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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | Ecological influence of exotic plants of Sonneratia apetala on understory macrofauna显示文摘The study aims to compare the differences of macrofauna communities of wetlands at 3-year-forest- age, 5-year-forest-age Sonneratia apetala artificial mangroves, 5-year-forest-age Kandelia candel ar- tificial mangroves with the same restoration background, and the naked tidal flat in the Qi'ao Island Mangrove Nature Reserve of Zhuhai, Guangdong Province. The results show that there were signif- icant structural differences in macrofauna communities among four kinds of habitats. The increase of biomass and species diversity of macrofauna at 3-year-forest-age S. apetala artificial mangroves was obviously faster than that at 5-year-forest-age K. candel artificial mangroves whose average tree height was close to that of 3-year-forest-age S. apetala artificial mangroves. The BIOENV analysis shows that it was related to the rapid growth of S. apetala, which rapidly changed the light level and shading conditions in the forests. The 5-year-forest-age S. apetala artificial mangroves had lower macrofauna species diversity but higher density and biomass than K. candel artificial mangroves with the same forest age. This was due to the rapid changes of physical and chemical properties of habitat soil by the ecological restoration of S. apetala artificial mangroves as well as the changed food sources possibly caused by the leaf-litter of such non-indigenous mangrove species S. apetala. However, further survey should be conducted on whether there are any negative ecological impacts of large-scale cultivation of S. apetala on macrofauna communities, so as to evaluate correctly S. apetala's role in the restoration of coastal mangrove ecosystems. | TANG Yijie FANG Zhanqiang CHEN Kang ZHANG Zaiwang ZHONG Yanting AN Dong YANG Xiongbang LIAO Baowen | 2012 | Acta Oceanologica Sinica2012，31，5： | 8 |
| 3 | Molecular cloning and characterization of antimicrobial peptides from skin of Hylarana guentheri显示文摘把抗菌剂肽(安培) 编码为 Hylarana guentheri 的皮肤的 cDNAs 被识别,也就是 temporin (五肽,称为的 temporin-GHa-GHd 和 temporin-GUa ) , brevinin-1 (一肽, brevinin-1GUb ) ,并且 brevinin-2 (八肽, brevinin-2GHd-2GHj,和 brevinin-2GHb ) 。14 肽中的十一个有新奇主要结构。综合 temporin GHa-GHd 有用途广泛的抗菌剂对克积极的细菌(葡萄球菌 aureus 和杆菌 subtilis ) 的活动,克否定的细菌(Escherichia coli, Vibrio alginolyticus,和 Pseudomonas aeruginosa ) ,以及真菌(Candida albicans ) 。在这些测试紧张之中, S。aureus 对有禁止的集中(MIC ) 在 6.8 和 12.9 M 之间珍视的最小的 temporin-GHa-GHd 最敏感。他们也对 Methicillin 抵抗的 S 展出了抗菌剂活动。有从 12.7 ~ 51.7 M 的 MIC 的 aureus。有趣地,第二等的结构预言证明在 temporin-GHb 没有螺旋,它说明那个螺旋没为 temporin-GHb 的抗菌剂活动被要求。NaCl (在 0.15-2 M 的最后的集中) 减少 temporin-GHa-GHd 的抗菌剂活动稍微,当时人的浆液和 S。aureus V8 朊酶没在抗菌剂活动有效果。扫描 E 的电子显微镜学图象。coli 和 S。aureus 证明微生物引起的房间的表面在有在 37 畲獧的 temporin-GHa-GHd 的处理的 1 h 以后更加不平、忏悔吗? | Zhu Dong Wenjie Luo Hengren Zhong Manchuriga Wang Yanting Song Shiming Deng Yingxia Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 3 |
| 4 | Stability of inner dump slope under coal pillar support:case study in an open‑pit coal mine显示文摘The stability of an inner dump slope was investigated under the efect of coal pillar support considering the development position of dumping.Based on the instability mechanism and load distribution characteristics of the supporting coal pillar,the three-dimensional mechanical efects of the supporting coal pillar are characterized.Using the two-dimensional equivalent principle and the residual thrust method,the stability of the inner dump slope was analyzed under the efect of pillar support at diferent dump development positions.The quantitative efects of various factors on the inner dump slope stability were revealed,and the coal pillar shape parameters were optimized through numerical simulations.The results indicate that the slope stability coefcient is linearly related to the top width and height of the coal pillar,slope angle,and base inclination angle,and has an exponential relation with the coal pillar strike length and slope height increment.There are quadratic and absolute value relations with the coal pillar outer and the inner bottom angle,respectively.The top width of the coal pillar in the inner dump of Shengli East No.2 open-pit coal mine should be at a level of+824 m,and the optimal top width and height are 15 and 36.7 m,respectively.The instability mechanism of the supporting and retaining coal pillar obtained by numerical simulations and the stability of the inner dump are in good agreement with the theoretical analysis.Our results provide a theoretical basis for the design,treatment,and safe implementation of similar open-pit mine slope engineering. | Guanghe Li Xiaoxu Yang Dong Wang Yanting Wang Xiangyu Yu | 2022 | International Journal of Coal Science & Technology2022，9，2： | 1 |
| 5 | Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics显示文摘 | Haojun Zhang Tingting Zhao Yuewen Gong Xi Dong Weiku Zhang Sifan Sun Hua Wang Yanting Gu Xiaoguang Lu Meihua Yan Ping Li | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 6 | NuSTAR View of the R-ΓCorrelation in the Hard State of Black Hole Lowmass X-Ray Binaries显示文摘The power law and reflection emission have been observed in the X-ray spectra of both black hole X-ray binaries(BHXRBs)and active galactic nuclei(AGNs),indicating a common physical origin of the X-ray emission from these two types of sources.The relevant parameters describing the shape of both components and the potential correlation between these parameters can provide important clues on the geometric and physical properties of the disk and the corona in these sources.In this work,we present a positive correlation between the photon indexΓand the reflection strength R for the low-mass BHXRBs in the hard state by modeling NuSTAR data,which is qualitatively consistent with the previous studies.We compare our results with the predictions from different theoretical disk-corona models.We show that the RIT correlation found in this work seems to favor the moving corona model proposed by Beloborodov.Our results indicate that the coronal geometry varies significantly among BHXRBs.We further compare our results with that of AGNs.We find that the reflection strength R is smaller than unity in the hard state of BHXRBs,while it can be as large as~5 in AGNs,which implies that the variations of the disk-coronal geometry of AGNs are more vigorous than that of the BHXRBs in the hard state. | Yanting Dong Zhu Liu Xinwu Cao | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 0 |
| 7 | Characterization and comparison of two C-type lectins with novel key motifs from mud crab Scylla paramamosain显示文摘As an important pattern recognition receptor(PRR)in the innate immune system,C-type lectin plays an important role in the innate immune process of invertebrates.Two C-type lectins Sp CTL-C and Sp CTL-D were characterized from mud crab(Scylla paramamosain).The predicted Sp CTL-C and Sp CTL-D proteins both contain a single carbohydrate-recognition domain(CRD)with key motif Gln-Pro-Ala(QPA)and Met-Pro-Ala(MPA),respectively.Sp CTL-C and Sp CTL-D transcripts distributed in all examined tissues,and the expression level was the highest in hepatopancreas.As PRR,the purifi ed recombinant proteins r Sp CTL-C and r Sp CTL-D have high affi nity for three kinds of pathogen-associated molecular patterns(PAMPs):β-glucan,lipopolysaccharide,and peptidoglycan.Besides,r Sp CTL-D can bind to all nine microorganisms tested,while r Sp CTL-C can bind to seven microorganisms except for Staphylococcus aureus and Micrococcus luteus.Both r Sp CTL-C and r Sp CTL-D showed agglutination activity towards fungi Pichia pastoris and Saccharomyces cerevisiae.However,r Sp CTL-C and r Sp CTL-D exhibited diff erent antimicrobial activities:r Sp CTL-D has a certain inhibitory eff ect on the growth of Vibrio fl uvialis and M.luteus,while r Sp CTL-C has no obvious inhibitory activity.The results show that r Sp CTL-C and r Sp CTL-D had better phagocytosis-promoting eff ect on M.luteus than the negative control.Meanwhile,both r Sp CTL-C and r Sp CTL-D had certain encapsulation-promoting activity.Collectively,two C-type lectins with novel key motifs make an important impact as PRR in immune response towards pathogens.At the same time,they play diff erent functions in the innate immunity of mud crab S.paramamosain. | Boxin ZENG Taiwei DONG Yanting XIA Shun YANG Mengmeng HUANG Hui FEI | 2022 | Journal of Oceanology and Limnology2022，40，4： | 0 |
| 8 | 乙肝病毒相关肝细胞癌的整合蛋白基因组学特征性研究显示文摘文章简介研究团队利用159例患者手术切除的肿瘤组织和临近的正常组织,首次进行了乙肝病毒相关肝细胞癌的蛋白基因组学特征性研究。通过蛋白基因组学整合分析,我们揭示了乙肝病毒相关肝细胞癌在多组学,关键信号通路激活状态,以及肝脏特异性代谢重编程等方面的诸多一致性和不一致性。 | Qing Gao Hongwen Zhu Liangqing Dong Weiwei Shi Ran Chen Zhijian Song Chen Huang Junqiang Li Xiaowei Dong Yanting Zhou Qian Liu Lijie Ma Xiaoying Wang Jian Zhou Yansheng Liu 8 Emily Boja Ana I.Robles Weiping Ma Pei Wang Yize Li Li Ding Bo Wen Bing Zhang Henry Rodriguez 高大明 周虎 樊嘉 | 2020 | 科学新闻2020，，2： | 0 |
| 9 | Sensitivity of livelihood strategy to livestock production and marketization:An empirical analysis of grasslands in Inner Mongolia,China显示文摘Recent researches have primarily focused on the relationship between livelihood strategies and livelihood capital,with few empirical studies on the sensitivity of livelihood strategies to livestock production and marketization in Inner Mongolia Autonomous Region of China.This study used an income distribution approach to categorize livelihood strategies of the respondents(n=394)into three types,i.e.,herder livelihood strategy(LS1),petty-herder livelihood strategy(LS2),and non-herder livelihood strategy(LS3).Using the multinomial logistic regression model,we compared livestock production and marketization across the three livelihood strategies.Our findings showed that(1)livestock production and marketization tended to favor LS1;(2)an increase in the land asset(contracted and rented grassland)and off-take rate increased the probability of households choosing LS1;(3)stocking rate was higher for LS1;and(4)the higher critical market-related risks perceived by herders were animal price and hay and corn price.Moreover,higher livestock price acted as a deterrent to diversifying into other livelihood strategies(LS2 and LS3).Finally,this study advocates for policies that will promote the land transfer market,adopt modern techniques in animal husbandry,improve the medium for disseminating market information to herders,and provide incentives for long-term livelihood transformation. | Saheed Olaide JIMOH DING Wenqiang DONG Haibin BAI Haihua YIN Yanting LIU Huihui HOU Xiangyang | 2021 | Regional Sustainability2021，2，4： | 0 |
| 10 | The correlation of miRNA expression and tumor mutational burden in uterine corpus endometrial carcinoma显示文摘Background:The relationship between microRNA(miRNA)expression patterns and tumor mutation burden(TMB)in uterine corpus endometrial carcinoma(UCEC)was investigated in this study.Methods:The UCEC dataset from The Cancer Genome Atlas(TCGA)database was used to identify the miRNAs that differ in expression between high TMB and low TMB sample sets.The total sample sets were divided into a training set and a test set.TMB levels were predicted using miRNA-based signature classifiers developed by Lasso Cox regression.Test sets were used to validate the classifier.This study investigated the relationship between a miRNA-based signature classifier and three immune checkpoint molecules(programmed cell death protein 1[PD-1],programmed cell death ligand 1[PD-L1],cytotoxic T lymphocyte-associated antigen 4[CTLA-4]).For the miRNA-based signature classifier,functional enrichment analysis was performed on the miRNAs.An analysis of the relationship between PD-1,PD-L1,and CTLA-4 immune checkpoint genes was carried out using the miRNA-based signature classifier.Results:We identified 27 differentially expressed miRNAs in miRNA-base signature.For predicting the TMB level,27-miRNA-based signature classifiers had accuracies of 0.8689 in the training cohort,0.8276 in the test cohort,and 0.8524 in the total cohort.The correlation between the miRNA-based signature classifier and PD-1 was negative,while the correlation between PD-L1 and CTLA4 was positive.Based on the miRNA profiling described above,we validated the expression levels of 9 miRNAs in clinical samples by quantitative reverse transcription PCR(qRT-PCR).Four of them were highly expressed and many cancer-related and immune-associated biological processes were linked to these 27 miRNAs.Thus,the developed miRNA-based signature classifier was correlated with TMB levels that could also predict TMB levels in UCEC samples.Conclusion:In this study,we investigated the relationship between a miRNAbased signature classifier and TMB levels in Uterine Corpus Endometrial Carcinoma.Further,this is the first study to confirm their relationship in clinical samples,which may provide more evidence support for immunotherapy of endometrial cancer. | YANYA CHEN HONGYUAN WU RUISI ZHOU HELING DONG XUEFANG ZHANG XUEWEI WU WENSHAN CHEN YANTING YOU YIFEN WU | 2023 | BIOCELL2023，47，6： | 0 |
| 11 | Purification and characterization of a salt-tolerant cellulase from the mangrove oyster, Crassostrea rivularis显示文摘有 pH 抵抗和高盐忍耐的宽范围的绗维素酶在红树属植物森林里从牡蛎 Crassostrea rivularis 生活的消化的腺被孤立。作为 CrCel 说出的 27 kDa 绗维素酶被净化由从在非减少的钠 dodecylsufate-polyacrylamide 胶化电气泳动以后的胶化的阴离子交换层析和抽取的 40.6 褶层。净化的绗维素酶的特定的活动是对 carboxymethyl 纤维素 CMC 的 23.4 U/mg。CrCel 的 N 终端氨基酸顺序决心是 NQKCQANSRV。CrCel 最好水解 -1,4-glucosidic 向木聚糖在纤维素材料和显示降级活动的非结晶的部分结合。K m 和 V 为 CMC 的 CrCel 的最大 价值决心是 2.1% 汵瑡潩 ? 景 ? 剄′獵湩 ? 浳污 ? 湩整晲牥湩 ? 乒 ? 楳乒 ? 灡牰慯档 ? 潢桴漠 ? 桴?散汬洠杩慲潴祲愠摮椠癮獡癩?桰湥瑯灹獥眠牥?楳湧晩捩湡汴?瑡整畮瑡摥眠敨?潣灭牡摥眠瑩?桴?潣瑮潲? | Tianchen An Zhu Dong Junchen Lv Yujun Liu Manchuriga Wang ShuangshuangWei Yanting Song Yingxia Zhang Shiming Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 0 |
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