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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | 烧结工艺使用气体燃料喷入技术减少CO_2排放显示文摘JFE钢铁公司开发了在烧结矿表面喷入含氢的气体燃料技术,可不增加焦粉配比,提高烧结矿质量。使用该技术,含氢气体可部分替代焦粉,使1200~1400℃的燃烧层变宽成为可能。通过X射线对多孔状的烧结饼进行CT检查与烧结锅试验,从理论到实践都证明了喷入燃料气体技术的使用效果。保持1200~1400℃的温度带,为生产高强度、高还原性的烧结矿至关重要,它能使合适的温度带变宽、液相率增加、提高1~5mm孔隙间的熔合并提升烧结矿强度。大于5mm的孔隙的烧结矿数量增多提高了料层的透气性,低温烧结工艺也抑制了铁矿石的自身熔化。而在未熔化的铁矿石中,小于1μm的微孔隙的存在也使烧结矿的还原性提高,从而改善烧结饼的孔隙结构,提高烧结矿质量。2009年1月,京浜1号烧结机应用了该技术,到目前为止工况稳定。结果,烧结工序的能源利用率大幅提升,减排CO2约6万t/a。 | Nobuyuki Oyama Yuji Iwami Satoshi Machida Takahide Higuchi Tetsuya Yamamoto Yushinori Watanabe Michitaka Sato Kanji Takeda Masakata Shimizu Koki Nishioka 何海良 | 2013 | 世界钢铁2013，，1： | 11 |
| 3 | Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice显示文摘AIM: To investigate whether a glucagon-like peptide-1(GLP-1) analogue inhibits nonalcoholic steatohepatitis(NASH), which is being increasingly recognized in Asia, in non-obese mice. METHODS: A methionine-choline-deficient diet(MCD) along with exendin-4(20 μg/kg per day, ip), a GLP-1 analogue, or saline was administered to male db/db mice(non-obese NASH model). Four or eight weeks after commencement of the diet, the mice were sacrificed and their livers were excised. The excised livers were examined by histochemistry for evidence of hepatic steatosis and inflammation. Hepatic triglyceride(TG) and free fatty acid(FFA) content was measured, and the expression of hepatic fat metabolism- and inflammation-related genes was evaluated. Oxidative stress-related parameters and macrophage recruitment were also examined using immunohistochemistry.RESULTS: Four weeks of MCD feeding induced hepatic steatosis and inflammation and increased the hepatic TG and FFA content. The expression of fattyacid transport protein 4(FATP4), a hepatic FFA influxrelated gene; macrophage recruitment; and the level of malondialdehyde(MDA), an oxidative stress marker, were significantly augmented by a 4-wk MCD. The levels of hepatic sterol regulatory element-binding protein-1c(SREBP-1c) m RNA(lipogenesis-related gene) and acyl-coenzyme A oxidase 1(ACOX1) m RNA(β-oxidation-related gene) had decreased at 4 wk and further decreased at 8 wk. However, the level of microsomal triglyceride transfer protein m RNA(a lipid excretion-related gene) remained unchanged. The administration of exendin-4 significantly attenuated the MCD-induced increase in hepatic steatosis, hepatic TG and FFA content, and FATP4 expression as well as the MCD-induced augmentation of hepatic inflammation, macrophage recruitment, and MDA levels. Additionally, it further decreased the hepatic SREBP-1c level and alleviated the MCD-mediated inhibition of the ACOX1 m RNA level. CONCLUSION: These results suggest that GLP-1 inhibits hepatic steatosis and inflammation through the inhibition of hepatic FFA influx and oxidative stress in a non-obese NASH model. | Takaya Yamamoto Yukiomi Nakade Taeko Yamauchi Yuji Kobayashi Norimitsu Ishii Tomohiko Ohashi Kiyoaki Ito Ken Sato Yoshitaka Fukuzawa Masashi Yoneda | 2016 | World Journal of Gastroenterology2016，22，8： | 10 |
| 4 | Unsedated transnasal small-caliber esophagogastroduoden oscopy in elderly and bedridden patients显示文摘AIM:To evaluate the safety of unsedated transnasal small-caliber esophagogastroduodenoscopy(EGD)for elderly and critically ill bedridden patients. METHODS:One prospective randomized comparative study and one crossover comparative study between transnasal small-caliber EGD and transoral conventional EGD was done(Study 1).For the comparative study, we enrolled 240 elderly patients aged>65 years old. For the crossover analysis,we enrolled 30 bedridden patients with percutaneous endoscopic gastrostomy (PEG)(Study 2).We evaluated cardiopulmonary effects by measuring arterial oxygen saturation(SpO2)and calculating the rate-pressure product(RPP)(pulse rate×systolic blood pressure/100)at baseline,2 and 5 min after endoscopic intubation in Study 1.To assess the risk for endoscopy-related aspiration pneumoniaduring EGD,we also measured blood leukocyte counts and serum C-reactive protein(CRP)levels before and 3 d after EGD in Study 2. RESULTS:In Study 1,we observed significant decreases in SpO2 during conventional transoral EGD, but not during transnasal small-caliber EGD(0.24%vs -0.24%after 2 min,and 0.18%vs-0.29%after 5 min, P=0.034,P=0.044).Significant differences of the RPP were not found between conventional transoral and transnasal small-caliber EGD.In Study 2,crossover analysis showed statistically significant increases of the RPP at 2 min after intubation and the end of endoscopy (26.8 and 34.6 vs 3.1 and 15.2,P=0.044,P=0.046), and decreases of SpO2(-0.8%vs-0.1%,P=0.042) during EGD with transoral conventional in comparison with transnasal small-caliber endoscopy.Thus,for bedridden patients with PEG feeding,who were examined in the supine position,transoral conventional EGD more severely suppressed cardiopulmonary function than transnasal small-caliber EGD.There were also significant increases in the markers of inflammation, blood leukocyte counts and serum CRP values,in bedridden patients after transoral conventional EGD,but not after transnasal small-caliber EGD performed with the patient in the supine position.Leukocyte count increased from 6053±1975/L to 6900±3392/L(P=0.0008)and CRP values increased from 0.93±0.24 to 2.49±0.91 mg/dL(P=0.0005)at 3 d after transoral conventional EGD.Aspiration pneumonia,possibly caused by the endoscopic examination,was found subsequently in two of 30 patients after transoral conventional EGD. CONCLUSION:Transnasal small-caliber EGD is a safer method than transoral conventional EGD in critically ill, bedridden patients who are undergoing PEG feeding. | Mika Yuki Yuji Amano Yoshinori Komazawa Hiroyuki Fukuhara Toshihiro Shizuku Shun Yamamoto Yoshikazu Kinoshita | 2009 | World Journal of Gastroenterology2009，15，44： | 8 |
| 5 | Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience显示文摘 | Yuji Nimura Junichi Kamiya Satoshi Kondo Masato Nagino Katsuhiko Uesaka Koji Oda Tsuyoshi Sano Hideo Yamamoto Naokazu Hayakawa | 2000 | Journal of Hepato - Biliary - Pancreatic Surgery2000，，2： | 6 |
| 6 | Evaluation of prognostic factors and scoring system in colonic perforation显示文摘AIM: To study the significance of scoring systems assessing severity and prognostic factors in patients with colonic perforation. METHODS: A total of 26 patients (9 men, 17 women; mean age 72.7 ± 11.6 years) underwent emergency operation for colorectal perforation in our institution between 1993 and 2005. Several clinical factors were measured preoperatively and 24 h postoperatively. Acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ), Mannheim peritonitis index (MPI) and peritonitis index of Altona (PIA Ⅱ) scores were calculated preoperatively. RESULTS: Overall postoperative mortality rate was 23.1% (6 patients). Compared with survivors, non- survivors displayed low blood pressure, low serum protein and high serum creatinine preoperatively, and low blood pressure, low white blood cell count, low pH, low PaO2/FiO2, and high serum creatinine postoperatively. APACHE Ⅱ score was significantly lower in survivors than in non-survivors (10.4 ± 3.84 vs 19.3 ± 2.87, P = 0.00003). Non-survivors tended to display high MPI score and low PIA Ⅱ score, but no signif icant difference was identif ied. CONCLUSION: Pre- and postoperative blood pressure and serum creatinine level appear related to prognosis of colonic perforation. APACHE Ⅱ score is most associated with prognosis and scores ≥ 20 are associated with signif icantly increased mortality rate. | Atsushi Horiuchi Yuji Watanabe Takashi Doi Kouichi Sato Syungo Yukumi Motohira Yoshida Yuji Yamamoto Hiroki Sugishita Kanji Kawachi | 2007 | World Journal of Gastroenterology2007，13，23： | 4 |
| 7 | Exploitation of shape memory alloy actuator using resistance feedback control and its development | Hiroki CHO Takaei YAMAMOTO Yuji TAKEDA Akihiko SUZUKI Toshio SAKUMA | 2010 | Progress in Natural Science:Materials International2010，20，1： | 3 |
| 8 | Complications of Hepatectomy for Hilar Cholangiocarcinoma显示文摘 | Masato Nagino Junichi Kamiya Katsuhiko Uesaka Tsuyoshi Sano Hideo Yamamoto Naokazu Hayakawa Michio Kanai Yuji Nimura | 2001 | World Journal of Surgery2001，，10： | 2 |
| 9 | Carbon-supported AuPd bimetallic nanoparticles synthesized by high-energy electron beam irradiation for direct formic acid fuel cell显示文摘 | Yuji Ohkubo Masashi Shibata Satoru Kageyama Satoshi Seino Takashi Nakagawa Junichiro Kugai Hiroaki Nitani Takao A. Yamamoto | 2013 | Journal of Materials Science2013，，5： | 2 |
| 10 | Endoscopic diagnosis of superficial non‐ampullary duodenal epithelial tumors in J apan: M ulticenter case series显示文摘 | Kenichi Goda Daisuke Kikuchi Yorimasa Yamamoto Kengo Takimoto Naomi Kakushima Yoshinori Morita Hisashi Doyama Takuji Gotoda Yuji Maehata Noritsugu Abe | 2014 | Digestive Endoscopy2014，，： | 2 |
| 11 | Friction and Wear of Water Imbricated PEEK and PPS Sliding Contacts显示文摘 | Yuji Yamamoto | 2002 | Wear2002，253，： | 1 |
| 12 | Right trisegment portal vein embolization for biliary tract carcinoma: Technique and clinical utility显示文摘 | Masato Nagino Junichi Kamiya Michio Kanai Katsuhiko Uesaka Tsuyoshi Sano Hideo Yamamoto Naokazu Hayakawa Yuji Nimura | 2000 | Surgery2000，，2： | 1 |
| 13 | Complications of Hepatectomy for Hilar Cholangiocarcinoma显示文摘 | Masato Nagino Junichi Kamiya Katsuhiko Uesaka Tsuyoshi Sano Hideo Yamamoto Naokazu Hayakawa Michio Kanai Yuji Nimura | 2001 | World Journal of Surgery2001，，10： | 1 |
| 14 | Friction and wear of water lubricated PEEK and PPS sliding contacts Part 2:Composites with carbon or glass fibre显示文摘 | Yuji Yamamoto Masaaki Hashimoto | 2004 | Wear2004，257，： | 1 |
| 15 | Advanced Glycation Endproduct-Induced Calcium Handling Impairment in Mouse Cardiac Myocytes显示文摘 | Ralica Petrova Yasuhiko Yamamoto Katsuhiko Muraki Hideto Yonekura Shigeru Sakurai Takuo Watanabe Hui Li Masayoshi Takeuchi Zenji Makita Ichiro Kato Shin Takasawa Hiroshi Okamoto Yuji Imaizumi Hiroshi Yamamoto | 2002 | Journal of Molecular and Cellular Cardiology2002，，10： | 1 |
| 16 | Right or left trisegment portal vein embolization before hepatic trisegmentectomy for hilar bile duct carcinoma显示文摘 | Masato Nagino Yuji Nimura Junichi Kamiya Satoshi Kondo Katsuhiko Uesaka Yukoh Kin Yasushi Kutsuna Naokazu Hayakawa Hideo Yamamoto | 1995 | Surgery1995，，6： | 1 |
| 17 | Friction and wear of water lubricated PEEK and PPS sliding contacts显示文摘 | Yuji Yamamoto Tadashi Takashima | 2002 | Wear2002，253，： | 1 |
| 18 | Changes in hepatic lobe volume in biliary tract cancer patients after right portal vein embolization显示文摘 | Masato Nagino Yuji Nimura Junichi Kamiya Satoshi Kondo Katsuhiko Uesaka Yukoh Kin Naokazu Hayakawa Hideo Yamamoto | 1995 | Hepatology1995，，2： | 1 |
| 19 | Plasma interleukin (IL)-18 (interferon-γ-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18显示文摘 | Taku Inokuchi Yuji Moriwaki Hiroko Tsutsui Asako Yamamoto Sumio Takahashi Zenta Tsutsumi Tuneyoshi Ka Kenji Nakanishi Tetsuya Yamamoto | 2005 | Cytokine2005，，1： | 1 |
| 20 | Usefulness of Plasma Brain Natriuretic Peptide Concentration for Predicting Subsequent Left Ventricular Remodeling After Coronary Angioplasty in Patients With Acute Myocardial Infarction显示文摘 | Atsushi Hirayama Hideo Kusuoka Hiroyoshi Yamamoto Yasushi Sakata Masanori Asakura Yoshiharu Higuchi Hiroya Mizuno Kazunori Kashiwase Yasunori Ueda Yuji Okuyama Masatsugu Hori Kazuhisa Kodama | 2006 | The American Journal of Cardiology2006，，4： | 1 |
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