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| 1 | Analysis of Pathological data of renal biopsy at one single center in China from 1987 to 2012显示文摘 | Zhang Xueguang Liu Shuwen Tang Li Wu Jie Chen Pu Yin Zhong Li Minxia Xie Yuansheng Cai Guangyan Wei Ribao Qiu Qiang Wang Yuanda Shi Suozhu Chen Xiangmei | 2014 | Chinese Medical Journal2014，，9： | 30 |
| 2 | Graphene-carbon nanotube hybrid films for high- performance flexible photodetectors显示文摘Graphene 活跃地为灵活、可拉长的设备作为候选人材料正在被探索。然而,基于 graphene 的灵活 photonic 设备的发展,即光电探测器,被碳原子的单个层的低吸收度妨碍。最近,货车 der Waals 结合了碳 nanotube 和 graphene 混血儿电影证明了像静脉的碳 nanotube 网络的优秀 photoresponsivity,和使用导致了显著地更高的机械力量。这里,我们第一次报导,有 51 A/W 和快回答 ~ 预定的 ~ 的高 photoresponsivity 的一个灵活光电探测器在可见范围上的 40 ms,揭示这个新兴的所有碳混血儿的唯一的潜力为灵活设备拍摄。另外,设备对重复弯曲展出好坚韧性,建议它在大区域的矩阵数组的适用性灵活光电探测器。 | Yujie Liu Yuanda Liu Shuchao Qin Yongbing Xu Rong Zhang Fengqiu Wang | 2017 | Nano Research2017，10，6： | 7 |
| 3 | Investigation of Amorphization of Nb-Si Alloys by Mechanical Alloying显示文摘Amorphous Nb_(62.5)Si_(37.5) and Nb_(75)Si_(25) alloys were produced from mixtures of elemental Nb and Si powders by mechanical alloying(MA).The structural changes of mechanically alloyed powders were monitored by x-ray diffraction.It was found that NbSi_(2),intermetallic compound was formed in the initial stage of MA of or Nb_(62.5)Si_(37.5) or Nb_(75)Si_(25) powders.With continued milling,the mixtures of intermetallic NbSi_(2) and elemental Nb transformed into amorphous Nb-Si alloys(Nb_(62.5)Si_(37.5) or Nb_(75)Si_(25)).The slow interdiffusion of Nb and Si and the slower diffusion of silicon atoms to niobium matrix than that of niobium atoms to silicon matrix were suggested to be responsible for the formation of intermetallic NbSi_(2).The amorphization of 3NbSi_(2)+7Nb mixtures(or NbSi_(2)+5Nb mixtures)is believed to be controlled by material transfer,which moves composition of line intermetallic NbSi2 off stoichiometry,and causes the matrix of elemental Nb deformed. | LI Bing MA Xueming LIU Lin QI Zhenzhong DONG Yuanda | 1994 | Chinese Physics Letters1994，11，11： | 4 |
| 4 | Perovskite-transition metal dichalcogenides heterostructures: recent advances and future perspectives显示文摘Transition metal dichalcogenides(TMDs)and perovskites are among the most attractive and widely investigated semiconductors in the recent decade.They are promising materials for various applications,such as photodetection,solar energy harvesting,light emission,and many others.Combining these materials to form heterostructures can enrich the already fascinating properties and bring up new phenomena and opportunities.Work in this field is growing rapidly in both fundamental studies and device applications.Here,we review the recent findings in the perovskite-TMD heterostructures and give our perspectives on the future development of this promising field.The fundamental properties of the perovskites,TMDs,and their heterostructures are discussed first,followed by a summary of the synthesis methods of the perovskites and TMDs and the approaches to obtain high-quality interfaces.Particular attention is paid to the TMD-perovskite heterostructures that have been applied in solar cells and photodetectors with notable performance improvement.Finally through our analysis,we propose an outline on further fundamental studies and the promising applications of perovskite-TMD heterostructures. | Ahmed Elbanna Ksenia Chaykun Yulia Lekina Yuanda Liu Benny Febriansyah Shuzhou Li Jisheng Pan Ze Xiang Shen Jinghua Teng | 2022 | Opto-Electronic Science2022，1，8： | 2 |
| 5 | Energetic particles’fluxes and dose in the Radiation Gene Box measured by space radiation detector onboard SJ-10 satellite显示文摘Background To evaluate the hazard of space radiation posing to the tissues,it is important to obtain exact fluxes of different radiation particles.The Radiation Gene Box(RGB)onboard SJ-10 spacecraft was an instrument designed to investigate the effects of space environment on the mESCs and drosophila.To derive the dose received by the tissues inside the RGB,the Space Radiation Detector(SRD)was installed inside it.Purpose The SRD was designed to derive the fluxes of electron,proton,hellion and gamma rays around it.If the type of the particles,the energies,the fluxes and the conversion coefficients are known,the dose received by the tissues could be evaluated.Methods The SRDwas designed as a △E-E solid-state telescope.By measuring the energy deposited in the three subdetectors,the particles’type and their energies could be discriminated.The data of SRDwere divided into 15 bins by the types of particles and their energy ranges.Results The gamma ray flux was higher than any other particle flux inside the RGB,and the electron was the most intense charge particle,while the helium ion was the most harmful radiation to the cells inside the RGB.Conclusion The dose rate inside the Radiation Gene Box was much higher than in the ground,but the integral dose of 12 days inside the RGB was about 2.13 mSv.It seemed unlikely to have obvious biological effects on the tissues of mice and drosophila. | Xingzhu Cui Yaqing Liu Wenxi Peng Jinzhou Wang Min Gao Dongya Guo Xiaohua Liang Ruirui Fan Huanyu Wang Yunlong Zhang Zhongjian Ma Mingyang Yan Hong Xiao Yuanda Jiang Haiying Hang | 2018 | Radiation Detection Technology and Methods2018，2，2： | 2 |
| 6 | Mechanically Driven Alloying and Structural Evolution of Nanocrystalline Fe_(60)Cu_(40) Powder显示文摘Highly supersaturated nanocrystalline fcc Fe60Cu40 alloy has been prepared by mechanical alloying of elemental powders. The phase transformation is monitored by X-ray diffraction (XRD),Mossbauer spectroscopy and extended X-ray absorption fine structure (EXAFS). The powder obtained after milling is of single fcc structure with grain size of nanometer order. The Mossbauer spectra of the milled powder can be fitted by two subspectra whose hyperfine magnetic fields are 16 MA/m and 20 MA/m while that of pure Fe disappeared. EXAFS results show that the radial structure function (RSF) of Fe K-edge changed drastically and finally became similar to that of reference Cu K-edge, while that of Cu K-edge nearly keeps unchanged in the process of milling. These imply that bcc Fe really transforms to fcc structure and alloying between Fe and Cu occurs truly on an atomic scale. EXAFS results indicate that iron atoms tend to segregate at the boundaries and Cu atoms are rich in the fcc lattice. Annealing experiments show that the Fe atoms at the interfaces are easy to cluster to α-Fe at a lower temperature, whereas the iron atoms in the lattice will form γ-Fe first at temperature above 350℃, and then transform to bcc | Yuanda DONG and Xueming MA(School of Materials Science and Engineering, Shanghai University, Shanghai 200072, China)Yuanzheng YANG(Dept. of Mechanical Engineering(2), South China University of Technology, Guangzhou 510641, China)Fangxin LIU and Genmiao WA | 1997 | Journal of Materials Science & Technology1997，13，4： | 1 |
| 7 | White Electroluminescence with Simultaneous Three-Color Emission from a Four-Armed Star-Shaped Single-Polymer System显示文摘有4,7二度的一个四手臂的塑造星的单个聚合物的系统(5-(4-( 9H-carbazol-9-yl )苯基) -4-hexylthiophen-2-yl)benzo[c][1,2,5]thiadiazole ( FTBT )作为一个红放射性的核心, polyfluorene ( PF )作为绿放射性的掺杂物作为蓝放射性的手臂和 1,3-benzo thiadiazole ( BT )被设计并且综合,在里面哪个红,绿,并且蓝色(红绿蓝)排放平衡能被小心地调整 FTBT 和 BT 的做的集中完成。一台典型 single-emissive-layer 设备(ITO/PEDOT : PSS/polymer/TPBI/LiF/Al ) 被学习并且讨论,与 1.59 cd·A −1 和 CIE 的发光效率(LE ) 认识到纯、稳定的白排出物协调(0.31, 0.34 ) 。设备的 high-color-quality 白人 electroluminescence 能主要从蓝 PF 手臂被归因于压制的分子间的相互作用,和部分精力转移到红、绿的掺杂物。 | Yuanda Jiu Jianyun Wang Chengfang Liu Wenyong Lai Lingling Zhao Xiangchun Li Yi Jiang Weidong Xu Xinwen Zhang Wei Huang | 2015 | Chinese Journal of Chemistry2015，33，8： | 1 |
| 8 | Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel显示文摘Exposure to a growth factor abundant milieu has remarkable regenerative and rejuvenating effects on organ diseases,tissue damage,and regeneration,including skeletal system defects and bone regeneration.Although the introduction of candidate growth factors into relevant fields has been reported,their regenerative effects remain unsatisfactory,mainly because of the experimental challenges with limited types of growth factors,elusive dosage adjustment,and asynchronous stem cell activation with cytokine secretion.Here,an innovative hydrogel recapitulating a growth factor-enriched microenvironment(GEM)for regenerative advantage,is reported.This sulfated hydrogel includes bone morphogenetic protein-2(BMP-2),an essential growth factor in osteogenesis,to direct mesenchymal stem cell(MSC)differentiation,stimulate cell proliferation,and improve bone formation.The semi-synthetic hydrogel,sulfonated gelatin(S-Gelatin),can amplify BMP-2 signaling in mouse MSCs by enhancing the binding between BMP-2 and BMP-2 type II receptors(BMPR2),which are located on MSC nuclei and activated by the hydrogel.Importantly,the dramatically improved cytokine secretion of MSCs throughout regeneration confirms the growth factor-acquiring potential of S-Gelatin/rhBMP-2 hydrogel,leading to the vascularization enhancement.These findings provide a new strategy to achieve an in situ GEM and accelerated bone regeneration by amplifying the regenerative capacity of rhBMP-2 and capturing endogenous growth factors. | Qinghao Zhang Yuanda Liu Jie Li Jing Wang Changsheng Liu | 2023 | Bioactive Materials2023，，2： | 0 |
| 9 | Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy显示文摘Despite the remarkable success of immune checkpoint inhibitors(ICIs),primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment(TME).Oncolytic viruses(OVs)can overcome the immunosuppressive TME and promote systemic antitumor immunity in hosts.Engineered OVs armed with ICIs would likely have improved effectiveness as a cancer therapy.According to the diverse immune cell landscapes among different types of tumors,we rationally and precisely generated three recombinant oncolytic adenoviruses(OAds):OAd-SIRPα-Fc,OAd-Siglec10-Fc and OAd-TIGIT-Fc.These viruses were designed to locally deliver SIRPα-Fc,Siglec10-Fc or TIGIT-Fc fusion proteins recognizing CD47,CD24 or CD155,respectively,in the TME to achieve enhanced antitumor effects.Our results suggested that OAd-SIRPα-Fc and OAd-Siglec10-Fc both showed outstanding efficacy in tumor suppression of macrophage-dominated tumors,while OAd-TIGIT-Fc showed the best antitumor immunity in CD8+T-cell-dominated tumors.Importantly,the recombinant OAds activated an inflammatory immune response and generated long-term antitumor memory.In addition,the combination of OAd-Siglec10-Fc with anti-PD-1 significantly enhanced the antitumor effect in a 4T1 tumor model by remodeling the TME.In summary,rationally designed OAds expressing ICIs tailored to the immune cell landscape in the TME can precisely achieve tumor-specific immunotherapy of cancer. | Daoyuan Xie Yaomei Tian Die Hu Yuanda Wang Yuling Yang Bailing Zhou Rui Zhang Zhixiang Ren Mohan Liu Jie Xu Chunyan Dong Binyan Zhao Li Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 10 | Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein(RNP)to inhibit herpes simplex virus1 infection in vitro and in vivo显示文摘Extracellular vesicles(EVs)have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins(RNPs),owing to their ability to minimize off-target effects and immune responses.However,enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within EVs.In response,we employed the Fc/Spa interaction system,in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV membrane.Simultaneously,the B domain of the Spa protein was fused to the C domain of cargos such as Cre or spCas9.Due to the robust interaction between Fc and Spa,this method enriched nearly twice the amount of cargo within the EVs.EVs loaded with spCas9 RNP targeting the HSV1 genome exhibited significant inhibition of viral replication in vitro and in vivo.Moreover,following neuron-targeting peptide RVG modification,the in vivo dosage in neural tissues substantially increased,contributing to the clearance of the HSV1 virus in neural tissues and exhibiting a lower off-target efficiency.These findings establish a robust platform for efficient EV-based SpCas9 delivery,offering potential therapeutic advantages for HSV1 infections and other neurological disorders. | Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 11 | Angiopoietin-1 mRNA and Bcl-2 expression following estradiol treatment in ovariectomized rats with focal cerebral ischemia/reperfusion injury显示文摘BACKGROUND:Estrogen has been clinically demonstrated to attenuate ischemic brain injury. However,the precise mechanisms remain controversial. OBJECTIVE:To investigate the effects of estradiol on angiopoietin-1 mRNA and Bcl-2 expression, as well as apoptosis and cerebral blood flow,in ovariectomized rats with focal cerebral ischemia following reperfusion. DESIGN,TIME AND SETTING:Randomized,controlled,animal experiment.The study was performed at the Central Laboratory,Chongqing Medical University from September to December 2005. MATERIALS:Estradiol benzoate was purchased from Shanghai Ninth Pharmaceutical Factory; com oil was purchased from Walmart Supercenter;TUNEL kit,rabbit anti-rat Bcl-2 polyclonal antibody,and biotin-labeled goat anti-rabbit antibody were purchased from Wuhan Boster,China. METHODS:Healthy,female,6-month-old Wistar rats-wild-type and estrogen alpha receptor gene knockout(ERKO)-were randomly divided into estradiol and control groups with 25 animals in each group.The rats were intramuscularly injected with estradiol benzoate(100μg/kg per day) at 30 days following bilateral ovariectomy or corn oil(1 mL/kg per day) for seven consecutive days.Following administration,cerebral ischemia/reperfusion models were established using the right middle cerebral artery occlusion(MCAO) method.After 30 minutes of MCAO,estradiol and control groups were separately injected with estradiol benzoate and corn oil with the above-mentioned doses. MAIN OUTCOME MEASURES:Cell apoptosis was determined by TUNEL;angiopoietin-1 mRNA and Bcl-2 gene expression was determined,respectively,by immunohistochemical staining and RT-PCR.In addition,changes in cerebral blood flow were measured by laser Doppler flowmetry. RESULTS:Changes in angiopoietin-1 mRNA and cerebral blood flow in estradiol-treated,wild-type, MCAO rats following ischemia/reperfusion were greater than in control rats(P<0.01 or 0.05). However,no significant difference was observed between estradiol-treated ERKO MCAO rats and control rats.In addition,estradiol-treated wild-type and ERKO MCAO rats exhibited significantly increased Bcl-2 expression(P<0.05) and decreased number of apoptotic cells in brain tissues compared with control groups(P<0.05). CONCLUSION:Estradiol upregulated angiopoietin-1 mRNA and Bcl-2 expression,suggesting that estradiol might be involved in protective mechanisms of cerebral ischemia/reperfusion injury. | Rong Gu Minghua Liu Yonghong Wang Yuanda Zhou Haixia He | 2009 | Neural Regeneration Research2009，4，10： | 0 |
| 12 | Structure and Electrical Characteristics of Zinc Oxide Thin Films Grown on Si (111) by Metal-organic Chemical Vapor Deposition显示文摘ZnO thin films were grown on Si(111) substrates by low-pressure metal-organic chemical vapor deposition.The crystal structures and electrical properties of as-grown sample were investigated by scanning electron microscopy(SEM) and conductive atomic force microscopy(C-AFM).It can be seen that with increasing growth temperature,the surface morphology of ZnO thin films changed from flake-like to cobblestones-like structure.The current maps were simultaneously recorded with the topography,which was gained by C-AFM contact mode.Conductivity for the off-axis facet planes presented on ZnO grains enhanced.Measurement results indicate that the off-axis facet planes were more electrically active than the c-plane of ZnO flakes or particles probably due to lower Schottky barrier height of the off-axis facet planes. | Yunfeng Wu Dongping Liu Naisen Yu Yuanda Liu Hongwei Liang Guotong Du | 2013 | Journal of Materials Science & Technology2013，29，9： | 0 |
| 13 | Venovenous extracorporeal membrane oxygenation for COVID-19 and influenza H1N1 associated acute respiratory distress syndrome:A comparative cohort study in China显示文摘Background Venovenous extracorporeal membrane oxygenation(VV-ECMO)has been demonstrated to be effective in treating patients with virus-induced acute respiratory distress syndrome(ARDS).However,whether the management of ECMO is different in treating H1N1 influenza and coronavirus disease 2019(COVID-19)-associated ARDS patients remains unknown.Methods This is a retrospective cohort study.We included 12 VV-ECMO-supported COVID-19 patients admitted to The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Eighth People's Hospital,and Wuhan Union Hospital West Campus between January 23 and March 31,2020.We retrospectively included VV-ECMO-supported patients with COVID-19 and H1N1 influenza-associated ARDS.Clinical characteristics,respiratory mechanics including plateau pressure,driving pressure,mechanical power,ventilatory ratio(VR)and lung compliance,and outcomes were compared.Results Data from 25 patients with COVID-19(n=12)and H1N1(n=13)associated ARDS who had received ECMO support were analyzed.COVID-19 patients were older than H1N1 influenza patients(P=0.004).The partial pressure of arterial carbon dioxide(PaCO_(2))and VR before ECMO initiation were significantly higher in COVID-19 patients than in H1N1 influenza patients(P<0.001 and P=0.004,respectively).COVID-19 patients showed increased plateau and driving pressure compared with H1N1 subjects(P=0.013 and P=0.018,respectively).Patients with COVID-19 remained longer on ECMO support than did H1N1 influenza patients(P=0.015).COVID-19 patients who required ECMO support also had fewer intensive care unit and ventilator-free days than H1N1.Conclusions Compared with H1N1 influenza patients,COVID-19 patients were older and presented with increased PaCO_(2) and VR values before ECMO initiation.The differences between ARDS patients with COVID-19 and influenza on VV-ECMO detailed herein could be helpful for obtaining a better understanding of COVID-19 and for better clinical management. | Yonghao Xu Yin Xi Shuijiang Cai Yuheng Yu Sibei Chen Weijie Guan Weibo Liang Hongkai Wu Weiqun He Xilong Deng Yuanda Xu Rong Zhang Manshu Li Jieyi Pan Zhenting Liang Ya Wang Shaofeng Kong Xiaoqing Liu Zheng Lv Yimin Li | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
| 14 | Structural Characteristics of Rapidly Quenched Al-Si Alloys显示文摘The structure of rapldly quenched Al-Si alloys (1 and 4 wt-%Si) was systematically studied by optical and transmission electron microscopy (TEM ) as welI as X-ray djffractjon (XRD). ExperimentaIresults show that rapid solidification refines the grain size. extends the solid solubility of Si in Al and Introduces a high density ot defects which exist in the forms of vacancies, dislocations and dislocation loops. etc.. The decomposition process of the alloys was fol lowed by using differential scanning calorimeter (DSC) and the activation energy for precipitation of Si was obtained through Kissinger analysis. The precipitation behaviour of Supersaturated Si in both samples was further examined by TEM. It was found that Si mainly precipitated inside the grains in Al-1 wt-%Si alloy. while in Al-4 wt-%Si alloy. nearly all the Si precipitates distributed along the grain boundaries. This may be due to the structure difference between the alloys in as-quenched | Lin LIU(Institute of Solid State Physics, Academia Sinica, Hefei, 230031, China)Yuanda DONG(Dept. of Metallurgy and Materials, Shanghai University of Technology, Shanghai, 200072, China) | 1994 | Journal of Materials Science & Technology1994，10，3： | 0 |
| 15 | Clipping discrete multi-tone for peak-power-constraint IM/DD optical systems显示文摘High peak-to-average power ratio(PAPR)is a major drawback of discrete multi-tone(DMT)in peak-power-constraint(PPC)intensity-modulation/direct-detection(IM/DD)optical systems.Symmetric clipping operation is a frequently-used and practical method for mitigating the PAPR of the DMT signal.However,clipping noise is inevitably induced by the symmetric clipping operation,thereby deteriorating the system’s performance.In this paper,we study the statistical characteristics of the clipping noise in detail.Depending on the statistical characteristics,clipping-noise-cancellation(CNC)algorithms are proposed to mitigate the clipping noise in the clipping DMT systems.Theoretically,the clipping noise can be completely removed using the low-density-parity-check-assisted CNC algorithm(LDPC-assisted CNC algorithm).To verify the superiority of the clipping DMT with the CNC algorithm,we conduct an experiment with a50 Gb/s DMT system using 10G-class commercial devices for the scenario of PPC passive optical networks.The receiver sensitivity of the clipping DMT system with the CNC algorithm can reach-24 d Bm at a 20%soft-decision forward-error-correction limit,which is 2.5 d B higher than that of the DMT system without clipping operation.The clipping operation and the CNC algorithm are added after the original digital signal processing,thereby demonstrating the potential to efectively overcome the drawback in DMT signals and other high-PAPR signals. | Ji ZHOU Liangchuan LI Jiale HE Xiaofeng LU Yu BO Guanyu WANG Yuanda HUANG Gengchen LIU Yanzhao LU Shecheng GAO Yuanhua FENG Shancheng ZHAO Weiping LIU Changyuan YU Zhaohui LI | 2023 | Science China(Information Sciences)2023，66，5： | 0 |
| 16 | All-carbon hybrids for high-performance electronics,optoelectronics and energy storage显示文摘The family of carbon allotropes such as carbon nanotubes(CNTs) and graphene, with their rich chemical and physical characteristics, has attracted intense attentions in the field of nanotechnology and enabled a number of disruptive devices and applications in electronics, optoelectronics and energy storage.Just as no individual 2 D(two-dimensional) material can meet all technological requirements of various applications, combining carbon materials of different dimensionality into a hybrid form is a promising strategy to optimize properties and to build novel devices operating with new principles. In particular, the direct synthesis of 2 D or 3 D(three-dimensional) sp2-hybridized all-carbon hybrids based on merging CNTs and graphene affords a great promise for future electronic, optoelectronic and energy storages. Here, we review the progress of all-carbon hybrids-based devices, covering material preparation, fabrication techniques as well as applied devices. Recent progress about large-scale synthesis and assembly techniques is highlighted,and with many intrinsic advantages, the all-carbon strategy opens up a highly promising approach to obtain high-performance integrated circuits. Moreover, this review will discuss the remaining challenges in the field and provide perspectives on future applications. | Shuchao QIN Yuanda LIU Hongzhu JIANG Yongbing XU Yi SHI Rong ZHANG Fengqiu WANG | 2019 | Science China(Information Sciences)2019，62，12： | 0 |
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