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| 1 | Interaction-Aware Cut-In Trajectory Prediction and Risk Assessment in Mixed Traffic显示文摘Accurately predicting the trajectories of surrounding vehicles and assessing the collision risks are essential to avoid side and rear-end collisions caused by cut-in.To improve the safety of autonomous vehicles in the mixed traffic,this study proposes a cut-in prediction and risk assessment method with considering the interactions of multiple traffic participants.The integration of the support vector machine and Gaussian mixture model(SVM-GMM)is developed to simultaneously predict cut-in behavior and trajectory.The dimension of the input features is reduced through Chebyshev fitting to improve the training efficiency as well as the online inference performance.Based on the predicted trajectory of the cut-in vehicle and the responsive actions of the autonomous vehicles,two risk measurements are introduced to formulate the comprehensive interaction risk through the combination of Sigmoid function and Softmax function.Finally,the comparative analysis is performed to validate the proposed method using the naturalistic driving data.The results show that the proposed method can predict the trajectory with higher precision and effectively evaluate the risk level of a cut-in maneuver compared to the methods without considering interaction. | Xianglei Zhu Wen Hu Zejian Deng Jinwei Zhang Fengqing Hu Rui Zhou Keqiu Li Fei-Yue Wang | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，10： | 2 |
| 2 | Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence显示文摘 | Yang Wang Wei Zhang Zongfu Wu Xianglei Zhu Chengping Lu | 2011 | Veterinary Microbiology2011，，1： | 1 |
| 3 | Constitutively active PKB/Akt inhibited apoptosis and down-regulated β1,4-galactosyltransferase 1 in hepatocarcinoma cells显示文摘 | Xiaoyu Zhu She Chen Xianglei Yin Aiguo Shen Shuying Ji Zonghou Shen Jianxin Gu | 2003 | Biochemical and Biophysical Research Communications2003，，2： | 1 |
| 4 | Performance of two different modules of long-strip multi-gap resistive plate chamber显示文摘Long-strip multi-gap resistive plate chamber(LMRPC) were built with(Module 1) or without(Module 2) adhesive tapes and silicones.Their performances were investigated by working gas mixtures of different gradient contents(Test 1:94%freon,5%iso-butane and 1%SF_6;Test 2:90%freon,5%iso-butane and 5%SF_6).Both the modules achieved 100%efficiency,with time resolutions of 75 and 70 ps.Comparatively,the Module 1 works with a lower applied HV at the higher noise level,and time resolution was not influenced greatly by the adhesive tapes and silicones. | CHEN Huangshan WANG Yi DING Weicheng QIU Xuezhong WANG Jingbo ZHU Xianglei CHENG Jianping LI Yuanjing | 2011 | Nuclear Science and Techniques2011，22，6： | 0 |
| 5 | Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate显示文摘Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals,controlling metabolic states beyond energy metabolism.However,whether glycolytic metabolites also play a role in controlling cell fate remains unexplored.Here,we find that low levels of glycolytic metabolite 3-phosphoglycerate(3-PGA)can switch phosphoglycerate dehydrogenase(PHGDH)from cataplerosis serine synthesis to pro-apoptotic activation of p53.PHGDH is a p53-binding protein,and when unoccupied by 3-PGA interacts with the scaffold protein AXIN in complex with the kinase HIPK2,both of which are also p53-binding proteins.This leads to the formation of a multivalent p53-binding complex that allows HIPK2 to specifically phosphorylate p53-Ser46 and thereby promote apoptosis.Furthermore,we show that PHGDH mutants(R135W and V261M)that are constitutively bound to 3-PGA abolish p53 activation even under low glucose conditions,while the mutants(T57A and T78A)unable to bind 3-PGA cause constitutive p53 activation and apoptosis in hepatocellular carcinoma(HCC)cells,even in the presence of high glucose.In vivo,PHGDH-T57A induces apoptosis and inhibits the growth of diethylnitrosamine-induced mouse HCC,whereas PHGDH-R135W prevents apoptosis and promotes HCC growth,and knockout of Trp53 abolishes these effects above.Importantly,caloric restriction that lowers whole-body glucose levels can impede HCC growth dependent on PHGDH.Together,these results unveil a mechanism by which glucose availability autonomously controls p53 activity,providing a new paradigm of cell fate control by metabolic substrate availability. | Yu-Qing Wu Chen-Song Zhang Jinye Xiong Dong-Qi Cai Chen-Zhe Wang Yu Wang Yan-Hui Liu Yu Wang Yiming Li Jian Wu Jianfeng Wu Bin Lan Xuefeng Wang Siwei Chen Xianglei Cao Xiaoyan Wei Hui-Hui Hu Huiling Guo Yaxin Yu Abdul Ghafoor Changchuan Xie Yaying Wu Zheni Xu Cixiong Zhang Mingxia Zhu Xi Huang Xiufeng Sun Shu-Yong Lin Hai-Long Piao Jianyin Zhou Sheng-Cai Lin | 2023 | Cell Research2023，33，11： | 0 |
| 6 | Current dilemma in photocatalytic CO_(2) reduction:real solar fuel production or false positive outcomings?显示文摘Solar driven carbon dioxide(CO_(2))recycling into hydrocarbon fuels using semiconductor photocatalysts offers an ideal energy conversion pathway to solve both the energy crisis and environmental degradation problems.However,the ubiquitous presence of carbonaceous contaminants in photocatalytic CO_(2) reduction system and the inferior yields of hydrocarbon fuels raise serious concerns about the reliability of the reported experimental results.Here in this perspective,we focus on the accurate assessment of the CO_(2) reduction products,systemically discuss the possible sources of errors in the product quantification,elaborate the common mistakes spread in the analysis of reaction products obtained in 13CO_(2) labelling experiments,and further propose reliable protocols for reporting the results of these isotopic tracing experiments.Moreover,the challenges and cautions in the precise measurement of O_(2) evolution rate are also depicted,and the amplification of the concentration of O_(2) in photoreactors well above the limit of detection is still demonstrated to be the most effective solution to this troublesome issue.We hope the viewpoints raised in this paper will help to assessment the reliability of the reported data in future,and also benefit the beginners that intend to dive in the photocatalytic CO_(2) reduction area. | Kai Zhang Qi Gao Cuiping Xu Dawei Zhao Qibin Zhu Zhonghui Zhu Jin Wang Cong Liu Haitao Yu Chen Sun Xianglei Liu Yimin Xuan | 2022 | Carbon Neutrality2022，1，1： | 0 |
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