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| 1 | Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth显示文摘 | Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang | 2014 | Cell Research2014，24，10： | 33 |
| 2 | Sphingosine-1-phosphate,a novel TREM2 ligand,promotes microglial phagocytosis to protect against ischemic brain injury显示文摘The mechanism of sphingosine-1-phosphate(S1P)-mediated phagocytosis remains unknown.Here,we found that S1P or FTY720(an analog of S1P)promoted microglial phagocytosis in stroke independent of S1PRs.First,we used computer simulation of molecular docking to predict that S1P might be a ligand for triggering receptor expressed on myeloid cells 2(TREM2).Next,microscale thermophoresis(MST),surface plasmon resonance(SPR)and liquid chromatography–tandem mass spectrometry(LC–MS/MS)were performed to reveal that S1P was a novel TREM2 ligand.Then,we confirmed the pro-phagocytosis of S1P targeting in Trem2-Dap12 transfected CHO cells and TREM2 knockdown microglia.Point mutation analysis showed that D104 was the critical binding residue.Trem2^(−/−)mice were used to demonstrate the role of S1P-induced phagocytosis targeting on TREM2 in protecting against ischemic brain injury.Finally,further studies revealed that apolipoprotein E(APOE)loaded with S1P was released by microglia and bound to apoptotic neurons via LDL receptor related protein 1B(LRP1B)and thereby induced microglia to phagocytose apoptotic neurons.Overall,the present work reveals for the first time that S1P acts as a novel endogenous ligand of TREM2 to effectively promote microglial phagocytosis.Our findings provide a new lead compound for developing immunomodulator targeting on TREM2. | Tengfei Xue Juan Ji Yuqin Sun Xinxin Huang Zhenyu Cai Jin Yang Wei Guo Ruobing Guo Hong Cheng Xiulan Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 3 | Experimental and Numerical Study of an 80-kW Zigzag Printed Circuit Heat Exchanger for Supercritical CO_(2)Brayton Cycle显示文摘In this study,an experimental system was built to investigate the global performance of an 80-k W zigzag printed circuit heat exchanger(PCHE).It could meet the requirement of the pre-cooler for the supercritical carbon dioxide(S-CO_(2))Brayton power cycle and the modified effectiveness considering the pinch point is between 61.5%and 79.3%.When the outlet S-CO_(2)temperature is near the pseudo-critical point,the thermo-physical properties have more effects on heat transfer performance compared to flow characteristics.For the local performance,the mass flow rates of both sides have crucial influences on the location where the peak of S-CO_(2)Nusselt number occurs while only the S-CO_(2)flow rate affects the variation of the peak value.In addition,the influence of the radius of curvature on the secondary-flow should not be ignored.In the end,new empirical correlations were proposed considering the drastic variations of the Prandtl number. | ZHANG Huzhong CHENG Keyong HUAI Xiulan ZHOU Jingzhi GUO Jiangfeng | 2021 | Journal of Thermal Science2021，30，4： | 3 |
| 4 | Design, Synthesis, Biological Evaluation and SARs of Novel Anthranilic Diamides Derivatives Containing Amide, Carbamate, Urea, and Thiourea Moieties显示文摘In order to discover potential ryanodine receptor insecticides, 21 novel anthranilic diamides analogues (C, D, E,and F) containing amide, carbamate, urea, and thiourea moieties were designed and synthesized based on bioiso-steric approach. The biological assays against oriental armyworm (Mythirnna separata) and diamondback moth(Plutella xylostella) indicated that these compounds displayed moderate to excellent activities. Especially, com-pound D1 showed 100% larvicidal activities against oriental armyworm at 1.0 mg.L^-1, equivalent to the standardchlorantraniliprole (100%, 1.0 mg·L^-1). Moreover, the larvicidal activity of D1 against diamondback moth was100% at 0.1 mg·L^-1, more effective than that of chlorantraniliprole (90%, 0.1 mg·L^-1). Therefore, D1 can be used asa new lead structure for the development of insecticidal agents. The preliminary structure-activity relationshipshowed that the introduction od carbamate groups into 4-position on the benzene ring of the N-phenylpyrazole moi-ety has a positive effect on the larvicidal activities. | Jingbo Liu Yuxin Li Xiulan Zhang Dandan Cheng Wei Wei Changchun Wu Yongtao Xie Lixia Xiong Zhengming Li | 2017 | Chinese Journal of Chemistry2017，35，3： | 2 |
| 5 | n-Octadecanethiol Self-Assembled Monolayer Coating with Microscopic Roughness for Dropwise Condensation of Steam显示文摘Here we presented a novel technology to achieve a Super-hydrophobic coating with microscopic roughness oncopper surface. First, make a layer of verdigris grow on the fresh pure copper surface. Gain it by exposing thecopper to air and the mist of acetic acid solution. The green coating is a mixture of basic copper(Ⅱ) carbonate andcopper(Ⅱ) acetate. Second heat the coating and make it decompose to CuO. Lastly, form an n-octadecanethiolself-assembled monolayers coating on the outermost surface. Contact angle test, scanning electron microscopeanalysis and electrochemical testing were carried out to characterize the surface, and a heat transfer experimentfor dropwise condensation of steam was performed also. Results show that the modified surface bears a few Super-hydrophobicfeatures, the static contact angle is higher than that in literatures, reaching 153.1±1.7°. The microscopicroughness can be seen in SEM images, differing much from H2O2 etched surface and bare copper surface.The condensation of steam on the surface is a typical form of dropwise condensation, in the measured rangeof temperature difference, under 0.1 MPa, the average convection heat transfer coefficients of the vertical surfaceare 1.7~2.1 times for those of film condensation. At the same time, the inhibition efficiency of surface is improvedto some extent comparing with the same kind of SAMs, which suggests that the lifetime of maintenancedropwise condensation would have the possibility to surpass the existing record. | Liang CHEN Shiqiang LIANG Runsheng YAN Yanjun CHENG Xiulan HUA Shuling CHEN | 2009 | Journal of Thermal Science2009，18，2： | 2 |
| 6 | Effects of Chemical Reaction Caused by Cooling Stream on Film Cooling Effectiveness显示文摘With the increase of inlet temperature of gas turbines, the benefits by using the conventional methods are likely to approach their limits. Therefore, it is essential to study novel film cooling methods for surpassing these current limits. Based on the theory of heat transfer enhancement, a film cooling method with chemical reaction by cool- ing stream is proposed. In order to test the feasibility of the proposed method, numerical simulations have been conducted. The classic flat plate structure with a 30 degree hole is used for the simulation. In the present study, the effects of the parameters in relation to the chemical reaction on film cooling effectiveness, such as chemical heat sink, volume changes, and reaction rate, are investigated numerically. The conventional film cooling is also calculated for the comparison. The results show that film cooling effectiveness is improved obviously due to the chemical reaction, and the reaction heat and reaction rate of cooling stream have an important effect on film ef- fectiveness. However, the effect of volume changes can be ignored. | Keyong Cheng Shiqiang Liang Xiulan Huai Wei Chen Yongxian Guo | 2012 | Journal of Thermal Science2012，21，1： | 1 |
| 7 | Rapid Purification, Characterization and Substrate Specificity of Heparinase From A Novel Species of Sphingobacterium sp显示文摘 | Chao Yapeng Gao Ningguo Cheng Xiulan | 2003 | J Biochem(Tokyo)2003，134，： | 1 |
| 8 | Spectroscopic Properties of Co2+:ZnAl2O4 Nanocrystals in Sol-gel Derived Glass-Ceramics显示文摘 | Duan Xiulan Yuan Duorong Cheng Xiufeng | 2003 | Journal of Physics and Chemistry of Solids2003，64，6： | 1 |
| 9 | Experimental Study on Flow Boiling Heat Transfer Characteristics of Microencapsulated Phase Change Material Suspension显示文摘Due to its core phase change characteristics,microencapsulated phase change material(MPCM)can make many base fluids have better heat transfer characteristics.In this paper,the flow boiling heat transfer characteristics of fluorinated liquid-based microencapsulated phase change material suspension(MPCMS)through vertical transparent quartz channel were studied.The effects of MPCM core phase change temperature and suspension flow velocity on boiling heat transfer coefficient and critical heat flux were discussed,respectively.The results show that the appropriate concentration of MPCMS can enhance both the boiling heat transfer coefficient and the critical heat flux.The strengthening effect becomes weak with the increase of suspension flow velocity.The maximum strengthening rates of critical heat flux appear at 0.05 m/s,which are 25%(MPCMS(70℃)),16%(MPCMS(58℃))and 10%(MPCMS(28℃)).The phase change temperature of the MPCM core has important effects on the boiling heat transfer coefficient and the critical heat flux.The results showed that the MPCM with core phase change temperature higher than the boiling temperature of base fluid has the best enhancement effect.Different bubble behavior in vertical tube with different heat flux can be observed by high-speed photography system.The particle core phase change in MPCMS inhibits the aggregation of bubbles and forms many small bubbles to enhance heat transfer.The work lays a foundation for further exploring the industrial application of MPCMS. | TAN Zhenyu LI Xunfeng HUAI Xiulan CHENG Keyong CHEN Junlin | 2023 | Journal of Thermal Science2023，32，4： | 0 |
| 10 | Numerical Investigation on Flow and Heat Transfer Performance of Supercritical Carbon Dioxide Based on Variable Turbulent Prandtlnumber Model显示文摘Flow and heat transfer characteristic of supercritical carbon dioxide(SCO_(2))are numerically investigated in the horizontal and vertical tubes.TWL turbulent Prandtl number model could well describe the behavior of SCO_(2) affected by the buoyancy.Under the cooling condition,the heat transfer performance of SCO_(2) along the upward direction is best and that along the downward direction is worst when bulk fluid temperatures are below the pseudocritical temperature.Reducing the ratio of heat flux to mass flux could decrease the difference of convective heat transfer coefficient in three flow directions.Under the heating condition,heat transfer deterioration only occurs in vertical upward and horizontal flow directions.Heat transfer deterioration of SCO_(2) could be delayed by increasing the mass flux and the deterioration degree is weakened in the second half of tube along the vertical upward flow direction.Compared with the straight tube,the corrugated tube shows better comprehensive thermal performance. | Xiaokai LIU Haiyan ZHANG Keyong CHENG Xiulan HUAI Haiyan LIAO Zhongmei ZHANG | 2021 | Mechanical Engineering Science2021，3，2： | 0 |
| 11 | A Comprehensive Review of Thermal Performance Improvement of High-Temperature Heat Pipes显示文摘Energy efficiency issues are being focused on the growing concern of global warming and environmental pollution.The high-temperature heat pipe(HTHP) is an effective and environmental-friendly heat transfer device employed in many industries,including solar power generation,high-temperature flue gas waste heat recovery,industrial furnaces,nuclear industries,and aviation.As a critical factor in HTHPs,thermal performance is mainly introduced in the entire paper.To date,most reviews have been published concerning one or several application scenarios.However,to the best of authors' knowledge,it is hard to find a review discussing how to improve the thermal performance of HTHPs comprehensively.First,the impact on the performance of three main components of HTHPs over the past 30 years is introduced:the working fluid,the HTHP structure,and the wick structure.Herein,it is a considerable review of the optimal operating conditions for each direction,and we expect this paper contribute to improving the thermal performance of HTHPs.Then,current numerical simulations and theoretical research on the heat transfer limit of HTHPs are recommended.The significant hypotheses used in numerical simulations and the present theoretical studies are compiled here.Finally,some potential future directions and tentative suggestions for HTHP research are put forward. | CHEN Qihan ZHOU Jingzhi ZHOU Guohui CHENG Keyong HUAI Xiulan WEI Gaosheng | 2024 | Journal of Thermal Science2024，33，2： | 0 |
| 12 | Film cooling with using the decomposition of an NH_3 cooling stream as a chemical heat sink显示文摘The inlet temperatures of gas turbines are generally increasing over time,so conventional cooling methods are likely to approach their useful limits.It is therefore essential to investigate novel cooling methods.Based on the theory of heat transfer enhancement,a novel film cooling method for gas turbine blades using a chemical heat sink is proposed.In this method,the endothermic reaction of an NH 3 cooling stream heated by the main gas stream takes place,reducing the convective heat transfer between the mainstream and the blades.Therefore,film cooling effectiveness is improved.To test the feasibility of the proposed method,numerical simulations were conducted,using the classical flat plate with a 30 degree angled cylindrical hole(diameter,D).Film cooling effectiveness at different blowing ratios(M = 0.5,1.0,and 1.5) were computed and compared with the results of conventional cooling methods.The simulation results show that the proposed method can enhance film cooling effectiveness not only in the stream-wise direction,but also in the span-wise direction.The span-averaged film effectiveness is improved in the presence of a chemical heat sink,with the value of X/D(the ratio of downstream distance from the center of the film hole to the diameter of the film hole) increasing downstream of the film hole.The novel film cooling approach showed the best performance at M = 0.5. | CHENG KeYong CHEN Wei LIANG ShiQiang GUO YongXian HUAI XiuLan GUI XiaoHong | 2012 | Chinese Science Bulletin2012，57，27： | 0 |
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