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| 1 | Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β cell dysfunction in isolated pancreatic islets显示文摘 | Chen-Yu Zhang Laura E. Parton Chian Ping Ye Stefan Krauss Ruichao Shen Cheng-Ting Lin John A. Porco Bradford B. Lowell | 2006 | Cell Metabolism2006，，6： | 3 |
| 2 | Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos显示文摘The Dux gene plays an important role in mouse embryo development(De Iaco et al.,2017;Hendrickson et al.,2017;Whiddon et al.,2017).It participates in the maternal-to-zygotic transition(MTZ),which mainly includes maternal transcript degradation and zygotic genome activation(ZGA)and is the key process for embryonic development.Approximately 11-100 copies of the DUX4 gene form a tandem cluster in the human genome(Snider et al.,2009,2010). | Yubing Liu Xinmei Lu Min Ye Ling Wang Rongxin Tang Zhiyong Yang Bongkoch Turathum Chenchen Liu Yujing Xue Menghua Wu Yannan Yang Ermeng Gao Di Zhang Feng Yang Keh-Kooi Kee Xingxu Huang Guanglei Li Ri-Cheng Chian | 2022 | Journal of Genetics and Genomics2022，49，10： | 1 |
| 3 | Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity-and high glucose-induced β cell dysfunction in isolated pancreatic islets显示文摘 | CHEN YU ZHANG LAURA E PARTON CHIAN PING YE | 2006 | Cell Metabolism2006，3，6： | 1 |
| 4 | Hybrid Method to Identify Second-trip Echoes Using Phase Modulation and Polarimetric Technology显示文摘For pulse Doppler radars,the widely used method for identifying second-trip echoes(STs)in the signal processing level yields significant misidentification in regions of high turbulence and severe wind shear.In the data processing level,although the novel algorithm for ST identification does not yield significant misidentification in specific regions,its overall identification performance is not ideal.Therefore,this paper proposes a hybrid method for the identification of STs using phase modulation(signal processing)and polarimetric technology(data processing).Through this approach,most of the STs are removed,whereas most of the first-trip echoes(FTs)remain untouched.Compared with the existing method using a signal quality index filter with an optimized threshold,the hybrid method exhibits superior performance(Heidke skill scores of 0.98 versus 0.88)on independent test datasets,especially in high-turbulence and severe-wind-shear regions,for which misidentification is significantly reduced. | Shuai ZHANG Jinzhong MIN Chian ZHANG Xingyou HUANG Jun LIU Kaihua WEI | 2021 | Advances in Atmospheric Sciences2021，38，3： | 1 |
| 5 | Engineering a Floxuridine-integrated RNA Prism as Precise Nanomedicine for Drug Delivery显示文摘Herein,we report a geometrically well-defined prism assembled by two floxuridine(F)integrated RNA strands as a precise nanomedicine for chemodrug delivery.Owing to the similarity between chemotherapeutic F and uridine(U),all uridines in the component RNA strands are replaced by F during their in vitro transcription syntheses.By specifically designing their sequences,F-containing S-shape tiles with the single-stranded loops are constructed and then further assemble into the RNA prism through T-junction interactions and sticky-end cohesions.The present study demonstrates that the F-integrated RNA prism can serve as an efficient platform for chemodrug delivery and anticancer treatment.We believe that the study would help the future development of RNA-based nanomedicine in various applications. | PAN Gaifang MA Yuan ZHANG Jiao GUO Yuanyuan DING Fei GE Huan LI Qifeng ZHU Xinyuan ZHANG Chian | 2020 | Chemical Research in Chinese Universities2020，36，2： | 1 |
| 6 | PROGNOSIS OF AGGRADATION IN THE LOWER YELLOW RIVER BY HISTORIC ANALYSIS OF THE MORPHOLOGY OF ITS ABANDONED ANCIENT CHANNEL显示文摘On the basis of analyzing historical records and field data, the process in the formation of longitudinal profile of the ancient Lower Yellow River channel (1194-1855) has been studied. It is found that the process of profile adjustment can be roughly divided into two stages. In the first stage, the river channel adjusts itself by steepening its slope to match the transportation of sediment load. In the second stage, aggradation raises the profile of the entire Lower Yellow River in order to balance the retrogressive effect of the seaward extension of the river mouth. A close relationship can be set up between the profile raising and the river course extension. The profile of the present Lower Yellow River is quite similar to that of the ancient Lower Yellow River channel and has changed little in the last forty years. It is thus concluded that the present Lower Yellow River has now also undergone a second stage of profile adjustment and the seaward extension of the river has become the main cause of the on-going aggradation in the river channel. Therefore, it is of fundamental importance to reduce the sediment influx into the estuarine area if the aggradation of the present Lower Yellow River is to be mitigated. | Zhang Ren and Xie Shunan (Professor, Tsinghua University, Beijing, China) (Lecturer, Tsinghua University, Beijing, Chian) | 1990 | International Journal of Sediment Research1990，5，2： | 0 |
| 7 | How fertility preservation guidelines have progressed worldwide:Potential implications and inspiration显示文摘To summarize fertility preservation (FP) guidelines and consensus provided by medical facilities worldwide. Five reference databases (PubMed/Embase, China BioMedical Literature Database, ClinicalKey, Wanfang Data, and China Knowledge Resource Integrated) and 7 guideline databases (Guideline International Network, National Collaborating Centre for Women’s and Children’s Health, National Guideline Clearinghouse, The National Institute for Health and Care Excellence, Scottish Intercollegiate Guidelines Network, New Zealand Guideline Group, and Canadian Medical Association infobase) were searched. Official websites of societies were searched to find relevant guidelines and consensus, and guidelines and published systematic reviews and consensus were reviewed from inception through May 2021. A literature search was performed regarding guidance offered in professional facilities, and 304 records (including 4 in Chinese) of existing guidelines for full-text review were found. Moreover, 55 guidelines were identified after a manual search. The literature review demonstrated that FP guidance and options were unevenly distributed worldwide for women who wanted to post-pone pregnancy or had impaired fertility after gonadal toxicity. With promising cancer survival rates and diversified family decisions, more attention should be paid to the improvement and update of accessible guidelines and regulatory infrastructure to inform patients about the available options and empower them to make informed choices. Restrictions to such services can be gradually eased due to the efficacy and safety of certain FP techniques for the right candidates to initiate pregnancy conception. | Min-Xin Chen Ying Zhang Qing-Qing Cai Shuo Zhang Ran Xu Hua Chen Yu Kang Yue Wu Ri-Cheng Chian Cong-Jian Xu | 2022 | Reproductive and Developmental Medicine2022，6，1： | 0 |
| 8 | Expression of Target Genes in Cumulus Cells Derived from Human Oocytes with and without Blastocyst Formation显示文摘Objective:The transcriptional profile of cumulus cells(CCs)during oocyte maturation provides information for predicting oocyte developmental competence.Our previous study using a mouse model indicated that there were nine different genes related to oocyte development potential expressed in CCs during oocyte maturation.The purpose of this study was to elucidate whether gene expression levels of CCs during oocyte maturation are associated with oocyte developmental competence.Methods:The human CCs collected from each oocyte were divided into two groups after tracking depending on whether or not they developed to the blastocyst stage:(1)the oocytes were developed to blastocyst stage after fertilization(B+)and(2)the oocytes were not developed to blastocyst stage after fertilization(B−).The expression levels of the nine selected genes(ARRB1,ATP2C1,CDH5,CNTNAP1,LGR4,MKLN1,RHOBTB1,SIX2,and SMC2)were examined.CCs were obtained from 29 women who were undergoing intracytoplasmic sperm injection treatment cycles.Quantitative reverse transcriptase-polymerase chain reaction analysis was performed on cumulus masses collected before insemination.Each sample was run three times.Statistically significant differences in mRNA expression of the target genes in independent samples were evaluated by two-tailed Student’s t-test,and P<0.05 was considered significantly different.Results:There were significant differences in the mRNA expression levels of ARRB1(P=0.016),LGR4(P=0.025),and SMC2(P=0.013)between the groups B+and B−.Gene expression of ARRB1,LGR4,and SMC2 in CCs is related to blastocyst development.Conclusions:Analysis of expression of ARRB1,LGR4,and SMC2 genes in CCs as biomarkers may provide predictive information on oocyte developmental competence before insemination and fertilization. | Tuan-Ping Zhou Di Zhang Ling-Bo Cai Yi-Xin Xu Li Shao Kai-Lu Liu Jia-Yin Liu Yu-Gui Cui Ling Wang Ri-Cheng Chian | 2019 | Reproductive and Developmental Medicine2019，3，2： | 0 |
| 9 | An Analysis of Reliability and Competitiveness of a Corporation in China | FAN Jin(Yangzhou University, Yangrhou 225009, China)ZHANG Jiewei(Dalian University of Technology, Dalian 116024, China)SHEN Ji(Yangzhou University, YangZhou 225009, Chian) | 1996 | Systems Science and Systems Engineering1996，6，2： | 0 |
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