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| 1 | Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures显示文摘AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures. | Yu Jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 16 |
| 2 | Timing of upper gastrointestinal endoscopy does not influence short-term outcomes in patients with acute variceal bleeding显示文摘AIM To examine the association between the timing of endoscopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.METHODS This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting(IPW) method. The primary outcome was the mortality of patients within 6 wk.RESULTS A total of 173 patients received urgent endoscopy(i.e., ≤ 12 h after admission), and 101 patients received nonurgent endoscopy(> 12 h after admission). The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before(P = 0.266) and after IPW(P = 0.639). The length of hospital stay was statistically different between the urgent group and non-urgent group(P = 0.033); however, there was no significant difference in the inhospital mortality rate between the two groups(8.1% vs 7.9%, P = 0.960). In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality(hazard ratio, 1.297; 95% confidence interval, 0.806-2.089; P = 0.284).CONCLUSION In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality. | Jeong-Ju Yoo Young Chang Eun Ju Cho Ji Eun Moon Sang Gyune Kim Young Seok Kim Yun Bin Lee Jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon | 2018 | World Journal of Gastroenterology2018，24，44： | 8 |
| 3 | Proton therapy for hepatocellular carcinoma:Current knowledges and future perspectives显示文摘Hepatocellular carcinoma(HCC) is the second leading cause of cancer-related death, as few patients can be treated with currently available curative local modalities. In patients with HCC where curative modalities are not feasible, radiation therapy(RT) has emerged as an alternative or combination therapy. With the development of various technologies, RT has been increasingly used for the management of HCC. Among these advances, proton beam therapy(PBT) has several unique physical properties that give it a finite range in a distal direction, and thus no exit dose along the beam path. Therefore, PBT has dosimetric advantages compared with X-ray therapy for the treatment of HCC. Indeed, various reports in the literature have described the favorable clinical outcomes and improved safety of PBT for HCC patients compared with X-ray therapy. However, there are some technical issues regarding the use of PBT in HCC, including uncertainty of organ motion and inaccuracy during calculation of tissue density and beam range, all of which may reduce the robustness of a PBT treatment plan. In this review, we discuss the physical properties, current clinical data, technical issues, and future perspectives on PBT for the treatment of HCC. | Gyu Sang Yoo Jeong Il Yu Hee Chul Park | 2018 | World Journal of Gastroenterology2018，24，28： | 8 |
| 4 | One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients显示文摘Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up. | Yeon Pyo Yoo Ki-Woon Kang Hyeon Soo Yoon Jin Cheol Myung Yu Jeong Choi Won Ho Kim Sang Hyun Park Kyung Tae Jung Myung Ho Jeong | 2013 | Journal of Geriatric Cardiology2013，10，3： | 7 |
| 5 | GC-MS analysis of volatile compounds of Perilla frutescens Britton var. Japonica accessions: morphological and seasonal variability显示文摘Objective: To investigate the composition of volatile compounds in the different accessions of Perilla frutescens(P. frutescens) collected from various habitats of China and Japan. Methods: In the present study, the essential oil from the leaves of P. frutescens cultivars from China and Japan was extracted by hydro-distillation and the chemical composition and concentration of the volatile components present in the oils were determined by gas chromatography–mass spectrometry(GC–MS) analysis. Results: Among the volatile components, the major proportion was of perilla ketone, which was followed by elemicin and beta-caryophyllene in the Chinese Perilla cultivars. The main component in the oil extracted from the Japanese accessions was myristicin, which was followed by perilla ketone and beta-caryophyllene. We could distinguish seven chemotypes, namely the perilla ketone(PK) type, perilla ketone, myristicin(PM) type, perilla ketone, unknown(PU) type, perilla ketone, beta-caryophyllene, myristicine(PB) type, perilla ketone, myristicin, unknown(PMU) type, perilla ketone, elemicine, myristicin, beta-caryophyllene(PEMB) type, and the perilla ketone, limonene, betacryophyllene, myristicin(L) type. Most of the accessions possessed higher essential oil content before the flowering time than at the flowering stage. The average plant height, leaf length, leaf width of the Chinese accessions was higher than those of the Japanese accessions. Conclusion:The results revealed that the harvest time and geographical origin caused polymorphisms in the essential oil composition and morphological traits in the Perilla accessions originating from China and Japan. Therefore, these chemotypes with desirable characters might be useful for industrial exploitation and for determining the harvest time. | Bimal Kumar Ghimire Ji Hye Yoo Chang Yeon Yu Ill-Min Chung | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 6 |
| 6 | The feasibility of combined transcatheter arterial chemoembolization and radiotherapy for advanced hepatocellular carcinoma显示文摘 | Ju‐Yeon Cho Yong‐Han Paik Hee Chul Park Jeong Il Yu Won Sohn Geum‐Youn Gwak Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo | 2014 | Liver Int2014，，5： | 5 |
| 7 | Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43显示文摘Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor effects.In this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal vein.Its ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary hepatocytes.Fucoidan was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 expression.It also significantly decreased liver metastasis in vivo.As regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling complex.In summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on hepatocytes.The results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects. | Yuri Cho Jung-Hwan Yoon Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Chung Yong Kim | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 3 |
| 8 | Risk Factors for Progression from Cytomegalovirus Viremia to Cytomegalovirus Disease after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘 | Ji Eun Jang Shin Young Hyun Yun Deok Kim Sul Hee Yoon Doh Yu Hwang Soo Jeong Kim Yuri Kim Jin Seok Kim June-Won Cheong Yoo Hong Min | 2012 | Biology of Blood and Marrow Transplantation2012，，6： | 2 |
| 9 | Erectile potentials of a new phosphodiesterase type 5 inhibitor, DA-8159, in diet-induced obese rats显示文摘瞄准:在导致食谱的肥胖的老鼠在可勃起的功能检验变化并且调查 DA-8159 的口头的功效,新磷酸二酯酶打 5 (PDE5 ) 禁止者,在在肥胖的老鼠的阴茎勃起以后。方法:老鼠被喂为 12 个星期的一本高精力的食谱并且把组划分了成三:一肥胖抵抗(或) 控制组,一肥胖容易(OP ) 控制组,和 OP-DA-8159 治疗(DA-8159 ) 组织。导致 electrostimulation 的可勃起的回答在所有组被测量。体重,血浆胆固醇,甘油三酸酯和葡萄糖层次也被测量。结果:在 OP 控制组,最大的 intracavernous 压力(ICP ) 和 ICP/blood 迫使(ICP/BP ) 在电的刺激以后的比率是比那些在显著地低的或控制组织。在 ICP/BP 比率,消肿时间和基线多孔的压力的曲线(AUC ) 下面的相应区域也是比在 OR 控制组的那些低的,但是这差别不是重要的。在 OP 组的体重获得,血浆胆固醇和甘油三酸酯水平比在 OR 组的那些显著地高。在管理 DA-8159 以后,最大的 ICP 和 ICP/BP 比率的重要增加被观察。在 DA-8159 组的相应 AUC 也比在二个控制组的那些高。而且,消肿时间是有 DA-8159 的显著地延长的术后疗法。结论:这些结果证明导致食谱的肥胖在老鼠和这些影响可勃起的功能可勃起的机能障碍(编辑) 能被处理与 DA-8159 改进,显示 DA-8159 可能是为与肥胖联系的编辑的一种处理选择。 | Jae-Young Yu Kyung-Koo Kang Moohi Yoo | 2006 | Asian Journal of Andrology2006，8，3： | 2 |
| 10 | Clinical Characteristics and VPS33B Mutations in Patients With ARC Syndrome显示文摘 | Joo Young Jang Kyung Mo Kim Gu-Hwan Kim Eunsil Yu Jin-Joo Lee Young Seo Park Han-Wook Yoo | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，3： | 2 |
| 11 | Alterations of Gefitinib Pharmacokinetics by Co-administration of Herbal Medications in Rats显示文摘Objective: To evaluate the potential pharmacokinetic interactions of the anticancer agent gefitinib(Iressa?) and the oriental medications Guipi Decoction(归脾汤, GPD, Guibi-tang in Korean) and Bawu Decoction(八物汤, BWD, Palmul-tang in Korean). Methods: Methylcellulose(MC, control), GPD(1,200 mg/kg), or BWD(6,000 mg/kg) was orally administered to rats either as a single dose or multiple doses prior to gefitinib administration. To examine the effects of a single dose of the herbal medicines, gefitinib(10 mg/kg) was orally administered after 5 min or 1 h of MC or the herbal medicine pretreatments. To examine the effects of the multiple doses of the herbal medicines, gefitinib(10 mg/kg) was orally administered following 7 consecutive days of the administration of MC or each herbal medicine. The plasma concentrations of gefitinib were determined with liquid chromatography-tandem mass spectrometry assay. The plasma concentration-time profiles of gefitinib were analyzed with a noncompartmental analysis. Results: Gefitinib was rapidly absorbed and showed a monoexponential decline with an elimination half-life of 3.7–4.1 h. The pharmacokinetics of gefitinib was not affected by GPD pretreatment. However, a significantly lower maximum plasma concentration(Cmax, P<0.05) and area under the curve(P<0.05), and a delayed time to reach Cmax(Tmax, P<0.01) were observed in both single-and multipledose BWD-pretreated rats compared with the control rats. Conclusions: BWD and not GPD might delay and interfere with gefitinib absorption. Further evaluations of the clinical significance of these findings are needed. | Kwon-Yeon Weon Min Gi Kim Soyoung Shin Tae Hwan Kim Sang Hoon Joo Eunsook Ma Seok Won Jeong Sun Dong Yoo Yu Seok Youn Beom Soo Shin | 2018 | Chinese Journal of Integrative Medicine2018，24，6： | 2 |
| 12 | Effect of cervical spine motion on neuroforamina dismensions显示文摘 | Yoo Yu Bayley J Zou D | 1992 | Spine1992，17，： | 2 |
| 13 | Autologous Adipose Tissue‐Derived Stem Cells Treatment Demonstrated Favorable and Sustainable Therapeutic Effect for Crohn’s Fistula显示文摘 | Woo Yong Lee Kyu Joo Park Yong Beom Cho Sang Nam Yoon Kee Ho Song Do Sun Kim Sang Hun Jung Mihyung Kim Hee‐Won Yoo Inok Kim Hunjoo Ha Chang Sik Yu | 2013 | Stem Cells2013，，11： | 2 |
| 14 | Distribution of antibody ti-ters to mycoplasma pneumoniae in korean children in2000-2003显示文摘 | Yu J Yoo Y Kim do K | 2005 | J Korean Med Sci2005，20，4： | 1 |
| 15 | Decrease in Apoptosis and Increase in Polyploidization of Megakaryocytes by Stem Cell Factor During Ex Vivo Expansion of Human Cord Blood CD34<sup>+</sup> Cells Using Thrombopoietin显示文摘 | Jeong‐HaeKie Woo‐IckYang Mi‐KyungLee Tae‐JungKwon Yoo‐HongMin Hyun‐OkKim Hyo‐SeopAhn Seock‐AhIm Hyung‐LaeKim Hae‐YoungPark Kyung‐HaRyu Wha‐SoonChung Myeong‐HeonShin Yu‐JinJung So‐YounWoo Hae‐KyungPark Ju‐YoungSeoh | 2009 | STEM CELLS2009，，1： | 1 |
| 16 | Efficacy of Adefovir-Based Combination Therapy for Patients with Lamivudine- and Entecavir-Resistant Chronic Hepatitis B Virus Infection显示文摘 | Yun Bin Lee Jeong-Hoon Lee Won-mook Choi Young Youn Cho Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Yuri Cho Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon Chung Yong Kim Hyo-Suk Lee | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 1 |
| 17 | Methacholine and adenosine 5'- monophosphate challenges in children with post-infectious bronchiolitis obliterans显示文摘 | Yoo Y Yu J Kim DK et d | 2006 | Eur Respir J2006，27，1： | 1 |
| 18 | Seroprevalence of anti-HAV among patients with chronic viral liver disease显示文摘AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009.RESULTS:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health Promotion.The anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver cirrhosis.The anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age.Multivariable analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus. | Hyun Chin Cho Seung Woon Paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul Yoo Hee Jung Son Seon Woo Kim | 2011 | World Journal of Gastroenterology2011，17，2： | 1 |
| 19 | Large area multicrystalline silicon solar cell fabrication using reac- tive ion etehing(RIE)显示文摘 | YOO JINSU YU GWONJONG YI JUNSIN | 2011 | Solar Energy Materials & So- lar Cells2011，95，1： | 1 |
| 20 | Birth month and sensitization to house du st mites in asthmatic children 显示文摘 | Yoo Y Yu J Kang H | 2005 | Allergy2005，60，10： | 1 |
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