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| 1 | The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis显示文摘 | Houping Wang Yang Li Jinjing Pan Dengji Lou Yanru Hu Diqiu Yu | 2017 | Molecular Plant2017，10，11： | 19 |
| 2 | Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4显示文摘histone H3 离氨酸的 Dimethylations 9 和离氨酸 27 是与抄写压抑联系的重要 epigenetic 标记。这里,我们作为为这二个镇压标记特定的新奇 histone demethylase 识别了 KIAA1718 (KDM7A ) 。用老鼠胚胎的干细胞,我们证明那 KIAA1718 表情在神经区别的早阶段增加了。基因击倒堵住的神经区别和效果被野类型的人的基因,并且不由催化地不活跃的异种救。另外, KIAA1718 的 overexpression 加速了神经区别。我们提供 KDM7A 的支持 neural 区别效果通过 FGF4 的直接 transcriptional 激活被调停的证据,一个信号分子在神经区别含有。因此,我们的学习识别了通过 FGF4 调整神经区别的双特性的 histone demethylase。 | Chengyang Huang Yang Xiang Yanru Wang Xia Li Longyong Xu Ziqi Zhu Ting Zhang Qingqing Zhu Kejing Zhang Naihe Jing Charlie Degui Chen | 2010 | Cell Research2010，20，2： | 15 |
| 3 | Rapid report of the 8 January 2022 M_(S)6.9 Menyuan earthquake,Qinghai,China显示文摘The M_(S)6.9 Menyuan earthquake in Qinghai Province,west China is the largest earthquake by far in 2022.The earthquake occurs in a tectonically active region,with a background b-value of 0.87 within 100 km of the epicenter that we derived from the unified catalog produced by China Earthquake Networks Center since late 2008.Field surveys have revealed surface ruptures extending 22 km along strike,with a maximum ground displacement of 2.1 m.We construct a finite fault model with constraints from In SAR observations,which showed multiple fault segments during the Menyuan earthquake.The major slip asperity is confined within 10 km at depth,with the maximum slip of 3.5 m.Near real-time back-projection results of coseismic radiation indicate a northwest propagating rupture that lasted for~10 s.Intensity estimates from the back-projection results show up to a Mercalli scale of IX near the ruptured area,consistent with instrumental measurements and the observations from the field surveys.Aftershock locations(up to January 21,2022)exhibit two segments,extending to~20 km in depth.The largest one reaches M_(S)5.3,locating near the eastern end of the aftershock zone.Although the location and the approximate magnitude of the mainshock had been indicated by previous studies based on paleoearthquake records and seismic gap,as well as estimated stressing rate on faults,significant surfacebreaching rupture leads to severe damage of the high-speed railway system,which poses a challenge in accurately assessing earthquake hazards and risks,and thus demands further investigations of the rupture behaviors for crustal earthquakes. | Hongfeng Yang Dun Wang Rumeng Guo Mengyu Xie Yang Zang Yue Wang Qiang Yao Chuang Cheng Yanru An Yingying Zhang | 2022 | Earthquake Research Advances2022，2，1： | 14 |
| 4 | Arabidopsis VQ10 interacts with WRKY8 to modulate basal defense against Botrytis cinerea显示文摘Recent studies in Arabidopsis have revealed that some VQ motif-containing proteins physically interact with WRKY transcription factors;however,their specific biological functions are still poorly understood.In this study,we confirmed the interaction between VQ10and WRKY8,and show that VQ10 and WRKY8 formed a complex in the plant cell nucleus.Yeast two-hybrid analysis showed that the middle region of WRKY8 and the VQ motif of VQ10 are critical for their interaction,and that this interaction promotes the DNA-binding activity of WRKY8.Further investigation revealed that the VQ10protein was exclusively localized in the nucleus,and VQ10was predominantly expressed in siliques.VQ10 expression was strongly responsive to the necrotrophic fungal pathogen,Botrytis cinerea and defense-related hormones.Phenotypic analysis showed that disruption of VQ10 increased mutant plants susceptibility to the fungal pathogen B.cinerea,whereas constitutive-expression of VQ10 enhanced resistance to B.cinerea.Consistent with these findings,expression of the defenserelated PLANT DEFENSIN1.2(PDF1.2)gene was decreased in vq10 mutant plants,after B.cinerea infection,but increased in VQ10-overexpressing transgenic plants.Taken together,our findings provide evidence that VQ10 physically interacts with WRKY8 and positively regulates plant basal resistance against the necrotrophic fungal pathogen B.cinerea. | Junqiu Chen Houping Wang Yang Li Jinjing Pan Yanru Hu Diqiu Yu | 2018 | Journal of Integrative Plant Biology2018，60，10： | 8 |
| 5 | Lignin biosynthesis by suppression of two O-methyl-transferases显示文摘Caffeic acid O-methyltransferase (COMT) and caffeoyl-CoA-3-O-methyltransferase (CCoAOMT) genes encode two methyltransferases at different substrate levels in lignin biosynthesis. We constructed two single antisense expression vectors containing the cDNA of COMT or CCoAOMT genes and one dual antisense expression vector containing cDNAs of both OMTs genes. The antisense constructs were transferred into tobacco mediated by Agrobac-terium tumefacience. PCR-Southern analysis indicated that antisense cDNAs had been integrated into the genome of the transgenic tobacco. The antisense genes were also expressed at transcriptional level displayed by Northern dot analysis. Klason lignin assay of 3-month-old transgenic tobaccos showed that repression in COMT or CCoAOMT alone could result in reduction of lignin content, more reduction was caused by suppression in CCoAOMT than in COMT. Furthermore, simultaneous suppression of both COMT and CCoAOMT resulted in more reduction than that of single gene, which indicated | ZHAO Huayan WEI Jianhua ZHANG Jinyu LIU Huirong WANG Tai SONG Yanru | 2002 | Chinese Science Bulletin2002，47，13： | 7 |
| 6 | PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis显示文摘histone H3 离氨酸 9 的 Dimethylation (H3K9me2 ) 是与抄写压抑联系的一个重要 epigenetic 标记。这里,我们识别了 PHF8, JmjC-domain-containing 蛋白质,为这个镇压标记特定的 histone demethylase。Recombinant 全身的野类型蛋白质能把 methylation 从 H3K9me2 移开,但是到丙氨酸 H247A 的保存 histidine 的变化废除 demethylase 活动。Overexpressed 外长的 PHF8 是 colocalized, B23 染色。内长的 PHF8 也是有 B23 和 fibrillarin 的 colocalized,二生长得很好的核蛋白质,建议那 PHF8 在核是局部性的并且可以调整 rRNA 抄写。确实, PHF8 跳了到 rDNA 基因的倡导者区域。减少的 PHF8 击倒 rRNA 的表示,和基因的 overexpression 导致了 rRNA 的 upregulation 抄本。附随地, H3K9me2 水平在 PHF8 击倒的房间在 rDNA 基因的倡导者区域被提高并且当野类型然而并非催化地不活跃的 H247A 变异的 PHF8 是 overexpressed 时,显著地减少了。因此,我们的学习为调整 rRNA 抄写的 H3K9me2 识别了 histone demethylase。 | Ziqi Zhu Yanru Wang Xia Li Yiqin Wang Longyong Xu Xiang Wang Tianliang Sun Xiaobin Dong Lulu Chen Hailei Mao Yi Yu Jingsong Li Pin Adele Chen Charlie Degui Chen | 2010 | Cell Research2010，20，7： | 7 |
| 7 | Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes显示文摘Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer(CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pathological characteristics, treatment protocols, and survival outcomes in Chinese CEC patients.Methods: A total of 500 Chinese CEC patients were selected from our 500,000 esophageal and gastric cardia carcinoma database(1973–2018). There were two main groups: patients treated with surgery, and patients receiving non-surgical treatments(radiotherapy, radiochemotherapy, and chemotherapy). The Chi-square test and Kaplan–Meier method were used to compare the continuous variables and survival.Results: Among the 500 CEC patients, 278(55.6%) were male, and the median age was 60.9 ± 9.4 years. A total of 496 patients(99.2%) were diagnosed with squamous cell carcinoma. In 171(34.2%) patients who received surgery, 22(12.9%) had undergone laryngectomy. In 322(64.4%) patients who received non-surgical treatments, 245(76.1%) received radiotherapy. Stratified survival analysis showed that only T stage was related with survival outcomes for CEC patients in the surgical group, and the outcomes between laryngectomy and non-laryngectomy patients were similar. It was noteworthy that the 5-year survival rate was similar in CEC patients among the different groups treated with surgery, radiotherapy, chemotherapy, or radiochemotherapy(P = 0.244). Conclusions: The CEC patients had similar survival outcomes after curative esophagectomy and radiotherapy, including those with or without total laryngectomy. These findings suggest that radiotherapy could be the initial choice for treatment of Chinese CEC patients. | Peinan Chen Xueke Zhao Fuyou Zhou Xin Song Shoujia Hu Yan Jin Xianzeng Wang Xuena Han ZongminFan Ran Wang Bei Li Wenli Han Panpan Wang Jilin Li Lixin Wan Liguo Zhang Qide Bao Fubao Chang Yanru Qin Zhiwei Chang Jianwei Ku Haijun Yang Ling Yuan Jingli Ren Xuemin Li Lidong Wang | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 8 | Pulping performance of transgenic poplar with depressed Caffeoyl-CoA O-methyltransferase显示文摘This paper evaluated pulping performance of 3-year-old field-grown transgenic poplar (Populus tremula × Populus alba). The transgenic poplar with anti-sense CCoAOMT had an about 13% decreased lignin content, in which a slight increment was found in S/G ratio. Chemical analysis showed that the transgenic poplar had significantly less benezene-ethanol extractive than that of control wood, but no significant differences were found in contents of ash, cold water extractive, hot water extractive, 1% NaOH extractive, holocellulose, pentosans and cellulose. Fiber assay demonstrated that down-regulation of CCoAOMT expression improved the fiber quality in transgenic poplar. Kraft pulping showed that lower lignin in transgenic poplar led to remarkable improved pulp quality and increased pulp yield. | WEI JianHua WANG YanZhen WANG HongZhi LI RuiFen LIN Nan MA RongCai QU LeQing SONG YanRu | 2008 | Chinese Science Bulletin2008，53，22： | 5 |
| 9 | Large numbersLarge numbers of new bacterial taxa found by Yunnan Institute of Microbiology显示文摘Extreme environments, primeval forest, sea sediments and plants in China yielded members of a new suborder, Jiangellineae, a new family Sinobacteraceae, and 23 new genera of actinomycetes and other bacteria. Three suggestions were made for further discoveries of new actinomycetes. First, natural habitats such as old growth forests, and extreme environments, should be given sampling priority; second, culturing procedures need to be constantly improved to mimic natural habitats; third, less than 98.5% similarity of 16S rRNA sequence to that of a known species could be used as an indicator of a new species. | JIANG Yi CAO YanRu ZHAO LiXing TANG ShuKun WANG Yun LI WenJun XU Ping LOU Kai MAO PeiHong XU LiHua | 2011 | Chinese Science Bulletin2011，56，8： | 5 |
| 10 | The landscape of gene-CDS-haplotype diversity in rice:Properties,population organization,footprints of domestication and breeding,and implications for genetic improvement显示文摘Polymorphisms within gene coding regions represent the most important part of the overall genetic diversity of rice.We characterized the gene-coding sequence-haplotype(gcHap)diversity of 45963 rice genes in 3010 rice accessions.With an average of 226±390 gcHaps per gene in rice populations,rice genes could be classified into three main categories:12865 conserved genes,10254 subspecific differentiating genes,and 22844 remaining genes.We found that 39218 rice genes carry>255179 major gcHaps of potential functional importance.Most(87.5%)of the detected gcHaps were specific to subspecies or populations.The inferred proto-ancestors of local landrace populations reconstructed from conserved predominant(ancient)gcHaps correlated strongly with wild rice accessions from the same geographic regions,supporting a multiorigin(domestication)model of Oryza sativa.Past breeding efforts generally increased the gcHap diversity of modern varieties and'caused significant frequency shifts in predominant gcHaps of 14266 genes due to independent selection in the two subspecies.Low frequencies of“favorable”gcHaps at most known genes related to rice yield in modern varieties suggest huge potential for rice improvement by mining and pyramiding of favorable gcHaps.The gcHap data were demonstrated to have greater power than SNPs for the detection of causal genes that affect complex traits.The rice gcHap diversity dataset generated in this study would facilitate rice basic research and improvement in the future. | Fan Zhang Chunchao Wang Min Li Yanru Cui Yingyao Shi Zhichao Wu Zhiqiang Hu Wensheng Wang Jianlong Xu Zhikang Li | 2021 | Molecular Plant2021，14，5： | 5 |
| 11 | Nanomechanical Behaviour of the Membranous Wings of Dragonfly Pantala flavescens Fabricius显示文摘 | Yanru Zhao Dongsheng Wang Jin Tong Jiyu Sun | 2016 | Journal of Bionic Engineering2016，13，3： | 5 |
| 12 | NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly显示文摘The impairment of mitochondrial bioenergetics,often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and safer cellular powerhouse holds the promise for protecting these organs in stressful conditions. Here, we demonstrate that NADH:ubiquinone oxidoreductase subunit AB1 (NDUFAB1), also known as mitochondrial acyl carrier protein, acts as a powerful cardio-protector by conferring greater capacity and efficiency of mitochondrial energy metabolism. In particular, NDUFAB1 not only serves as a complex I subunit, but also coordinates the assembly of respiratory complexes I, II, and III, and supercomplexes, through regulating iron-sulfur biosynthesis and complex I subunit stability. Cardiac-specific deletion of Ndufab1 in mice caused defective bioenergetics and elevated ROS levels, leading to progressive dilated cardiomyopathy and eventual heart failure and sudden death. Overexpression of Ndufab1 effectively enhanced mitochondrial bioenergetics while limiting ROS production and protected the heart against ischemia-reperfusion injury. Together, our findings identify that NDUFAB1 is a crucial regulator of mitochondrial energy and ROS metabolism through coordinating the assembly of respiratory complexes and supercomplexes, and thus provide a potential therapeutic target for the prevention and treatment of heart failure. | Tingting Hou Rufeng Zhang Chongshu Jian Wanqiu Ding Yanru Wang Shukuan Ling Qi Ma Xinli Hu Heping Cheng Xianhua Wang | 2019 | Cell Research2019，29，9： | 4 |
| 13 | Preparation of Aminated Lignin through Etherification and Amination显示文摘A new method for the preparation of aminated lignin(AEL) through etherification and amination reaction was presented. Chlorine atoms were firstly introduced into lignin through its etherification with epichlorohydrin. Then, hydrophilic amine groups were grafted to the modified lignin structure through amination with ethylenediamine to obtain AEL. Subsequent acidification of AEL led to the ionized aminated lignin(IAEL). The results of our analyses showed that the nitrogen content of AEL was 6.9%. Foaming and emulsifying experiments indicated that AEL had better foamability and emulsifying properties than IAEL. Surface tension tests showed that AEL and IAEL had similar critical micelle concentration(CMC). However, IAEL had lower surface tension(36.33 mN/m) than AEL(42.89 mN/m) at CMC. These results demonstrate the promising applicability of AEL as an emulsifier and that of IAEL as feedstock in the production of detergent and dispersant. | ChangZhou Chen BingXin Wang YanRu Zhang Ting Shi Jun Liu XiLuan Wang YongMing Fan | 2018 | Paper And Biomaterials2018，3，2： | 4 |
| 14 | Characteristics of the coseismic geomagnetic disturbances recorded during the 2008 M_w 7.9 Wenchuan Earthquake and two unexplained problems显示文摘Twenty-seven FHDZ-M15 combined geomagnetic observation systems(each of which is equipped with a fluxgate magnetometer and a proton magnetometer)had been installed in the China geomagnetic network before the 2008 Wenchuan earthquake,during which coseismic disturbances were recorded by 26 fluxgate magnetometer observatories.The geomagnetic disturbances have similar spatial and temporal patterns to seismic waves,except for various delays.Six proton magnetometer observatories recorded coseismic disturbances with very small amplitudes.In addition,fluxgate magnetometers registered largeamplitude disturbances that are likely to have included responses to seismic waves.However,two problems remain unresolved.First,why do these geomagnetic disturbances always arrive later than P waves?Second,why do the geomagnetic disturbances have spatial and temporal directivity similar to the main rupture direction of the earthquake?Solving these two problems may be crucial to find the mechanism responsible for generating these geomagnetic anomalies. | YaLi Wang Tao Xie YanRu An Chong Yue JiuYang Wang Chen Yu Li Yao Jun Lu | 2019 | Earth and Planetary Physics2019，3，5： | 4 |
| 15 | Morphological and physiological analysis of narrow and striped leaf 1(nsl1) mutant of rice(Oryza sativa L.) and the gene mapping显示文摘The shape and color of rice leaves are important agronomic traits that directly influence the proportion of sunlight energy utilization and ultimately affect the yield and quality.A new mutant exhibiting stable inheritance was identified as derived from ethyl methane sulfonate(EMS)-treated restorer Jinhui 10,tentatively named as narrow and striped leaf 1(nsl1).The nsl1 displayed pale white leaves at the seeding stage and then white striped leaves in parallel to the main vein at the jointing stage.Meanwhile,its leaf blades are significantly narrower than the control group of Jinhui 10.The chloroplast structures of cells in the white striped area of the nsl1 mutant break down,and the photosynthetic pigments are significantly lower than that of the wild type.Moreover,fluorescence parameters,such as F0,F v/F m,U psII,qp,and ETR,in the nsl1 mutant are significantly lower than those of the wild type,and the photosynthetic efficiency is also significantly decreased.These changes in leaf color and shape,together with physiological changes in the nsl1,result in smaller plant height and a decrease in the most important agronomic traits,such as the number of grains per panicle,grain weight,etc.Genetic analysis shows that the narrow and striped traits of the nsl1 mutant are controlled by a single recessive nuclear gene,which is located between InDel 16and InDel 12 in chromosome 3.The physical distance is204 kb.So far,no similar genes of such leaf color and shape in this area have been reported.This study has laid a solid foundation for the gene cloning and function analysis of NSL1. | Fangming Zhao Yong Zhang Yanru Wu Tongming Wang Ling Ma Zhenglin Yang Xia Wei Xianchun Sang Yinghua Ling Nan Wang Changwei Zhang Guanghua He | 2014 | Chinese Science Bulletin2014，59，9： | 3 |
| 16 | The effect of serum luteinizing hormone on trigger day with a GnRH antagonist protocol in IVF/ICSI treatment显示文摘Objective:To investigate the effect of serum luteinizing hormone(LH)on trigger day with a Gonadotrophinreleasing hormone(GnRH)antagonist protocol in patients receiving in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSI)treatment for pregnancy outcomes.Methods:We retrospectively reviewed the medical documents of patients receiving IVF/ICSI with fresh embryo transfers from the Reproductive Medicine Center of Peking University People's Hospital between January 2016 and December 2018.730 patients were included and divided into three groups by their serum LH level determined on trigger day.All patients were categorized into Group A,Group B,and Group C based on LH concentrations<1.0 IU/L,1.0–5.0 IU/L,and from 5.0 to 10.0 IU/L on trigger day during the cycle,respectively.Comparisons were made between the three groups.Results:There was a significant difference in implantation rates between Group A and Group C(24.8%versus 40.1%,respectively,P<0.05).The clinical pregnancy rates(39.3%versus 54.3%,respectively,P=0.078)and live birth rate(LBR)(32.1%versus 46.5%,respectively,P=0.116),though the differences were not significant.Multivariate logistic regression analysis showed that the OR of Group C for clinical pregnancy(OR=1.849,P=0.040)and for LBR(OR=1.915,P=0.034)were significant using Group A as the base level.Conclusions:Our study has demonstrated that patients with higher serum LH levels(5.0–10.0 IU/L)on trigger day in the GnRH antagonist protocol may confer better clinical outcomes than those with lower LH levels(<1.0 IU/L). | Yanru Hou Li Tian Huixin Liu Jiajia Ai Yanbin Wang Huan Shen | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，4： | 2 |
| 17 | Screening and flocculating properties of bioflocculant-producing microorganisms显示文摘Screening of bioflocculant-producing microorganisms was carried out. A strain that secreted excellent bioflocculant was isolated from municipal sewage using the spread plate technique, identified as Klebsiella sp. by the analytical profile index (API) identification system, and named A9. Several important factors that had an effect on A9’s bioflocculant-producing and flocculating activity were studied. A total of 4 g/L Kaolin suspension was used to measure the flocculating activity of the bioflocculant from A9. It was found that maltose and urea were A9’s best carbon and nitrogen sources, respectively, and the flocculating activity of the floccu- lating agent from A9 was markedly increased by the addition of trivalent cations such as Fe3+ and Al3+; furthermore, the bioflocculant produced by A9 was most effective when the pH value was 6.0. | Yanling Sheng Qiang Zhang Yanru Sheng Chengbin Li and Huajun Wang | 2006 | Journal of University of Science and Technology Beijing2006，13，4： | 2 |
| 18 | Differential mitochondrial calcium responses in different cell types detected with a mitochondrial calcium fluorescent indicator, mito-GCaMP2显示文摘Mitochondrial 钙在 mitochondrial 新陈代谢,处理的房间钙,和房间死亡起一个关键作用。然而,有关 mitochondrial 钙规定的一些机制仍然是未知的,特别 mitochondrial 钙怎么结合 cytosolic 钙。在这个工作,我们构造了新奇 mitochondrial 钙荧光灯由基因操作的指示物(mito-GCaMP2 ) 。Mito-GCaMP2 与高效率被进口进线粒体并且荧光灯与 tetramethyl 玫瑰精甲基酉旨的 co 局部性的信号, mitochondrial 膜潜力指示物。mitochondrial 禁止者明确地减少了 mito-GCaMP2 的信号。mito-GCaMP2 的明显的 Kd 是在 pH 的 195.0 nmol/L 8.0 在成年老鼠 cardiomyocytes。而且,我们观察到 mito-GCaMP2 比较喜欢线粒体包围的碱的 pH。在 HeLa 房间,我们发现了那 mitochondrial 钙([Ca2+] mito ) 对 cytosolic 钙的变化作出回应([Ca2+] cyto ) 由组织安或 thapasigargin 导致了。而且,外部 Ca2+(100 mol/L ) 直接导致了增加[Ca2+] 在 permeabilized HeLa 房间的 mito。然而,在老鼠 cardiomyocytes [Ca2+] mito 没对电的踱步或咖啡因刺激的 cytosolic 钙 transients 作出回应。在 permeabilized cardiomyocytes,免费 Ca2+ 反复增加了的 600 nmol/L 荧光灯 mito-GCaMP2 的信号,它排除了 mito-GCaMP2 在 cardiomyocytes 线粒体失去了它的函数的可能性。这些结果证明 mitochondrial 钙的反应在不同房间系是多样的并且建议在 cardiomyocytes 的线粒体可以有特殊防卫机制控制钙流动。 | Min Chen Yanru Wang Tingting Hou Huiliang Zhang Aijuan Qu Xianhua Wang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，10： | 2 |
| 19 | 6 - 20 Primary Design of a C-band Traveling-wave Cell显示文摘 | Wang Yanru Zhang Zimin Cao Shuchun Shen Xiaokang Zhao Quantang Jing Yi Zong Yang | 2013 | IMP & HIRFL Annual Report2013，，1： | 2 |
| 20 | Detection of circulating tumor cells in peripheral blood from patients with gastric cancer using piRNAs as markers显示文摘 | Long Cui Yanru Lou Xinjun Zhang Hui Zhou Hongxia Deng Haojun Song Xiuchong Yu Bingxiu Xiao Weihua Wang Junming Guo | 2011 | Clinical Biochemistry2011，，13： | 2 |
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