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| 1 | Research and development of drug delivery systems based on drug transporter and nano-formulation显示文摘In recent years,the continuous occurrence of multi-drug resistance in the clinic has made people pay more attention to the transporter.Changes in the expression and activity of transporters can cause corresponding changes in drug pharmacokinetics and pharmacodynamics.The drug-drug interactions(DDI)caused by transporters can seriously affect drug effectiveness and toxicity.In the development of pharmaceutical preparations,people have increasingly concerned about the effects and regulation of transporters in drug effects.To improve the targeting and physicochemical properties of drugs,the development of targeted agents is very rapid.Among them,novel nano-formulations are the best.With the continuous innovation and development of nano-formulation,its application has become more and more extensive.Nano-formulation has exerted certain advantages in the drug development based on transporters,and is also involved in the combination of targeted transporters.This review focuses on the application of novel nano-agents targeting transporters and the introduction of drug-transporter-based nano-formulations. | Yi Peng Lu Chen Sheng Ye Yu Kang Junqing Liu Su Zeng Lushan Yu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 8 |
| 2 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 3 | Electromagnetic and microwave absorption properties of Er-Ho-Fe alloys显示文摘The Er_xHo_(2-x)Fe_(17)(x = 0.0, 0.1,0.2, 0.3, 0.4) powders were prepared by arc melting and high energy ball milling method. The influence of the Er substitution on phase structure, morphology, saturation magnetization,electromagnetic parameters was investigated by X-ray diffraction(XRD),scanning electron microscopy(SEM), vibrating sample magnetometer(VSM) and vector network analyzer(VNA),respectively. The results show that the saturation magnetization increases and the average particle size increases with the increase of Er content. The minimum absorption peak frequency shifts towards a lower frequency region with the increase of Er content. The Er_(0.3)Ho_(1.7)Fe_(17) powder can achieve the minimum RL of-24.07 dB at 6.96 GHz with a thickness of 2.0 mm and the minimum RL is less than-20 dB at the thickness range from 2.0 to 3.0 mm. The minimum RL of Er_(0.3)Ho_(1.7)Fe_(17) is-37.26 dB at5.68 GHz and the frequency bandwidth of R<-10 dB reaches about 1.2 GHz with a thickness of 2.4 mm.And the microwave absorbing properties of the composite with different weight ratios of Er_(0.3)Ho_(1.7)Fe_(17)/graphene were researched. The microwave absorbing peaks of the composite shift to lower frequency with the increase of graphene content. The values of the minimum RL of Er_(0.3)Ho_(1.7)Fe_(17)/graphene are close to-10 dB with absorbing coating thicknesses increased. | Jialiang Luo Shunkang Pan Lichun Cheng Peihao Lin Yu He Junqing Chang | 2018 | Journal of Rare Earths2018，36，7： | 3 |
| 4 | Simulation and analysis of the carrying capacity for road networks using a grid-based approach显示文摘The number of vehicles that a road network can carry is limited.When the limit is exceeded,the network system is not able to function effectively.In this paper,an updated cellular automaton model for grid networks with all-way stop-controlled intersections is proposed to simulate the network level critical density and carrying capacity under different conditions,which essentially indicates the limit number of vehicles that the network can handle before going into gridlock.In the proposed model,two update rules,including lane-changing and the longitudinal location update,are adopted to describe the vehicle’s movements on road segments according to the driving condition on the road and the vehicle’s direction in the downstream intersection.The vehicle’s movements in intersection areas are prioritized based on vehicle’s position,so as to prevent collisions within the intersection area.The simulation results show that an increase in network size is able to expand the carrying capacity of a road network,whereas the expansion rate is lower than the change rate in the network size.The carrying capacity is also associated with the structure of road network.The carrying capacity is inversely proportional to the number of intersections,and proportional to the length of the road in the network.Also,optimizing the origin-destination(O-D)distribution can increase the carrying capacity of an urban road network. | Junqing Shi Linwu Chen Fengxiang Qiao Lei Yu Qing Li Guilian Fan | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，4： | 3 |
| 5 | Influence of catalyst types on the microwave- induced pyrolysis of sewage sludge显示文摘 | Ying Yu Junqing Yu Sun Bing | 2014 | Journal of Analytical and Applied Pyrolysis2014，106，： | 1 |
| 6 | Stannate conversion coatings on Mg-8Li alloy显示文摘 | Lihui Yang Milin Zhang Junqing Li Xiang Yu Zhongyi Niu | | 0，，1： | 1 |
| 7 | Upgrading pyrolytic carbon-blacks (CBp) from end-of-life tires: Characteristics and modification methodologies显示文摘Over 1 billion end-of-life tires(ELTs)are generating annually,and 4 billion ELTs are currently abandoned in landfills and stockpiles worldwide,according to the statistics,leading to the environmental and health risks.To circumvent these issues,pyrolysis,as an attractive thermochemical process,has been addressed to tackle the ELTs'problem to reduce the risks as well as increase the material recycling.However,due to the lack of systematic characteristic analysis and modification methods,poor quality of CBp limits the improvement of ELTs pyrolysis in industry applications,which plays a crucial role in the economic feasibility of pyrolysis process.In this review,we have summarized the state-of-the-art characteristics and modification methodologies of the upgrading of CBp,to in-depth understand the surface microstructures and physiochemical properties o f CBp for the foundation for modification afterwards.By virtue of the proper selection of modification methods and modifying agents,the new generation of multifunctional carbon materials with desired properties can be instead of the traditional materials of CB,promising broader and various application fields. | Jiaxue Yu Junqing Xu Zhenchen Li Wenzhi He Juwen Huang Junshi Xu Guangming Li | 2020 | Frontiers of Environmental Science & Engineering2020，14，2： | 1 |
| 8 | Resilience patterns of human mobility in response to extreme urban floods显示文摘Large-scale disasters can disproportionately impact different population groups,causing prominent disparity and inequality,especially for the vulnerable and marginalized.Here,we investigate the resilience of human mobility under the disturbance of the unprecedented‘720’Zhengzhou flood in China in 2021 using records of 1.32 billion mobile phone signaling generated by 4.35 million people.We find that although pluvial floods can trigger mobility reductions,the overall structural dynamics of mobility networks remain relatively stable.We also find that the low levels of mobility resilience in female,adolescent and older adult groups are mainly due to their insufficient capabilities to maintain business-as-usual travel frequency during the flood.Most importantly,we reveal three types of counter-intuitive,yet widely existing,resilience patterns of human mobility(namely,‘reverse bathtub’,‘ever-increasing’and‘ever-decreasing’patterns),and demonstrate a universal mechanism of disaster-avoidance response by further corroborating that those abnormal resilience patterns are not associated with people’s gender or age.In view of the common association between travel behaviors and travelers’socio-demographic characteristics,our findings provide a caveat for scholars when disclosing disparities in human travel behaviors during flood-induced emergencies. | Junqing Tang Pengjun Zhao Zhaoya Gong Hongbo Zhao Fengjue Huang Jiaying Li Zhihe Chen Ling Yu Jun Chen | 2023 | National Science Review2023，10，8： | 1 |
| 9 | Optimized Residual Vector Quantization for Efficient Approximate Nearest Neigh- bor Search 显示文摘 | Ai Liefu Yu Junqing He Yunfeng | 2015 | Multimedia Systems2015，，： | 1 |
| 10 | Recent strategies for constructing efficient interfacial solar evaporation systems显示文摘Interfacial solar evaporation(ISE)is a promising technology to relieve worldwide freshwater shortages owing to its high energy conversion efficiency and environmentally sustainable potential.So far,many innovative materials and evaporators have been proposed and applied in ISE to enable highly controllable and efficient solar-to-thermal energy conversion.With rational design,solar evaporators can achieve excellent energy management for lowering energy loss,harvesting extra energy,and efficiently utilizing energy in the system to improve freshwater production.Beyond that,a strategy of reducing water vaporization enthalpy by introducing molecular engineering for water-state regulation has also been demonstrated as an effective approach to boost ISE.Based on these,this article discusses the energy nexus in two-dimensional(2D)and three-dimensional(3D)evaporators separately and reviews the strategies for design and fabrication of highly efficient ISE systems.The summarized work offers significant perspectives for guiding the future design of ISE systems with efficient energy management,which pave pathways for practical applications. | Yida Wang Junqing Hu Li Yu Xuan Wu Yingying Zhang Haolan Xu | 2023 | Nano Research Energy2023，2，2： | 1 |
| 11 | Synthesis, characterization and anticorrosion performance of molybdate pillared hydrotalcite/ in situ created ZnO composite as pigment for Mg–Li alloy protection显示文摘 | Xiang Yu Jun Wang Milin Zhang Lihui Yang Junqing Li Piaoping Yang Dianxue Cao | 2008 | Surface & Coatings Technology2008，，3： | 1 |
| 12 | Geological characteristics and genesis of subbottom pinnoite deposit of Da Qaidam salt lake in Qaidam Basin显示文摘Da Qaidam salt lake is known for its both liquid and solid boron resource.Data from previous investigation of the Da Qaidam salt lake provided a comparable framework for this study that focused on investigating the section beneath the bottom of the perennial salt lake,including the timing, | Gao Chunliang Yu Junqing Min Xiuyun Cheng Aiying Zhang Lisa He Xianhu Xin Shouzhen Hong Rongchang | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 1 |
| 13 | Multi-objective network optimization combining topology and routing algorithms in multi-layered satellite networks显示文摘In satellite communication studies, the multi-layered satellite network (MLSN) can take advan-tage of both wide coverage and low time delay.Furthermore, the issue of stable networking anddynamic reconstructing methods is still worth ex-ploring. However, current studies rarely involvethe combination of the routing algorithm and thenetwork topology. | Zhuoming LI Huiyun XIA Yu ZHANG Junqing QI Shaohua WU Shushi GU | 2018 | Science China(Information Sciences)2018，61，8： | 0 |
| 14 | An FPS-ZM1-encapsulated zeolitic imidazolate framework as a dual proangiogenic drug delivery system for diabetic wound healing显示文摘Inhibitors that target diabetes pathology-related signaling pathways have great therapeutic potential for diabetic wound healing.Metal–organic frameworks(MOFs)are increasingly popular drug delivery systems that have high loading capacity and can release their intrinsic metal ions to act as bioactive agents.In light of this,a receptor for advanced glycation end products(RAGE)inhibitor,4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide(FPS-ZM1),was loaded into a cobalt(Co)-based MOF(zeolitic imidazolate framework-67,ZIF-67)to fabricate FPS-ZM1 encapsulated ZIF-67(FZ@ZIF-67)nanoparticles(NPs).As a result,FZ@ZIF-67 NPs could dually deliver Co ions and FPS-ZM1 in a controlled manner for over 14 days.Our in vitro study showed that FZ@ZIF-67 NPs not only enhanced angiogenesis by delivering Co ions but also released FPS-ZM1 to promote M2 macrophage polarization and attenuated high glucose(HG)-and/or inflammation-induced impairment of angiogenesis through RAGE inhibition.Moreover,in an in vivo study,FZ@ZIF-67 NPs markedly improved re-epithelialization,collagen deposition,neovascularization,and relieved inflammation in diabetic wounds in rats.This study not only provides a low-cost,effective,and synergistic proangiogenic bioactive agent but also demonstrates that targeting diabetes-related pathological signaling pathways is necessary to ameliorate vascularization impairment during diabetic wound healing. | Yi Sun Bingbo Bao Yu Zhu Junjie Shen Xuanzhe Liu Tao Gao Junqing Lin Tengli Huang Jia Xu Yimin Chai Xianyou Zheng | 2022 | Nano Research2022，15，6： | 0 |
| 15 | Seismic energy dispersion compensation by multi-scale morphology显示文摘Seismic energy decays while propagating subsurface, which may reduce the resolution of seismic data. This paper studies the method of seismic energy dispersion compensation which provides the basic principles for multi-scale morphology and the spectrum simulation method. These methods are applied in seismic energy compensation. First of all, the seismic data is decomposed into multiple scales and the effective frequency bandwidth is selectively broadened for some scales by using a spectrum simulation method. In this process, according to the amplitude spectrum of each scale, the best simulation range is selected to simulate the middle and low frequency components to ensure the authenticity of the simulation curve which is calculated by the median method, and the high frequency component is broadened. Finally, these scales are reconstructed with reasonable coefficients, and the compensated seismic data can be obtained. Examples are shown to illustrate the feasibility of the energy compensation method. | Yu Junqing Wang Runqiu Liu Taoran Zhang Zhenglong Wu Jian Jiang Yongyong Sun Lipeng Xia Pei | 2014 | Petroleum Science2014，11，3： | 0 |
| 16 | Research of Virtual Experiment Based on Flex and XML显示文摘In this paper, the design of a virtual experiment system based on Flex and XML is described. The system adopts three-layer architecture and it is composed of four modules. Flex is used to design user interface, and XML is used as data format between layers or modules. Data services are used to store or retrieve the information of experiment components or experiment scenes. Principles for the design of simulation engine and simulation scheduler are discussed. The design of the simulation engine for 'Digital Logic' course is described in detail. The system has been implemented in the experiment teaching of Digital Logic. Teaching results and the feedback from students demonstrate that the virtual experiment system can improve the effects of experiment teaching and arouse the learning interests of students. | TANG Jiufei OUYANG Xingming YU Junqing | 2012 | Wuhan University Journal of Natural Sciences2012，17，1： | 0 |
| 17 | Activation of AMPKα1 is essential for regulatory T cell function and autoimmune liver disease prevention显示文摘Regulatory T cells(Treg cells)are crucial for maintaining immune tolerance.Compromising the regulatory function of Treg cells can lead to autoimmune liver disease.However,how Treg cell function is regulated has not been fully clarified.Here,we report that mice with AMP-activated protein kinase alpha 1(AMPKα1)globally knocked out spontaneously develop immune-mediated liver injury,with massive lymphocyte infiltration in the liver,elevated serum alanine aminotransferase levels,and greater production of autoantibodies.Both transplantation of wild-type bone marrow and adoptive transfer of wild-type Treg cells can prevent liver injury in AMPKα1-KO mice.In addition,Treg cell-specific AMPKα1-KO mice display histological features similar to those associated with autoimmune liver disease,greater production of autoantibodies,and hyperactivation of CD4^(+)T cells.AMPKα1 deficiency significantly impairs Treg cell suppressive function but does not affect Treg cell differentiation or proliferation.Furthermore,AMPK is activated upon T cell receptor(TCR)stimulation,which triggers Foxp3 phosphorylation,suppressing Foxp3 ubiquitination and proteasomal degradation.Importantly,the frequency of Treg cells and the phosphorylation levels of AMPK at T172 in circulating blood are significantly lower in patients with autoimmune liver diseases.Conclusion:Our data suggest that AMPK maintains the immunosuppressive function of Treg cells and confers protection against autoimmune liver disease. | Huaiping Zhu Zhaoyu Li Junqing An Miao Zhang Yu Qiu Ming-Hui Zou | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 18 | Analysis of the chloroplast genomes of four Pinus species in Northeast China:Insights into hybrid speciation and identification of DNA molecular markers显示文摘Species of the Pinus genus provide a classical model for studying hybrid speciation.Although studies on two narrowly distributed species(P inus funebris and P.takahasii)concluded that they originated from two widespread species(P.sylvestris and P.densiflora)via hybrid speciation,the conclusion was based on a low number of informative restriction sites.In this study,we analyzed the sequences of four Pinus chloroplast(cp)genomes(P.sylvestris,P.densiflora,P.funebris and P.takahasii)to clarify whether hybrid speciation was involved.The complete cp-genomes of Pinus species ranged in size from 119,865 to 119,890 bp,similar to other Pinus species.Phylogenetic results based on the whole cp-genomes showed P.sylvestris clustered with P.funebris and P.takahasii,which suggested that P.sylvestris was the paternal parent in hybridization events.In an analysis of simple sequence repeats(SSRs),we detected a total of 69 SSRs repeats among the four Pinus cp-genomes;most were A or T bases.In addition,we identified divergent hotspot regions among the four Pinus cp-genomes(trnE-clpP,cemA-ycf4,petD-rpoA,psbD-trnT,and trnN-chlL),in P.sylvestris(psbD-trnT,trnN-chlL,psbB and rps8)and in P.densiflora(trnE-clpP,petD-rpoA,ycf3 intron,psbD-trnT,and trnN-chlL).The genome information found in this study provides new insights into hybrid speciation in P inus and contributes to a better understanding of the phylogenetic relationships within the Pinus genus. | Tao Yu Zhiyuan Jia Buddhi Dayananda Junqing Li Xiaolei Guo Liang Shi Xiaowen Yuan Yan Gao | 2022 | Journal of Forestry Research2022，33，6： | 0 |
| 19 | Personalized Emotion Space for Video Affective Content Representation显示文摘A personalized emotion space is proposed to bridge the 'affective gap' in video affective content understanding. In order to unify the discrete and dimensional emotion model, fuzzy C-mean (FCM) clustering algorithm is adopted to divide the emotion space. Gaussian mixture model (GMM) is used to determine the membership functions of typical affective subspaces. At every step of modeling the space, the inputs rely completely on the affective experiences recorded by the audiences. The advantages of the improved V-A (Velance-Arousal) emotion model are the personalization, the ability to define typical affective state areas in the V-A emotion space, and the convenience to explicitly express the intensity of each affective state. The experimental results validate the model and show it can be used as a personalized emotion space for video affective content representation. | SUN Kai,YU Junqing,HUANG Yue,HU Xiaoqiang,LIU Qing College of Computer Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China | 2009 | Wuhan University Journal of Natural Sciences2009，14，5： | 0 |
| 20 | Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer显示文摘Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical field.However,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy.Though photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration depth.Here,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction.The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated.Moreover,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis. | Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu | 2021 | Research2021，，1： | 0 |
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