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| 1 | Preparation and evaluation of nattokinaseloaded self-double-emulsifying drug delivery system显示文摘In the present study,we prepared nattokinase-loaded self-double-emulsifying drug delivery system(SDEDDS)and investigated its preliminary pharmacodynamics.The type and concentration of oil phase,inner aqueous phase and emulsifier were screened to prepare optimum nattokinase-loaded SDEDDS.Next,the optimum formulations were characterized based on microstructure,volume-weighted mean droplet size,self-emulsifying rate,yield,storage stability,in vitro release and in vivo pharmacodynamics studies.The water/oil/watermultiple emulsions exhibited typicalmultiple structure,with relatively small volumeweighted mean droplet size 6.0±0.7μm and high self-emulsifying ability(self-emulsifying time<2 min).Encapsulation of nattokinase was up to 86.8±8.2%.The cumulative release of nattokinase within 8 h was about 30%,exhibiting a sustained release effect.The pharmacodynamics study indicated that nattokinase-loaded SDEDDS could significantly prolong the whole blood clotting time in mouse and effectively improve the carrageenan-induced tail thrombosis compared with nattokinase solution.Moreover,we showed that SDEDDS could successfully self-emulsify into water/oil/water multiple emulsions upon dilution in dispersion medium with gentle stirring and effectively protect nattokinase activity in gastric environment.Our findings suggested that SDEDDS could be a promising strategy for peptide and protein drugs by oral administration. | Xiaona Wang Sifan Jiang Xinyue Wang Jie Liao Zongning Yin | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，5： | 9 |
| 2 | Distributed Photovoltaic Generation in the Electricity Market:Status,Mode and Strategy显示文摘With the increasingly serious climate change and energy crisis,photovoltaic(PV)generation,as one of the most important renewable energy resources,has experienced dramatic growth worldwide due to its environmental friendliness.How-ever,the uncertainty and intermittency of PV bring inevitable challenges to power systems.With the rapid development of distributed PV and the continuous evolution of the electricity market,increasingly high penetration levels of distributed PV generation have led to a series of problems in power system operations,such as voltage fluctuation,frequency deviation,etc.The market participation of distributed PV needs to be solved.Reasonable market participation form,market mechanism and bidding strategies are vital to the development of distributed PV in the electricity market.This paper comprehensively reviews the development and impacts of distributed PV in the electricity market and discusses the relevant market modes and bidding strategies in detail. | Sifan Jiang Can Wan Chen Chen Erbao Cao Yonghua Song | 2018 | CSEE Journal of Power and Energy Systems2018，4，3： | 7 |
| 3 | A novel aldo-keto reductase gene, IbAKR, from sweet potato confers higher tolerance to cadmium stress in tobacco显示文摘High concentrations of Cd can inhibit growth and reduce the activity of the photosynthetic apparatus in plants. In several plant species, aldo-keto reductases(AKRs) have been shown to enhance tolerance to various abiotic stresses by scavenging cytotoxic aldehydes;however, few AKRs have been reported to enhance Cd stress tolerance. In this study, the gene Ib AKR was isolated from sweet potato. The relative expression levels of Ib AKR increased significantly(approximately 3-fold) after exposure to 200 mmol$L–1 Cd Cl2 or 10 mmol$L–1 H2 O2. A subcellular localization assay showed that Ib AKR is predominantly located in the nucleus and cytoplasm.Ib AKR-overexpressing tobacco plants showed higher tolerance to Cd stress than wild-type(WT). Transgenic lines showed a significant ability to scavenge malondialdehyde(MDA) and methylglyoxal(MG). In addition,proline content and superoxide dismutase activity were significantly higher and H2 O2 levels were significantly lower in the transgenic plants than in the WT. Quantitative real-time PCR analysis showed that the reactive oxygen species(ROS) scavenging genes encoding guaiacol peroxidase(GPX), ascorbate peroxidase(APX), monodehydroascorbate reductase(MDHAR) and peroxidase(POD) were significantly upregulated in transgenic plants compared to WT under Cd stress. These findings suggest that overexpressing Ib AKR enhances tolerance to Cd stress via the scavenging of cytotoxic aldehydes and the activation of the ROS scavenging system. | Jinxi HUO Bing DU Sifan SUN Shaozhen HE Ning ZHAO Qingchang LIU Hong ZHAI | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 4 |
| 4 | A278C mutation of dihydropteridine reductase decreases autophagy via mTOR signaling显示文摘 | Qin Si Sifan Sun Yanting Gu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 3 |
| 5 | 3D carbon network supported porous SiOC ceramics with enhanced microwave absorption properties显示文摘Porous SiOC ceramic was successfully prepared by pyrolysis of dimethylsilicone oil,silane coupling agent and melamine foam.The microwave absorbing properties of porous SiOC were studied for the first time.At the matching layer thickness of 3.0 mm,the paraffin-based composite with porous SiOC displays a minimum reflection coefficient(RC)of-39.13 d B(11.76 GHz)and an effective absorption bandwidth(EAB)of 4.64 GHz which are much larger than that of paraffin-based composite with ordinary SiOC.It is found that the porous structure of SiOC is crucial to achieve its high microwave absorption performance by improving both the polarization loss and conduction loss.The enhanced polarization loss is originated from the dipole polarization and interfacial polarization,while the improvement of conduction loss is attributed to the carbon skeleton of porous SiOC.These results indicate that porous SiOC ceramic is a promising candidate for high-performance ceramic-based microwave absorbing materials. | Chen Chen Sifan Zeng Xiaochun Han Yongqiang Tan Wanlin Feng Huahai Shen Shuming Peng Haibin Zhang | 2020 | Journal of Materials Science & Technology2020，54，19： | 3 |
| 6 | Identification, through transcriptome analysis, of transcription factors that regulate anthocyanin biosynthesis in different parts of red-fleshed apple 'May' fruit显示文摘Anthocyanins, a class of flavonoid compounds that provide pigmentation to plant organs, are beneficial components of the human diet and there is an interest in understanding the regulation of their formation in crop plants. The apple cultivar ‘May’ represents an excellent model for the study of anthocyanin metabolism due to the spatial color pattern of its flesh, which transitions sequentially from red to white to red again,from the outside to the inside of the apple fruit. To screen the transcription factors involved in the anthocyanin pathway, transcriptomes from differently colored sections of ‘May’ fruits were analyzed by RNA sequencing. Kyoto Encyclopedia of Genes and Genomes(KEGG) database was used to analyse the gene expression data. The results suggested differentially expressed genes(DEGs) that are related to phytohormones are involved in regulating anthocyanin biosynthesis. K-means clustering analysis revealed 167 common DEGs between different sections of fruit with the same expression pattern as candidates for regulating anthocyanin synthesis. Further analysis showed that nine of the 167 DEGs were annotated as transcription factors and quantitative real time PCR(qRT-PCR) confirmed that their expression was obviously higher in red regions of the fruit, consistent with their roles as hub genes that regulate anthocyanin synthesis. This study provides valuable results for future studies of anthocyanin synthesis in apple fruit. | Hua Li Shiyao Duan Weilei Sun Sifan Wang Jie Zhang Tingting Song Ji Tian Yuncong Yao | 2022 | Horticultural Plant Journal2022，8，1： | 2 |
| 7 | Development of superconducting microcalorimeters for the HUBS mission显示文摘Hot Universe Baryon Surveyor(HUBS)is a proposed space‐borne observatory for X‐ray astronomy.The primary scientific objectives of the mission are to fill a void in probing the ecosystem of galaxies and thus to advance our understanding of galaxy formation and evolution,which is of fundamental importance in cosmology.More specifically,HUBS aims at directly detecting soft X‐ray emission from diffuse gas of temperature exceeding 106 K,which is theoretically postulated to permeate the large structures in the cosmic web and also fill the extended halo of galaxies.However,although some indirect evidence exists,the presence of such hot gas has yet to be well established observationally,due to the lack of effective tools to probe it.In this paper,we describe the design of HUBS,focusing on its scientific payload,which employs superconducting technologies in the detector system,and particularly on progress in the development of superconducting microcalorimeters. | Sifan Wang Guole Wang Naihui Chen Yanling Chen Wei Cui Jiao Ding Fajun Li Yajie Liang Qian Wang Yeru Wang | 2022 | Superconductivity2022，，4： | 2 |
| 8 | A fast antibiotic detection method for simplified pretreatment through spectra-based machine learning显示文摘Antibiotics are widely used in medicine and animal husbandry.However,due to the resistance of antibiotics to degradation,large amounts of antibiotics enter the environment,posing a potential risk to the ecosystem and public health.Therefore,the detection of antibiotics in the environment is necessary.Nevertheless,conventional detection methods usually involve complex pretreatment techniques and expensive instrumentation,which impose considerable time and economic costs.In this paper,we proposed a method for the fast detection of mixed antibiotics based on simplified pretreatment using spectral machine learning.With the help of a modified spectrometer,a large number of characteristic images were generated to map antibiotic information.The relationship between characteristic images and antibiotic concentrations was established by machine learning model.The coefficient of determination and root mean squared error were used to evaluate the prediction performance of the machine learning model.The results show that a well-trained machine learning model can accurately predict multiple antibiotic concentrations simultaneously with almost no pretreatment.The results from this study have some referential value for promoting the development of environmental detection technologies and digital environmental management strategies. | Yicai Huang Jiayuan Chen Qiannan Duan Yunjin Feng Run Luo Wenjing Wang Fenli Liu Sifan Bi Jianchao Lee | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 2 |
| 9 | Tandem Molecular Self-Assembly Selectively Inhibits Lung Cancer Cells by Inducing Endoplasmic Reticulum Stress显示文摘The selective formation of nanomaterials in cancer cells and tumors holds great promise for cancer diagnostics and therapy.Until now,most strategies rely on a single trigger to control the formation of nanomaterials in situ.The combination of two or more triggers may provide for more sophisticated means of manipulation.In this study,we rationally designed a molecule(Comp.1)capable of responding to two enzymes,alkaline phosphatase(ALP),and reductase.Since the A549 lung cancer cell line showed elevated levels of extracellular ALP and intracellular reductase,we demonstrated that Comp.1 responded in a stepwise fashion to those two enzymes and displayed a tandem molecular self-assembly behavior.The selective formation of nanofibers in the mitochondria of the lung cancer cells led to the disruption of the mitochondrial membrane,resulting in an increased level of reactive oxygen species(ROS)and the release of cytochrome C(Cyt C).ROS can react with proteins,resulting in endoplasmic reticulum(ER)stress and the unfolded protein response(UPR).This severe ER stress led to disruption of the ER,formation of vacuoles,and ultimately,apoptosis of the A549 cells.Therefore,Comp.1 could selectively inhibit lung cancer cells in vitro and A549 xenograft tumors in vivo.Our study provides a novel strategy for the selective formation of nanomaterials in lung cancer cells,which is powerful and promising for the diagnosis and treatment of lung cancer. | Debin Zheng Yumiao Chen Sifan Ai Renshu Zhang Zhengfeng Gao Chunhui Liang Li Cao Yaoxia Chen Zhangyong Hong Yang Shi Ling Wang Xingyi Li Zhimou Yang | 2019 | Research2019，，1： | 1 |
| 10 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 11 | The Comparison of Cold tolerance of Three Species of Evergreen Broad-leaved Woody Plants显示文摘[Objectives]This study aimed to select evergreen broad-leaved woody plants with higher ornamental value and stronger cold tolerance for introduction from the south to the north,and to apply them to urban greening,so as to enrich the plant community structure of the landscape in the northern region.[Methods]Three species of evergreen broad-leaved woody plants,i.e.,Ligustrum lucidum,Ilex cornuta and Eriobotrya japonica,were selected as the experimental materials.The morphological performances and the changes of the physiological indexes were observed and measured during the overwintering period in the open field in Beijing.The relationship between the indexes and the low temperature was also analyzed.The strength of cold tolerance of the three species was compared.[Results]The electrical conductivity,the contents of MDA and proline were negatively correlated with the corresponding low temperature.The contents of soluble sugar and soluble protein increased with the dropping temperature,but they had little response to the short-term temperature rise.[Conclusions]Combined with morphological and physiological indexes,it was found that the changes of the contents of proline and soluble sugar among the physiological indexes were closely related to the cold tolerances of the three tree species of broad-leaved woody plants.The cold tolerance of I.cornuta was the strongest,E.japonica was the second,and that of L.lucidum was the worst. | Sifan LI Mengyan LI Runfang ZHANG Pingsheng LENG Man SHEN | 2021 | Agricultural Biotechnology2021，10，2： | 1 |
| 12 | Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression显示文摘 | Sifan Chen Xincai Xiao Xiang Feng Wenxue Li Niman Zhou Lin Zheng Yanshuang Sun Zili Zhang Wei Zhu | 2012 | The Journal of Nutritional Biochemistry2012，，9： | 1 |
| 13 | Drug discovery of sclerostin inhibitors显示文摘Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy. | Sifan Yu Dijie Li Ning Zhang Shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 14 | Local engineering of topological phase in monolayer MoS2显示文摘Monolayer transition metal dichalcogenides(TMDCs) with the 1 T0 structure are a new class of large-gap two-dimensional(2 D) topological insulators, hosting topologically protected conduction channels on the edges. However, the 1 T0 phase is metastable compared to the 2 H phase for most of 2 D TMDCs, among which the 1 T0 phase is least favored in monolayer MoS2. Here we report a clean and controllable technique to locally induce nanometer-sized 1 T0 phase in monolayer 2 H-MoS2 via a weak Argon-plasma treatment,resulting in topological phase boundaries of high density. We found that the stabilization of 1 T0 phase arises from the concerted effects of S vacancies and the tensile strain. Scanning tunneling spectroscopy(STS) clearly reveals a spin-orbit band gap(~60 meV) and topologically protected in-gap states residing at the 1 T0-2 H phase boundary, which are corroborated by density-functional theory(DFT) calculations.The strategy developed in this work can be generalized to a large variety of TMDCs materials, with potentials to realize scalable electronics and spintronics with low dissipation. | Zhichang Wanga Xiaoqiang Liu Jianqi Zhu Sifan You Ke Bian Guangyu Zhang Ji Feng Ying Jiang | 2019 | Science Bulletin2019，64，23： | 1 |
| 15 | Relaxor behavior and superior ferroelectricity of Y_(2)O_(3)-doped(Ba_(0.98)Ca_(0.02))(Ti_(0.94)Sn_(0.04)Zr_(0.02))O_(3) lead-free ceramics显示文摘To upgrade the electric properties of lead-free piezoceramics,(1-x)(Ba_(0.98)Ca_(0.02)Ti_(0.94)Sn_(0.04)Zr_(0.02))O_(3)-xY_(2)O_(3)(abbreviated as(1-x)BCTSZ-xY,x=0 mol%,0.02 mol%,0.04 mol%,0.06 mol%,0.08 mol%and 0.1 mol%)ceramics were successfully synthesized by traditional solid-state sintering method.The phase structure and microstructure of ceramics were investigated by X-ray diffraction(XRD),scanning electron microscopy(SEM)and piezoresponse force microscopyeramics(PFM).The electric properties of ceramics were researched through piezoelectric,dielectric and ferroelectric test instruments.The results show that all samples have pure perovskite structure and favorable electric properties.The optimal electric properties which especially include superior ferroelectric properties are gained when Y_(2)O_(3)content is 0.06 mol%(d_(33)=419 pC/N,k_(p)=52%,T_(c)=89.5℃,ε_(r)=26900,tanδ=2.86%,P_(r)=14.41μC/cm^(2),Ec=1.8 kV/cm).Moreover,the temperature-dependent dielectricity of samples shows apparent relaxor behavior under different frequencies.The Curie-Weiss law further proves that all samples are typical relaxor ferroelectrics,and the relaxor degree of samples decreases with increase of Y_(2)O_(3)content.In conclusion,Y_(2)O_(3)plays a significant role in enhancing electric properties of BCTSZ ceramics. | Sifan Wang Qibin Liu Enpei Cai Fanghui Mou An Xue | 2022 | Journal of Rare Earths2022，40，6： | 1 |
| 16 | Regulating wrinkling patterns by periodic surface stiffness in film-substrate structures显示文摘Surface wrinkling of materials holds promise for important applications in diverse fields such as multifunctional surfaces and biomedical engineering. For these applications, it is of interest to attain various surface wrinkles with tunable wavelengths and amplitudes. Through a combination of experiments and numerical simulations, we here propose a method to regulate the wrinkling patterns in a film-substrate system by introducing periodic surface stiffness, which is generated through sequential specified ultraviolet-ozone(UVO) treatments. Both experiments and numerical simulations demonstrate that the proposed technique can produce various patterns with wide, tunable geometrical features and anisotropy. The effects of surface stiffness distribution, the exposure durations of UVO-treatments, and the loading biaxiality are examined on the generated surface patterns. | LI Bo ZENG ChongQing YIN SiFan FENG XiQiao | 2019 | Science China(Technological Sciences)2019，62，5： | 1 |
| 17 | Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression显示文摘 | Sifan Chen Xincai Xiao Xiang Feng Wenxue Li Niman Zhou Lin Zheng Yanshuang Sun Zili Zhang Wei Zhu | 2012 | The Journal of Nutritional Biochemistry2012，，9： | 1 |
| 18 | Photo-induced anti-Markovnikov hydroalkylation of unactivated alkenes employing a dual-component initiator显示文摘Metal-free anti-Markovnikov hydroalkylation of unactivated alkenes with cyanoacetate has been developed,featuring the use of a dual-component initiator containing an organic photocatalyst and a radical precursor.When combined,the two components can undergo visible light-induced singleelectron transfer,and serve as a versatile and effective alkyl radical generator. | Yachao Zhang Liang-Liang Mao Sifan Hu Yi Luan Huan Cong | 2021 | Chinese Chemical Letters2021，32，2： | 1 |
| 19 | Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics显示文摘 | Haojun Zhang Tingting Zhao Yuewen Gong Xi Dong Weiku Zhang Sifan Sun Hua Wang Yanting Gu Xiaoguang Lu Meihua Yan Ping Li | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 20 | Status and Correlates of Hypersomnia in Hospitalized Patients with Unipolar Depression—Beijingf Henanf and Shandong,China,August 2019-March 2021显示文摘Summary What is already known about this topic?Hypersomnia is an atypical characteristic of unipolar depression(UD),indicating a high risk of bipolar depression.Identifying the symptom should be prioritized in patients with UD.However,the status and correlated factors of hypersomnia greatly varied across investigations.What is added by this report? | Yun Chen Lyufeng Zhang Sifan Hu Hongle Zhang Qiqing Sun Mengyue Hong Yuying Qian Lin Lu Hongqiang Sun | 2021 | China CDC weekly2021，3，42： | 0 |
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