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| 1 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 2 | 解析胃癌前病变及早期胃癌的单细胞转录组网络显示文摘文章简介本研究采集了一组处于胃癌前病变不同阶段及早期胃癌患者,这些患者还具有胃灼痛、大便干燥、舌苔黄或厚等若干中医'胃火'相关临床表现。通过解析单细胞网络,研究发现高表达MUC6的腺粘膜细胞随着疾病的进展出现了肠样干细胞表型,提示其可能是介导肿瘤发生的关键步骤。 | 张鹏 Mingran Yang Yiding Zhang Shuai Xiao Xinxing Lai Aidi Tan Shiyu Du 李梢 | 2020 | 科学新闻2020，，2： | 7 |
| 3 | The Co_3O_4 nanosheet array as support for MoS_2 as highly efficient electrocatalysts for hydrogen evolution reaction显示文摘The electrochemical hydrogen evolution reaction(HER) on a non-precious electrocatalyst in an alkaline environment is of essential importance for future renewable energy. The design of advanced electrocatalysts for HER is the most important part to reduce the cost and to enhance the efficiency of water splitting. MoS_2 is considered as one of the most promising electrocatalysts to replace the precious Pt catalyst.Herein, for the first time, we have successfully loaded MoS_2 electrocatalysts onto the Co_3O_4 nanosheet array to catalyze HER with a low onset potential of ~76 mV. The high hydrogen evolution activity of MoS_2 supported on the Co_3O_4 nanosheet array may be attributed to the increased active sites and the electronic interactions between MoS_2 and Co_3O_4. | Xiao Sun Jia Huo Yide Yang Lei Xu Shuangyin Wang | 2017 | Journal of Energy Chemistry2017，26，6： | 4 |
| 4 | Characteristics of typhoon disturbed gaps in an old-growth tropical montane rainforest in Hainan Island, China显示文摘Disturbances that create gaps can shape the structure and function of forests. However, such disturbance regimes in Asian tropical montane rainforests remain largely unquantified. Least studied are typhoon disturbances that are attributable to climate change. We investigated gap characteristics in terms of size, age, and gapmaker to quantify the gap disturbance regimes in an intact old-growth tropical montane rainforest on Hainan Island,China. The intensity of typhoons has increased since 1949,and typhoon winds blow mostly(45.5%) from the northeast corner of Hainan Island, resulting in a higher frequency of gaps in the northeast. A total of 221 gap-makers(trees that fell to create canopy gaps) and 53 gaps were observed in a 3.16 ha old-growth rainforest. Most canopy gaps(85%)were <200 m^2. The average size of canopy gaps was smaller in the rainforest than in other tropical forests, while the average size of expanded gaps was similar to those in other tropical forests. The maximum age of gaps was 23.5 years indicating that gaps had more rapid turnover than other parts of tropical forests. The frequency distribution of gap-makers followed a lognormal distribution with a distinctive peak at three gap-makers, which was different from the inverse J-shaped curve typical of other tropical forests. Gaps were recorded mainly on slopes between 20° and 35° and wood density of gap-makers was between 0.6 and 0.7 g cm^(-3). Our results suggest that small-scale disturbance was the dominant agent of gap formation in this old-growth rainforest that is subject to increasing typhoon disturbances. | Huai Yang Shirong Liu Kunfang Cao Jingxin Wang Yide Li Han Xu | 2017 | Journal of Forestry Research2017，28，6： | 3 |
| 5 | Mass‑Spring‑Damping Theory Based Equivalent Mechanical Model for Cylindrical Lithium‑ion Batteries under Mechanical Abuse显示文摘An equivalent mechanical model with the equivalent physical meaning of mass-spring-damping is proposed for cylindrical lithium-ion batteries through experiments and theory.The equivalent mechanical model of a cylindrical lithium-ion battery consists of a spring-damping parallel unit.Therefore,a spring-damping parallel unit connecting a damping unit in series is selected to construct the constitutive characteristics of the battery under mechanical abuse.Comparison results show that the equivalent mechanical model can more effectively describe the mechanical properties of the batteries than most cubic fitting models,of which the average relative error of the equivalent mechanical model under different states-of-charge is less than 6.75%.Combined with the proposed equivalent mechanical model,the failure process of the batteries was simulated and analyzed using LS-Dyna and HyperWorks.Under rigid rod tests,failure occurred at the core and bottom of the batteries;under hemispherical punch tests,failure occurred at the core and top,consistent with the experimental results.The average prediction error for the failure displacement under different abuse conditions is less than 4%in the simulations.The equivalent mechanical model requires only a few parameters and can be recognized easily.In the future,the model can be used in safety warning devices based on mechanical penetration. | Wenwei Wang Yiding Li Cheng Lin Sheng Yang | 2020 | Chinese Journal of Mechanical Engineering2020，33，2： | 3 |
| 6 | Apoptotic regulation and tRNA显示文摘Apoptotic regulation is critical to organismal homeostasis and protection against many human disease processes such as cancer.Significant research efforts over the past several decades have illuminated many signaling molecules and effecter proteins responsible for this form of programmed cell death.Recent evidence suggests that transfer RNA(tRNA)regulates apoptotic sensitivity at the level of cytochrome c-mediated apoptosome formation.This finding unexpectedly places tRNA at the nexus of cellular biosynthesis and survival.Here we review the current understanding of both the apoptotic machinery and tRNA biology.We describe the evidence linking tRNA and cytochrome c in depth,and speculate on the implications of this link in cell biology. | Yide Mei Aaron Stonestrom Ya-Ming Hou Xiaolu Yang | 2010 | Protein & Cell2010，1，9： | 3 |
| 7 | Fluoro-Hydroxylation of gem-Difluoroalkenes:Synthesis of 18O-labeled α-CF3 Alcohols显示文摘in this paper,a fluoro-hydroxylation of gem-difluoroalkenes is demonstrated.This protocol uses sequential electrophilic fluorination with Selectfluor and nucleophilic hydroxylation with H218o,which can be used to prepare 18Oo-labeled α-CF3 alcohols from gem-difluorostyrenes.The reaction is typically carried out at room temperature within 4h in good to excellent yields.Other nucleophiles (besides H218o),such as alcohols,carboxylic acid, acetonitrile and N,N-dimethylformamide,are also suitable for this difunctionalization of gem-difluoroalkenes. | Jingyu Hu Yide Yang Zhengzhao Lou Chuanfa Ni Jinbo Hu | 2018 | Chinese Journal of Chemistry2018，36，12： | 3 |
| 8 | China’s ion-adsorption rare earth resources, mining consequences and preservation显示文摘 | X. Jin Yang Aijun Lin Xiao-Liang Li Yiding Wu Wenbin Zhou Zhanheng Chen | 2013 | Environmental Development2013，，： | 2 |
| 9 | Photo-thermoelectric effect induced electricity in stretchable graphene-polymer nanocomposites for ultrasensitive strain sensing显示文摘Stretchable strain sensors play an increasingly important role in artificial intelligent devices.However,high-performanee strain sensors havebeen slowly developed owing to the harsh requirement of self-powered function,long cycle life and high resolution.Here,we report aself-powered stretchable graphene-ecoflex composite strain sensor based on photo-thermoelectric(PTE)effect induced electricity.Thedevice exhibits a high strain sensitivity of-0.056 In(nA)/%with strains ranged from 0%to 20%under 980 nm light illumination,where thestrain sensitivity can be found to in crease with in creasi ng light inte nsity.The strain sensor maintains outstanding dyn amic stability un derperiodic strains ranged from 0 to 100%in 100 cycles.The sensing resolution can be as high as 0.5%with both the response and recovery timeof less than 0.6 s.It can precisely monitor human joint motions and stretchable strains by implanting the device in pork. | Ding Zhang Yiding Song Lu Ping Suwen Xu De Yang Yuanhao Wang Ya Yang | 2019 | Nano Research2019，12，12： | 2 |
| 10 | Smart ZnS@C filler for super-anticorrosive self-healing zinc-rich epoxy coating显示文摘The zinc-rich epoxy cathodic protection coating is the most widely used anticorrosion material for marine steel.However,traditional conductive fillers lack the intelligent self-healing effect,which limits the long-term anticorrosion performance.Herein,with uniform carbon-coated ZnS(ZnS@C)nanoballs as the smart active release filler,we propose an anticorrosive and self-healing zinc-rich maleic anhydride epoxy coating.Due to the high pore filling efficiency of the nanoballs,the water vapor transmission rate of the coating with an initial corrosion efficiency of 99.92%and a low-frequency impedance of|Z|f=10mHz=3.88×10^(10) Ω·cm^(2),was reduced by 52%.The carbon-shell of the nanoball increases electron transmission paths in the coating and improves conductivity by nearly two orders of magnitude,which effectively activates more Zn-sites and extends the cathodic protection time.Moreover,once the steel-substrate undergoes regional corrosion,the SO_(4)^(2-)hydrolyzes from the ZnS-core of the nanoball and reacts with iron ions on the corroded area accurately and intelligently to fill the gap and self-heals into a new dense barrier layer(Fe_(2)(SO_(4))_(3),etc.),which significantly improves the shielding protection ability during the long-term usage of the coating.The effective anticorrosion time of the proposed coating could be up to 3,400 h. | Kai Yang Yixue Duan Guicheng Liu Guoyan Ma Hao Fu Xuyong Chen Manxiang Wang Gangqiang Zhu Woochul Yang Yiding Shen | 2022 | Nano Research2022，15，5： | 1 |
| 11 | Trans- formation of a marker-free and vector-free antisense ACC oxidase gene cassette into melon via the pollen- tube pathway显示文摘 | Hao Jinfeng Niu Yiding Yang Baojun | 2011 | Bioteehnol Lett2011，33，： | 1 |
| 12 | Review of pulse-coupled neural networks显示文摘 | Zhaobin Wang Yide Ma Feiyan Cheng Lizhen Yang | 2009 | Image and Vision Computing2009，，1： | 1 |
| 13 | Regeneration behaviors of Fe/Si‐2 and Fe–Mn/Si‐2 catalysts for C2H6 dehydrogenation with CO2 to C2H4显示文摘 | Longya Xu Jinxiang Liu Hong Yang Yide Xu Qingxia Wang Liwu Lin | 1999 | Catalysis Letters (-)1999，，2： | 1 |
| 14 | Rheological Behaviour for Polymer Melts and Concentrated Solutions Part Ⅲ: A New Multiple Entanglement Model to Predict the Dependence of Linear Viscoelastic Function (η_0, Ψ_(10)~0,η_(ext)~0) on the Ranges of Primary Molecular Weights and th显示文摘It is shown theoretically that the viscoelasticity of polymer melts is determined by three combining factorst they are the primary molecular weight and its distribution, the number of entanglement sites on polymer chain and the sequence distribution of constituent chains in entanglement spacings. A unified quantity for the three combing factors is the average constrained dimensional number of constituent chains in the long entanglement spacings (v). A new relation of v to the primary molecular weight and the number of testing polymers were derived from the multiple entanglement and reptation model, and a new method for determining v was proposed. The dependences of linear viscoelastic functions on the primary molecular weight and its distribution were derived by the statistical method. When Mn=6Me to 18 Me, the values of (v) can range from 3.33 to 3.70. Their values are in a good agreement with the experiment data, and it can slightjy vary with the different species of polymers and the different ranges of molecular weight of | Mingshi SONG and Jincai YANG (Research Institute of Polymeric Materials, Beijing University of Chemical Technology, Beijing, 100029, China)Yiding SHEN(North West Institute of Light Industry, Shanxi Xianyang, 712087, China) | 1995 | Journal of Materials Science & Technology1995，11，3： | 1 |
| 15 | 显示文摘 | Jin Yide Fang Shaohua Li Yang Shin-ichi Hirano Kazuhiro Tachihana | 2011 | Journal of Power Sources2011，196，10： | 1 |
| 16 | Calibration and application of airborne pushbroomhyperspectralimager (PHI)显示文摘 | Shu Rong Xue Yongqi Yang Yide | 2004 | SPIE2004，5234，： | 1 |
| 17 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 18 | Review of pulse-coupled neural networks显示文摘 | Zhaobin Wang Yide Ma Feiyan Cheng Lizhen Yang | 2010 | Image and Vision Computing2010，28，2010： | 1 |
| 19 | review of pulse-coupled neural networks显示文摘 | WANG Zhaobin MA Yide CHENG Feiyan YANG Lizhen | 2010 | Image and Vision Computing2010，28，1： | 1 |
| 20 | Thoughts and suggestions on how to safeguard fishing rights and ensure stability in the new situation显示文摘 | Chen Yide Ma Weijun and Yang Changjian | 2012 | China Aquatic2012，，3： | 1 |
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