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| 1 | 863 genomes reveal the origin and domestication of chicken显示文摘Despite the substantial role that chickens have played in human societies across the world,both the geographic and temporal origins of their domestication remain controversial.To address this issue,we analyzed 863 genomes from a worldwide sampling of chickens and representatives of all four species of wild jungle fowl and each of the five subspecies of red jungle fowl(RJF).Our study suggests that domestic chickens were initially derived from the RJF subspecies Gallus gallus spadiceus whose present-day distribution is predominantly in southwestern China,northern Thailand and Myanmar.Following their domestication,chickens were translocated across Southeast and South Asia where they interbred locally with both RJF subspecies and other jungle fowl species.In addition,our results show that the White Leghorn chicken breed possesses a mosaic of divergent ancestries inherited from other subspecies of RJF.Despite the strong episodic gene flow from geographically divergent lineages of jungle fowls,our analyses show that domestic chickens undergo genetic adaptations that underlie their unique behavioral,morphological and reproductive traits.Our study provides novel insights into the evolutionary history of domestic chickens and a valuable resource to facilitate ongoing genetic and functional investigations of the world's most numerous domestic animal. | Ming-Shan Wang Mukesh Thakur Min-Sheng Peng Yu Jiang Laurent Alain Francois Frantz Ming Li Jin-Jin Zhang Sheng Wang Joris Peters Newton Otieno Otecko Chatmongkon Suwannapoom Xing Guo Zhu-Qing Zheng Ali Esmailizadeh Nalini Yasoda Hirimuthugoda Hidayat Ashari Sri Suladari Moch Syamsul Arifin Zein Szilvia Kusza Saeed Sohrabi Hamed Kharrati-Koopaee Quan-Kuan Shen Lin Zeng Min-Min Yang Ya-Jiang Wu Xing-Yan Yang Xue-Mei Lu Xin-Zheng Jia Qing-Hua Nie Susan Joy Lamont Emiliano Lasagna Simone Ceccobelli Humpita Gamaralalage Thilini Nisanka Gunwardana Thilina Madusanka Senasige Shao-Hong Feng Jing-Fang Si Hao Zhang Jie-Qiong Jin Ming-Li Li Yan-Hu Liu Hong-Man Chen Cheng Ma Shan-Shan Dai Abul Kashem Fazlul Haque Bhuiyan Muhammad Sajjad Khan Gamamada Liyanage Lalanie Pradeepa Silva Thi-Thuy Le Okeyo Ally Mwai Mohamed Nawaz Mohamed Ibrahim Megan Supple Beth Shapiro Olivier Hanotte Guojie Zhang Greger Larson Jian-Lin Han Dong-Dong Wu Ya-Ping Zhang | 2020 | Cell Research2020，30，8： | 7 |
| 2 | The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis显示文摘 | Mustafa S. Ascha Ibrahim A. Hanouneh Rocio Lopez Tarek Abu‐Rajab Tamimi Ariel F. Feldstein Nizar N. Zein | 2010 | Hepatology2010，，6： | 4 |
| 3 | Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension显示文摘AIM: To study the small bowel (SB) mucosa on biopsy in cirrhotic patients with portal hypertension and in non-cirrhotic controls and grade fi ndings according to the Marsh criteria. METHODS: We prospectively enrolled 51 consecutive patients undergoing an upper endoscopy for their routine medical care. Twenty f ive patients with cirrhosis and portal hypertension were compared to 26 controls. We obtained coeliac serology and multiple upper small bowel biopsies on all 51 patients. A GI pathologist interpreted biopsies and graded fi ndings according to the Marsh criteria. We assessed equivalence in Marsh grade between cirrhotic and non-cirrhotic controls using the Mann-Whitney test for equivalence. RESULTS: Gender, ethnicity and age were similar between both groups. Marsh grades were equivalent between the groups. Grade of 0 was present in 96% and grade of 1 was present in 4% of both groups and there was no villus atrophy or decrease in villus/crypt ratio in patients with portal hypertension. CONCLUSION: This study provides evidence for the lack of villus atrophy in patients with cirrhosis and portal hypertension, and supports the continuous reliance on the Marsh criteria when the diagnosis of coeliac disease is to be made in the presence of cirrhosis. | Jamilé Wakim-Fleming Nizar N Zein Ana Bennett Rocio Lopez Janice Santisi William D Carey | 2008 | World Journal of Gastroenterology2008，14，41： | 4 |
| 4 | Alpha-1 antitrypsin deficiency and the risk of hepatocellular carcinoma in end-stage liver disease显示文摘AIM:To evaluate the association between alpha-1 antitrypsin deficiency(A1ATD) and hepatocellular carcinoma(HCC) in patients with end-stage liver disease(ESLD).METHODS:Patients with cirrhosis and ESLD referred to the Cleveland Clinic Foundation for liver transplantation between 2003 and 2014 were included in the study(N = 675). ESLD was defined as having histological features of cirrhosis and/or radiological evidence of cirrhosis in the context of portal hypertension(ascites,variceal bleeding,thrombocytopenia,or hepatic encephalopathy). A1 ATD was diagnosed using phenotype characterization(MZ or ZZ),liver biopsy detection of PAS-positive diastaseresistant(PAS+) globules,or both. Patients with other causes of liver diseases such as hepatitis C virus(HCV),alcoholic liver disease and non-alcoholic steatohepatitis(NASH) or NASH were also included in the study. HCC was diagnosed by using imaging modalities,biopsy findings,or explanted liver inspection. Follow-up time was defined as the number of years from the diagnosis of cirrhosis to the diagnosis of hepatocellular carcinoma,or from the diagnosis of cirrhosis to the last follow up visit. The rate of HCC was assessed using time-tointerval analysis for interval censored data.RESULTS:This study included 675 patients. 7% of subjects had A1ATD(n = 47). Out of all subjects who did not have A1 ATD,46% had HCV,17% had alcoholic liver disease,19% had NASH and 18% had another primary diagnosis. Of the 47 subjects with A1 ATD,15 had a primary diagnosis of A1ATD(PI*ZZ phenotype and PAS+ globules),8 had a PI*MZ phenotype alone,14 had PAS+ alone,and 10 had both the PI*MZ phenotype and PAS+. Median follow-up time was 3.4(25th,75 th percentiles:1,5.2) years. The overall rate of hepatocellular carcinoma in all subjects was 29%(n = 199). In the A1 ATD group,the incidence rate of HCC was 8.5% compared to 31% in the group of patients with other causes of cirrhosis(P = 0.001). Patients with ESLD due to A1 ATD had the lowest yearly cumulative rate of hepatocellular carcinoma at 0.88% per year compared to 2.7% for those with HCV cirrhosis,1.5% in patients with NASH and 0.9% in alcohol-induced liver disease(P < 0.001).CONCLUSION:Within this group of patients with ESLD,there was no significant association between A1 ATD and increased risk of HCC. | Clara Antoury Rocio Lopez Nizar Zein James K Stoller Naim Alkhouri | 2015 | World Journal of Hepatology2015，7，10： | 3 |
| 5 | Electroplating of mild steel by aluminium in a first generation ionic liquid: A green alternative to commercial Al-plating in organic solvents显示文摘 | Q.X. Liu S. Zein El Abedin F. Endres | 2006 | Surface & Coatings Technology2006，，3： | 3 |
| 6 | Production of High Purity Multi-Walled Carbon Nanotubes from Catalytic Decomposition of Methane显示文摘当催化剂被描述,与 NiO/TiO2 经由甲烷的催化分解生产的多围的碳 nanotubes (MWNT ) 的 Acid-based 纯化过程。由在空和酸倒流中联合氧化,杂质例如非结晶的碳,碳 nanoparticles,和 NiO/TiO2 催化剂,被消除。扫描电子显微检查法(SEM ) 和传播电子显微检查法(TEM ) 想象证实杂质的移动。碳 nanotubes 纯净的百分比用热 gravimetric (TGA ) 被分析。用这个过程, MWNT 的 99.9 wt% 纯净被获得。给词调音:多围的碳 nanotubes;纯化;酸倒流;氧化;甲烷; | Kong Bee Hong Aidawati Azlin Binti Ismail Mohamed Ezzaham Bin Mohd Mahayuddin Abdul Rahman Mohamed Sharif Hussein Sharif Zein | 2006 | Journal of Natural Gas Chemistry2006，15，4： | 3 |
| 7 | CO_x-Free Hydrogen and Carbon Nanofibers Produced from Direct Decomposition of Methane on Nickel-Based Catalysts显示文摘甲烷的直接分解在 700 点用一个改正床反应堆被执行 ?? 为没有艇长的氢和碳 nanofibers 的生产的 6 号元素碳的化学符号。NiO-M/SiO2 催化剂的催化表演(在哪儿 M=AgO,咕咕叫, CuO, FeO, MnOx 和哞) 在甲烷,分解被调查。试验性的结果显示在测试催化剂之中, NiO/SiO2 与 CuO 支持了给最高的氢收益。另外,包括 Al2O3, CeO2, La2O3, SiO2,和 TiO2,最合适的催化剂载体的考试证明在 NiO-CuO 上的甲烷的分解赞成 SiO2 支持。而且,到对甲烷分解的 SiO2 支持上的 CuO 的 NiO 的最佳比率是坚定的。自从氢的高产率在这催化剂上被获得,试验性的结果证明到 CuO 的 NiO 的最佳重量比率在 8:2 (w/w ) 掉落了。给词调音:甲烷分解;氢;碳 nanofibers; | Siang-Piao Chai Sharif Hussein Sharif Zein Abdul Rahman Mohamed | 2006 | Journal of Natural Gas Chemistry2006，15，4： | 2 |
| 8 | The Role of Rifaximin in the Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis显示文摘 | Mohamad A. Hanouneh Ibrahim A. Hanouneh Jana G. Hashash Ryan Law Jamak Modaresi Esfeh Rocio Lopez Nyla Hazratjee Thomas Smith Nizar N. Zein | 2012 | Journal of Clinical Gastroenterology2012，，8： | 2 |
| 9 | Mn/Ni/TiO_2 Catalyst for the Production of Hydrogen and Carbon Nanotubes from Methane Decomposition显示文摘 | Zein S H S Mohamed A R | | 0，，： | 2 |
| 10 | Electrodeposition of aluminium from 1-butyl-1-methylpyrrolidinium chloride/AlCl 3 and mixtures with 1-ethyl-3-methylimidazolium chloride/AlCl 3显示文摘 | P. Giridhar S. Zein El Abedin F. Endres | 2012 | Electrochimica Acta2012，，： | 2 |
| 11 | Polymorphisms in the interleukin-10, tumor necrosis factor-α, and transforming growth factor-β1 genes in chronic hepatitis C patients treated with interferon and ribavirin显示文摘 | Pedro G Vidigal Jeffrey J Germer Nizar N Zein | 2002 | Journal of Hepatology2002，，2： | 2 |
| 12 | The Inflamed Liver and Atherosclerosis: A Link Between Histologic Severity of Nonalcoholic Fatty Liver Disease and Increased Cardiovascular Risk显示文摘 | Naim Alkhouri Tarek Abu-Rajab Tamimi Lisa Yerian Rocio Lopez Nizar N. Zein Ariel E. Feldstein | 2010 | Digestive Diseases and Sciences2010，，9： | 2 |
| 13 | Electrodeposition of nanoscale silicon in a room temperature ionic liquid显示文摘 | S. Zein El Abedin N. Borissenko F. Endres | 2004 | Electrochemistry Communications2004，，5： | 2 |
| 14 | A Comparative Evaluation of EUS-Guided Biliary Drainage and Percutaneous Drainage in Patients with Distal Malignant Biliary Obstruction and Failed ERCP显示文摘 | Mouen A. Khashab Ali Kord Valeshabad Elham Afghani Vikesh K. Singh Vivek Kumbhari Ahmed Messallam Payal Saxena Mohamad El Zein Anne Marie Lennon Marcia Irene Canto Anthony N. Kalloo | 2015 | Digestive Diseases and Sciences2015，，2： | 2 |
| 15 | A pilot trial of pentoxifylline in nonalcoholic steatohepatitis 显示文摘 | Adams LA Zein CO Angulo P | 2004 | Am J Gastroenterol2004，99，12： | 1 |
| 16 | Electrodeposition of aluminium from 1-butyl-1-methylpyrrolidinium chloride/AlCl 3 and mixtures with 1-ethyl-3-methylimidazolium chloride/AlCl 3显示文摘 | P. Giridhar S. Zein El Abedin F. Endres | 2012 | Electrochimica Acta2012，，： | 1 |
| 17 | Hepatitis C virus genotypes in the United State : epidemiology, pathogeneicity, and response to interferon therapy显示文摘 | Zein NN Rakela J Krawitt EL | 1996 | Ann Intern Med1996，125，： | 1 |
| 18 | Electrodeposition of nanocrystalline aluminium from a chloroaluminate ionic liquid显示文摘 | S. Zein El Abedin P. Giridhar P. Schwab F. Endres | 2010 | Electrochemistry Communications2010，，8： | 1 |
| 19 | Fused dep- osition modeling of novel scaffold architectures for tissue engi- neering applieations 显示文摘 | ZEIN I HUTMACHER D W TAN K C | 2002 | Biomaterials2002，23，4： | 1 |
| 20 | Body mass index, lifetime smoking intensity and lung cancer risk显示文摘 | Mariam El‐Zein Marie‐Elise Parent Belinda Nicolau Anita Koushik Jack Siemiatycki Marie‐Claude Rousseau | 2013 | Int. J. Cancer2013，，7： | 1 |
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