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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Overexpression of microRNA-124 promotes the neuronal differentiation of bone marrow-derived mesenchymal stem cells显示文摘microRNAs(miRNAs) play an important regulatory role in the self-renewal and differentiation of stem cells. In this study, we examined the effects of miRNA-124(miR-124) overexpression in bone marrow-derived mesenchymal stem cells. In particular, we focused on the effect of overexpression on the differentiation of bone marrow-derived mesenchymal stem cells into neurons. First, we used GeneChip technology to analyze the expression of miRNAs in bone marrow-derived mesenchymal stem cells, neural stem cells and neurons. miR-124 expression was substantially reduced in bone marrow-derived mesenchymal stem cells compared with the other cell types. We constructed a lentiviral vector overexpressing miR-124 and transfected it into bone marrow-derived mesenchymal stem cells. Intracellular expression levels of the neuronal early markers β-III tubulin and microtubule-associated protein-2 were significantly increased, and apoptosis induced by oxygen and glucose deprivation was reduced in transfected cells. After miR-124-transfected bone marrow-derived mesenchymal stem cells were transplanted into the injured rat spinal cord, a large number of cells positive for the neuronal marker neurofilament-200 were observed in the transplanted region. The Basso-Beattie-Bresnahan locomotion scores showed that the motor function of the hind limb of rats with spinal cord injury was substantially improved. These results suggest that miR-124 plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells into neurons. Our findings should facilitate the development of novel strategies for enhancing the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation for spinal cord injury. | Defeng Zou Yi Chen Yaxin Han Chen Lv Guanjun Tu | 2014 | Neural Regeneration Research2014，9，12： | 15 |
| 3 | Changes of Precipitation Infiltration Recharge in the Circumstances of Coal Mining Subsidence in the Shen-Dong Coal Field,China显示文摘煤采矿沉淀是在采矿区域的一个通用环境地质的问题。由作为研究领域选择 Shen 盾煤采矿沉淀区域,这篇论文在降水渗入学习变化再装在这种情况下借助于领域的煤采矿沉淀,地质的调查和实验室模拟试验,它被期望在采矿区域为 eco 环境的恢复提供一个科学基础。结果显示在沉淀的不稳定的阶段,在 Shen 盾采矿区域的沉淀的三种类型在降水渗入上有积极效果再装,并且完整厚度的基岩沉淀的类型有最大的影响。在沉淀,在长期的干旱以后的降水渗入进程和在通风地区的潮湿移植的稳定的阶段经历三个不同阶段:在降水前的蒸发渗入,渗入向上的渗入渗入在在降水以后的降水和蒸发渗入期间。在一个重降雨渗入过程期间,在好沙,粗糙的沙和罚款粗糙的沙的二元的结构的弄湿的前面运动由二个阶段组成:在降水,弄湿的前面运动距离与深度在有线性关系期间弄湿前面运动的阶段,和在降水,弄湿的前面运动距离与深度在有力量功能关系以后弄湿前面运动的阶段。弄湿的前面运动速度被降雨数量和岩性学在通风地区影响。作为深度增加,然而,运动速度将指数地腐烂。 | ZHANG Fawang SONG Yaxin ZHAO Hongmei HAN Zhantao WANG Dong | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 11 |
| 4 | Advances in alternating electromagnetic field data processing for earthquake monitoring in China显示文摘The alternating electromagnetic(EM) field is one of the most sensitive physical fields related to earthquakes. There have been a number of publications reporting EM anomalies associated with earthquakes. With increasing applications and research of artificial-source extremely low frequency EM and satellite EM technologies in earthquake studies, the amount of observed data from the alternating EM method increases rapidly and exponentially, so it is imperative to develop suitable and effective methods for processing and analyzing the influx of big data. This paper presents research on the self-adaptive filter and wavelet techniques and their applications to analyzing EM data obtained from ground measurements and satellite observations, respectively. Analysis results show that the self-adaptive filter method can identify both natural- and artificial-source EM signals, and enhance the ratio between signal and noise of EM field spectra, apparent resistivity, and others. The wavelet analysis is capable of detecting possible correlation between EM anomalies and seismic events. These techniques are effective in processing and analyzing massive data obtained from EM observations. | ZHAO GuoZe BI YaXin WANG LiFeng HAN Bing WANG Xiao XIAO QiBin CAI JunTao ZHAN Yan CHEN XiaoBin TANG Ji WANG JiJun | 2015 | Science China Earth Sciences2015，58，2： | 7 |
| 5 | In situ observation of C_(60)(C(COOH)_(2))_(2) interacting with living cells using fluorescence microscopy显示文摘The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this pur- pose, the C60 derivative C60(C(COOH)2)2, a thera- peutic agent for degeneration diseases of central nervous system, was synthesized, purified and characterized. Its interaction with the living cell and penetration of the cellular membrane were in situ studied using the real time imaging technique, and its potential cytotoxicity was also examined by flow cy- tometry. The results indicate that C60(C(COOH)2)2 can easily enter cells, and is mainly located in cytoplasm by fluorescein labeling. Furthermore, C60(C(COOH)2)2 can carry the molecule that cannot cross cellular membranes into cells, because fluo- rescein compound itself cannot enter the cell or ad- here to membrane. At concentrations ranging from 1×10?2 to 1×102 mg/L, C60(C(COOH)2)2 does not show any detectable cytotoxicity. | YE Chang CHEN Chunying CHEN Zhen MENG Huan XING Li JIANG Yaxin YUAN Hui XING Gengmei ZHAO Feng ZHAO Yuliang CHAI Zhifang FANG Xiaohong HAN Dong CHEN Long WANG Chen WEI Taotao | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 6 | Earthquake Electromagnetic Precursor Anomalies Detected by a New Ground-based Observation Network显示文摘It is a debated topic if there are any observable precursor anomalies prior to the earthquake(EQ hereafter)and if the stronger EQ can be successfully predicted.During last few decades quite a lot of observable electromagnetic(EM)precursors were published by using techniques equipped in either satellites or on ground-based stations.But there are only a few cases that the shortterm precursor anomalies of EM field before earthquakes were observed by using alternate EM fields on ground.This paper will present a new EM observation network built in recent years and show a new finding of EM field with the variation of a one-year cycle observed using the network.As an example,the short-term precursor anomalies of apparent resistivity before the Yangbi EQ(Ms 5.1)occurred on March 27,2017 in Yunnan Province will be studied.The observed anomalous phenomena indicate that the anomaly before the EQ can be captured only if reasonable effective methods including sophisticated analytical techniques are used,and it is believed that continuously observed data on the fixed observation network for a long time is an effective means for studying anomalies that appeared before earthquakes.This network can also play an important role in studying the EM environment from space. | Bing HAN Guoze ZHAO Lifeng WANG Ji TANG Yaxin BI Yan ZHAN Xiaobin CHEN Qibin XIAO Jihong ZHANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 3 |
| 7 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 8 | Molecular cloning and characterization of chemokinc-like factor 1 ( CKLF1 ), a novel human eytnkine with unique structure and potential ehenaotaetie activity显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochem J2001，357，： | 1 |
| 9 | Molecular cloning and characterization of chemokine-like factor 1(CKLF1), a novel human cytokine with unique structure and potential chemotatic activity显示文摘 | Wenling HAN Yaxin LOU Junmin TANG | 2001 | Biochem J2001，357，1： | 1 |
| 10 | Molecular cloning and characterization of chemokine-like factor 1 ( CKLF1 ), a novel human cytokine with unique structure and potential chemotactic activity 显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochemistry2001，57，1： | 1 |
| 11 | Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity显示文摘 | Wenling Han Yaxin Lou Junmin Tang | 2001 | Biochem J2001，357，： | 1 |
| 12 | The Stimulating effect of chemokine-like factors (CKLFs) on skeletal muscle cells 显示文摘 | Han Wenling Xia Donglan Lou Yaxin | 2001 | Cell Biol Int2001，25，10： | 1 |
| 13 | Molecular cloning and characterization of chemokine-like factorl ( CKLF ), a novel human cytekine with unique structure and potential chemotactic activity显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochem J2001，357，4： | 1 |
| 14 | The Stimulating effect of chemokine like factors (CKLFs) on skeletal muscle cells 显示文摘 | Han Wenling Xia Donglan Lou Yaxin | 2001 | Cell Biol Inte2001，25，10： | 1 |
| 15 | Molecular cloning and characterization of chemokine-like factor 1 ( CKLF1 ), a novel human cytokine with unique structure and potential chemotactic activity显示文摘 | Wenling HAN Yaxin LOU Dalong MA | 2001 | Biochem J2001，357，1： | 1 |
| 16 | Automatic Anomaly Detection for Swarm Observations显示文摘The Swarm satellite mission was launched on 22 November 2013,it is the first European Space Agency’s constellation of three satellites,dedicated to monitoring geomagnetic field changes.The measurements delivered by the three satellites are very valuable for a range of applications,including the earthquake prediction study.However,for more than 5 years,relatively little advancement has been achieved in establishing a systematic approach for detecting anomalies from the satellite measurements for predicting earthquakes.This paper presents the challenges of developing a pragmatic framework for automatic anomaly detection and highlights innovative features of functional components developed.Through a case study we demonstrate a functionality pipeline of the system in detecting anomalies,and present our solutions to coping with data sparsity and parameter tuning as well as insights into the differences between discovering seismic anomalies from periodic and non-periodic data observed by the Swarm satellites. | Yaxin BI Vyron CHRISTODOULOU George WILKIE Guoze ZHAO Peter NICHOLL Mingjun HUANG Bin HAN Ji TANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 1 |
| 17 | Molecular cloning and characterization of chemokine-like factor 1 (CKLF1),a novel human cytokine with unique structure and potential chemotactic activity显示文摘 | Han Wenling Lou Yaxin Tang Junmin | 2001 | Biochem J2001，357，： | 1 |
| 18 | Stepwise superposition approximation approach for analytical solutions with non-zero initial concentration using existing solutions of zero initial concentration in contaminate transport显示文摘Analytical solutions for contaminant transport are widely used for both theoretical and practical purposes.However,many existing solutions are obtained subject to an initial condition of zero concentration,which is often unrealistic in many practical cases.This article proposed a stepwise superposition approximation approach to solve the non-zero initial concentration problem for first-type and third-type boundary conditions by using the existing zero initial concentration solution.Theoretical examples showed that the approach was highly efficient if a proper superposition scheme with relative concentration increments was constructed.The key parameter that controlled the convergence speed was the time increment(△t) multiplied by the rate constant(λ).The approach served also as an alternative way to make a convenient concentration calculation even if the non-zero initial concentration solution of a problem was known. | Hongtao Wang Rong Han Yan Zhao Wenjing Lu Yaxin Zhang | 2011 | Journal of Environmental Sciences2011，23，6： | 0 |
| 19 | Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus—China,2011–2021显示文摘Summary What is already known about this topic?Joint effects of gestational weight gain(GWG)and hyperglycemia on adverse pregnancy outcomes suggest that lower optimal GWG is optimal for women with gestational diabetes mellitus(GDM).However,there is still a lack of guidelines.What is added by this report?Optimal weekly GWG range after diagnosis of GDM for underweight,normal-weight,overweight,and obese women was 0.37–0.56 kg/week,0.26–0.48 kg/week,0.19–0.32 kg/week,and 0.12–0.23 kg/week,respectively.What are the implications for public health practice?The findings may be used to inform prenatal counseling regarding optimal gestational weight gain for women with gestational diabetes mellitus,and suggest the need for weight gain management. | Jinlang Lyu Yin Sun Yuelong Ji Nana Liu Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Liangkun Ma Haijun Wang | 2023 | China CDC weekly2023，5，9： | 0 |
| 20 | Erratum to:Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides显示文摘Erratum to Nano Research 2023,16(7):9768-9780 http://gffzzd3cc09b8251d45dfsqqfvfwwp0w5u6f5w.ffgz.tsg.suse.edu.cn/10.1007/s12274-023-5645-7 The complete affiliations of co-author Yiying Lu is Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China and Department of Pharmacy,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China. | Mengting Lin Linjie Wu Yiying Lu Xiaoyan Bao Haiqing Zhong Qi Dai Qiyao Yang Yiyi Xia Xin Tan Yaxin Qin Ruolin Jiang Min Han | 2023 | Nano Research2023，16，7： | 0 |
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