantly associated with flowering time.The protein encoded by the candidate gene is localized primarily to the nucleus.Furthermore,soybean and Brassica napus plants overexpressing Glyma.06G204300 exhibited early flowering.We conclude that despite their similar effects on flowering time,QNE1 and E4 may control flowering time through different regulatory mechanisms,based on expression studies and weighted gene co-expression network analysis of flowering time-related genes.Deciphering the molecular basis of QNE1 control of flowering time enriches our knowledge of flowering gene networks in soybean and will facilitate breeding soybean cultivars with broader latitudinal adaptation. | Zhengjun Xia Hong Zhai Yanfeng Zhang Yaying Wang Lu Wang Kun Xu Hongyan Wu Jinglong Zhu Shuang Jiao Zhao Wan Xiaobin Zhu Yi Gao Yingxiang Liu Rong Fan Shihao Wu Xin Chen Jinyu Liu Jiayin Yang Qijian Song Zhixi Tian | 2022 | Science China(Life Sciences)2022，65，12： | 1 |
| 7 | Sunlight photocatalytic degradation of ofloxacin using UiO-66/wood composite photocatalysts显示文摘This study synthesized UiO-66(Zr)in situ on wood via a one-step solvothermal method.UiO-66/wood was successfully prepared and its catalytic performance for the ofloxacin(OFX)photodegradation under simulate sunlight was also explored.UiO-66/wood exhibited a better catalytic performance,and its degradation rate constant was about 1.2 and 1.5 times than that of UiO-66 and wood,respectively.The effects of solution initial concentration,pH of the system and dosage of the photocatalyst were explored.Additionally,the active species trapping experiments and UV-vis diffused reflectance spectra measurements were conducted to investigated the photocatalytic mechanism of the UiO-66/wood composite,superoxide radical(O_(2)^(·-))and hydroxyl radical(^(·)OH)were the main reactive species.In addition,the possible degradation pathways of OFX were analyzed by LC-MS.Meanwhile,the UiO-66/wood showed outstanding stability and reusability after 4 cycles experiments.The removal performance of UiO-66/wood towards real samples showed it has potential in actual application. | Linhong Shi Xue Zou Tengfei Wang Dongmei Wang Meikun Fan Zhengjun Gong | 2022 | Chinese Chemical Letters2022，33，1： | 1 |
| 8 | Research Progress in Corneal Cross-linking Agents显示文摘Corneal collagen cross-linking with UVA-riboflavin is currently the only method for preventing the progression of keratoconus from the pathological perspective. Topical application of a direct cross-linking agent is now attracting widespread attention in clinical settings..This article reviews the research progress in the application of indirect or direct cross-linking agents(e.g., riboflavin, glucose, ribose, glutaraldehyde,formaldehyde,.glyceraldehyde,.short chain aliphatic β-nitro alcohol, and genipin) in the treatment of corneal diseases and analyzes the cross-linking efficacy,.toxicity,.and merits and disadvantages of each cross-linking agent,.providing clinical information for further studies. | Na Li Xiujun Peng Zhengjun Fan | 2014 | Eye Science2014，29，2： | 1 |
| 9 | New techniques to improve classical corneal collagen cross-linking treatment显示文摘 | Li Na Peng Xiujun Fan Zhengjun Xia Yu Wu Tengfei | 2014 | Chinese Medical Journal2014，，8： | 1 |
| 10 | Identification of Early Peach Aphid Infestation Based on Hyperspectral Imaging Technology显示文摘Peach aphid is a common pest and hard to detect.This study employs hyperspectral imaging technology to identify early damage in green cabbage caused by peach aphid.Through principal component transformation and multiple linear regression analysis,the correlation relation between spectral characteristics and infestation stage is analyzed.Then,four characteristic wavelength selection methods are compared and optimal characteristic wavelengths subset is determined to be input for modelling.One linear algorithm and two nonlinear modelling algorithms are compared.Finally,support vector machine(SVM)model based on the characteristic wavelengths selected by multi-cluster feature selection(MCFS)acquires the highest identification accuracy,which is 98.97%.These results indicate that hyperspectral imaging technology have the ability to identify early peach aphid infestation stages on green cabbages. | Yangyang Fan Wenjie Feng Zhengjun Qiu Shuai Wang | 2023 | Journal of Beijing Institute of Technology2023，32，3： | 0 |
| 11 | Variation in Central Corneal Thickness during Open- or Closed-Eye Riboflavin Instillation for Corneal Collagen Cross-linking显示文摘Purpose:To assess the effect of having an open or closed eye on the variation in central corneal thickness during riboflavin instillation for corneal collagen cross-linking (CXL).Methods:.Thirty eyes of 15 New Zealand White rabbits underwent an in vivo anterior segment optical coherence tomography (OCT) examination at 0,10,20,and 30 min after riboflavin instillation on the de-epithelialized corneal surface.Each eye of every rabbit was randomly placed into one of two different treatment groups(open-eye or closed-eye)during the instillation;.the examinations were performed one after the other.After instillation for 30 min,the changes in the corneal stroma and anterior chamber were observed by slit lamp.Results:.A significant decrease in the central corneal thickness(CCT).was demonstrated during riboflavin instillation;.the variations were smaller in the measurements performed with the eye closed than with the eye open.(81.36±15.13μm and129.20±12.05μm respectively)..Both methods turned the corneal stroma and anterior chamber yellow.Conclusion:Keeping the eye closed during riboflavin instillation reduced the decrease in the CCT..The same yellow change in the corneal stroma and anterior chamber occurred,but the exposure time of the ocular surface was shorter.Therefore,.keeping the eye closed was a more effective and safer method than keeping the eye open. | Na Li Xiujun Peng Zhengjun Fan Xu Pang Yu Xia | 2013 | Eye Science2013，28，4： | 0 |
| 12 | A Case Report:Severe Bullous Skin Reaction Induced by Anti-PD-1 Antibody(Toripalimab)Therapy in a Patient with Thymic Carcinoma显示文摘The development of immune checkpoint inhibitors,such as those targeting programmed cell death protein 1(PD-1),represents a major breakthrough in cancer therapy.Although immune checkpoint blockade therapy has a favorable risk/benefit ratio,it causes significant immune-related adverse events(irAEs),such as cutaneous reactions,in particular,severe bullous skin reactions and toxic epidermal necrolysis.Here,we report a case of a 51-year-old woman with malignant thymoma who developed a severe bullous skin reaction(characterized by a systemic rash,bullae,epidermal desquamation,and Stevens-Johnson syndrome)as a result of treatment with the PD-1 inhibitor toripalimab.The patient was treated with high doses of glucocorticoid,intravenous immunoglobulin,and intensive care,and eventually recovered from the severe irAEs.The intravenous injection of anti-PD-1 antibodies induces cutaneous reactions,which are associated with higher mortality rates.High doses of glucocorticoid combined with intravenous immunoglobulin are effective in alleviating such irAEs.Thus,improving the level of care and preventing skin infections can effectively reduce the risk of death. | Chong TENG Xiaowei SONG Chengjuan FAN Yashuang ZHAO Lina DU Siqi MAN Yuanyuan HU Zhengjun JIANG Tao XIN | 2022 | Clinical Cancer Bulletin2022，1，3： | 0 |
| 13 | Comparison of Central Corneal Thickness using Ultrasound Pachymetry during Corneal Collagen Cross-linking显示文摘Purpose:To study variation in central corneal thickness (CCT) during corneal collagen cross-linking(CXL) using ultrasound pachymetry. Methods:Twenty patients (26 eyes) with progressing keratoconus undergoing riboflavin-UVA-induced CXL were involved in this study. Intraoperative CCT measurement using ultrasonic pachymetry was performed during the procedure.Measurements were obtained before operation, after epithelial removal, after riboflavin drop instillation, and after UVA irradiation. Results:Mean CCT was 495±56 and 450±52 μm before and after epithelial removal, respectively. Mean CCT was 443±42 and 411±39 μm after riboflavin drop instillation and after UVA irradiation, respectively. Statistically significant decreases in CCT occurred between the preoperative period and after epithelial removal, after riboflavin drop instillation and after UVA irradiation. Twenty-six eyes from 20 patients undergoing CXL were divided into 2 groups (I with CCT≥400 μm after UVA irradiation and II with CCT<400 μm after UVA irradiation). No statistically significant difference was noted between I and II in preoperative endothelial cell count, but a statistically greater postoperative endothelial cell count was noted in I compared to II. A statistically significant difference was evident between preoperative and postoperative endothelial cell counts in Group II (P<0.05). Conclusion:Performing CXL with the use of riboflavin and UVA irradiation resulted in a statistically significant decrease in CCT, to a level where the corneal endothelium may be damaged.(Eye Science 2013; 28:15-19) | Xu Pang Xiujun Peng Zhengjun Fan Hongzhen Jia Tengfei Wu | 2013 | Eye Science2013，28，1： | 0 |
| 14 | Construction Path of Farmer Education and Training System in the Context of Rural Revitalization显示文摘It is very important to establish a farmer education and training system for the revitalization of rural talents.This paper analyzed the necessity and new requirements for the construction of a farmer education and training system in the new era.It pointed out the specific path for construction of farmer education and training system from accurately grasping the development direction of farmer education and training,accelerating the construction of a new pattern of farmer education and training,comprehensively promoting the high-quality development of farmer education and training,and actively creating a good atmosphere for farmer education and training,so as to promote the revitalization of rural talents. | Xiao FAN Wanyong PENG Zhengjun HUANG | 2021 | Asian Agricultural Research2021，13，9： | 0 |
| 15 | Multi-functional and multi-scenario applications for MXene aerogels with synergistically enhanced asymmetric modules显示文摘The development of multifunctional materials and synergistic applications of various functions are important conditions for integrated and miniaturized equipment.Here,we developed asymmetric MXene/aramid nanofibers/polyimides(AMAP)aerogels with different modules using an integrated molding process.Cleverly asymmetric modules(layered MXene/aramid nanofibers section and porous MXene/aramid nanofibers/polyimides section)interactions are beneficial for enhanced performances,resulting in low reflection electromagnetic interference(EMI)shielding(specific shielding effectiveness of 2483(dB·cm^(3))/g and a low R-value of 0.0138),high-efficiency infrared radiation(IR)stealth(ultra-low thermal conductivity of 0.045 W/(m·K)and IR emissivity of 0.32 at 3–5μm and 0.28 at 8–14μm),and excellent thermal management performances of insulated Joule heating.Furthermore,these multifunctional AMAP aerogels are suitable for various application scenarios such as personal and building protection against electromagnetic pollution and cold,as well as military equipment protection against infrared detection and EMI. | Junru Yao Jintang Zhou Feng Yang Guiyu Peng Yijie Liu Zhengjun Yao Fan Wu Haibo Zeng | 2024 | Nano Research2024，17，4： | 0 |
| 16 | A histological examination of corneal epithelium after iontophoresis with different riboflavin solutions显示文摘To the Editor:Currently,from a pathological point of view,corneal collagen crosslinking(CXL)with riboflavin is the only new therapy for controlling keratoconus progression.Riboflavin,as a photosensitizer,can be activated after the ultraviolet radiation in the cornea and prevent it from damaging intraocular organizations.Therefore,the concentration of riboflavin in the corneal stroma must be maintained at a sufficient level during the treatment.[1]Riboflavin,a type of water-soluble macromolecule,is resistant to permeating the corneal epithelial barrier.Thus,de-epithelial eye-dripping was adopted conventionally with complications such as inevitable pain,long recovery time,potential risk of infection,and so on;transepithelial corneal CXL is increasingly becoming a research hotspot.It is thus critically important to improve the transepithelial penetration of riboflavin.Although iontophoresis was reported,it had a slightly higher effect with no clear mechanism analysis.[2,3,4]Corneal epithelium is lipophilic and hydrophobic,and hydrophilic drugs enter corneal stroma via intercellular pathways.In this study,permeability effects of riboflavin in different solvents into the cornea via iontophoresis were compared,and the changes of corneal epithelial cell layer organizations were analyzed to examine the solvent components that are most beneficial to iontophoresis and investigate the underlying mechanism of the penetration effect. | Na Li Zhengjun Fan Xiujun Peng | 2022 | Chinese Medical Journal2022，，6： | 0 |
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