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| 1 | Efficacy, risk factors and complications of endoscopic polypectomy: Ten year experience at a single center显示文摘AIM: To examine the efficacy and complications of colonoscopic resection of colorectal polypoid lesions. METHODS: We retrospectively reviewed 1354 polypectomies performed on 1038 patients over a ten- year period. One hundred and sixty of these were performed for large polyps, those measuring ≥ 20 mm. Size, shape, location, histology, the technique of polypectomy used, complications, drugs assumption and associated intestinal or extra intestinal diseases were analyzed. For statistical analysis, the Pearson χ2 test, NPC test and a Binary Logistic Regression were used. RESULTS: The mean patient age was 65.9 ± 12.4 years, with 671 men and 367 women. The mean size of polyps removed was 9.45 ± 9.56 mm while the size of large polyps was 31.5 ± 10.8 mm. There were 388 pedunculated and 966 sessile polyps and the most common location was the sigmoid colon (41.3%). The most frequent histology was tubular adenoma (55.9%) while for the large polyps was villous (92/160 -57.5%). Coexistent malignancy was observed in 28 polyps (2.1%) and of these, 20 were large polyps. There were 17 procedural bleeding (1.3%) and one perforation. The statistical analysis showed that cancer is correlated to polyp size (P < 0.0001); sessile shape (P < 0.0001) and bleeding are correlated to cardiac disease (P = 0.034), tubular adenoma (P = 0.016) and polyp size.CONCLUSION: The endoscopic resection is a simple and safe procedure for removing colon rectal neoplastic lesions and should be considered the treatment of choice for large colorectal polyps. The polyp size is an important risk factor for malignancy and for bleeding. | Pierluigi Consolo Carmelo Luigiano Giuseppe Strangio Maria Grazia Scaffidi Giuseppa Giacobbe Giovanna Di Giuseppe Agata Zirilli Luigi Familiari | 2008 | World Journal of Gastroenterology2008，14，15： | 33 |
| 2 | Estrogens in males: what have we learned in the last 10 years?显示文摘This review focuses on the role of estrogen in men, mainly in male reproduction. The continuing increase in data obtained, and recent discoveries in this area will enable a better understanding of male physiology; these, in turn, will have important clinical implications. | Vincenzo Rochira Antonio R. M. Granata Bruno Madeo Lucia Zirilli Giuseppina Rossi Cesare Carani | 2005 | Asian Journal of Andrology2005，7，1： | 15 |
| 3 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 4 | A numerical method to price exotic path-dependent options on an underlying described by the Heston stochastic volatility model显示文摘 | BALLESTRA L V PACELLI G ZIRILLI F | 2007 | Journal of Banking & Finance2007，31，： | 1 |
| 5 | At the end of a two-year follow-up elevated TSH levels normalize or remain unchanged in most the children with subclinical hypothyroidism 显示文摘 | De Luca F Wasniewska M Zirilli G | 2010 | Ital J Pediatr2010，36，： | 1 |
| 6 | A novel compound heterozygous mutation of the aromatize gene in an adult man: reinforced evi- dence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome显示文摘 | Maffei L Roehira V Zirilli L | 2007 | Clin Endocrinal (Oxt)2007，67，2： | 1 |
| 7 | The fusion of different resolution SAR image显示文摘 | Costantiti M Farina A Zirilli F | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
| 8 | Compter-aided Instruction in Wave Propagation Phenomena显示文摘 | Pallini Luca Piroli Sabina Stacchio Luca Zirilli Francesco | 1998 | Engineering Science and Education Journal1998，7，5： | 1 |
| 9 | The fusion of different resolution SAR image显示文摘 | COSTANTITI M FARINA A ZIRILLI E | | 0，，1： | 1 |
| 10 | Estrogen resistance and aromamse deficiency in humans显示文摘 | Carani C Fabbi M Zirilli L | 2002 | J Soc Biol2002，196，3： | 1 |
| 11 | The fusion of different resolution SAR images显示文摘 | COSTANTINI M FARINA A ZIRILLI F | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
| 12 | A novel compound heterozygous mutation of the aromatase gene in an adult man: reinforced evidence on the relationship between congenital oestrogen deficiency, adiposity and the metabolic syndrome 显示文摘 | Maffei L Rochira V Zirilli L | 2007 | Clin Endocrinol2007，67，2： | 1 |
| 13 | The fusion of different resolution SAR image显示文摘 | FARINA A ZIRILLI F | 1997 | Proeeding of the IEEE1997，85，1： | 1 |
| 14 | The use of wavelets in the operator expansion method for time-dependent acous- tic obstacle scattering显示文摘 | Recchioni M C Zirilli F | 2004 | SIAM Journal on Scientific Computing2004，25，4： | 1 |
| 15 | The fusion of different resolution SAR images显示文摘 | Costantini M Farina A Zirilli F | 1997 | Proceedings of the IEEE1997，85，1： | 1 |
| 16 | A novel mutation in the human aromatase gene: insights on the relationship among serum estradiol, longitudinal growth and bone mineral density in an adult man under estrogen replacement treatment 显示文摘 | Lanfranco F Zirilli L Baldi M | 2008 | Bone2008，43，： | 1 |
| 17 | Intelligent ship autopilots-A historical perspective显示文摘 | Roberts G N Sutton R Zirilli A | 2003 | Mechatronics2003，13，： | 1 |
| 18 | Human models of aromatase deficiency显示文摘 | Zirilli L Rochira V Diazzi C | 2008 | J Steroid Biochem Mol Biol2008，109，35： | 1 |
| 19 | Global optimization and stochastic differential equations显示文摘 | ALUFFI-PENTINI F PARISI V ZIRILLI F | 1985 | Journal of Optimization Theory and Applications1985，47，1： | 1 |
| 20 | A novel mutation in the human aromatase gene: insights on the relationship among serum estradiol,longitudinal growth and bone mineral density in an adult man under estrogen replacement treatment显示文摘 | Lanfranco F Zirilli L Baldi M | 2008 | Bone2008，43，3： | 1 |
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