|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato显示文摘野土豆种类有实质的 phenotypic 和生理的差异。这里,我们基于茄属节 Petota 的 201 就职的 genomic 分析报导对野、栽培的土豆种类的一个全面评价。我们定序这 201 就职的染色体并且识别了 6 ? 487 ? 从在 clade 的 167 就职的 006 高质量的单个核苷酸多型性(SNP ) 4 茄属节 Petota,包括 146 野并且有宽广地理分布的 21 栽培双土豆就职。染色体宽的基因变化分析比栽培土豆,和在农学地重要的疾病抵抗的高得多的基因差异,基因在野土豆被观察的证明野土豆的差异高。由关于已知的量的特点 loci (QTL ) 利用信息,而且,我们在选择下面识别了 609 基因,包括那些在 tubers 与痛苦的损失相关,那些在 tuberization 包含了,土豆的二个主要驯养的特点。种系发生的分析在 clade 揭示了所有种类的一个纵贯的部门 4,不是就那些在 S.? brevicaule 建筑群,和进一步支持的 S。是的 candolleanum 栽培土豆和在南部的秘鲁的栽培土豆的 monophyletic 起源的祖先。另外,我们分析了 S. 的染色体 ? candolleanum 并且鉴别 529 基因在栽培土豆输了。一起,在这研究产生的分子的标记为为土豆繁殖有用的农学地重要的基因的鉴定提供一个珍贵资源。 | Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric Schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang | 2018 | Molecular Plant2018，11，3： | 8 |
| 2 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 3 | Development of pot-cover effect apparatus with freezing-thawing cycles显示文摘‘Pot-cover effect’ refers to the phenomenon of moisture accumulation beneath the pavement under condensation or desublimation because the vapor transfer in the soil is blocked by the pavement. To study this phenomenon in the laboratory, we have developed the pot-cover effect apparatus with freezing-thawing cycles(PEAFC), which consists of three parts, namely, the vapor transfer system, the temperature control system, and the temperature and water content monitoring system. The major functions of this apparatus include: simulation of both vapor transfer and freezing-thawing cycling in the soil, real-time monitoring of the temperature and the water content in soil samples, and one-dimensional heat and moisture transfer in the samples. The FDR(frequency domain reflectometry) sensors of the apparatus are calibrated and a calibration formula is proposed to eliminate the water content measurement errors induced by temperature changes. Constant temperature difference tests and a freezing-thawing cycling test are conducted with the apparatus. Results indicate that the apparatus can control the water replenishment in the soil samples, monitor the vapor transfer in the samples in real time, and simulate the vapor transfer process under the condition of the freezing-thawing cycling in the soil. These tests verify the effectiveness and reliability of the apparatus, which indicates that the development purpose is achieved. | LUO Ting CHEN Han YAO YangPing WANG NaiDong QU Xiao | 2019 | Science China(Technological Sciences)2019，62，9： | 2 |
| 4 | Formation and microstructural characterization of whey protein isolate/beet pectin coacervations by laccase catalyzed cross-linking显示文摘 | Bingcan Chen Hongjun Li Yangping Ding Huayi Suo | 2012 | LWT - Food Science and Technology2012，，1： | 1 |
| 5 | Dietary Nonallergic Factors and Atopy显示文摘 | Jing Cheng Jing Chen Xiaozhong Gui Yangping Chen Ting Zhong | 2011 | Journal of US-China Medical Science2011，8，3： | 1 |
| 6 | Empirical formula for β^--decay half-lives of r-process nuclei显示文摘Experimental data ofβ--decay half-lives of nuclei with atomic number between 20 and 190 are investigated.A systematic formula has been proposed to calculateβ^--decay half-lives of neutron-rich nuclei,with a particular consideration on shell and pair effects,the decay energy Q as well as the nucleon numbers(Z,N).Although the formula has relatively few parameters,it reproduces the experimentalβ^--decay half-lives of neutron-rich nuclei very well.The predicted half-lives for the r-process relevant nuclei obtained with the current formula serve as reliable input in the r-process model calculations. | Yong Zhou ZhiHong Li YouBao Wang YongShou Chen Bing Guo Jun Su YunJu Li ShengQuan Yan XinYue Li ZhiYu Han YangPing Shen Lin Gan Sheng Zeng Gang Lian WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 1 |
| 7 | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling显示文摘 | Xiangzheng Chen Yangping Wu Yangfu Jiang Yan Zhou Yuxi Wang Yuqin Yao Cheng Yi Lantu Gou Jinliang Yang | 2012 | Journal of Molecular Medicine2012，，11： | 1 |
| 8 | Fabricationofelectro-catalyst layers for direct methanol fuel cells显示文摘 | Chen C Y YangP Lee Y S | 2005 | Power Sources2005，141，： | 1 |
| 9 | Formation and microstructural characterization of whey protein isolate/ beet pectin coacervations by laccase catalyzed cross-linking 显示文摘 | Chen Bingcan Li Hongjun Ding yangping | 2012 | LWT- Food Science and Technology2012，47，1： | 1 |
| 10 | Jinping Underground Laboratory Common Experimental Platform for Nuclear Astrophysics显示文摘The accurate measurement of key reactions based on underground laboratory has been an international frontier of nuclear astrophysics.The project aims to build an common platform for Jinping Underground Laboratory for Nuclear Astrophysics(JUNA).As the basis,the project will support the study of JUNA physics experi- | LIAN Gang CHEN Lihua CUI Baoqun LI Yunju SU Jun SHEN Yangping YAN Shengquan ZHANG Huanyu LIU Ping REN Jie | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 11 | Ultrasonic cavitation-enabled microfluidic approach toward the continuous synthesis of cesium lead halide perovskite nanocrystals显示文摘Ligand assisted reprecipitation(LARP)is a widely used method for cesium lead halide perovskite nanocrystals(NCs)synthesis.Nevertheless,the ultrafast kinetics of LARP,as well as the inefficient transport properties and discontinuity of batch reactors,challenge the particle size control and experimental repeatability.To address these issues,an ultrasonic cavitation-enabled microfluidic approach was developed to achieve the continuous synthesis of cesium lead halide perovskite via LARP.It was found that the mixing between the good solvent and antisolvent in the microchannel was greatly enhanced by intensive ultrasonic cavitation.The mixing time could be reduced to below 10 ms under the irradiation of 35 W ultrasound.By modulating the mixing degree,LARP was proved to be a mixing-sensitive process.The effects of ultrasonic power,ultrasonic treatment time,total flow rate,water additive,and reprecipitation temperature on the synthesis of CsPbBr_(3) NCs were systematically investigated.As compared to CsPbBr_(3) NCs synthesized in the batch reactor,the sample synthesized via the ultrasonic cavitation-enabled microfluidic approach possessed stronger photoluminescence intensity and better repeatability.Moreover,the ultrasonic cavitation-enabled microfluidic approach could also realize the continuous synthesis of cesium lead halide perovskite NCs with different halide compositions to cover a wide visible spectrum(426-661 nm).The ultrasonic cavitation-enabled microfluidic approach paved the way for the large-scale of high-quality cesium lead halide perovskite NCs. | Mingzhi Li Zhikai Liu Wang Yao Chao Xu Yangping Yu Mei Yang Guangwen Chen | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
| 12 | Interleukin 35 protects cardiomyocytes following ischemia/reperfusion-induced apoptosis via activation of mitochondrial STAT3显示文摘Mitochondrial reactive oxygen species(mtROS)-induced apoptosis has been suggested to contribute to myocardial ischemia/reperfusion injury.Interleukin 35(IL-35),a novel anti-inflammatory cytokine,has been shown to protect the myocardium and inhibit mtROS production.However,its effect on cardiomyocytes upon exposure to hypoxia/reoxygenation(H/R)damage has not yet been elucidated.The present study aimed to investigate the potential protective role and underlying mechanisms of IL-35 in H/R-induced mouse neonatal cardiomyocyte injury.Mouse neonatal cardiomyocytes were challenged to H/R in the presence of IL-35,and we found that IL-35 dose dependently promotes cell viability,diminishes mtROS,maintains mitochondrial membrane potential,and decreases the number of apoptotic cardiomyocytes.Meanwhile,IL-35 remarkably activates mitochondrial STAT3(mitoSTAT3)signaling,inhibits cytochrome c release,and reduces apoptosis signaling.Furthermore,co-treatment of the cardiomyocytes with the STAT3 inhibitor AG490 abrogates the IL-35-induced cardioprotective effects.Our study identified the protective role of IL-35 in cardiomyocytes following H/R damage and revealed that IL-35 protects cardiomyocytes against mtROS-induced apoptosis through the mitoSTAT3 signaling pathway during H/R. | Fengyun Zhou Ting Feng Xiangqi Lu Huicheng Wang Yangping Chen Qiuxia Zhang Xinlu Zhang Jiancheng Xiu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
| 13 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 14 | Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis显示文摘Dear Editor,To date,the effect of colorectal cancer(CRC)-derived extracellular vesicles(EVs)on liver pre-metastatic niche(PMN)remain incompletely understood.1 To investigate the role of CRC-derived EVs in the remodeling of the liver PMN,we isolated EVs from CT26 cell culture supernatant.The characteristics of EVs(the morphology,size,and markers)were identified by transmission electron microscopy(TEM),Nanoparticle Tracking Analysis(NTA),and western blotting(Supplementary Fig.S1a–e).Then,BALB/c mice with an intact liver immune status were pretreated with CRCderived EVs and phosphate-buffered saline(PBS)for one month,and a liver metastasis model was established via spleen injection of tumor cells to determine whether EVs influence liver metastasis(Fig.1a).Two hours after the operation,in vivo imaging indicated that the animal model was successfully established,and the tumor fluorescence intensity in the liver was consistent between the two groups(Supplementary Fig.S2a,b).Amazingly,the liver tumor fluorescence intensity in the EVs group was significantly stronger than that in the PBS group after 24 h(Fig.1b;Supplementary Fig.S2c,d).The number of liver tumor nodules in the EVs group was also significantly higher than that in the PBS group on day 4(Fig.1c;Supplementary Fig.S2e,f). | Xuyang Yang Yaguang Zhang Yang Zhang Huifang Li Li Li Yangping Wu Xiangzheng Chen Lei Qiu Junhong Han Ziqiang Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 15 | 2-7 Voltage Calibration and Energy Spread Measurement of 320 kV Platform at the Institute of Modern Physics显示文摘Four key reactions, 12C(, )13O, 13C(, n)16O, 25Mg(p, )26Al and 19F(p, )16O, will be studied for the first time within or near the astrophysical relevant energy regions (Gamow window) at Jinping Underground laboratory for Nuclear Astrophysics (JUNA)[1], which will take the advantage of the ultra-low background of China JinPing underground Laboratory (CJPL), high current accelerator based on ECR source and a highly sensitive detection system. | Wang Shuo Li Kuoang Xu Shiwei Ma Shaobo Tang Xiaodong Zhang Ningtao Su Jun Shen Yangping Chen Han Chen Zhijun Pei Changjin Zhu Hao Zhang Zirui Zhang Naibo Wang Shouyu | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | Photometric analysis of a blue straggler eclipsing binary in the old open cluster NGC 2141显示文摘To understand the formation mechanism of blue stragglers in open clusters, we conducted a photometric analysis for a blue straggler eclipsing binary in the old open cluster NGC 2141. By using the least square fitting of times of minima, we derived the ephemeris and redetermined the orbital period of this system to be 0.6227 d. We have also done a photometric analysis for light curve with the Wilson-Devinney Code (2003). The photometric solutions reveal a semi-detached binary with the secondary component filling its Roche lobe. The photometric mass ratio M2/M1 (secondary/primary) was determined to be 0.190±0.002 and the ratio of V-band luminosity L2/L1(V) is about 0.033±0.001, which indicates the secondary component is overluminous. Thus, this blue straggler likely results from a substantial mass exchange between these two components. | LUO YangPing WANG Bo CHEN HaiLiang ZHANG XiaoBin HAN ZhanWen | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员