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| 1 | Experimental Investigation into Characteristics of Plasma Aerodynamic Actuation Generated by Dielectric Barrier Discharge显示文摘This article carries out synthetic measurements and analysis of the characteristics of the asymmetric surface dielectric barrier discharge plasma aerodynamic actuation.The rotational and vibrational temperatures of an N2 (C3Пu) molecule are measured in terms of the optical emission spectra from the N2 second positive system.A simplified collision-radiation model for N2(C) and N2+(B) is established on the basis of the ratio of emission intensity at 391.4 nm to that at 380.5 nm and the ratio of emission intensity at 371.1 nm to that at 380.5 nm for calculating temporal and spatial averaged electron temperatures and densities.Under one atmosphere pressure,the electron temperature and density are on the order of 1.6 eV and 1011cm-3 respectively.The body force induced by the plasma aerodynamic actuation is on the order of tens of mN while the induced flow velocity is around 1.3m/s.Starting vortex is firstly induced by the actuation;then it develops into a near-wall jet,about 70 mm downstream of the actuator.Unsteady plasma aerodynamic actuation might stimulate more vortexes in the flow field.The induced flow direction by nanosecond discharge plasma aerodynamic actuation is not parallel,but vertical to the dielectric layer surface. | Wu Yun Li Yinghong Jia Min Song Huimin Su Changbing Pu Yikang | 2010 | Chinese Journal of Aeronautics2010，23，1： | 20 |
| 2 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 3 | Meta-analysis of cognitive function in Chinese first-episode schizophrenia: MATRICS Consensus Cognitive Battery (MCCB) profile of impairment显示文摘Background Compromised neurocognition is a core feature of schizophrenia. With increasing studies researching cognitive function of Chinese patients with first-episode schizophrenia (FES) using MATRICS Consensus Cognitive Battery (MCCB), it is not clear about the level and pattern of cognitive impairment among this population. Aim To provide a meta-analysis systematically analysing studies of neurocognitive function using MCCB in Chinese patients with FES. Methods An independent literature search of both Chinese and English databases up to 13 March 2019 was conducted by two reviewers. Standardised mean difference (SMD) was calculated using the random effects model to evaluate the effect size. Results 56 studies (FES=3167, healthy controls (HC)=3017) were included and analysed. No study was rated as 'high quality' according to Strengthening the Reporting of Observational Studies in Epidemiology. Compared with HCs, Chinese patients with FES showed impairment with large effect size in overall cognition (SMD=-1.60,95% Cl -1.82 to -1.38,厂=67%) and all seven cognitive domains, with the SMD ranging from -0.87 to -1.41. In nine MCCB subtests, patients with FES showed significant difference in Symbol Coding (SMD=-1.90), Trail Making Test (TMT)(SMD=-1.36), Continuous Performance Test-Identical Pairs (SMD=-1.33), Hopkins Verbal Learning Test (SMD=-1.24), Brief Visuospatial Memory Test (SMD=-1.18), Mazes (SMD=-1.16), Category Fluency (SMD=-1.01), Spatial Span (SMD=-0.69) and Mayer-Salovey-Caruso Emotional Intelligence Test (SMD=-0.38). Conclusions Our meta-analysis demonstrates that Chinese patients with FES show neurocognitive deficits across all seven MCCB cognitive domains and all nine subtests, particularly in two neurocognitive domains: speed of processing and attention/vigilance, with the least impairment shown in social cognition. Symbol Coding and TMT may be the most sensitive tests to detect cognitive deficit in Chinese patients with FES. | Huijuan Zhang Yao Wang Yuliang Hu Yikang Zhu Tian hong Zhang Jijun Wang Ke Ma Chuan Shi Xin Yu Chunbo Li | 2019 | General Psychiatry2019，32，3： | 13 |
| 4 | GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia显示文摘The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. | Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li | 2020 | Neuroscience Bulletin2020，36，2： | 9 |
| 5 | Dynamic modeling of hydrostatic guideway considering compressibility and inertia effect显示文摘静水力学的 guideways 被用作一种选择由于高僵硬并且在重机床的高抑制联系轴承。为了改进适用的动态特征,组织,静水力学的 guidway 的动态建模应该精确地被知道。这份报纸就惯性的效果而言论述一个 mass-spring-Maxwell 模型,压榨,压缩的可能性并且静态的适用。决定动态模型系数,在排水量和油电影的动态力量之间的不同诉讼的数字模拟与流畅的代码被执行。当它受到一个小摆动振幅时,模拟结果证明静水力学的 guidway 能作为一个线性系统被拿。基于一个动态模型和数字模拟,每个动态模型参数被 Levenberg-Marquardt 算法计算。鉴定结果证明那个 mass-spring-damper 模型是静水力学的 guidway 的最适当的动态模型。这份报纸为类似的静水力学的轴承的动态模型的分析提供一本参考书和准备。 | Yikang DU Kuanmin MAO Yaming ZHU Fengyun WANG Xiaobo MAO Bin LI | 2015 | Frontiers of Mechanical Engineering2015，10，1： | 6 |
| 6 | A novel satellite-equipped receiver for autonomous monitoring of GNSS navigation signal quality显示文摘Global navigation satellite system(GNSS) comes with potential unavoidable application risks such as the sudden distortion or failure of navigation signals because its satellites are generally operated until failure. In order to solve the problems associated with these risks, receiver autonomous integrity monitoring(RAIM) and ground-based signal quality monitoring stations are widely used. Although these technologies can protect the user from the risks, they are expensive and have limited region coverage. Autonomous monitoring of satellite signal quality is an effective method to eliminate these shortcomings of the RAIM and ground-based signal quality monitoring stations; thus, a new navigation signal quality monitoring receiver which can be equipped on the satellite platform of GNSS is proposed in this paper. Because this satellite-equipped receiver is tightly coupled with navigation payload, the system architecture and its preliminary design procedure are first introduced. In theory, code-tracking loop is able to provide accurate time delay estimation of received signals. However, because of the nonlinear characteristics of the navigation payload, the traditional code-tracking loop introduces errors. To eliminate these errors, the dummy massive parallel correlators(DMPC) technique is proposed. This technique can reconstruct the cross correlation function of a navigation signal with a high code phase resolution. Combining the DMPC and direct radio frequency(RF) sampling technology, the satellite-equipped receiver can calibrate the differential code bias(DCB) accurately. In the meantime, the abnormities and failures of navigation signal can also be monitored. Finally, the accuracy of DCB calibration and the performance of fault monitoring have been verified by practical test data and numerical simulation data, respectively. The results show that the accuracy of DCB calibration is less than 0.1 ns and the novel satellite-equipped receiver can monitor the signal quality effectively. | YANG Jian YANG YiKang LI Ji Sheng LI HengNian YANG TianShe | 2016 | Science China(Technological Sciences)2016，59，7： | 6 |
| 7 | Permeation into but not across the cornea:Bioimaging of intact nanoemulsions and nanosuspensions using aggregation-caused quenching probes显示文摘Nanoemulsions(NEs) and nanosuspensions(NSs) show great potential in enhancing the ocular bioavailability of therapeutics through topical delivery. However, transocular fate of intact NEs and NSs is still inconclusive. In this study, an aggregation-caused quenching fluorescent probe is used to track precorneal retention and transocular transportation of intact NEs and NSs, while coumarin 6 is used to mimick the cargo. NEs show superior precorneal retention to NSs. Both the two types of nanocarriers can permeate into but not across the cornea. The smaller NEs(100 nm) permeate better into the cornea than the bigger ones(210 nm). Nanocarriers in the cornea serves as depots. The released cargo molecules can penetrate across the cornea and diffuse into the lens. Moreover, the conjunctiva-scleral route may be potential to deliver drugs to the back of the eye, In conclusion, the study provides useful tools and information in the field of transocular transportation of nanoparticles. | Dailei Liu Bo Wan Jianping Qi Xiaochun Dong Weili Zhao Wei Wu Yikang Dai Yi Lu Zhongjian Chen | 2018 | Chinese Chemical Letters2018，29，12： | 4 |
| 8 | Design and optimization of low-energy transfer orbit to Mars with multi-body environment显示文摘This paper discusses the problem of design and optimization of low-energy transfer orbit with multi-body environment. A new integrative method is proposed to effectively solve the problem, in which the parameterized patched manifolds in CR3BP(circular restricted three-body problems), the shape-based method with multi-body environment, the homotopic method with multi-body environment, and the low-thrust capturing and descending algorithm with multi-body environment are all included. Firstly, the parameters describing the patched manifolds in CR3 BP are optimized until the least total absolute velocity increment has been got, including the employment of the shape-based method with multi-body environment. Secondly, the low-thrust control laws of the transfer orbit are optimized employing the homotopic method with multi-body environment that transfers the fuel optimization problem to an easier energy optimization problem. Thirdly, the low-thrust descending orbit around Mars is computed using the laws proposed in this paper. As a typical example, the Earth-Mars transfer orbit design is discussed. The results showed that the parameters describing the patched manifolds could be optimized by the DE(differential evolution) algorithm effectively; the homotopic method with multi-body environment could get the optimal value that meets the first order optimality conditions; and the low-thrust descending orbit could effectively be captured by Mars and finally become a circular parking orbit around it by the hypothesis control laws proposed in this paper. It shows that the final fuel cost is much less than the optimal transfer in the patched two-body problems. In conclusion, the method proposed in this paper could effectively solve the low-energy low-thrust optimal control problem in multi-body environment for the future deep space explorations. | LU Yi LI HengNian LI JiSheng CHE Zheng YANG YiKang YANG Yuan SUN Yang | 2015 | Science China(Technological Sciences)2015，58，10： | 3 |
| 9 | The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice显示文摘 | Premysl Bercik Emmanuel Denou Josh Collins Wendy Jackson Jun Lu Jennifer Jury Yikang Deng Patricia Blennerhassett Joseph Macri Kathy D. McCoy Elena F. Verdu Stephen M. Collins | 2011 | Gastroenterology2011，，2： | 2 |
| 10 | Electronic circular dichroism behavior of chiral Phthiobuzone显示文摘Phthiobuzone is a bis(thiosemicarbazone)derivative with a single chiral center which has been used as a racemate in the clinical treatment of herpes and trachoma diseases.In this study,its two enantiomers were prepared from chiral amino acids and their absolute configurations were investigated by electronic circular dichroism(ECD)combined with modern quantum-chemical calculations using time-dependent density functional theory.It was found that solvation changed both the conformational distribution and the ECD spectrum of each conformer.The theoretical ECD spectra of the two enantiomers were in good agreement with the experimentally determined spectra of the corresponding isomers in dimethyl sulfoxide.The ECD behavior of the bis(thiosemicarbazone)chromophore in a chiral environment is also discussed.Our results indicate that ECD spectroscopy may be a useful tool for the stereochemical evaluation of chiral drugs. | Li Li Lin Wang Yikang Si | 2014 | Acta Pharmaceutica Sinica B2014，4，2： | 2 |
| 11 | Operation of wind-turbine-driven dfig systems under distorted grid voltage conditions:analysis and experimental validations显示文摘 | Xu Hailiang Hu Jiabing He Yikang | 2012 | IEEE Transactions on Power Electronics2012，27，5： | 1 |
| 12 | Autonomous operation of hybrid microgrid with AC and DC subgrids显示文摘 | Loh P C Li Ding Chai Yikang | 2012 | IEEE Transactions on Power Electronics2012，28，5： | 1 |
| 13 | In-depth research on direct torque control of permanent magnet synchronous显示文摘 | Hu Yuwen Tian Cun Gu Yikang | 2002 | Industrial Electronics Society IEEE 2002 28th Annual Conference2002，2，58： | 1 |
| 14 | Improved control of DFIG systems during network unbalance using PI-R current regulators显示文摘 | Hu Jiabing He Yikang Xu Lie | 2009 | IEEE Transactions on Industrial Electronics2009，56，2： | 1 |
| 15 | Improved control of DFIG systems during network unbalance using PI-R current regulators显示文摘 | Hu Jiabing He Yikang Xu Lie | 2009 | IEEE Transactions on Industrial Electronics2009，56，2： | 1 |
| 16 | Improved rotor current control of wind turbine driven doubly-fedinduction generators during network voltage unbalance显示文摘 | Hu Jiabing He Yikang Xu Lie | 2010 | Electric Power Systems Research2010，80，7： | 1 |
| 17 | Modeling and control of gridconnected voltage-sourced converters under generalized unbalanced operation conditions 显示文摘 | HU Jiabing HE Yikang | 2008 | Transaction on Energy Conversion2008，23，3： | 1 |
| 18 | Reinforced control and operation of DFIG-based wind-power-generation system under unbalanced grid voltage conditions 显示文摘 | Jiabing Hu Yikang He | 2009 | IEEE Transactions on Energy Conversion2009，24，4： | 1 |
| 19 | Improved control of DFIG systems during network unbalance using PI-R current regulators显示文摘 | Hu Jiabing He Yikang Xu Lie | 2009 | IEEE Transactions Industry Electronic2009，56，2： | 1 |
| 20 | Modeling and control of grid: connected vohage-sourced converters under generalized unbalanced operation conditions 显示文摘 | HU Jiabing HE Yikang | 2008 | IEEE Transactions on Energy Conversion2008，23，3： | 1 |
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