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| 1 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 2 | Miscibility behavior of ethylene/vinyl acetate and C5 petroleum resin by FTIR imaging显示文摘 | ZHOU X ZHANGP D LI Z F | 2007 | Analytical Sciences2007，23，7： | 1 |
| 3 | The analysis and dissimilarity comparison of community structure 显示文摘 | ZhangP Li M H Wu J S | 2006 | Physica A-Statistical Mechanics and Its Applications2006，367，： | 1 |
| 4 | The innovations in China’s primary health care reform: Development and characteristics of the community health services in Hangzhou显示文摘Objective:This study focuses on Hangzhou,a Chinese city with a population of nine million urban and rural residents,to examine the successful development and innovation experience of its primary health care service system during the new health reform in China since 2009 and then dis-seminate the findings through international third parties.Methods:Measures such as data analysis,study of documents and regulations,fieldwork,and expert discussions were used to systematically investigate primary health care in Hangzhou.The findings will have a profound practical impact on the health reform for nine million rural and urban residents throughout Hangzhou’s municipal boroughs.Results:Community health services in Hangzhou are characterized as follows:They are gov-ernment led;they are guaranteed with enough financing,personnel,facilities,and regulation;sup-ported by the unified information platform;general practitioners have been assigned the key role of health‘gatekeepers’;they provide primary care combined with basic public health services;there are integrated urban and rural health services and insurance coverage;and there is health care-pen-sion-nursing integration and general practitioner-contracted‘smart’services.Preliminary data collection and analysis indicate that the basic health status of Hangzhou residents is superior to that of residents of China as a whole,and some health indicators in Hangzhou are comparable to those in Western developed countries.Conclusion:It is reasonable to believe that the primary health care level in China,including Hangzhou,will be further developed and promoted with indexed performance evaluations and more effective implementation of additional measures. | Feng Lin Qihong Sun Zhangping Peng Jun Cai Philip Geanacopoulos Lin Li Yun Zhao Xin Zhang Xiaoxiao Chen | 2015 | Family Medicine and Community Health2015，3，3： | 1 |
| 5 | Existence of positive periodic solutions to nonlinear second order differntial equations显示文摘 | Li Fuyi Liang Zhangping | 2005 | Appl Math Lett2005，18，11： | 1 |
| 6 | Identification of MAM1s in Regulation of 3C Glucosinolates Accumulation in Allopolyploid Brassica juncea显示文摘Allopolyploid Brassica juncea is particularly enriched in sinigrin,a kind of 3C aliphatic glucosinolates(GSLs),giving rise to characteristic taste after picking.However,the molecular mechanism underlying 3C aliphatic GSLs biosynthesis in this species remains unknown.In this study,we genome-widely identified GSLs metabolic genes,indicating different evolutionary rate of GSLs metabolic genes between subgenomes of B.juncea.Eight methythioalkylmalate synthase(MAMs)homologs were identified from B.juncea,in which six MAM1s were located in chloroplast and the other two were not detected with any expression.Furthermore,BjMAM1-4,BjMAM1-5,and BjMAM1-6 displayed higher expression levels in leaves than other tissues.Silenced expression analysis revealed that BjMAM1-4 and BjMAM1-6 function in 3C and 4C aliphatic GSLs accumulation.The specificity of the substrate selection for the second cycle reaction is much lower than that of the first cycle,suggesting these genes may preferentially catalyze 3C aliphatic GSLs biosynthesis.Our study provides insights into the molecular mechanism underlying the accumulation of 3C aliphatic GSLs,thereby facilitating the manipulation of aliphatic GSLs content in B.juncea. | Zhangping Li Changtong Zhang Qingze Cai Yulan Zhou Zhongyuan Hu Mingfang Zhang Jinghua Yang | 2020 | Horticultural Plant Journal2020，6，6： | 0 |
| 7 | When Will the New Campaign to Invest in China Come?显示文摘Foreign investment has played a more and more important role in promoting the economic development in China. But a full decline in foreign-capital attraction appeared for the first time in 1999. Experts predict that foreign investment in China has not fallen to the lowest point. | Li Zhangping Ma Yu | 2000 | China's Foreign Trade2000，，3： | 0 |
| 8 | Research Progress on Toxicity of Natural Compounds显示文摘There are many active substances in natural resources.After years of research,researchers at home and abroad have extracted active compounds and proved that these compounds have low toxicity and high efficiency,but the toxicity of these compounds cannot be ignored.In this paper,the research progress on the toxicity of compounds isolated from various natural substances is reviewed,which provides a reference for the further development and rational utilization of natural compounds. | Zhangping Zhou Zilong Fu Yan Li Biao Ren Ling Duan Song Teng Zhuoxuan Liang | 2021 | Proceedings of Anticancer Research2021，5，2： | 0 |
| 9 | Three Cases Infected with Avian Influenza A(H5N6)Virus-Chongqing Municipality,China,January-September,2021显示文摘Summary What is already known about this topic?The World Health Organization(WHO)has reported a total of 48 cases by October 15,2021.The continuous genomic reassortments of H5N6 and other subtype avian influenza viruses(AIVs)pose a long-term threat to public health and the poultry industry.What is added by this report?Three new cases of H5N6 that occurred from January to September 2021 in Chongqing Municipality,China were reported in this study.Epidemiological information of the three cases showed raising poultry and visiting live poultry market contributed to these infections,and there was no evidence of human-to-human transmission of H5N6 currently but a potential spatial cluster.An increase of H5N6 cases was recorded in the area.What are the implications for public health practice?In case of unexplained pneumonia or severe respiratory infection,the patients’epidemiological history of contact with poultry or live poultry markets(LPMs)may be an important interrogation to help diagnose.Extensive and long-term surveillance of avian influenza viruses in LPMs is essential. | Kun Su Zhen Yu Yu Lan Ju Wang Shuang Chen Li Qi Yaokai Chen Yun Tang Yu Xiong Zhangping Tan Mingyue Wang Sheng Ye Dayan Wang Hua Ling William JLiu Xiaoni Zhong Qin Li Wenge Tang | 2022 | China CDC weekly2022，4，1： | 0 |
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