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| 1 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 2 | 术中神经电生理监测在单椎板入路选择性神经后根离断术中的作用显示文摘目的单椎板入路选择性神经后根离断术(SL-SDR)治疗痉挛性脑瘫完全依赖术中神经电生理监测结果。本研究旨在讨论SL-SDR术中肌电图判读对神经根选择和离断的影响及作用。方法回顾分析2016年5月至2019年3月在上海交通大学附属儿童医院神经外科采用改良神经电生理监测离断方案指导下SL-SDR治疗的痉挛性脑瘫患儿的临床资料,重点关注术中肌电图判读及其与术前临床表现的相关性,以及比较采用不同神经电生理监测离断方案解读术中肌电图时的神经后根选择差异。结果共纳入318例患儿,男性231例、女性87例,平均年龄5.9岁,32例为偏瘫、161例为双侧瘫、125例为四肢瘫。每例患儿有2~8组目标肌群(术前肌张力≥2级)。术中神经电生理监测结果显示,探测的21728枚神经小根[(68.3±8.2)枚/例]中6272枚(28.9%)与肛门括约肌相关,15456枚[(48.6±7.6)枚/例]与下肢肌群相关,其中,神经后根11009枚[(34.6±7.4)枚/例]。共有3370枚[(10.6±4.7)枚/例]符合改良神经后根离断方案,其中3061枚50%部分离断、309枚75%部分离断。术前粗大运动功能分级(GMFCS)分级Ⅰ~Ⅴ级的离断率(部分离断的神经后根数/下肢肌群相关神经后根数)分别为15.8%、22.3%、33.4%、41.8%和45.7%。75%部分离断的离断率随术前GMFCS分级的递增而增加,分别为1.5%、4.8%、8.5%、14.1%和15.2%。术后3周,2068组目标肌群肌张力显著降低[(1.7±0.5)级对(2.7±0.6)级]。术前GMFCS分级Ⅰ和Ⅱ级患儿采用传统离断方案约有20%的病例无法识别任何1枚约20%需离断的神经后根,而随着患儿术前GMFCS分级的递增,传统与改良方案离断的符合率逐步提高,分别为39.5%、41.3%、52.2%、54.1%和62.8%。结论由于SL-SDR完全依赖于术中肌电图判读,使得术中神经电生理监测显得至关重要。改良神经电生理监测离断方案指导下的SL-SDR可以安全、有效治疗痉挛性脑瘫。SL-SDR术中肌电图及其与临床表现相关的预后,可以使临床医师更好地理解此类患儿脊髓神经元环路的运作模式。 | Xiao B Constatntini S Browd SR Zhan Q Jiang W Mei R 詹琪佳(编译) | 2020 | 中国现代神经疾病杂志2020，20，4： | 4 |
| 3 | Structure and magnetic properties of Fe-Co nanowires in selfassembled arrays显示文摘 | Zhan Q F Chen Z Y Xue D S | 2002 | Phy Rev B2002，66，134436： | 2 |
| 4 | Fluid geoanalysis in the Chinese Continental Scientific Drilling Project 显示文摘 | Luo L Q Zhan X C Sun Q | 2004 | Geostandards and C eoanalytical Research2004，28，2： | 1 |
| 5 | Long-term follow-up of mri-guided bilateral anterior capsulotomy in patients with refractory schizophrenia 显示文摘 | Liu W Hao Q Zhan S | 2014 | Stereotact Funct Neurosurg2014，92，3： | 1 |
| 6 | Physicochemic~tl characterization of a high molecular weight bioactive 显示文摘 | Liu Y Zhan J Tang Q | 2014 | Carbol~vd Polym2014，101，： | 1 |
| 7 | Continuous adminis- tration of recombinant human endostatin (Endostar) : a pre -clini- cal safety study显示文摘 | HUANG R F ZHAN Q ZHOU X L | 2012 | Exp Ther Med2012，3，6： | 1 |
| 8 | Semiconductor@ Metal-Organic Framework Core-Shell Heterostnwtures: A Case of ZnO@ ZIF-8 Nanorods with Selective Photoeleetrochemical Response显示文摘 | Zhan W Kuang Q Zhou J etal | 2013 | Journal of the American Chemical Society2013，135，5： | 1 |
| 9 | Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation显示文摘 | ZHAN S GUO Q H LI M H | 2010 | Development2010，137，23： | 1 |
| 10 | Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation显示文摘 | ZHAN S GUO Q LI M | 2010 | Development2010，137，23： | 1 |
| 11 | Applied Field Mossbauer Study of Shape Anisotropy in Fe Nanowire Arrays显示文摘 | Zhan Q F He W Ma X | 2004 | Appl Phys Lett2004，85，20： | 1 |
| 12 | Pro- gress in HIRFL CSR显示文摘 | ZHAN W L XU H S XIAO G Q | 2010 | Nuclear Physics A2010，834，69： | 1 |
| 13 | Thermally stable light- emitting polymers of substituted polyaoetylenes显示文摘 | YU G LIU Y Q ZHAN X W | 2000 | Thin Solid Films2000，363，： | 1 |
| 14 | GADD45 induction of a G_2/M cell cycle checkpoint显示文摘 | Wang XW Zhan Q Coursen JO | 1999 | Proc Nat Acad Sci USA1999，96，7： | 1 |
| 15 | A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia显示文摘 | Kastan MB Zhan Q El-Deiry WS | 1992 | Cell1992，71，4： | 1 |
| 16 | Photosensitized degradation of bisphenol A involving reactive oxygen species in the presence of humic substances显示文摘 | Zhan M J Yang X Xian Q M | 2006 | Chemosphere2006，63，3： | 1 |
| 17 | Trapping metallic Rayleigh particles with radial polarization显示文摘 | Zhan Q | 2004 | Optics Express2004，12，15： | 1 |
| 18 | Semiconductor@metal-organic framework core-shell heterostructures:A case of ZnO@ZIF-8 nanorods with selective photoelectrochemical response显示文摘 | Zhan W W Kuang Q Zhou J Z | 2013 | Journal of the American Chemical Society2013，135，5： | 1 |
| 19 | The significant role of oxygen vacancy in Cu/Zr02 catalyst for enhancing water- gas-shift performance显示文摘 | Chen C Q Ruan C X Zhan Y Y | 2014 | International Journal of Hydrogen Energy2014，，： | 1 |
| 20 | Biochemical and structural characterization of the human TL1A ectodomain 显示文摘 | Zhan C Yah Q Patskovsky Y | 2009 | Biochemistry2009，48，32： | 1 |
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