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| 1 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 2 | Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling显示文摘 | Xiangzheng Chen Yangping Wu Yangfu Jiang Yan Zhou Yuxi Wang Yuqin Yao Cheng Yi Lantu Gou Jinliang Yang | 2012 | Journal of Molecular Medicine2012，，11： | 1 |
| 3 | Mod- eling goals and functions of micro gas turbine system by multilevel flow models显示文摘 | Zhou Yangping Yoshikawa H Wu Wei | 2006 | Information and Media Technologies2006，1，2： | 1 |
| 4 | Effect of manganese on the ferrum phases of B319 aluminum alloy in lost foam casting显示文摘1 .Introduction Lost foam casting (LFC) process represents an important milestone in development of new casting technology, and is called as an innovative technology for tomorrow. At present, many studies on aluminum alloy associated with LFC process mainly concentrate on the casting process itself and its coating, thermal residual transformation, | ~*Guohua WU~1, Min XIE~2 Yangping ZHU~1, Wenjiang DING~1 (1. School of materials, Shanghai Jiao Tong University, Shanghai 200030, P. R. China 2. School of Adult Education, Shanghai Jiao Tong University, Shanghai 200030, P. R. China) | 2004 | China Foundry2004，1，2： | 0 |
| 5 | Therapeutic potential of an anti-HER2 single chain antibody-DM1 conjugates for the treatment of HER2-positive cancer显示文摘Antibody–drug conjugates(ADCs)take the advantage of monoclonal antibodies to selectively deliver highly potent cytotoxic drugs to tumor cells,which have become a powerful measure for cancer treatment in recent years.To develop a more effective therapy for human epidermal growth factor receptor 2(HER2)-positive cancer,we explored a novel ADCs composed of anti-HER2 scFv–HSA fusion antibodies conjugates with a potent cytotoxic drug DM1.The resulting ADCs,T-SA1–DM1 and T-SA2–DM1(drug-to-antibody ratio in the range of 3.2–3.5)displayed efficient inhibition in the growth of HER2-positive tumor cell lines and the half-maximal inhibitory concentration on SKBR-3 and SKOV3 cells were both at the nanomolar levels in vitro.In HER2-positive human ovarian cancer xenograft models,T-SA1–DM1 and T-SA2–DM1 also showed remarkable antitumor activity.Importantly,three out of six mice exhibited complete remission without regrowth in the high-dose group of T-SA1–DM1.On the basis of the analysis of luminescence imaging,anti-HER2 scFv–HSA fusion antibodies,especially T-SA1,showed strong and rapid tumor tissue penetrability and distribution compared with trastuzumab.Collectively,the novel type of ADCs is effective and selective targeting to HER2-positive cancer,and may be a promising antitumor drug candidate for further studies. | Hang Zhang Yuxi Wang Yangping Wu Xiaohua Jiang Yiran Tao Yuqin Yao Yujia Peng Xiangzheng Chen Yuyin Fu Lin Yu Ruixue Wang Qinhuai Lai Weirong Lai Wenting Li Yuhuan Kang Shuli Yi Ying Lu Lantu Gou Min Wu Jinliang Yang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 6 | New Measurement of Thick Target Yield for Narrow Resonance at E_x=9.17MeV in (13)~C(p,γ)(14)~N Reaction显示文摘(13)^C(p,γ)(14)^N reaction is useful to study the evolution of stars in astrophysics,as it is one of the important process in the CNO(carbon-nitrogen-oxygen)cycle of nucleosynthesis.When the proton beam is accelerated to 1.747MeV,a narrow resonance with the radiation of high energyγray(9.17 MeV)will occur.Since integrated cross section is large and uniqueness to nitrogen,the 9.17MeV radiation is useful to study photonuclear reaction and detect nitrogenous explo-sives. | DANG Yongle WANG Naiyan GUO Bing HE Chuangye LIU Fulong FU Guangyong WU Di HAN Zhiyu SHEN Yangping | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 7 | Prediction of tree crown width in natural mixed forests using deep learning algorithm显示文摘Crown width(CW)is one of the most important tree metrics,but obtaining CW data is laborious and timeconsuming,particularly in natural forests.The Deep Learning(DL)algorithm has been proposed as an alternative to traditional regression,but its performance in predicting CW in natural mixed forests is unclear.The aims of this study were to develop DL models for predicting tree CW of natural spruce-fir-broadleaf mixed forests in northeastern China,to analyse the contribution of tree size,tree species,site quality,stand structure,and competition to tree CW prediction,and to compare DL models with nonlinear mixed effects(NLME)models for their reliability.An amount of total 10,086 individual trees in 192 subplots were employed in this study.The results indicated that all deep neural network(DNN)models were free of overfitting and statistically stable within 10-fold cross-validation,and the best DNN model could explain 69%of the CW variation with no significant heteroskedasticity.In addition to diameter at breast height,stand structure,tree species,and competition showed significant effects on CW.The NLME model(R^(2)=0.63)outperformed the DNN model(R^(2)=0.54)in predicting CW when the six input variables were consistent,but the results were the opposite when the DNN model(R^(2)=0.69)included all 22 input variables.These results demonstrated the great potential of DL in tree CW prediction. | Yangping Qin Biyun Wu Xiangdong Lei Linyan Feng | 2023 | Forest Ecosystems2023，10，3： | 0 |
| 8 | Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis显示文摘Dear Editor,To date,the effect of colorectal cancer(CRC)-derived extracellular vesicles(EVs)on liver pre-metastatic niche(PMN)remain incompletely understood.1 To investigate the role of CRC-derived EVs in the remodeling of the liver PMN,we isolated EVs from CT26 cell culture supernatant.The characteristics of EVs(the morphology,size,and markers)were identified by transmission electron microscopy(TEM),Nanoparticle Tracking Analysis(NTA),and western blotting(Supplementary Fig.S1a–e).Then,BALB/c mice with an intact liver immune status were pretreated with CRCderived EVs and phosphate-buffered saline(PBS)for one month,and a liver metastasis model was established via spleen injection of tumor cells to determine whether EVs influence liver metastasis(Fig.1a).Two hours after the operation,in vivo imaging indicated that the animal model was successfully established,and the tumor fluorescence intensity in the liver was consistent between the two groups(Supplementary Fig.S2a,b).Amazingly,the liver tumor fluorescence intensity in the EVs group was significantly stronger than that in the PBS group after 24 h(Fig.1b;Supplementary Fig.S2c,d).The number of liver tumor nodules in the EVs group was also significantly higher than that in the PBS group on day 4(Fig.1c;Supplementary Fig.S2e,f). | Xuyang Yang Yaguang Zhang Yang Zhang Huifang Li Li Li Yangping Wu Xiangzheng Chen Lei Qiu Junhong Han Ziqiang Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
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