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| 1 | Review of 4Pi Fluorescence Nanoscopy显示文摘Since the 1990s,continuous technical and scientific advances have defied the diffraction limit in microscopy and enabled three-dimensional(3D)super-resolution imaging.An important milestone in this pursuit is the coherent utilization of two opposing objectives(4Pi geometry)and its combination with superresolution microscopy.Herein,we review the recent progress in 4Pi nanoscopy,which provides a 3D,non-invasive,diffraction-unlimited,and isotropic resolution in transparent samples.This review includes both the targeted and stochastic switching modalities of 4Pi nanoscopy.The schematics,principles,applications,and future potential of 4Pi nanoscopy are discussed in detail. | Xiang Hao Yiming Li Shuang Fu Yanghui Li Yingke Xu Cuifang Kuang Xu Liu | 2022 | Engineering2022，8，4： | 2 |
| 2 | Effect of MMT on Flame Retardancy of PLA/IFR/LDH Composites显示文摘Nano filler synergistic intumescent flame retardant(IFR)system is an effective way to improve the flame retardant properties of polymer.In this study,the effects of montmorillonite(MMT)on the flame retardant properties of polylactic acid/layered double hydroxides(PLA/LDH)and PLA/IFR/LDH were investigated.The results show that both LDH and LDH/IFR can reduce the peak heat release rate(HRR)of PLA and prolong the combustion time of PLA;When a proportionate MMT is introduced into PLA/LDH and PLA/IFR/LDH systems,respectively,MMT will not only affect the degradation process of PLA composites during combustion,but also the PLA composites can form a more stable carbon layer during combustion,which could decrease the peak HRR and prolong combustion time of PLA composite.Furthermore,when 0.5 wt%MMT is incorporated,the peak HRR of LDH/IFR/LDH composite is reduced by 16.17%and the combustion time is prolonged by about 70 s.This study can provide an opportunity to further optimize the properties of intumescent flame retardant polymer. | Ping Zhang Siyu Gan Lin Chen Hao Chen Chunhui Jia Yingke Fu Ying Xiong | 2022 | Journal of Renewable Materials2022，10，11： | 1 |
| 3 | Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells显示文摘Phospholipase D(PLD)and its product phosphatidic acid(PA)function as pleiotropic factors in the regulation of cancer progression,which includes the promotion of cell growth,survival,cell migration,and angiogenesis.1 Chemical inhibition of the enzymatic activity of PLD1 and PLD2,or genetic down-regulation of their expression both induce tumor suppression,1 while the compounds for PLD expression inhibition are barely reported.Here,we astonishingly found that the anti-hyperglycemic agents biguanides decreased PLD1 protein expression in cancer cells and further investigated its underlying regulatory mechanism. | Yuanfa Yao Hanbing Li Xinyi Wang Yuanhai Sun Xuqin Zhao Weiwei Zha Jiaqiang Zhou Derek Toomre Junfen Fu Yingke Xu | 2023 | Genes & Diseases2023，10，5： | 0 |
| 4 | Aligned 3D porous polyurethane scaffolds for biological anisotropic tissue regeneration显示文摘A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering field.In this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic byproducts.After optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in vivo.Thus,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on. | Weiwei Lin Wanling Lan Yingke Wu Daiguo Zhao Yanchao Wang Xueling He Jiehua Li Zhen Li Feng Luo Hong Tan Qiang Fu | 2020 | Regenerative Biomaterials2020，7，1： | 0 |
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