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| 1 | Cloning, expression, and characterization of a novel diketoreductase from Acinetobacter baylyi显示文摘oxidoreductases 催化的羰基组的减小涉及所有生物过程并且经常是重要 biocatalyst 的一个班。在这篇文章,我们报导指定为 diketoreductase (DKR ) 能与优秀 stereoselectivity 在 diketo 酉旨把二个羰基组归结为相应 dihydroxy 酉旨的新奇的酶。DKR 被反向的基因方法从 Acinetobacter baylyi 克隆,不同类地在 Escherichia coli 表示了,并且净化了到由二色析法的步的同质。这新奇的酶展出了双余因子特性,与在 NADPH 上的 NADH 的偏爱。DKR 催化的 dihydroxy 酉旨产品仅仅是有两 diastereomeric 过量的 3R,5S 立体异构, enantiomeric 过量珍视超过 99.5% 。另外,酶的一些生物化学的性质例如最佳的 pH 和温度,也被描绘。而且,顺序分析显示这新酶对细菌的 3-hydroxyacyl 辅酶相应 -- 脱氢酶。基于唯一的催化活动和优秀 stereoselectivity,更重要地, DKR 能在珍贵 chiral 药中介的合成被利用,例如 Lipitor ? 。 | Xuri Wu Nan Liu Yunmian He Yijun Chen | 2009 | Acta Biochimica et Biophysica Sinica2009，41，2： | 3 |
| 2 | Microstructure and Mechanical Properties of AlSi10Mg Alloy Manufactured by Laser Powder Bed Fusion Under Nitrogen and Argon Atmosphere显示文摘In order to study the effect of gas atmosphere on forming performance of laser powder bed fusion(LPBF),AlSi10 Mg alloy was prepared by direct forming and in situ laser remelting under the shielding gas of argon and nitrogen in this study,and its micro structure and properties were characterized and tested,respectively.The results show that the forming performance of AlSi10 Mg under nitrogen atmosphere is better than that of argon.Moreover,in situ laser remelting method can effectively enhance the relative density and mechanical properties of AlSi10 Mg,in which the densification is increased to 99.5%.In terms of mechanical properties,after in situ remelting,ultimate tensile strength under argon protection increased from444.85±8.73 to 489.45±3.20 MPa,and that under nitrogen protection increased from 459.21±13.77 to 500.14±5.15 MPa.In addition,the elongation is nearly doubled and the micro-Vickers hardness is increased by 20%.The research results provide a new regulation control method for the customization of AlSi10 Mg properties fabricated by LPBF. | Yunmian Xiao Yongqiang Yang Shibiao Wu Jie Chen Di Wang Changhui Song | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，3： | 2 |
| 3 | Immunological features and the ability of inhibitory effects on enzymatic activity of an epitope vaccine composed of cholera toxin B subunit and B cell epitope from Helicobacter pylori urease A subunit显示文摘 | Le Guo Xiaokang Li Feng Tang Yunmian He Yingying Xing Xuepeng Deng Tao Xi | 2012 | Applied Microbiology and Biotechnology2012，，5： | 1 |
| 4 | Isolation and structural characterization of a novel polysaccharide prepared from Arca subcrenata Lischke显示文摘 | Yunmian He Chunhui Liu Yuxing Chen | 2007 | The society for Biotech nology2007，，104： | 1 |
| 5 | Precision medicine in the treatment of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer has a poor prognosis. Current therapies for pancreatic cancer have limited effects. In the past decade, precision medicine has shown great potential for clinical applications. In this review, different strategies for applying precision medicine to the treatment of pancreatic cancer are described. | Jianlin Chen Yunmian Chu Jin He Lei Zheng Xu Che | 2016 | Oncology and Translational Medicine2016，2，4： | 0 |
| 6 | Determination of ^(129)I in Environmental Water显示文摘Determinationof^(129)IinEnvironmentalWaterXieYunmian,BanYing,JiangSongsheng,HeMing,JiangShan129Ihasahalf-lifeof1.57×107awithβ?.. | Xie Yunmian, Ban Ying, Jiang Songsheng, He Ming, Jiang Shan | 1996 | 中国原子能科学研究院年报1996，，1： | 0 |
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