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| 1 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 2 | Compter-aided Instruction in Wave Propagation Phenomena显示文摘 | Pallini Luca Piroli Sabina Stacchio Luca Zirilli Francesco | 1998 | Engineering Science and Education Journal1998，7，5： | 1 |
| 3 | High Performance Algorithms Based on a New Wavelet Expansion for Time Dependent Acoustic Obstacle Scattering显示文摘This paper presents a highly parallelizable numerical method to solve time dependent acoustic obstacle scattering problems.The method proposed is a generalization of the“operator expansion method”developed by Recchioni and Zirilli[SIAM J.Sci.Comput.,25(2003),1158-1186].The numerical method proposed reduces,via a perturbative approach,the solution of the scattering problem to the solution of a sequence of systems of first kind integral equations.The numerical solution of these systems of integral equations is challenging when scattering problems involving realistic obstacles and small wavelengths are solved.A computational method has been developed to solve these challenging problems with affordable computing resources.To this aim a new way of using the wavelet transform and new bases of wavelets are introduced,and a version of the operator expansion method is developed that constructs directly element by element in a fully parallelizable way.Several numerical experiments involving realistic obstacles and“small”wavelengths are proposed and high dimensional vector spaces are used in the numerical experiments.To evaluate the performance of the proposed algorithm on parallel computing facilities,appropriate speed up factors are introduced and evaluated. | Lorella Fatone Giuseppe Rao Maria Cristina Recchioni Francesco Zirilli | 2007 | Communications in Computational Physics2007，2，6： | 0 |
| 4 | Acoustic Scattering Cross Sections of Smart Obstacles: A Case Study显示文摘Acoustic scattering cross sections of smart furtive obstacles are studied and discussed.A smart furtive obstacle is an obstacle that,when hit by an incoming field,avoids detection through the use of a pressure current acting on its boundary.A highly parallelizable algorithm for computing the acoustic scattering cross section of smart obstacles is developed.As a case study,this algorithm is applied to the(acoustic)scattering cross section of a'smart'(furtive)simplified version of the NASA space shuttle when hit by incoming time-harmonic plane waves,the wavelengths of which are small compared to the characteristic dimensions of the shuttle.The solution to this numerically challenging scattering problem requires the solution of systems of linear equations with many unknowns and equations.Due to the sparsity of these systems of equations,they can be stored and solved using affordable computing resources.A cross section analysis of the simplified NASA space shuttle highlights three findings:i)the smart furtive obstacle reduces the magnitude of its cross section compared to the cross section of a corresponding'passive'obstacle;ii)several wave propagation directions fail to satisfactorily respond to the smart strategy of the obstacle;iii)satisfactory furtive effects along all directions may only be obtained by using a pressure current of considerable magnitude.Numerical experiments and virtual reality applications can be found at the website:http://gffzzec7daba562864d4eh50cnov959fuf6wv0.ffgz.tsg.suse.edu.cn/ceri/zirilli/w7. | Lorella Fatone Maria Cristina Recchioni Francesco Zirilli | 2011 | Communications in Computational Physics2011，10，8： | 0 |
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