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| 1 | Evaluation of the Mechanisms Underlying Amino Acid and Microbiota Interactions in Intestinal Infections Using Germ-Free Animals显示文摘Intestinal infectious diseases refer to the inflammatory changes in the intestinal tract caused by pathogens(including bacteria,viruses,fungi,protozoa,or parasites)or their toxic products.A large number of microorganisms colonize the intestinal tract of healthy people,which together with the intestinal epithelium constitute the biological barrier of the intestinal tract to resist infectious diseases.As an“invisible organ,”the intestinal flora is closely related to human nutrition metabolism and intestinal infections.A variety of intestinal flora participates in the nutritional metabolism of amino acids,and the small molecular substances produced by the amino acid metabolism through the intestinal flora can enhance intestinal immunity and resist bacterial infections.In turn,amino acids can also regulate the composition of the intestinal flora,maintain the steady-state of the intestinal flora,protect the intestinal barrier,and inhibit colonization by pathogenic bacteria.As a model animal with a clear microbial background,germ-free(GF)animals can clarify the mechanisms of interactions between intestinal microbes and amino acid metabolism in intestinal infections by combining genetic engineering technology and multi-omics studies.This article reviews related researches on the involvement of intestinal microbes in host amino acid metabolism and resistance to intestinal infections and discusses the advantages of GF animal models for studying the underlying mechanisms.The GF animal model is helpful to further study the intervention effects of amino acid metabolism of targeted intestinal flora on intestinal infections. | Yapeng Yang Peng Bin Shiyu Tao Guoqiang Zhu Zhifeng Wu Wei Cheng Wenkai Ren Hong Wei | 2021 | Infectious Microbes & Diseases2021，3，2： | 1 |
| 2 | Rapid Purification, Characterization and Substrate Specificity of Heparinase From A Novel Species of Sphingobacterium sp显示文摘 | Chao Yapeng Gao Ningguo Cheng Xiulan | 2003 | J Biochem(Tokyo)2003，134，： | 1 |
| 3 | Nitrogen doped porous carbon-based bifunctional oxygen electrocatalyst with controllable phosphorus content for zinc-air battery显示文摘The controllable construction of non-noble metal based bifunctional catalysts with high activities towards oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is of great significance,but remains a challenge.Herein,we reported an effective method to synthesize cobalt-nitrogen doped mesoporous carbon-based bifunctional oxygen electrocatalyst with controllable phosphorus content(Co-N-P_(X)-MC,X=0.5,1.0,1.5,2.0).The mesoporous carbon substrate endowed the asprepared samples with more exposed active surface(236.50 m^(2)·g^(−1))and the most appropriate doping ratio of phosphorus had been investigated to be 1.5(Co-N-P1.5-MC).For ORR,Co-N-P1.5-MC exhibited excellent catalytic activity with more positive onset potential(1.01 V)and half-wave potential(0.84 V)than the other samples.For OER,Co-N-P1.5-MC also showed a low overpotential of 415 mV.Combining experimental results and density-functional theory(DFT)calculations,the outstanding bifunctional catalytic performance of Co-N-P1.5-MC was due to the synergistic cooperation between the P and N dopants,which could reduce the reaction barriers and was favorable for ORR and OER.Moreover,the Zn-air battery using Co-N-P1.5-MC as the cathode showed remarkable battery performance with high stability(could operate stably for over 160 h at 10 mA·cm^(−2))and maximum power density(119 mW·cm^(−2)),demonstrating its potential for practical applications.This work could provide significant enlightenment towards the design and construction of bifunctional oxygen electrocatalyst for next-generation electrochemical devices. | Shichang Cai Zihan Meng Gaojie Li Yu An Yapeng Cheng Erjun Kan Bo Ouyang Haining Zhang Haolin Tang | 2023 | Nano Research2023，16，4： | 0 |
| 4 | 一种用于HIRFL-CSR的超薄真空膜窗研究显示文摘Energetic heavy ion beams from the HIRFL-CSR RIBLL2 will be extracted from the accelerator vacuum through a film vacuum window of thin metal.The transmission efficiency,mechanical strength to sustain the atmospheric pressure,film material(pure titanium),the rise of the film temperature(Because the beam intensity is very low,this issue becomes trivial)and the seal form(filamentary silver and sealing groove)are the main concerns. | Wan Yapeng Meng Jun Luo Cheng Niu Zhiwei Hu Zhenjun Gao Yanmin | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 5 | HIAF薄壁真空室在线烘烤方案研究显示文摘To keep eddy currents at a tolerable level,thin-walled stainless steel vacuum chambers with wall thickness of 0.3 mm are needed in HAIF BRing magnets.To withstand atmospheric pressure the thin-walled vacuum chambers are supported by ribs which is parallel to the magnetic field lines.In order to obtain the extremely high vacuum(XHV),the chambers have to be bakeable to 220-300℃.According to a given design requirement,the in-situ bake-out scheme of XHV thin-walled chambers with a narrow magnetic gap was studied,where the temperature of surrounding magnetic elements is strictly controlled to below 80℃. | Wan Yapeng Meng Jun Luo Cheng Hu Zhenjun Gao Yanmin Xie Wenju | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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