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| 1 | Soil Microbial Community Structure in Diverse Land Use Systems:A Comparative Study Using Biolog,DGGE,and PLFA Analyses显示文摘Biolog,16S rRNA gene denaturing gradient gel electrophoresis(DGGE) ,and phospholipid fatty acid(PLFA) analyses were used to assess soil microbial community characteristics in a chronosequence of tea garden systems(8-,50-,and 90-year-old tea gardens) ,an adjacent wasteland,and a 90-year-old forest. Biolog analysis showed that the average well color development(AWCD) of all carbon sources and the functional diversity based on the Shannon index decreased(P < 0.05) in the following order:wasteland > forest > tea garden. For the DGGE analysis,the genetic diversity based on the Shannon index was significantly lower in the tea garden soils than in the wasteland. However,compared to the 90-year-old forest,the tea garden soils showed significantly higher genetic diversity. PLFA analysis showed that the ratio of Gram positive bacteria to Gram negative bacteria was significantly higher in the tea garden soils than in the wasteland,and the highest value was found in the 90-year-old forest. Both the fungal PLFA and the ratio of fungi to bacteria were significantly higher in the three tea garden soils than in the wasteland and forest,indicating that fungal PLFA was significantly affected by land-use change. Based on cluster analysis of the soil microbial community structure,all three analytical methods showed that land-use change had a greater effect on soil microbial community structure than tea garden age. | XUE Dong YAO Huai-Ying GE De-Yong HUANG Chang-Yong | 2008 | Pedosphere2008，18，5： | 56 |
| 2 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 3 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 4 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 5 | Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation显示文摘BACKGROUND Unconjugated bilirubin(UCB) is generally considered toxic but has gained recent prominence for its anti-inflammatory properties. However, the effects of it on the interaction between intestinal flora and organisms and how it influences immune responses remain unresolved.AIM To investigate the role of UCB in intestinal barrier function and immune inflammation in mice with dextran-sulfate-sodium-induced colitis.METHODS Acute colitis was induced by 3%(w/v) dextran sulfate sodium salt in drinking water for 6 d followed by untreated water for 2 d. Concurrently, mice with colitis were administered 0.2 mL UCB(400 μmol/L) by intra-gastric gavage for 7 d.Disease activity index(DAI) was monitored daily. Mice were sacrificed at the end of the experiment. The length of the colon and weight of the spleen were recorded. Serum level of D-lactate, intestinal digestive proteases activity, and changes to the gut flora were analyzed. In addition, colonic specimens were analyzed by histology and for expression of inflammatory markers and proteins.RESULTS Mice treated with UCB had significantly relieved severity of colitis, including lower DAI, longer colon length, and lower spleen weight(colon length: 4.92 ±0.09 cm vs 3.9 ± 0.15 cm; spleen weight: 0.33 ± 0.04 vs 0.74 ± 0.04, P < 0.001). UCB administration inactivated digestive proteases(chymotrypsin: 18.70 ± 0.69 U/g vs44.81 ± 8.60 U/g; trypsin: 1.52 ± 0.23 U/g vs 9.05 ± 1.77 U/g, P < 0.01), increased expression of tight junction(0.99 ± 0.05 vs 0.57 ± 0.03, P < 0.001), decreased serum level of D-lactate(31.76 ± 3.37 μmol/L vs 54.25 ± 1.45 μmol/L, P < 0.001), and lowered histopathological score(4 ± 0.57 vs 7 ± 0.57, P < 0.001) and activity of myeloperoxidase(46.79 ± 2.57 U/g vs 110.32 ± 19.19 U/g, P < 0.001). UCB also regulated the intestinal microbiota, inhibited expression of tumor necrosis factor(TNF) α and interleukin 1β(TNF-α: 52.61 ± 7.81 pg/mg vs 105.04 ± 11.92 pg/mg,interleukin 1β: 13.43 ± 1.68 vs 32.41 ± 4.62 pg/mg, P < 0.001), decreased expression of Toll-like receptor 4(0.61 ± 0.09 vs 1.07 ± 0.03, P < 0.001) and myeloid differentiation primary response gene 88(0.73 ± 0.08 vs 1.01 ± 0.07, P <0.05), and increased expression of TNF-receptor-associated factor 6(0.79 ± 0.02 vs0.43 ± 0.09 P < 0.05) and inhibitor of kappa B α(0.93 ± 0.07 vs 0.72 ± 0.07, P < 0.05)in the colon.CONCLUSION UCB can protect intestinal barrier function, regulate normal intestinal homeostasis, and suppress inflammation via the Toll-like receptor 4/nuclear factor-κB signaling pathway. | Jia-Dong Zheng Yan He Heng-Yuan Yu Yuan-Li Liu Yi-Xuan Ge Xue-Ting Li Xue Li Yan Wang Meng-Ru Guo Yi-Lin Qu Xiao-Fa Qin Ming-Shan Jiang Xiu-Hong Wang | 2019 | World Journal of Gastroenterology2019，25，15： | 26 |
| 6 | Infection with novel coronavirus(SARS-CoV-2)causes pneumonia in Rhesus macaques显示文摘The 2019 novel coronavirus(SARS-CoV-2)outbreak is a major challenge for public health.SARS-CoV-2 infection in human has a broad clinical spectrum ranging from mild to severe cases,with a mortality rate of^6.4%worldwide(based on World Health Organization daily situation report).However,the dynamics of viral infection,replication and shedding are poorly understood.Here,we show that Rhesus macaques are susceptible to the infection by SARS-CoV-2.After intratracheal inoculation,the first peak of viral RNA was observed in oropharyngeal swabs one day post infection(1 d.p.i.),mainly from the input of the inoculation,while the second peak occurred at 5 d.p.i.,which reflected on-site replication in the respiratory tract.Histopathological observation shows that SARS-CoV-2 infection can cause interstitial pneumonia in animals,characterized by hyperemia and edema,and infiltration of monocytes and lymphocytes in alveoli.We also identified SARS-CoV-2 RNA in respiratory tract tissues,including trachea,bronchus and lung;and viruses were also re-isolated from oropharyngeal swabs,bronchus and lung,respectively.Furthermore,we demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2.The non-human primate model that we established here provides a valuable platform to study SARS-CoV-2 pathogenesis and to evaluate candidate vaccines and therapeutics. | Chao Shan Yan-Feng Yao Xing-Lou Yang Yi-Wu Zhou Ge Gao Yun Peng Lian Yang Xue Hu Jin Xiong Ren-Di Jiang Hua-Jun Zhang Xiao-Xiao Gao Cheng Peng Juan Min Ying Chen Hao-Rui Si Jia Wu Peng Zhou Yan-Yi Wang Hong-Ping Wei Wei Pang Zheng-Fei Hu Long-Bao Lv Yong-Tang Zheng Zheng-Li Shi Zhi-Ming Yuan | 2020 | Cell Research2020，30，8： | 19 |
| 7 | Cutting force prediction for circular end milling process显示文摘A deduced cutting force prediction model for circular end milling process is presented in this paper. Traditional researches on cutting force model usually focus on linear milling process which does not meet other cutting conditions, especially for circular milling process. This paper presents an improved cutting force model for circular end milling process based on the typical linear milling force model. The curvature effects of tool path on chip thickness as well as entry and exit angles are analyzed, and the cutting force model of linear milling process is then corrected to fit circular end milling processes. Instantaneous cutting forces during circular end milling process are predicted according to the proposed model. The deduced cutting force model can be used for both linear and circular end milling processes. Finally, circular end milling experiments with constant and variable radial depth were carried out to verify the availability of the proposed method. Experiment results show that measured results and simulated results corresponds well with each other. | Wu Baohai Yan Xue Luo Ming Gao Ge | 2013 | Chinese Journal of Aeronautics2013，26，4： | 16 |
| 8 | Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway显示文摘Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to disability.Inflammatory cell infiltration,severe joint breaking and systemic bone loss are the main clinical symptoms.In this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory cytokines.Punicalagin(PUN)is an active substance extracted from pomegranate peel.We found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA mice.PUN effectively alleviated the high expression of inflammatory cytokines in synovial tissue in vivo.PUN treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment group.However,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was increased.In addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand IL-18.Mechanistically,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of macrophages.We concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA. | Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao Hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu Yuefeng Hao Yi Xue Dechun Geng | 2022 | Science China(Life Sciences)2022，65，3： | 14 |
| 9 | Paleoenvironmental records from the northern South China Sea since the Last Glacial Maximum显示文摘Core ZHS-176 contains the paleoenvironmental records from the northern South China Sea (NSCS) since the Last Glacial Maximum (LGM). A coupled approach based on clay mineral assemblages, planktonic foraminiferal oxygen and carbon isotopes, and calcium carbonate content is used to trace the sources of the fine-grained sediment and to investigate the paleoenviornmental evolution in this area. Clay mineral assemblages are dominated by illite (average about 39%) and chlorite (about 27%), which comes mainly from Taiwan and the East China Sea. Kaolinite, which accounts for about 13%, comes mainly from the Zhujiang (Pearl) River, and Luzon Island is the main source for smectite (about 21%). The planktonic foraminiferal oxygen isotopic oscillations during the last glacial period are coeval with climate variations recorded in the Greenland ice core and Western Pacific sediment. These variations include the LGM, Heinrich event 1, Bφlling-Allerφd (B/A), and Younger Dryas. For the Holocene, three periods of strong precipitation (S1-S3) and three periods of weak precipitation (W1-W3) are identified. The oxygen isotopic record exhibits corre-lation with climate records from distant regions, including the high-latitude Northern Hemisphere, providing evidence for global tele-connection among regional climate. A brief, negative planktonic foraminiferal carbon isotopic excursion during B/A reflects increased methane released from marine gas hydrate due to the rapid warming of the water. By comparing calcium carbonate content curves of the core ZHS-176 with these of other five boreholes lying above the lysocline, a remarkable low calcium carbonate event is found during the early Holocene in NSCS. | GE Qian CHU Fengyou XUE Zuo LIU J Paul DU Yuansheng FANG Yinxia | 2010 | Acta Oceanologica Sinica2010，29，3： | 13 |
| 10 | Chemical characteristics of haze particles in Xi'an during Chinese Spring Festival: Impact of fireworks burning显示文摘Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year(LNY) period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM_(2.5) samples in Xi'an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content(LWC) of the fine aerosols. PM_(2.5) during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard(75 μg/m^3). K^+(28 wt.% of the total ion mass) was the most abundant ion in the LNY period, followed by SO_4^(2-)(25 wt.%) and Cl-(18 wt.%). In contrast, NO_3^-(34 wt.%) was the most abundant species in the haze periods(hourly PM32-2.5> 75 μg/m), followed by SO_4(29.2 wt.%) and NH_4^+(16.3 wt.%), while SO_4^(2-)(35 wt.%) was the most abundant species in the clean periods(hourly PM_(2.5)< 75 μg/m^3), followed by NO_3^-(23.1 wt.%) and NH_4^+(11 wt.%). Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K_2SO_4 and KCl, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO--3/SO_4^(2-) and NH_4^+/SO_4^(2-) indicated that heterogeneous reaction of HNO_3 with NH_3 was an important formation pathway of particulate nitrate and ammonium during the LNY period. | Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang Cong Cao Jin Li Shuagshuang Ge Yuning Xie Xinpei Wang Guoyan Xue | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 11 | The dimension and morphology of alveolar bone at maxillaryanterior teeth in periodontitis: a retrospective analysis usingCBCT显示文摘The morphology of the alveolar bone at the maxillary anterior teeth in periodontitis patients was evaluated by cone-beam computed tomography(CBCT) to investigate the distribution of alveolar defects and provide guidance for clinical practice. Ninety periodontitis patients and 30 periodontally healthy individuals were selected to determine the morphology of the alveolar bone at the maxillary anterior teeth according to the degree of bone loss, tooth type, sex and age. The differences in the dimensions between periodontitis patients and healthy individuals were compared, and the distribution of alveolar bone defects was analyzed.A classification system was established regarding the sagittal positions and angulations of the teeth. The buccal residual bone was thicker and the lingual bone was thinner in the periodontitis patients than in the periodontally healthy individuals, and there were differences between the different tooth types, sexes and age subgroups. The buccal undercut was close to the alveolar ridge, while fenestration was reduced and the apical bone height was higher in periodontitis patients than in periodontally healthy individuals.The apical bone height increased with the aggravation of bone loss and age. The proportions of different sagittal positions changed with the aggravation of bone loss. Moreover, the teeth moved more buccally regarding the positions of the maxillary anterior teeth.The morphology of the alveolar bone at the maxillary anterior teeth differed between periodontitis patients and healthy individuals,and the differences were related to the degree of bone loss, tooth type, sex and age. | Xue Zhang Yuchao Li Ziming Ge Haijiao Zhao Lei Miao Yaping Pan | 2020 | International Journal of Oral Science2020，12，1： | 10 |
| 12 | Lake records and LGM climate in China显示文摘Chinese lake status database has provided systematic geological records of much higher lake level and fresher water than today at the LGM from western China. This wet condition was significant contrast with very dry conditions in eastern China. Together with lake studies from Eurasian continents, there was a wet-condition belt from the Mediterranean and the Middle East, Central Asia to western China. Palaeoclimate simulations confirmed that the wet conditions in western China were produced by decrease of the evaporation and increase of precipitation by positive anomaly of annual P-E of 70-95 mm/a between the LGM and today. The westerlies enhanced in the strength and shifted southwards-eastwards in the position, and the low thermal conditions in the Eurasian continent creating temperature 4-16℃ lower than today and relatively low evaporation, were the major two important climate conditions to yield cold-wet climates in western China. | Ge Yu Bin Xue Sumin Wang Jian Liu | 2000 | Chinese Science Bulletin2000，45，13： | 9 |
| 13 | Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippocampus of rats with hyperlipidemia and middle cerebral artery thrombus显示文摘Electroacupuncture(EA)has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipemia complicated by cerebral ischemia.However,there are few studies on the results and mechanism of the effect of EA in reducing blood lipid level or promoting neural repair after stroke in hyperlipidemic subjects.In this study,EA was applied to a rat model of hyperlipidemia and middle cerebral artery thrombosis and the condition of neurons and astrocytes after hippocampal injury was assessed.Except for the normal group,rats in other groups were fed a high-fat diet throughout the whole experiment.Hyperlipidemia models were established in rats fed a high-fat diet for 6 weeks.Middle cerebral artery thrombus models were induced by pasting 50%FeCl3 filter paper on the left middle cerebral artery for 20 minutes on day 50 as the model group.EA1 group rats received EA at bilateral ST40(Fenglong)for 7 days before the thrombosis.Rats in the EA1 and EA2 groups received EA at GV20(Baihui)and bilateral ST40 for 14 days after model establishment.Neuronal health was assessed by hematoxylin-eosin staining in the brain.Hyperlipidemia was assessed by biochemical methods that measured total cholesterol,triglyceride,low-density lipoprotein and high-density lipoprotein in blood sera.Behavioral analysis was used to confirm the establishment of the model.Immunohistochemical methods were used to detect the expression of glial fibrillary acidic protein and nerve growth factor in the hippocampal CA1 region.The results demonstrated that,compared with the model group,blood lipid levels significantly decreased,glial fibrillary acidic protein immunoreactivity was significantly weakened and nerve growth factor immunoreactivity was significantly enhanced in the EA1 and EA2 groups.The repair effect was superior in the EA1 group than in the EA2 group.These findings confirm that EA can reduce blood lipid,inhibit glial fibrillary acidic protein expression and promote nerve growth factor expression in the hippocampal CA1 region after hyperlipidemia and middle cerebral artery thrombosis.All experimental procedures and protocols were approved by the Animal Use and Management Committee of Beijing University of Chinese Medicine,China(approval No.BUCM-3-2018022802-1002)on April 12,2018. | Na-Ying Xue Dong-Yu Ge Rui-Juan Dong Hyung-Hwan Kim Xiu-Jun Ren Ya Tu | 2021 | Neural Regeneration Research2021，16，1： | 9 |
| 14 | Spatial Distribution of Liver Cancer Incidence in Shenqiu County,Henan Province,China:a Spatial Analysis显示文摘Liver cancer is a common and leading cause of cancer death in China.We used the cancer registry data collected from 2009 to 2011 to describe the spatial distribution of liver cancer incidence at village level in Shengqiu county,Henan province,China.Spatial autocorrelation analysis was employed to detect significant differences from a random spatial distribution of liver cancer incidence.Spatial scan statistics were used to detect and evaluate the clusters of liver cancer cases. | SUN Jie HUANG Hui XIAO Ge Xin FENG Guo Shuang YU Shi Cheng XUE Yu Tang WAN Xia YANG Gong Huan SUN Xin | 2015 | Biomedical and Environmental Sciences2015，28，3： | 7 |
| 15 | Lactic Acid Inhibits NF-kB Activation by Lipopolysaccharide in Rat Intestinal Mucosa Microvascular Endothelial Cells显示文摘To investigate whether lactic acid could inhibit the LPS-activation of NF-kB p65 in rat intestinal mucosa microvascular endothelial cells (RIMMVECs), RIMMVECs, cultured in vitro, were pretreated with different concentrations of lactic acid and then exposed to lipopolysaccharide (LPS). Cells and cell culture media were then collected at different time intervals. Production of tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6) was examined at the protein level by enzyme-linked immunosorbent assay. The influence of lactic acid on the LPS-activation of NF-kB was examined at mRNA and protein levels by real-time quantitative PCR and Western blot analysis, respectively. TNF-a and IL-6 protein levels were significantly decreased after pretreatment with lactic acid compared with cells exposed to LPS only. After pretreatment with 7.5, 5.0, and 2.5 μL mL-1 lactic acid, NF-kB mRNA levels were increased by 1.51-, 2.62- and 3.00-fold, respectively, compared with levels in control cells without LPS treatment. Western blot analysis indicated that the level of NF-kB p65 in the lactic acid-pretreated group was significantly lower than that in the group treated with LPS only (positive control) and was unchanged compared with the group without LPS treatment (blank control). These results suggest that lactic acid may inhibit LPS-activation of NF-kB, leading to the down-regulation of TNF-a and IL-6. | LIU Jing XUE Jiu-zhou ZHU Zhi-ning HU Ge REN Xiao-ming | 2011 | Agricultural Sciences in China2011，10，6： | 7 |
| 16 | Dispersal of the Zhujiang River(Pearl River) derived sediment in the Holocene显示文摘High-resolution Chirp profiling and coring reveals an elongated(ca. 400 km) Holocene Zhujiang River(Pearl River)-derived mud area(maximum thickness > 20 m) extending from the Zhujiang River Delta, southwestward off the Guangdong coast, to the Leizhou Peninsula. Two depo-centers, one proximal and one distal, are identified. On the continental shelf off the west Guangdong Province, the mud is deposited in water depth shallower than 50 m; while to the southeast of the Zhujiang River Estuary, the mud area can extend to the-120 m isobath. A combined analysis with the stratigraphic sequences of other muddy deposits in the Western Pacific marginal seas(mainly Changjiang(Yangtze) and Huanghe(Yellow) Rivers derived) indicates that the initiation of the Zhujiang River muddy deposit can be further divided into two stages: Stage 1 is before the mid-Holocene sea-level highstand(ca. 7.0 cal. ka BP), the proximal mud was mostly deposited after 9.0 cal. ka BP, when the sea-level rose slowly after the Meltwater Pulse-1C; Stage 2, after the mid-Holocene sealevel highstand, clinoform developed on the continental shelf off the west Guangdong Province, extending ca. 400 km from the Zhujiang River Estuary. The proximal clinoform thins offshore, from ca. 10 m thickness around 5–10 m water depth to less than 1–2 m around 20–30 m water depth. In addition, we also find a developed distal clinoform in the east of the Leizhou Peninsula. | GE Qian LIU J.P. XUE Zuo CHU Fengyou | 2014 | Acta Oceanologica Sinica2014，33，8： | 6 |
| 17 | The role of new energy in carbon neutral显示文摘Carbon dioxide is an important medium of the global carbon cycle,and has the dual properties of realizing the conversion of organic matter in the ecosystem and causing the greenhouse effect.The fixed or available carbon dioxide in the atmosphere is defined as'gray carbon',while the carbon dioxide that cannot be fixed or used and remains in the atmosphere is called'black carbon'.Carbon neutral is the consensus of human development,but its implementation still faces many challenges in politics,resources,technology,market,and energy structure,etc.It is proposed that carbon replacement,carbon emission reduction,carbon sequestration,and carbon cycle are the four main approaches to achieve carbon neutral,among which carbon replacement is the backbone.New energy has become the leading role of the third energy conversion and will dominate carbon neutral in the future.Nowadays,solar energy,wind energy,hydropower,nuclear energy and hydrogen energy are the main forces of new energy,helping the power sector to achieve low carbon emissions.'Green hydrogen'is the reserve force of new energy,helping further reduce carbon emissions in industrial and transportation fields.Artificial carbon conversion technology is a bridge connecting new energy and fossil energy,effectively reducing the carbon emissions of fossil energy.It is predicted that the peak value of China’s carbon dioxide emissions will reach 110×10^(8) t in 2030.The study predicts that China’s carbon emissions will drop to 22×10^(8) t,33×10^(8) t and 44×10^(8) t,respectively,in 2060 according to three scenarios of high,medium,and low levels.To realize carbon neutral in China,seven implementation suggestions have been put forward to build a new'three small and one large'energy structure in China and promote the realization of China’s energy independence strategy. | ZOU Caineng XIONG Bo XUE Huaqing ZHENG Dewen GE Zhixin WANG Ying JIANG Luyang PAN Songqi WU Songtao | 2021 | Petroleum Exploration and Development2021，48，2： | 6 |
| 18 | Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma显示文摘AIM: To investigate transarterial chemoembolization(TACE) with hepatic infusion of oxaliplatin and 5-fluorouracil and Lipiodol chemoembolization in large hepatocellular carcinoma(HCC).METHODS: In this retrospective study, 132 patients with unresectable HCCs larger than 10 cm were treated with hepatic infusion of oxaliplatin and 5-fluorouracil followed by Lipiodol chemoembolization. The primary endpoint was overall survival(OS). Sixteen-week disease-control rate, time to progression(TTP), and major complications were also studied. Univariate and multivariate analyses were performed to identify prognostic factors affecting OS and TTP.RESULTS: A total of 319 procedures were performed in the 132 patients. Eleven(8.3%) patients received radical resection following TACE treatment(median time to initial TACE 4.3 ± 2.3 mo). The median OS and TTP were 10.3 and 3.0 mo respectively, with a 50.0% 16-wk disease-control rate. Major complications were encountered in 6.0%(8/132) of patients following TACE and included serious jaundice in 1.5%(2/132) patients, aleukia in 1.5%(2/132), and hepatic failure in 3.0%(4/132). One patient died within one month due to serious hepatic failure and severe sepsis after receiving the second TACE. The risk factor associated with TTP was baseline alpha-fetoprotein level, and vascular invasion was an independent factor related to OS.CONCLUSION: Hepatic infusion of oxaliplatin and 5-fluorouracil followed by lipiodolized-chemoembolization is a safe and promising treatment for patients with HCCs larger than 10 cm in diameter. | Jing-Huan Li Xiao-Ying Xie Lan Zhang Fan Le Ning-Ling Ge Li-Xin Li Yu-Hong Gan Yi Chen Ju-Bo Zhang Tong-Chun Xue Rong-Xin Chen Jing-Lin Xia Bo-Heng Zhang Sheng-Long Ye Yan-Hong Wang Zheng-Gang Ren | 2015 | World Journal of Gastroenterology2015，21，13： | 6 |
| 19 | Protective effects of sirtuin 3 on titanium particle-induced osteogenic inhibition by regulating the NLRP3 inflammasome via the GSK-3β/β-catenin signalling pathway显示文摘Periprosthetic osteolysis(PPO)remains the key factor in implant failure and subsequent revision surgery and is mainly triggered by wear particles.Previous studies have shown that inhibition of osteoblastic differentiation is the most widespread incident affecting the interface of trabecular and loosening prostheses.Additionally,the NLRP3 inflammasome is activated by prosthetic particles.Sirtuin3,an NAD+-dependent deacetylase of mitochondria,regulates the function of mitochondria in diverse activities.However,whether SIRT3 can mitigate wear debris-induced osteolysis by inhibiting the NLRP3 inflammasome and enhancing osteogenesis has not been previously reported.Therefore,we investigated the role of SIRT3 during the process of titanium(Ti)particle-induced osteolysis.We revealed that upregulated SIRT3 dramatically attenuated Ti particle-induced osteogenic inhibition through suppression of the NLRP3 inflammasome and improvement of osteogenesis in vivo and in vitro.Moreover,we found that SIRT3 interference in the process of Ti particle-induced osteolysis relied on the GSK-3β/β-catenin signalling pathway.Collectively,these findings indicated that SIRT3 may serve as a rational new treatment against debris-induced PPO by deacetylase-dependent inflammasome attenuation. | Kai Zheng Jiaxiang Bai Ning Li Meng Li Houyi Sun Weicheng Zhang Gaoran Ge Xiaolong Liang Huaqiang Tao Yi Xue Yuefeng Hao Chen Zhu Yaozeng Xu Dechun Geng | 2021 | Bioactive Materials2021，6，10： | 5 |
| 20 | The spatial distribution of major and trace elements of surface sediments in the northeastern Beibu Gulf of the South China Sea显示文摘A multi-index analysis including grain size, major and trace elements is performed on the surface sediments from the northeastern Beibu Gulf to trace the sources of the sediments and to understand the controlling factors for elements distribution. The mean grain size exhibits a wide variation ranging from 0.09Φ to 8.05Φ with an average value of 5.33Φ. The average contents of major elements descend in an order of c(SiO_2)>c(Al_2O_3)>c(Fe_2O_3)>c(CaO)>c(MgO)>c(K_2O)>c(Na_2O)>c(TiO_2)>c(P_2O_5)>c(MnO), while those of trace elements exhibit a descending order of c(Sr)>c(Rb)>c(V)>c(Zn)>c(Cr)>c(Pb)>c(Ni)>c(Cu)>c(As). On the basis of elementary distribution characteristics and statistical analyses, the study area is divided into the four zones: Zone I is located in the northeastern coastal area of the gulf, which receives large amount of fluvial materials from local rivers in Guangxi and Guangdong, China, and the Qiongzhou Strait; Zone Ⅱ is located in the center of the study area, where surface sediments exhibits a multiple source; Zone Ⅲ is located in the Qiongzhou Strait, where surface sediments are dominated by materials from the Zhujiang River and Hainan; Zone IV is located in the southwest of the study area, where surface sediments are mainly originated from the Red River and Hainan. The statistical analyses of sediment geochemical characteristics reveal that the grain size, which is mainly influenced by hydrodynamics and mineral composition of terrigenous materials, is the leading factor controlling the elementary distribution.Meanwhile, impacts from anthropogenic activities and marine biogenic process will also be taken into consideration. | Qian Ge George Z Xue Liming Ye Dong Xu Jianru Zhao Fengyou Chu | 2019 | Acta Oceanologica Sinica2019，38，3： | 5 |
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