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| 1 | Shexiang Tongxin dropping pill(麝香通心滴丸)protects against sodium laurate-induced coronary microcirculatory dysfunction in rats显示文摘OBJECTIVE:To investigate the protective effects of Shexiang Tongxin dropping pill(麝香通心滴丸,STDP)in a rat model of coronary microcirculatory dysfunction(CMD).METHODS:Sprague-Dawley rats were allocated randomly into four groups:sham,CMD model,STDP,and nicorandil.After 4 weeks of treatment,CMD was induced by injection of sodium laurate(0.2 m L,2 g/L)into the left ventricle while obstructing the ascending aorta.Rats in the sham group underwent an identical surgical procedure but were administered physiological(0.9%)saline(0.2 m L).Twenty-four hours after surgery,blood samples were collected for biochemical analyses and enzyme-linked immunosorbent assays.Heart tissues were removed for histopathology staining;apoptosis and inflammatory cytokines were examined by Western blotting.RESULTS:The STDP group had a lower level of creatine kinase-myocardial band,lactate dehydrogenase,and cardiac troponin-I than that in the CMD model group.Infiltration of inflammatory cells,myocardial ischaemia,and microthrombosis were relieved in the STDP group compared with CMD model group.Levels of endothelin-1,nuclear factor-kappa B,tumour necrosis factor-α,interleukin-6,interleukin-1β,malondialdehyde,B-cell lymphoma(Bcl)-2-associated X protein,and caspase-3 were lower,and levels of nitric oxide,Bcl-2,and superoxide dismutase were higher,in the STDP group in comparison with the CMD model group.CONCLUSION:STDP pretreatment improved the CMD induced by sodium laurate via anti-inflammatory,anti-apoptosis,and anti-oxidant mechanisms. | LIU Huahua ZHAO Jingjing ZHU Yeke TANG Weiliang PENG Fang PAN Sunlei FU Guosheng | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 6 |
| 2 | Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects显示文摘Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018. | Qihao Wu Bastien Nay Min Yang Yeke Ni Hong Wang Ligong Yao Xuwen Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 3 | Sialoblastoma:MRI findings 显示文摘 | Yeke|er E Dursun M Gun F | 2004 | Pediatr Radiol2004，34，12： | 1 |
| 4 | Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure显示文摘 | Yu Fu Zhengang Zhao Yeke Wu Keming Wu Xiaouan Xu Yue Liu Chongyi Tong | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
| 5 | The effect of varying healing times on orthodontic mini-implant stability: a microscopic computerized tomographic and biomechanical analysis显示文摘 | Qiang Zhang Lixing Zhao Yeke Wu Hui Wang Zhihe Zhao Zhenrui Xu Xing Wei Tian Tang | 2011 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2011，，4： | 1 |
| 6 | A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration显示文摘Articular cartilage damage is a universal health problem.Despite recent progress,chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration.Loss-of-function changes are frequently observed in chondrocyte expansion and other pathological conditions,but the characteristics and intermediate molecular mechanisms remain unclear.In this study,we demonstrate a time-lapse atlas of chondrocyte dedifferentiation to provide molecular details and informative biomarkers associated with clinical chondrocyte evaluation.We performed various assays,such as single-cell RNA sequencing(scRNA-seq),live-cell metabolic assays,and assays for transposase-accessible chromatin with high-throughput sequencing(ATAC-seq),to develop a biphasic dedifferentiation model consisting of early and late dedifferentiation stages.Early-stage chondrocytes exhibited a glycolytic phenotype with increased expression of genes involved in metabolism and antioxidation,whereas late-stage chondrocytes exhibited ultrastructural changes involving mitochondrial damage and stress-associated chromatin remodeling.Using the chemical inhibitor BTB06584,we revealed that early and late dedifferentiated chondrocytes possessed distinct recovery potentials from functional phenotype loss.Notably,this two-stage transition was also validated in human chondrocytes.An image-based approach was established for clinical use to efficiently predict chondrocyte plasticity using stage-specific biomarkers.Overall,this study lays a foundation to improve the quality of chondrocytes in clinical use and provides deep insights into chondrocyte dedifferentiation. | Yishan Chen Yeke Yu Ya Wen Juan Chen Junxin Lin Zixuan Sheng Wenyan Zhou Heng Sun Chengrui An Jiansong Chen Weiliang Wu Chong Teng Wei Wei Hongwei Ouyang | 2022 | Bone Research2022，10，3： | 1 |
| 7 | Evolution of the Yangtze River and its biodiversity显示文摘Documenting the origins of megadiverse(sub)tropical aquatic ecosystems is an important goal for studies of evolution and ecology.Nonetheless,the geological and ecological establishment of the modern Yangtze River remains poorly understood.Here,we reconstruct the geographic and ecological history of an endemic clade of East Asian fishes based on the mitochondrial phylogenomics analysis of Cyprinidae using 15 fossil calibrations.We estimate an ancestral condition of benthic spawning with demersal or adhesive eggs in southern East Asia before23 Ma and a derived condition of riverine spawning with semibuoyant eggs in the Yangtze by18 Ma.These results imply the formation of Yangtze riverine ecosystems around the Oligocene-Miocene boundary in response to plateau uplift and monsoon strengthening.Some of these cyprinids reverted to benthic spawning with adhesive eggs by15 Ma,a time of rising to peak net diversification rates,indicating the formation of potamo-lacustrine ecosystems by the mid-Miocene during a strong East Asian summer monsoon.Our study provides increased spatiotemporal resolution for the co-evolutionary histories of the Yangtze River and its biodiversity and highlights biological evidence concerning the geomorphological dynamics of the Yangtze River. | Feng Chen Ge Xue Yeke Wang Hucai Zhang Peter D.Clift Yaowu Xing Jun He James S.Albert Jun Chen Ping Xie | 2023 | The Innovation2023，4，3： | 0 |
| 8 | Molecular Mechanisms of Spawning Habits for the Adaptive Radiation of Endemic East Asian Cyprinid Fishes显示文摘Despite the widespread recognition of adaptive radiation as a driver of speciation,the mechanisms by which natural selection generates new species are incompletely understood.The evolutionary radiation of endemic East Asian cyprinids has been proposed as evolving through a change in spawning habits,involving a transition from semibuoyant eggs to adhesive eggs in response to crosslinked river-lake system formation.Here,we investigated the molecular mechanisms that underpin this radiation,associated with egg hydration and adhesiveness.We demonstrated that semibuoyant eggs enhance hydration by increasing the degradation of yolk protein and accumulation of Ca2+and Mga+ions,while adhesive eggs improve adhesiveness and hardness of the egg envelope by producing an adhesive layer and a unique 4th layer to the egg envelope.Based on multiomics analyses and verification tests,we showed that during the process of adaptive radiation,adhesive eggs downregulated the'vitellogenin degradation pathway','zinc metalloprotease pathway,'and'ubiquitin-proteasome pathway'and the pathways of Ca^(2+)and Mg^(2+)active transport to reduce their hydration.At the same time,adhesive eggs upregulated the crosslinks of microfilament-associated proteins and adhesive-related proteins,the hardening-related proteins of the egg envelope,and the biosynthesis of glycosaminoglycan in the ovary to generate adhesiveness.These findings illustrate the novel molecular mechanisms associated with hydration and adhesiveness of freshwater fish eggs and identify critical molecular mechanisms involved in the adaptive radiation of endemic East Asian cyprinids.We propose that these key egg attributes may function as“magic traits”in this adaptive radiation. | Feng Chen Yeke Wang Jun He Liang Chen Ge xue Yan Zhao Yanghui Peng Carl mith Jia Zhang Jun Chen Ping Xie | 2023 | Research2023，，1： | 0 |
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