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| 1 | Exogenous plant MIR168a specifically targets mammalian LDLRAPI: evidence of cross-kingdom regulation by microRNA显示文摘 | Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang | 2012 | Cell Research2012，22，1： | 155 |
| 2 | Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions显示文摘 | Zhen Bian Li-Min Li Rui Tang Dong-Xia Hou Xi Chen Chen-Yu Zhang Ke Zen | 2010 | Cell Research2010，20，9： | 15 |
| 3 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 4 | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2显示文摘Mutations and transient conformational movements of the receptor binding domain(RBD)that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).To mitigate viral escape,we developed a cocktail of neutralizing antibodies(NAbs)targeting epitopes located on different domains of spike(S)protein.Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs,targeting the N-terminal domain(NTD)and RBD domain of S,effective at n M concentrations.Remarkably,a combination of RBD-targeting NAbs and NTD-binding NAbs,FC05,enhanced the neutralization potency in cell-based assays and an animal model.Results of competitive surface plasmon resonance assays and cryo-electron microscopy(cryo-EM)structures of antigen-binding fragments bound to S unveil determinants of immunogenicity.Combinations of immunogens,identified in the NTD and RBD of S,when immunized in rabbits and macaques,elicited potent protective immune responses against SARS-CoV-2.More importantly,two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge,without observable antibody-dependent enhancement of infection.These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD. | Li Zhang Lei Cao Xing-Su Gao Bin-Yang Zheng Yong-Qiang Deng Jing-Xin Li Rui Feng Qian Bian Xi-Ling Guo Nan Wang Hong-Ying Qiu Lei Wang Zhen Cui Qing Ye Geng Chen Kui-Kui Lu Yin Chen Yu-Tao Chen Hong-Xing Pan Jiaping Yu Wenrong Yao Bao-Li Zhu Jianping Chen Yong Liu Cheng-Feng Qin Xiangxi Wang Feng-Cai Zhu | 2021 | National Science Review2021，8，8： | 4 |
| 5 | Experiment Study of the Evolution of Coral Sand Particle Clouds in Water显示文摘The motion of particle clouds(i.e.,sediment clouds)usually can be found in engineering applications such as wastewater discharge,land reclamation,and marine bed capping.In this paper,a series of laboratory tests are conducted on coral sand to investigate the shape feature of the single particle and the mixing processes of the coral sand particle clouds.The shape of coral sand particle is measured and quantified.The experimental results demonstrate that the shape of coral sand particles tends to be spherical as the particle size decreases,and empirical equations were established to explain the variation of D50 and fS,50 of coral sand.Compared with the silica sand,the evolution of the coral sand particle cloud still experiences three stages,but the threshold for the Reynolds number of particle clouds entering the next stage changes.Further,the normalized axial distance of the coral sand particle clouds is 58%smaller.The frontal velocity exhibits similar varying tendency for the coral sand particle cloud.Considering the difference in shape between coral sand particles and silica sand particles,a semi-empirical formula was proposed based on the original silica sand prediction formula by adding the shape factor and the experimental data of 122μm≤D_(50)≤842μm.It can predict the frontal velocity of the coral sand particle clouds. | CHEN Jie YAO Zhen JIANG Chang-bo WU Zhi-yuan DENG Bin LONG Yuan-nan BIAN Cheng | 2022 | China Ocean Engineering2022，36，5： | 2 |
| 6 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 2 |
| 7 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 1 |
| 8 | Photoluminescence properties of Ce3 + and Mn2 + -activated Ba9 SO2 Si60t phosphor for white light e- mitting diodes显示文摘 | Bian Liu Wang Ting Song Zhen | 2013 | Chin Phys B2013，22，07： | 1 |
| 9 | Comparison of serum human epididymis protein 4 and carbohydrate antigen 125 as markers in ovarian cancer: A meta-analysis 显示文摘 | Zhen S Bian LH Chang LL | 2014 | Mol Clin 0ncol2014，2，4： | 1 |
| 10 | Comparison of serum human epididymis protein 4 and carbohydrate antigen125 as markers in ovarian cancer: A meta?analysis显示文摘 | Shuai Zhen Li?Hong Bian Li?Li Chang Xin Gao | 2014 | Molecular and Clinical Oncology2014，，： | 1 |
| 11 | Steroid receptor coactivator-1:The central intermediator linking multiple signals and functions in the brain and spinal cord显示文摘The effects of steroid hormones are believed to be mediated by their nuclear receptors(NRs).The p160 coactivator family,including steroid receptor coactivator-1(SRC-1),2 and 3,has been shown to physically interact with NRs to enhance their transactivational activities.Among which SRC-1 has been predominantly localized in the central nervous system including brain and spinal cord.It is not only localized in neurons but also detectable in neuroglial cells(mainly localized in the nuclei but also detectable in the extra-nuclear components).Although the expression of SRC-1 is regulated by many steroids,it is also regulated by some non-steroidal factors such as injury,sound and light.Functionally,SRC-1 has been implied in normal function such as development and ageing,learning and memory,central regulation on reproductive behaviors,motor and food intake.Pathologically,SRC-1 may play a role in the regulation of neuropsychiatric disorders(including stress,depression,anxiety,and autism spectrum disorder),metabolite homeostasis and obesity as well as tumorigenesis.Under most conditions,the related mechanisms are far from elucidation;although it may regulate spatial memory through Rictor/mTORC2-actin polymerization related synaptic plasticity.Several inhibitors and stimulator of SRC-1 have shown anti-cancer potentials,but whether these small molecules could be used to modulate ageing and central disorder related neuropathology remain unclear.Therefore,to elucidate when and how SRC-1 is turned on and off under different stimuli is very interesting and great challenge for neuroscientists. | Zhaoyou Meng Xiaoya Wang Dongmei Zhang Zhen Lan Xiaoxia Cai Chen Bian Jiqiang Zhang | 2022 | Genes & Diseases2022，9，5： | 1 |
| 12 | Glutathione S-transferase polymorphism interactions with smoking status and HPV infection in cervical cancer risk:an evidence-based meta-analysis显示文摘 | Zhen S Hu C M Bian L H | 2013 | Plo S one2013，8，83： | 1 |
| 13 | A Robust Reserve Scheduling Method Considering Asymmetrical Wind Power Distribution显示文摘Nowadays, limited predictability and controllability of wind power are regarded as some bottlenecks to wind generation integration with the power system. This paper introduces a robust reserve scheduling method, where the spinning reserve allocation among conventional units is considered as well.The method applies to asymmetrical wind power distribution,and offers control on the degree of solution's conservatism by changing the robustness budget. Meanwhile, distributional information of wind power is represented by mean value and asymmetrical bounds. Furthermore, the model is converted into a deterministic programming problem with dual theory. Case studies for asymmetrically distributed wind power illustrate its effectiveness. | Guanzhong Wang Qiaoyan Bian Huanhai Xin Zhen Wang | 2018 | IEEE/CAA Journal of Automatica Sinica2018，5，5： | 1 |
| 14 | Characteristics of the Middle-Late Triassic sedimentary facies assemblages in the Songpan-Ruoergai area显示文摘在 Songpan-Ruoergai 区域的中间迟了的三叠纪的沉积岩石主要由石灰质的淤泥石头,泥泞石灰石,锂的 arkose,长石的 litharenite,泥石头, wormkslk, oolithic 石灰石,和 conglcrnerate 组成。除了空闲地增加东方纵和绿色的石灰石床,沙岩的石灰质的部件显然增加。丰富的 benthic 和植物石块和他们的 clasts 发生薄这些岩石。沉积 stnjctures 主要包含 flaser,平行,平坦,起浪,并且鲱鱼骨头十字床上用品。这些数据 coevsJly 暗示中间迟了的三叠纪的沉积扔了在河,湖和潮环境。另外,岩石显示分级的、平行、圆丘般的床上用品,和沙的迭合,暴风雨存款的一个特征特征。 | YAN Zhen YU Liangjun LI Jiliang BIAN Qiantao WANG Zongqi YANG Yongcheng | 2007 | Progress in Natural Science:Materials International2007，17，3： | 1 |
| 15 | Solid solubility and photoluminescence of Y3Al5O12:Ce3= prepared by using (Y1? x Ce x )2O3 as precursor显示文摘 | Liu Si-Jia Peng Tong-Jiang Song Zhen Bian Liu Song Gong-Bao Liu Quan-Lin | 2014 | Chinese Physics B2014，，4： | 1 |
| 16 | AgPdCo hollow nanospheres electrocatalyst with high activity and stability toward the formate electrooxidation显示文摘The widespread commercial application of direct formate fuel cell(DFFC)is limited by the lack of efficient electrocatalysts for the formate oxidation reaction(FOR).AgPdCo hollow nanospheres(H-NSs)with jagged surfaces are successfully synthesized via a facile method involving the wet-chemical synthesis of AgPdCo nanospheres(NSs)and galvanic replacement reaction between Pd salt and AgPdCo NSs.Surpassing Ag_(30)Pd_(69)Co_(1) NSs and most of previously reported electrocatalysts,Ag_(9)Pd_(90)Co_(1) H-NSs exhibit extremely high FOR activity with a peak current density of 3.08 A·mg_(Pd)^(−1).Apart from the competitive activity,Ag_(9)Pd_(90)Co_(1) H-NSs show greatly improved chronoamperometric and cycling stability,whereby the current density retains about 0.24 A·mg_(Pd)^(−1) after 3,600 s electrocatalysis and the mass activity maintains 54.06%of the initial value after 500 cycles.The unique hollow nanosphere and synergistic effect are responsible for the enhanced activity and stability.This study will provide new clues for the development of outstanding electrocatalysts. | Qiao Wang Fuyi Chen Quan Tang Longfei Guo Tao Jin Bowei Pan Junpeng Wang Zhen Li Bo Kou Weiqi Bian | 2021 | Nano Research2021，14，7： | 1 |
| 17 | In-depth research of multidrug resistance related cell surface glycoproteome in gastric cancer显示文摘 | Kai Li Zhen Sun Jianyong Zheng Yuanyuan Lu Yangyang Bian Mingliang Ye Xin Wang Yongzhan Nie Hanfa Zou Daiming Fan | 2013 | Journal of Proteomics2013，，： | 1 |
| 18 | TiO2 nanotube array film prepared by anodization as anode material for lithium ion batteries显示文摘 | Zhen Wei Zheng Liu Rongrong Jiang Chaoqing Bian Tao Huang Aishui Yu | | Journal of Solid State Electrochemistry0，，： | 1 |
| 19 | TiO2 nanotube array film prepared by anodization as anode material for lithium ion batteries显示文摘 | Zhen Wei Zheng Liu Rongrong Jiang Chaoqing Bian Tao Huang Aishui Yu | 2010 | Journal of Solid State Electrochemistry2010，，6： | 1 |
| 20 | Comparison of serum human epididymis protein 4 and carbohydrate antigen 125 as markers in ovarian cancer:A meta-analysis显示文摘 | Zhen S Bian LH Chang LL | 2014 | Mol Clin Oncol2014，2，4： | 1 |
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