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| 1 | A 2-bp insertion(c.6768insCC) in MC1R causes recessive white coat color in Bama miniature pigs显示文摘Coat color is an important characteristic of various breeds of domestic animal species.Variation in farm animal coat color is of considerable interest for concealment,communication and protection against solar radiation(Slominski et al.,2004).It also plays an important role in the regulation of physiological processes(Miyagi and Terai,2013).Bama miniature pigs are a native breed | Qitao Jia Chunwei Cao Hai Tang Ying Zhang Qiantao Zheng Xiao Wang Rui Zhang Xianlong Wang Ailing Luo Hong Wei Anming Meng Qi Zhou Hongmei Wang Jianguo Zhao | 2017 | Journal of Genetics and Genomics2017，44，4： | 5 |
| 2 | Femtosecond Laser Fabrication of Cavity Microball Lens (CMBL) inside a PMMA Substrate for Super‐Wide Angle Imaging显示文摘 | Chong Zheng Anming Hu Kenneth D. Kihm Qian Ma Ruozhou Li Tao Chen W. W. Duley | 2015 | Small2015，，25： | 1 |
| 3 | Will China’s airline industry survive the entry of high-speed rail?显示文摘 | Xiaowen Fu Anming Zhang Zheng Lei | 2011 | Research in Transportation Economics2011，，1： | 1 |
| 4 | Will China's airline indus- try survive the entry of high-speed rail?显示文摘 | Xiaowen Fu Anming Zhang Zheng Lei | 2012 | Research in Transportation Economics2012，1325，： | 1 |
| 5 | A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment显示文摘Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies. | Xiao Wang Chunwei Cao Yongshun Li Tang Hai Qitao Jia Ying Zhang Qiantao Zheng Jing Yao Guosong Qin Hongyong Zhang Ruigao Song Yanfang Wang Guanghou Shui Sin Man Lam Zhonghua Liu Hong Wei Anming Meng Qi Zhou Jianguo Zhao | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
| 6 | Covalently tethering disulfonic acid moieties onto polyoxometalate boosts acid strength and catalytic performance for hydroxyalkylation/alkylation reaction显示文摘Solid acid catalysts are widely used in the production of various high-value added and industrially important chemicals.Although the use of organosilicon compounds to modify the vacancy site has been extensively studied,the covalent tethering-SO_(3)H functionalized organosilicon modified polyoxometalates(POMs)has been rarely reported.In this work,two catalysts(TBA_(4)[SiW_(11)O_(39)(O(SiC_(3)H_(6)SO_(3)H)_(2))](compound 2)and TBA_(4)[SiW_(11)O_(39)(O(SiC_(8)H_(8)SO_(3)H)_(2))](compound 3))were synthesized successfully through covalently grafting different sulfonic acid(-SO_(3)H)groups onto[SiW_(11)O_(39)]^(8−)cluster,respectively.Compound 2 was achieved by surface grafting and in situ oxidation(3-mercaptopropyl)-trimethoxysilane,while compound 3 was achieved by surface grafting of 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane.Strong Brønsted acid strength of compounds 2 and 3 can be demonstrated by different methods including potentiometric titration,pyridine adsorption studies,and the ^(31)P trimethylphosphine oxides(TMPO)nuclear magnetic resonance(NMR).The systematic investigation of the relationship among POM structures,acid strength,and electron density was carried out based on density functional theory(DFT)calculation and experimental results,which revealed that covalent modification of compounds 2 and 3 decreased the electron density of the O-H bond,and promoted the release of H^(+).When applied in hydroxyalkylation/alkylation(HAA)reaction of 2-methylfuran(2-MF)with cyclohexanone,compound 2 exhibited better catalytic performance with conversion of ~93%,monocyclic fuel precursors(1a)yield of 79.9% and selectivity of 85.7% than compound 3,which can be attributed to strong Brønsted acid and the intramolecular hydrogen-bonding interactions between the neighboring -SO_(3)H moieties in compound 2.Finally,compound 2 also showed excellent catalytic activity in the HAA reaction of 2-MF with several different aldehydes and ketones(e.g.,furfuraldehyde,5-methylfurfuraldehyde,acetone,butyraldehyde and 4-methoxybenzaldehyde).This result opens a new pathway for design and fabrication of novel solid acid catalysts. | Lifei Lian Yubing Liu Xianfeng Yi Hanbin Hu Xiang Chen Hongqiang Li Wei Chen Anming Zheng Yu-Fei Song | 2022 | Science China Chemistry2022，65，4： | 1 |
| 7 | ABC model and floral evolution显示文摘The paper introduces the classical ABC model of floral development and thereafter ABCD, ABCDE and quartet models, and presents achievements in the studies on floral evolution such as the improved understanding on the relationship of reproductive organs between gnetophytes and angiosperms, new results in perianth evolution and identified homology of floral organs between dicots and monocots. The evo-devo studies on plant taxa at different evolutionary levels are useful to better understanding the homology of floral organs, and to clarifying the mysteries of the origin and sub-sequent diversification of flowers. | LI Guisheng, MENG Zheng, KONG Hongzhi, CHEN Zhiduan & LU Anming Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Correspondence should be addressed to Meng Zheng (e-mail: zhmeng@ ns.ibcas.ac.cn) and Lu Anming (e-mail:anmin@ns.ibcas.ac.cn) | 2003 | Chinese Science Bulletin2003，48，24： | 1 |
| 8 | Boron environments in B-doped and ( B, N ) -codoped Ti02 photocata-lysts :a combined solid-state NMR and theoretical calculation study 显示文摘 | FENG Ningdong ZHENG Anming WANG Qiang | 2011 | Journal of Physical Chemistry C2011，115，6： | 1 |
| 9 | Aberrantly Methylated MGMT,hMLH1 and hMSH2 in Tumor and Serum DNA of Gliomas Patients显示文摘OBJECTIVE This study is to investigate the prevalence ofpromoter CpG island methylation of O^6-methylguananine-DNAmethyltransferase (MGMT), mismatch repair genes (hMLH1 andhMSH2) in both tumor and serum samples of gliomas.METHODS Methylation-specific PCR (MSP) was employed todetect promoter CpG island methylation of the MGMT, hMLH1and hMSH2 genes in 39 samples taken from surgery and 32samples of pretreatment serum all from the patients with gliomas.RESULTS Promoter CpG island methylation of MGMT, hMLH1and hMSH2 was detected and the results were 46.2%, 10.3% and20.5%, respectively in tumor DNA of the cases with gliomas,and 40.6%, 9.4% and 18.8%, respectively in serum DNA of thecases. The methylation pattern in primary tumor and serum wasfound to be concordant in matched tissue and serum samplesof 21 patients. In the cases with positive result of methylationfor MGMT, hMLH1 and hMSH2 in tumor tissues, the results ofdetection for those in the paired serum sample were 77.8% (7/9),66.7% (2/3) and 75.0 % (3/4), respectively. False positive resultswere not obtained in any of the patients who did not exhibitmethylation. No association was found between the promotermethylation of MGMT, hMLH1, and hMSH2 genes in primarygliomas and gender, age, localization, grade of malignant or tumorstage.CONCLUSION Promoter CpG island methylation is a frequentevent in gliomagenesis. Methylation analysis appears to bea promising predictive factor of the prognosis for the gliomapatients treated with alkylating drugs and a noninvasive tumormarker in serum DNA. | Changqing Zheng Shouping Ji Feng Gong Anming Li Junli Tai Subuo Li Yingli Wang Hongyu Chang Hongwei Gao Yangpei Zhang | 2009 | Chinese Journal of Clinical Oncology2009，6，1： | 0 |
| 10 | Spatiotemporal changes of typical glaciers and their responses to climate change in Xinjiang,Northwest China显示文摘Glaciers are highly sensitive to climate change and are undergoing significant changes in mid-latitudes.In this study,we analyzed the spatiotemporal changes of typical glaciers and their responses to climate change in the period of 1990-2015 in 4 different mountainous sub-regions in Xinjiang Uygur Autonomous Region of Northwest China:the Bogda Peak and Karlik Mountain sub-regions in the Tianshan Mountains;the Yinsugaiti Glacier sub-region in the Karakorum Mountains;and the Youyi Peak sub-region in the Altay Mountains.The standardized snow cover index(NDSI)and correlation analysis were used to reveal the glacier area changes in the 4 sub-regions from 1990 to 2015.Glacial areas in the Bogda Peak,Karlik Mountain,Yinsugaiti Glacier,and Youyi Peak sub-regions in the period of 1990-2015 decreased by 57.7,369.1,369.1,and 170.4 km^(2),respectively.Analysis of glacier area center of gravity showed that quadrant changes of glacier areas in the 4 sub-regions moved towards the origin.Glacier area on the south aspect of the Karlik Mountain sub-region was larger than that on the north aspect,while glacier areas on the north aspect of the other 3 sub-regions were larger than those on the south aspect.Increased precipitation in the Karlik Mountain sub-region inhibited the retreat of glaciers to a certain extent.However,glacier area changes in the Bogda Peak and Youyi Peak sub-regions were not sensitive to the increased precipitation.On a seasonal time scale,glacier area changes in the Bogda Peak,Karlik Mountain,Yinsugaiti Glacier,and Youyi Peak sub-regions were mainly caused by accumulated temperature in the wet season;on an annual time scale,the correlation coefficient between glacier area and annual average temperature was-0.72 and passed the significance test at P<0.05 level in the Karlik Mountain sub-region.The findings of this study can provide a scientific basis for water resources management in the arid and semi-arid regions of Northwest China in the context of global warming. | HUANG Xiaoran BAO Anming GUO Hao MENG Fanhao ZHANG Pengfei ZHENG Guoxiong YU Tao QI Peng Vincent NZABARINDA DU Weibing | 2022 | Journal of Arid Land2022，14，5： | 0 |
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