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| 1 | Hacking the optical diffraction limit: Review on recent developments of fluorescence nanoscopy显示文摘Subject to the diffraction limit, the resolution of conventional optical microscopy is constrained to about 200 and 500 nm in the lateral and axial planes, respectively. The advantage of optical microscopy in the life sciences over electronic microscopy, especially fluorescence microscopy, drives scientists to develop novel 'hacks' to reach nanoscale resolutions by optical means. In this review, three aspects of the techniques are discussed: (1) lateral super-resolution; (2) axial super-resolution; (3) super-resolution in three dimensions. The principles of how the methods achieve the cross-barrier resolution are discussed, and recent advances in current techniques are described. With these methods, the use of fluorescence microscopy is growing quickly toward a new era: fluorescence nanoscopy that will reveal 2 orders of magnitude more information on cellular structure and dynamics. | DING YiChen XI Peng REN QiuShi | 2011 | Chinese Science Bulletin2011，56，18： | 7 |
| 2 | Subvoxel light-sheet microscopy for high-resolution high-throughput volumetric imaging of large biomedical specimens显示文摘A key challenge when imaging whole biomedical specimens is how to quickly obtain massive cellular information over a large field of view(FOV).We report a subvoxel light-sheet microscopy(SLSM)method enabling high-throughput volumetric imaging of mesoscale specimens at cellular resolution.A nonaxial,continuous scanning strategy is developed to rapidly acquire a stack of large-FOV images with three-dimensional(3-D)nanoscale shifts encoded.Then,by adopting a subvoxel-resolving procedure,the SLSM method models these low-resolution,cross-correlated images in the spatial domain and can iteratively recover a 3-D image with improved resolution throughout the sample.This technique can surpass the optical limit of a conventional light-sheet microscope by more than three times,with high acquisition speeds of gigavoxels per minute.By fast reconstruction of 3-D cultured cells,intact organs,and live embryos,SLSM method presents a convenient way to circumvent the trade-off between mapping large-scale tissue(>100 mm3)and observing single cell(∼1-μm resolution).It also eliminates the need of complicated mechanical stitching or modulated illumination,using a simple light-sheet setup and fast graphics processing unit-based computation to achieve high-throughput,high-resolution 3-D microscopy,which could be tailored for a wide range of biomedical applications in pathology,histology,neuroscience,etc. | Peng Fei Jun Nie Juhyun Lee Yichen Ding Shuoran Li Hao Zhang Masaya Hagiwara Tingting Yu Tatiana Segura Chih-Ming Ho Dan Zhu Tzung KHsiaic | 2019 | Advanced Photonics2019，1，1： | 6 |
| 3 | Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge显示文摘The gut microbiota is involved in host responses to high altitude.However,the dynamics of intestinal microecology and their association with altitude-related illness are poorly understood.Here,we used a rat model of hypobaric hypoxia challenge to mimic plateau exposure and monitored the gut microbiome,short-chain fatty acids(SCFAs),and bile acids(BAs)over 28 d.We identified weight loss,polycythemia,and pathological cardiac hypertrophy in hypoxic rats,accompanied by a large compositional shift in the gut microbiota,which is mainly driven by the bacterial families of Prevotellaceae,Porphyromonadaceae,and Streptococcaceae.The aberrant gut microbiota was characterized by increased abundance of the Parabacteroides,Alistipes,and Lactococcus genera and a larger Bacteroides to Prevotella ratio.Trans-omics analyses showed that the gut microbiome was significantly correlated with the metabolic abnormalities of SCFAs and BAs in feces,suggesting an interaction network remodeling of the microbiome-metabolome after the hypobaric hypoxia challenge.Interestingly,the transplantation of fecal microbiota significantly increased the diversity of the gut microbiota,partially inhibited the increased abundance of the Bacteroides and Alistipes genera,restored the decrease of plasma propionate,and moderately ameliorated cardiac hypertrophy in hypoxic rats.Our results provide an insight into the longitudinal changes in intestinal microecology during the hypobaric hypoxia challenge.Abnormalities in the gut microbiota and microbial metabolites contribute to the development of high-altitude heart disease in rats. | Zhiyuan Pan Yichen Hu Zongyu Huang Ni Han Yan Li Xiaomei Zhuang Jiye Yin Hui Peng Quansheng Gao Wenpeng Zhang Yong Huang Yujun Cui Yujing Bi Zhenjiang Zech Xu Ruifu Yang | 2022 | Science China(Life Sciences)2022，65，10： | 5 |
| 4 | New Localities and Palaeoscolecid Worms from the Cambrian(Stage 4,Series 2)Guanshan Biota in Kunming,Yunnan,South China显示文摘The Guanshan Biota from the Cambrian Stage 4 Wulongqing Formation is a typical Burgess-shale type Lagerst?tte that had witnessed the Cambrian explosion. Here we report two new localities of the Guanshan Biota,which is located at Baimei village,south of Kunming and Xinglong village,Wuding County,Yunnan Province respectively. Both localities produce soft-body fossils and several new taxa,e.g. a new species of palaeoscolecidans(Palaeoscolex xinglongensis sp. nov.) reported herein. The comparative study of the new species with similar form not only indicates that there is a diversification of palaeoscolecid species in Guanshan Biota,but also strengthens the ties between the older Chengjiang Biota and the younger Kaili Biota(and also the coeval Burgess Shale community). Three paleoecological features,including high diversity,little disparity and richness of palaeoscolecid worms,are summarized as a case study to represent the differences between Guanshan and Chengjiang Biota. | LIU Jianni HAN Jian LI Jinshu WU Yichen PENG Jie QI Nan YANG Yiyao LI Juan | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 4 |
| 5 | QTL-Seq Identified a Major QTL for Grain Length and Weight in Rice Using Near Isogenic F_2 Population显示文摘Mapping and isolation of quantitative trait loci(QTLs)or genes controlling grain size or weight is very important to uncover the molecular mechanisms of seed development and crop breeding.To identify the QTLs controlling grain size and weight,we developed a near isogenic line F_2(NIL-F_2)population,which was derived from a residual heterozygous plant in an F_7 generation of recombinant inbred line(RIL).With the completion of more than 30×whole genome re-sequencing of the parents,two DNA bulks for large and small grains,a total of 58.94 Gb clean nucleotide data were generated.A total of455 262 single nucleotide polymorphisms(SNPs)between the parents were identified to perform bulked QTL-seq.A candidate genomic region containing SNPs strongly associated with grain length and weight was identified from 15 to 20 Mb on chromosome 5.We designated the major QTL in the candidate region as q TGW5.3.Then,q TGW5.3 was further validated with PCR-based conventional QTL mapping method through developing simple sequence repeat and Insertion/Deletion markers in the F_2 population.Furthermore,recombinants and the progeny tests delimited the candidate region of q TGW5.3 to 1.13 Mb,flanked by HX5009(15.15 Mb)and HX5003(16.28 Mb).A set of NILs,selected from the F_2 population,was developed to evaluate the genetic effect of q TGW5.3.Significant QTL effects were detected on grain length,grain width and 1000-grain weight of H12-29 allele with 1.14 mm,-0.11 mm and 3.11 g,which explained 99.64%,95.51%and 97.32%of the phenotypic variations,respectively. | QIN Yaobin CHENG Peng CHENG Yichen FENG Yue HUANG Derun HUANG Tingxu SONG Xianjun YING Jiezheng | 2018 | Rice science2018，25，3： | 2 |
| 6 | D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration显示文摘Accumulated oxidative damage may lead to irreversible retinal pigmented epithelium(RPE)cell death,which is considered to be the primary cause of dry age-related macular degeneration(AMD),leading to blindness in the elderly.However,an effective therapy for this disease is lacking.Here,we described a robust high-content screening procedure with a library of 814 protective compounds and found that D609 strongly protected RPE cells from sodium iodate(SI)-induced oxidative cell death and prolonged their healthy survival.D609 effectively attenuated excessive reactive oxygen species(ROS)and prevented severe mitochondrial loss due to oxidative stress in the RPE cells.Surprisingly,the potent antioxidative effects of D609 were not achieved through its own reducibility but were primarily dependent on its ability to increase the expression of metallothionein.The injection of this small water-soluble molecule also showed an explicit protective effect of the RPE layer in an SI-induced AMD mouse model.These findings suggested that D609 could serve as a novel antioxidative protector of RPE cells both in vitro and in vivo and unveiled a novel antioxidative mechanism of D609,which may ultimately have clinical applications for the treatment of AMD. | Bowen Wang Li Wang Sijie Gu Yankun Yu Huaxing Huang Kunlun Mo He Xu Fanzhu Zeng Yichen Xiao Lulu Peng Chunqiao Liu Nan Cao Yizhi Liu Jin Yuan Hong Ouyang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 7 | SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation显示文摘The nucleocapsid(N)protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation,which enables its incorporation into stress granules(SGs)of host cells.However,whether SG invasion by N protein occurs in the scenario of SARS-CoV-2 infection is unknow,neither do we know its con-sequence.Here,we used SARS-CoV-2 to infect mam-malian cells and observed the incorporation of N protein into SGs,which resulted in markedly impaired self-dis-assembly but stimulated cell cellular clearance of SGs.NMR experiments further showed that N protein binds to the SG-related amyloid proteins via non-specific tran-sient interactions,which not only expedites the phase transition of these proteins to aberrant amyloid aggre-gation in vitro,but also promotes the aggregation of FUS with ALS-associated P525L mutation in cells.In addition,we found that ACE2 is not necessary for the infection of SARS-CoV-2 to mammalian cells.Our work indicates that SARS-CoV-2 infection can impair the dis-assembly of host SGs and promote the aggregation of SG-related amyloid proteins,which may lead to an increased risk of neurodegeneration. | Yichen Li Shuaiyao Lu Jinge Gu Wencheng Xia Shengnan Zhang Shenqing Zhang Yan Wang Chong Zhang Yunpeng Sun Jian Lei Cong Liu Zhaoming Su Juntao Yang Xiaozhong Peng Dan Li | 2022 | Protein & Cell2022，13，8： | 1 |
| 8 | Spatio-temporal Variation of PM_(2.5) in China from 1998 to 2016显示文摘With the rapid development of China's economy,people's demand for a healthy living environment is increasing,and air quality has gradually been widely concerned by all sectors of society.Using the big data of air quality monitoring from 1998 to 2016,based on the exploratory spatio-temporal analysis method,this paper explored the spatio-temporal evolution of PM_(2.5) at the national scale,and drew the following conclusions:①PM_(2.5) heavy pollution is mainly in central and eastern China,north and south China,and the pollution degree is relatively light in northwest and northeast China.Meanwhile,PM_(2.5) concentration in heavily polluted areas increased significantly over time,while PM_(2.5) concentration in low-polluted areas showed a long-term stable trend.②The number and area of cities with moderate and high PM_(2.5) pollution levels showed an inverted U-shaped curve from 1998 to 2016,and 2007 was the inflection point.③The spatial autocorrelation coefficient of PM_(2.5) is high over the years,and the spatial neighbor effect of PM_(2.5) is significant.The high-pollution clusters are mainly concentrated in the Beijing-Tianjin-Hebei region,the Yangtze River Delta and the Pearl River Delta,and the pollution concentration in these three regions has increased rapidly in recent years.It is necessary to focus on joint prevention and control. | Jianghui WANG Peng ZHOU Yichen LIN Longhao ZHANG Mengyu WU | 2022 | Meteorological and Environmental Research2022，13，1： | 1 |
| 9 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 10 | DualFace:Two-stage drawing guidance for freehand portrait sketching显示文摘Special skills are required in portrait painting, such as imagining geometric structures and facial detail for final portrait designs. This makes it a difficult task for users, especially novices without prior artistic training, to draw freehand portraits with high-quality details. In this paper, we propose dualFace, a portrait drawing interface to assist users with different levels of drawing skills to complete recognizable and authentic face sketches. Inspired by traditional artist workflows for portrait drawing, dualFace gives two-stages of drawing assistance to provide global and local visual guidance. The former helps users draw contour lines for portraits (i.e., geometric structure), and the latter helps users draw details of facial parts, which conform to the user-drawn contour lines. In the global guidance stage, the user draws several contour lines, and dualFace then searches for several relevant images from an internal database and displays the suggested face contour lines on the background of the canvas. In the local guidance stage, we synthesize detailed portrait images with a deep generative model from user-drawn contour lines, and then use the synthesized results as detailed drawing guidance. We conducted a user study to verify the effectiveness of dualFace, which confirms that dualFace significantly helps users to produce a detailed portrait sketch. | Zhengyu Huang Yichen Peng Tomohiro Hibino Chunqi Zhao Haoran Xie Tsukasa Fukusato Kazunori Miyata | 2022 | Computational Visual Media2022，8，1： | 1 |
| 11 | A comprehensive evaluation of flowering plant diversity and conservation priority for national park planning in China显示文摘Establishment of a national park protection system in China,including the latest target proposed to protect at least 30%of the land area,calls for a comprehensive exploration of conservation priorities incorporating multiple diversity facets.We herein evaluate the spatial distribution of Chinese flowering plants from the perspectives of richness,uniqueness,vulnerability,and evolutionary history,by integrating three mega-phylogenies and comprehensive distribution data.We detect significantly high consistency among hotspots of different diversity measures for Chinese flowering plants,suggesting that multiple facets of evolutionary diversity are concentrically distributed in China.Affording legal protection to these areas is expected to maximize positive conservation outcomes.We propose two integrative diversity indices by incorporating three richness-based and three phylogeny-based measures,respectively.Both methods identify areas with high species richness,but the integrative phylogeny-based index also locates key areas with ancient and unique evolutionary histories(e.g.,Ailao-Wuliang Mts,Dabie Mts,Hainan rainforest,Karst area of Yunnan-Guizhou-Guangxi,Nanling Mts,and southeast coastal regions).Of all the diversity indices explored,phylogenetic endemism maximizes the incidental protection of other indices in most cases,emphasizing its significance for conservation planning.Finally,42 priority areas are identified by combining the 5%-criterion hotspots of two integrative indices and the minimum area to protect all threatened species analyzed.These priorities cover only 13.3%of China's land area,but host 97.1%of species richness(23,394/24,095),96.5%of endemic species(11,841/12,274),100%of threatened species(2,613/2,613),and 99.3%of phylogenetic diversity for flowering plants involved in this study.These frameworks provide a solid scientific basis for national park planning in China. | Limin Lu Lina Zhao Haihua Hu Bing Liu Yuchang Yang Yichen You Danxiao Peng Russell L.Barrett Zhiduan Chen | 2023 | Fundamental Research2023，3，6： | 1 |
| 12 | Maternal genetic history of southern East Asians over the past 12,000 years显示文摘Southern East Asia,including Guangxi and Fujian provinces in China,is home to diverse ethnic groups,languages,and cultures.Previous studies suggest a high complexity regarding population dynamics and the history of southern East Asians.However,large-scale genetic studies on ancient populations in this region are hindered by limited sample preservation.Here,using highly efficient DNA capture techniques,we obtain 48 complete mitochondrial genomes of individuals from Guangxi and Fujian in China and reconstruct their maternal genetic history over the past 12,000 years.We find a strong connection between southern East Asians dating to~12,000-6000 years ago and present-day Southeast Asians.In addition,stronger genetic affinities to northern East Asians are observed in historical southern East Asians than Neolithic southern East Asians,suggesting increased interactions between northern and southern East Asians over time.Overall,we reveal dynamic connections between ancient southern East Asians and populations located in surrounding regions,as well as a shift in maternal genetic structure within the populations over time. | Yalin Liu Tianyi Wang Xichao Wu Xuechun Fan Wei Wang Guangmao Xie Zhen Li Qingping Yang Peng Cao Ruowei Yang Feng Liu Qingyan Dai Xiaotian Feng Wanjing Ping Bo Miao Yun Wu Yichen Liu Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，10： | 1 |
| 13 | Maternal genetic structure of a neolithic population of the Yangshao culture显示文摘The Yangshao culture is one of the most influential Neolithic cultures in East Asia.The populations associated with the Yangshao culture were widely distributed along the Yellow River basin and were suggested to play a profound role in the present-day East Asians.To date,the population of the Yangshao culture is largely investigated through archaeological studies. | Bo Miao Yichen Liu Wanfa Gu Qingli Wei Qian Wu Wenjun Wang Ming Zhang Manyu Ding Tianyi Wang Juncen Liu Feng Liu Peng Cao Qingyan Dai Ruowei Yang Xiaotian Feng Wanjing Ping Weihong Hou Haibing Yuan Qiaomei Fu | 2021 | Journal of Genetics and Genomics2021，48，8： | 0 |
| 14 | Progress in phase III clinical trials of molecular targeted therapy and immunotherapy for glioblastoma显示文摘Glioblastoma(GBM)is the most common primary central nervous system tumor,whose prognosis remains poor under the sequential standard of care,such as neurosurgery followed by concurrent temozolomide radiochemotherapy and adjuvant temozolomide chemotherapy in the presence or absence of tumor treating fields.Accordingly,the advent of molecular targeted therapy and immunotherapy has opened a new era of tumor management.A diverse range of targeted drugs have been tested in patients with GBM in phase III clinical trials.However,these drugs are ineffective for all patients,as evidenced by the fact that only a minority of patients in these trials showed prolonged survival.Furthermore,there are several published phase III clinical trials that involve immune checkpoint inhibitors,peptide vaccines,dendritic cell vaccines,and virotherapy.Accordingly,this review comprehensively overviews existing studies of targeted drugs and immunotherapy for glioma and discusses the challenge and perspective of targeted drugs and immunotherapy for glioma to clarify future directions. | Yuekun Wang Shenglan Li Yichen Peng Wenbin Ma Yu Wang Wenbin Li | 2023 | Cancer Innovation2023，2，2： | 0 |
| 15 | Thianthrene Radical Cation as a Transient SET Mediator:Photoinduced Thiocyanation and Selenocyanation of Arylthianthrenium Salts显示文摘Comprehensive Summary A novel transient SET mediator approach has been developed for the photoinduced radical-radical cross coupling reaction.Using the in-situ generated thianthrene radical cation as the transient SET mediator,the thiocyanation and selenocyanation of aryl thianthrenium salts have been realized under the mild conditions without the need for photocatalyst or single electron donor.In comparison with the photocatalyst enabled process,the protocol features mild conditions,simple manipulation,a broad substrate scope,excellent functional group and heterocycle tolerance.Due to the feasible accessibility of aryl thianthrenium salts,this method has also been applied in the efficient synthesis of a bioactive molecule,and the late-stage functionalization of complex arenes. | Xiao-Yue Chen Xin Kuang Yichen Wu Jian Zhou Peng Wang | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 16 | Ancient DNA reveals the maternal genetic history of East Asian domestic pigs显示文摘Zoo-archaeological and genetic evidence suggest that pigs were domesticated independently in Central China and Eastern Anatolia along with the development of agricultural communities and civilizations.However,the genetic history of domestic pigs,especially in China,has not been fully explored.In this study,we generate 42 complete mitochondrial DNA sequences from~7500-to 2750-year-old individuals from the Yellow River basin.Our results show that the maternal genetic continuity of East Asian domestic pigs dates back to at least the Early to Middle Neolithic.In contrast,the Near Eastern ancestry in European domestic pigs saw a near-complete genomic replacement by the European wild boar.The majority of East Asian domestic pigs share close haplotypes,and the most recent common ancestor of most branches dates back to less than 20,000 years before present,inferred using new substitution rates of whole mitogenomes or combined protein-coding regions.Two major population expansion events of East Asian domestic pigs coincided with changes in climate,widespread adoption of introduced crops,and the development of agrarian societies.These findings add to our understanding of the maternal genetic composition and help to complete the picture of domestic pig evolutionary history in East Asia. | Ming Zhang Yichen Liu Zhipeng Li Peng Lü Jacob D.Gardner Maolin Ye Jihuai Wang Miaomiao Yang Jing Shao Weilin Wang Qingyan Dai Peng Cao Ruowei Yang Feng Liu Xiaotian Feng Lizhao Zhang Enwei Li Yunzheng Shi Zehui Chen Shilun Zhu Weiwei Zhai Tao Deng Ziyuan Duan E.Andrew Bennett Songmei Hu Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 17 | Versatile photonic molecule switch in multimode microresonators显示文摘Harnessing optical supermode interaction to construct artificial photonic molecules has uncovered a series of fundamental optical phenomena analogous to atomic physics.Previously,the distinct energy levels and interactions in such two-level systems were provided by coupled microresonators.The reconfigurability is limited,as they often require delicate external field stimuli or mechanically altering the geometric factors.These highly specific approaches also limit potential applications.Here,we propose a versatile on-chip photonic molecule in a multimode microring,utilizing a flexible regulation methodology to dynamically control the existence and interaction strength of spatial modes.The transition between single/multi-mode states enables the“switched-off/on”functionality of the photonic molecule,supporting wider generalized applications scenarios.In particular,“switched-on”state shows flexible and multidimensional mode splitting control in aspects of both coupling strength and phase difference,equivalent to the a.c.and d.c.Stark effect.“Switched-off”state allows for perfect low-loss single-mode transition(Qi~10 million)under an ultra-compact bend size(FSR~115 GHz)in a foundry-based silicon microring.It breaks the stereotyped image of the FSR-Q factor trade-off,enabling ultra-wideband and high-resolution millimeter-wave photonic operations.Our demonstration provides a flexible and portable solution for the integrated photonic molecule system,extending its research scope from fundamental physics to real-world applications such as nonlinear optical signal processing and sixth-generation wireless communication. | Zihan Tao Bitao Shen Wencan Li Luwen Xing Haoyu Wang Yichen Wu Yuansheng Tao Yan Zhou Yandong He Chao Peng Haowen Shu Xingjun Wang | 2024 | Light(Science & Applications)2024，13，3： | 0 |
| 18 | 畅享自然——让老年人乐享幸福生活的生态社区公园设计显示文摘为了更好地照顾老年人,护理模式正在一步步由家庭护理向社区护理转变。该项目以自然恢复、低影响发展、自我维持的生态社区为设计理念,旨在创造一个健康舒适的户外空间,为老年人提供互动、娱乐和教育服务,加强老年人与家人之间的联系,并完善社区内外的社交网络。项目地址位于安徽省合肥市中心的仙桥社区。该社区占地0.46平方公里,有6个相对独立的居民区。原有社区景观设计陈旧,建筑密度高,仅有一个公共广场和一个袖珍公园,区域内居民很少有接触到绿色和自然的机会。 | Peng Chen Yichen Lou Kun Qian Zhengwei Xing Yunxin Han Wenjun Liu Hongbo Chen Wenqi Chen Xinmiao Zhu Lang Qin Xueying Liu Yu Leng Xinya Hu Suheng Yao | 2023 | 工业设计2023，，9： | 0 |
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