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| 1 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019，25，15： | 5 |
| 2 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer显示文摘 | Yusuke Tajima Kimiyasu Yamazaki Yuki Masuda Masanori Kato Daisuke Yasuda Takeshi Aoki Takashi Kato Masahiko Murakami Mitsuharu Miwa Mitsuo Kusano | 2009 | Annals of Surgery2009，，1： | 3 |
| 3 | Risk Factors for Lymph Node Metastasis from Gastric Cancers with Submucosal Invasion显示文摘 | Yusuke Tajima Masahiko Murakami Kimiyasu Yamazaki Yuki Masuda Shigeo Aoki Masanori Kato Atsushi Sato Satoru Goto Koji Otsuka Takashi Kato | 2010 | Annals of Surgical Oncology2010，，6： | 2 |
| 4 | Rapid detection of gene mutations responsible for non-syndromic aortic aneurysm and dissection using two different methods: resequencing microarray technology and next-generation sequencing显示文摘 | Haruya Sakai Shinichi Suzuki Takeshi Mizuguchi Kiyotaka Imoto Yuki Yamashita Hiroshi Doi Masakazu Kikuchi Yoshinori Tsurusaki Hirotomo Saitsu Noriko Miyake Munetaka Masuda Naomichi Matsumoto | 2012 | Human Genetics2012，，4： | 1 |
| 5 | A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer显示文摘 | Yuki Masuda Koichi Ito Morichika Konishi Hiroaki Nanba | 2010 | Cancer Immunology, Immunotherapy2010，，10： | 1 |
| 6 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging in Gastric Cancer显示文摘 | Yusuke Tajima Kimiyasu Yamazaki Yuki Masuda Masanori Kato Daisuke Yasuda Takeshi Aoki Takashi Kato Masahiko Murakami Mitsuharu Miwa Mitsuo Kusano | 2009 | Annals of Surgery2009，，1： | 1 |
| 7 | Maitake 13 - glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cispla- tin in mice 显示文摘 | Yuki Masuda Munechika Inane Ayu Miyata | 2009 | International Immunopharmacology2009，9，5： | 1 |
| 8 | A polysaccharide extracted from Grifala frndosa enhances the ant- tulnor activily of bone marrow- derived dendritic cell- based immunotherapy aginst murine colon cancer显示文摘 | Yuki Masuda Koichi Ito Morichika Konishi | 2010 | Cancer Immunol Immunother2010，59，： | 1 |
| 9 | Unmanipulated HLA 2–3 Antigen-Mismatched (Haploidentical) Stem Cell Transplantation Using Nonmyeloablative Conditioning显示文摘 | Hiroyasu Ogawa Kazuhiro Ikegame Satoshi Yoshihara Manabu Kawakami Tatsuya Fujioka Tomoki Masuda Yuki Taniguchi Hitomi Hasei Katsuji Kaida Takayuki Inoue Eui Ho Kim Ichiro Kawase | 2006 | Biology of Blood and Marrow Transplantation2006，，10： | 1 |
| 10 | Daunorubicin can eliminate iPS-derived cancer stem cells via ICAD/CAD-independent DNA fragmentation显示文摘Aim:To identify a drug that can effectively eliminate these cancer stem cells(CSCs)and determine its mode of action.Methods:CSCs were obtained from mouse induced pluripotent stem cells(miPSCs)using cancer cell-conditioned media.Drug screening was performed on these cells or after transplantation into mice.Apoptosis was analyzed by flow cytometry and western blotting.Results:Drug screening studies showed that daunorubicin,a topoisomerase II inhibitor,is specifically cytotoxic to miPS-CSCs.Daunorubicin-induced apoptosis was found to be associated with p53 accumulation,activation of the caspase cascade,and oligonucleosomal DNA fragmentation.Treatment with the caspase inhibitor abolished daunorubicin-induced DNA fragmentation and was therefore considered to act downstream of caspase activation.This was also suppressed by treatment with a Ca2+-specific chelator,which suggested that CAD endonuclease does not contribute.Moreover,no obvious ICAD reduction/degradation was detected.Conclusion:Daunorubicin effectively eliminated CSCs,which are dependent on the p53/caspase signaling cascade.The current findings provided the basis for further studies on CSC-targeted drugs for the development of cancer treatment strategies. | Akimasa Seno Akifumi Mizutani Kazuki Aizawa Ryoma Onoue Junko Masuda Naotaka Ochi Saki Taniguchi Tatsuyuki Sota Yuki Hiramoto Taisuke Michiue Neha Nair Masaharu Seno | 2019 | Cancer Drug Resistance2019，2，2： | 1 |
| 11 | Antioxidant Properties of Gingerol Related Compounds from Ginger显示文摘 | Yuki Masuda Hiroe Kikuzak Masashi Hisamoto | 2004 | BioFactors2004，，： | 1 |
| 12 | Are the windows to the soul the same in the East and West? 显示文摘 | Masaki Yuki Maddux W W Takahiko Masuda | 2007 | Joumal of Experimental Social Psychology2007，，43： | 1 |
| 13 | Sentinel Node Mapping Guided by Indocyanine Green Fluorescence Imaging During Laparoscopic Surgery in Gastric Cancer显示文摘 | Yusuke Tajima Masahiko Murakami Kimiyasu Yamazaki Yuki Masuda Masanori Kato Atsushi Sato Satoru Goto Koji Otsuka Takashi Kato Mitsuo Kusano | 2010 | Annals of Surgical Oncology2010，，7： | 1 |
| 14 | Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells显示文摘 | Ken Kurokawa Toshihito Tanahashi Tsutomu Iima Yuta Yamamoto Yoko Akaike Kensei Nishida Kiyoshi Masuda Yuki Kuwano Yoshiki Murakami Masakazu Fukushima Kazuhito Rokutan | 2012 | Journal of Gastroenterology2012，，8： | 1 |
| 15 | Purification, N-terminal Amino Acid Sequence, and Some Properties of CuZn-superoxide Dismutase from Japanese Flounder(Paralichthys oli_aceus) Hepato-pancreas显示文摘 | Kiyoshi Osatomi Yuki Masuda Kenji Hara | 2001 | Comparative Biochemistry and Physiology Part B2001，128，： | 1 |
| 16 | Prognostic significance of the Ki67 scoring categories in breast cancer subgroups显示文摘 | Naoki Niikura Shinobu Masuda Nobue Kumaki Tang Xiaoyan Mizuho Terada Mayako Terao Takayuki Iwamoto Risa Oshitanai Toru Morioka Banri Tuda Takuho Okamura Yuki Saito Yasuhiro Suzuki Yutaka Tokuda | 2013 | Clinical Breast Cancer2013，，： | 1 |
| 17 | Macrophage J774.1 cell is activated by MZ-Fraction (Klasma-MZ) polysaccharide in Grifola frondosa显示文摘 | Yuki Masuda Noriko Kodama Hiroaki Nanba | 2006 | Mycoscience2006，，6： | 1 |
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