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| 1 | Inuence of oxytetracycline on the structure and activity of microbial community in wheat rhizosphere soil显示文摘The microbial community composition in wheat rhizosphere was analyzed by detecting colony forming units (CFUs) in agar plates. The total CFUs in rhizosphere were 1.04 × 109/g soil with 9.0 × 108/g bacteria, 1.37 × 108/g actinomyces and 3.6 × 106/g fungi. The 10 dominant bacteria were isolated from wheat rhizosphere and were grouped into genus Bacillus according to their full length 16S rRNA gene sequences. Although belonging to the same genus, the isolated strains exhibited dierent sensitivities to oxytetracycline. When a series of the rhizosphere soil was exposed under various concentrations of oxytetracycline, the microbial community structure was highly aected with significant decline of CFUs of bacteria and actinomyces (22.2% and 31.7% at 10 mg/kg antibiotic, respectively). This inhibition was clearly enhanced with the increase exposure dosage of antibiotic and could not be eliminated during 30 d incubation. There was no obvious inuence of this treatment on fungi population. Among the four soil enzymes (alkaline phosphatase, acidic phosphatase, dehydrogenase and urease), only alkaline phosphatase was sensitive to oxytetracycline exposure with 41.3% decline of the enzyme activity at 10 mg/kg antibiotic and further decrease of 64.3%-80.8% when the dosage over 30 mg/kg. | YANG Qingxiang, ZHANG Jing, ZHU Kongfang, ZHANG Hao College of Life Sciences, Henan Normal University, Xinxiang 453007, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 36 |
| 2 | Application of Cellulose Nanofibril as a Wet-end Additive in Papermaking:A Brief Review显示文摘Recently,cellulose nanofibril(CNF)has emerged as a promising,sustainable reinforcement with outstanding potential in material science.Owing to the properties of CNF,it has been explored in food,cosmetic,and pharmaceutical applications,as well as in industrial applications such as paints,drill muds,packaging,and papermaking.The application of CNF in papermaking is expected to be implemented in the near future to broaden the commercial market of cellulose.Numerous studies and patents have reported on the manufacturing,properties,and applications of nanocellulose.This present paper focuses on the recent progresses in the application of CNF as a wet-end additive in papermaking. | Guihua Yang Guangrui Ma Ming He Xinxiang Ji Hye Jung Youn Hak Lae Lee Jiachuan Chen | 2020 | Paper And Biomaterials2020，5，2： | 9 |
| 3 | Some Uniqueness Results for a Class of Quasilinear Elliptic Eigenvalue Problems | Guo Zongming Yang Zuodong (Department of Mathematics,Henan Normal University,Xinxiang 453002,China) | 1998 | Acta Mathematica Sinica,English Series1998，14，2： | 7 |
| 4 | The New Synthesis of Azo Urea from Substituted Semicarbazide显示文摘Using N-bromosuccinimide and pridine as the 0xidation s}-stem to dehydrogenale anly substituted semicarbazide to form azo compounds is described for the firs1 time in this paper Nine azo conlpounds have been prepared in excellent lield under mild condition This method onle needs simple instrument and short reaction | Xiao Yang WANG Yu Lu WANG Jian Ping LI Cai ’Lan W’ANG Hong WANG (Department of Chemistry ,Henan Normal University Xinxiang 453002 ) | 1997 | Chinese Chemical Letters1997，8，6： | 5 |
| 5 | Two hydroxypyruvate reductases encoded by OsHPR1 and OsHPR2 are involved in photorespiratory metabolism in rice显示文摘Mutations in the photorespiration pathway display a lethal phenotype in atmospheric air,which can be fully recovered by elevated CO2.An exception is that mutants of peroxisomal hydroxypyruvate reductase(HPR1)do not have this phenotype,indicating the presence of cytosolic bypass in the photorespiration pathway.In this study,we constructed overexpression of the OsHPR1 gene and RNA interference plants of OsHPR1 and OsHPR2 genes in rice(Oryza sativa L.cv.Zhonghua 11).Results from reverse transcription-polymerase chain reaction(RT-PCR),Western blot,and enzyme assays showed that HPR1 activity changed significantly in corresponding transgenic lines without any effect on HPR2 activity,which is the same for HPR2.However,metabolite analysis and the serine glyoxylate aminotransferase(SGAT)activity assay showed that the metabolitefiux of photorespiration was disturbed in RNAi lines of both HPR genes.Furthermore,HPR1 and HPR2proteins were located to the peroxisome and cytosol,respectively,by transient expression experiment.Double Research mutant hpr1 hpr2 was generated by crossing individual mutant of hpr1 and hpr2.The phenotypes of all transgenic lines were determined in ambient air and CO2-elevated air.The phenotype typical of photorespiration mutants was observed only where activity of both HPR1 and HPR2 were downregulated in the same line.Thesefindings demonstrate that two hydroxypyruvate reductases encoded by OsHPR1and OsHPR2 are involved in photorespiratory metabolism in rice. | Nenghui Ye Guozhen Yang Yan Chen Chan Zhang Jianhua Zhang Xinxiang Peng | 2014 | Journal of Integrative Plant Biology2014，56，2： | 2 |
| 6 | An Efficient Solid-State Synthesis of N-Aryl-2-phenyldiazenecarboxamides显示文摘A new and efficient solid-state reaction using K3Fe(CN)6/KOH to oxidize diaryl semicarbazides for preparing azo compounds has been reported. Nine N-aryl-2-phenyl-diazenecarboxamides have been synthesized in excellent yields with simple instrument. | Jian Ping LI1*, Qian Fu LUO1, Yi Yang SHEN2, Yu Lu WANG1, Hong WANG1 1College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453002 2Department of Chemistry, Luoyang Teacher’s College, Luoyang 471000 | 2001 | Chinese Chemical Letters2001，12，2： | 2 |
| 7 | Lepton flavor violating Z-boson decays at GigaZ as a probe of supersymmetry显示文摘This paper briefly reviews the lepton flavor violating Z-decays at GigaZ as a probe of supersymmetry by focusing on Z → i j in two representative supersymmetric models: the minimal supersymmetric model without R-parity and the supersymmetric seesaw model.The work concludes that under the current experimental constraints from LEP and i → j γ,these rare decays can still be enhanced to reach the sensitivity of the GigaZ.Therefore,supersymmetry can be probed via these decays at GigaZ. | YANG JinMin 1,2 1 Department of Physics,Henan Normal University,Xinxiang 453007,China 2 Institute of Theoretical Physics,Chinese Academy of Sciences,Beijing 100190,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 1 |
| 8 | Synthesis of three-dimensional hierarchical cobalt hydroxide microstructures显示文摘β-Co(OH)2 with three-dimensional (3-D) structures was prepared by a simple hydrothermal method. It was found that the amount of cetyltrimethylammonium bromide (CTAB), the pH value, and the reaction time all had an important influence on the formation of this morphology. The products were characterized by X-ray diffraction, energy-dispersive X-ray analysis, and scanning electron microscopy. A possible mechanism of the formation of the 3-D microstructures of β-Co(OH)2 was proposed. | SONG XuChun1, ZHAO Yang2, ZHENG YiFan3, YANG E1 & LIU ZhiSheng1 1Institute of Physical Chemistry, Department of Chemistry, Fujian Normal University, Fuzhou 350007, China 2Department of Chemistry, Henan Normal University, Xinxiang 453007, China 3College of Chemical Engineering & Materials Science, Zhejiang University of Technology, Hangzhou 310014, China | 2010 | Science China Chemistry2010，53，4： | 1 |
| 9 | Partition airflow varying features of chaos-theory-based coalmine ventilation system and related safety forecasting and forewarning system显示文摘To realize real-time monitoring and short-term forecasting and forewarning of coalmine ventilation systems(CVS), in this paper, we first established a joint surface and underground CVS safety management system consisting of main ventilation fan, safety-partition linked passageways, and air-required locations. We then applied chaos theory to identify the air quantity and gas concentration of underground partition boundaries, and adopted a fixed data quantity, multi-step progressive, weighted first-order local-domain method to setup a chaos prediction model and a CVS safety forecasting and forewarning system formed by the normal change level, orange forewarning level, and red alarm level. We next conduct the on-field application of the system in a coalmine in Jining, Shandong, China. The results showed that (1) in the statistical scale of 5 min, the changes in both air quantity and gas concentration along CVS partition airflow boundaries were characteristic of chaos and could be used for short-term chaos prediction, and the latter was more chaotic than the former;(2) the setup chaos prediction model had a higher prediction precision and the established safety prediction system could not only predict the variation in CVS stability but also reflect the rationality of underground mining intensity. Thus, this CVS safety forecasting and forewarning system is of better application value. | Zhang Xiaoqiang Cheng Weimin Zhang Qin Yang Xinxiang Du Wenzhou | 2017 | International Journal of Mining Science and Technology2017，27，2： | 1 |
| 10 | Developing an efficient and visible prime editing system to restore tobacco 8-hydroxy-copalyl diphosphate gene for labdane diterpene Z-abienol biosynthesis显示文摘Prime editing(PE)is a versatile CRISPR-Cas based precise genome-editing platform widely used to introduce a range of possible base conversions in various organisms.However,no PE systems have been shown to induce heritable mutations in tobacco,nor in any other dicot.In this study,we generated an efficient PE system in tobacco that not only introduced heritable mutations,but also enabled anthocyanin-based reporter selection of transgene-free T_(1) plants.This system was used to confer Zabienol biosynthesis in the allotetraploid tobacco cultivar HHDJY by restoring a G>T conversion in the NtCPS2 gene.High levels of Z-abienol were detected in the leaves of homozygous T_(1) plants at two weeks after topping.This study describes an advance in PE systems and expands genome-editing toolbox in tobacco,even in dicots,for use in basic research and molecular breeding.And restoring biosynthesis of Z-abienol in tobacco might provide an efficient way to obtain Z-abienol in plants. | Jianduo Zhang Lu Zhang Chengwei Zhang Yongxing Yang Huayin Liu Lu Li Shengxue Zhang Xianggan Li Xinxiang Liu Ya Liu Jin Wang Guangyu Yang Qingyou Xia Weiguang Wang Jinxiao Yang | 2023 | Science China(Life Sciences)2023，66，12： | 1 |
| 11 | Studies of binding constants and interaction of drugs to trans-activation response RNA by capillary electrophoresis显示文摘 | Ding Li Zhang XinXiang Chang WenBao Lin Wei Yang Ming | 2005 | Analytica Chimica Acta2005，543，： | 1 |
| 12 | SYNTHESIS AND CHARACTERIZATION OF AMINO-ACID SCHIFF BASE AND ITS GERMANIUM COMPLEX显示文摘SYNTHESISANDCHARACTERIZATIONOFAMINO-ACIDSCHIFFBASEANDITSGERMANIUMCOMPLEX￥DongMaICAI;WuJuLI;LinYANG;QuanLing;ZanSHI;(Departmen... | Dong MaI CAI Wu Ju LI Lin YANG Quan Ling Zan SHI (Department of Chemistry, Henan Normal University, Xinxiang, 453002)Kun Hua LIN (Henan fortitute of Chemietry. Zhengzhou, 450003) | 1994 | Chinese Chemical Letters1994，5，2： | 0 |
| 13 | PROX1 restrains ferroptosis via SCD transcription activation in colorectal cancer显示文摘Colorectal cancer(CRC)is one of the most commonly diagnosed cancers and the second most common cause of cancer-related mortality worldwide.Although several therapeutic approaches have been developed for CRC in recent years,the prognosis of patients who develop chemotherapy resistance remains poor.Ferroptosis is an iron and lipid reactive oxygen species(ROS)-dependent form of programmed cell death,and it is distinct from other forms of regulatory cell death at multiple levels[1].Ferroptosis is regulated by a complex network and is a research hotspot as a promising therapeutic target in human cancers. | Ruoxin Zhang Dakui Luo Zezhi Shan Yufei Yang Yi Qin Qingguo Li Xinxiang Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，4： | 0 |
| 14 | circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer显示文摘Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer cells.Accumulating evidence has revealed that circRNAs play a critical role in the progression of several cancers,including colorectal cancer(CRC).However,the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still limited.Here,we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and tumorigenesis.Methods:circRNA microarray was performed with three pairs of tumor and non-tumor tissues from CRC patients.The expression of circRNAs were determined by quantitative PCR(qPCR)and in situ hybridization(ISH).The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing circRNAs.The regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array,RNA pull-down/mass spectrometry,RNA immunoprecipitation assay,luciferase reporter assay,chromatin immunoprecipitation analysis,and fluorescence in situ hybridization(FISH).Results:Among circRNAs,circCAPRIN1 was most significantly upregulated in CRC tissue specimens.circCAPRIN1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC patients.Downregulation of circCAPRIN1 suppressed proliferation,migration,and epithelial-mesenchymal transition of CRC cells,while circCAPRIN1 overexpression had opposite effects.RNA sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid metabolism.Moreover,circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1(ACC1)expression.Further mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2(STAT2)to activate ACC1 transcription,thus regulating lipid metabolism and facilitating CRC tumorigenesis.Conclusions:These findings revealed the oncogenic role and mechanism of circCAPRIN1 in CRC.circCAPRIN1 interacted with STAT2 to promote CRC tumor progression and lipid synthesis by enhancing the expression of ACC1.circCAPRIN1 may be considered as a novel potential diagnostic and therapeutic target for CRC patients. | Yufei Yang Dakui Luo Yang Shao Zezhi Shan Qi Liu Junyong Weng Weijing He Ruoxin Zhang Qingguo Li Ziliang Wang Xinxiang Li | 2023 | Cancer Communications2023，43，1： | 0 |
| 15 | CARATHEODORY INEQUALITY FOR ANALYTIC OPERATOR FUNCTION显示文摘Suppose H is a complex Hilbert space, A H(Δ) denotes the set of all analytic operator functions on Δ, and the set N H(Δ)={f(z)|f(z) is an analytic operator function on the open uint disk Δ, f(z)f(w)=f(w)f(z),f *(z)f(z)=f(z)f *(z),z,w∈Δ}. The note proves that if f(z)∈N H(Δ),(or A H(Δ))‖f(z)‖≤1,z∈Δ then‖f′(T)‖≤(1-‖T‖ 2) -1 ‖I-f *(T)f(T)‖ 12 ‖I-f(T)f *(T)‖ 12 , where T∈L(H)(orT *T=TT *,respectively),‖T‖<1,Tf=fT. | Yang Changsenof Math., Henan Normal Univ., Xinxiang 453002. | 2001 | Applied Mathematics(A Journal of Chinese Universities)2001，16，3： | 0 |
| 16 | ppGpp is present in,and functions to regulate sleep of,Drosophila显示文摘Sleep is essential for animals,and receives inputs from circadian,homeostasis,and environment,yet the mechanisms of sleep regulation remain elusive.Discovery of molecules in living systems and demonstration of their functional roles are pivotal in furthering our understanding of the molecular basis of biology.Here,we report that guanosine-50-diphos-phate,30-diphosphate(ppGpp)is present in Drosophila,and plays an important role in regulation of sleep and starvation-induced sleep loss(SISL).ppGpp is detected in germ-free Drosophila and hydrolyzed by an enzyme encoded by the mesh1 gene in Drosophila.Nighttime sleep and SISL were defected in mesh1 mutant flies,and rescued by expression of wildtype Mesh1,but not the enzymatically defective mutant Mesh1E66A.Ectopic expression of RelA,the Escherichia coli synthetase for ppGpp,phenocopied mesh1 knockout mutants,whereas overexpression of Mesh1 resulted in the opposite phenotypes,supporting that ppGpp is both necessary and sufficient in sleep regulation.A chemo connectomic screen followed by genetic intersection experiments implicates the Dilp2 neurons in the pars intercerebralis(PI)brain region as the site of ppGpp function.Our results have thus validated the presence of ppGpp in Drosophila and revealed a physiological role of ppGpp in sleep regulation for the first time. | Xihuimin Dai Wei Yang Xiaohui Zhang Enxing Zhou Renbo Mao Ying Liu Tao Wang Wenxia Zhang Xinxiang Zhang Yi Rao | 2023 | hLife2023，1，2： | 0 |
| 17 | Chinese guidelines for the application of colon cancer staging recognition systems based on artificial intelligence platforms (2021)显示文摘The incidence and mortality of colon cancer in China are increasing each year.At present,treatment selection for colon cancer patients mainly depends on imaging results,which require a large number of radiologists to interpret.In China,there is a shortage and uneven distribution of experienced radiologists,which leads to delays and bias in the evaluation of imaging data.Based on these considerations,the Colorectal Surgery Group of the Surgery Branch of the Chinese Medical Association in collaboration with experts at Beihang University has independently developed an artificial intelligence(AI)-based recognition system for the preoperative determination of colon cancer stage to partially replace the work of and relieve the pressure on radiologists.These guidelines aim to standardize the use of AI-based recognition systems in the preoperative staging of colon cancer and guide their clinical application. | Yun Lu Shuai Li Yuan Gao Yong Dai Bo Feng Fanghai Han Jiagang Han Jingjing He Xinxiang Li Guole Lin Qian Liu Guiying Wang Quan Wang Zhenning Wang Zheng Wang Aiwen Wu Bin Wu Yingchi Yang Hongwei Yao Wei Zhang Jianping Zhou Aimin Hao Zhongtao Zhang 无 | 2021 | Intelligent Medicine2021，1，1： | 0 |
| 18 | APPLICATIONS OF FAST SIMULATED ANNEALING IN NEURAL NETWORKS显示文摘APPLICATIONSOFFASTSIMULATEDANNEALINGINNEURALNETWORKS￥YiLinCAO;QingZhang;LUShu;TingYANG(DepartmentofChemistry,HenanNormalUnive... | Yi Lin CAO Qing Zhang LU Shu Ting YANG(Department of Chemistry, Henan Normal University, Xinxiang, 453002)Hong Lin LIU(Shanghai Institute of Mentallurgy, Academia Sinica, Shanghai, 200050) | 1996 | Chinese Chemical Letters1996，7，4： | 0 |
| 19 | ION NEUTRALIZATION AT THE SURFACE OF A CONTAMINATED COMPOSITE SYSTEM显示文摘1INTRODUCTIONGrowinginteresthasbeendevotedtothestudyofsupported-metalcompositesystemsinceaspecificbehavioristobeexpectedfromt... | Yang Zongxian Wei Shuyi Zhang TaoDepartment of Physics, Henan Normal University Xinxiang 453002 | 1998 | 原子与分子物理学报1998，15，S1： | 0 |
| 20 | Performance of the suspension method in large cross-section shallow-buried tunnels显示文摘Large cross-section tunnel construction induces ground surface settlements, potentially endangering both subterranean projects and nearby above-ground structures. A novel tunnel construction method, known as the suspension method,is introduced in this paper to mitigate surface settlement. The suspension method employs vertical tie rods to establish a structural connection between the initial tunnel support system and the surface steel beam, thereby exerting effective control settlements. To analyze the performance of the proposed method, systematic numerical simulations were conducted based on the practical engineering of Harbin Subway Line 3. The surface settlement and vault settlement characteristics during construction are investigated. The results show a gradual increment in both surface and vault settlement throughout the construction process, culminating in a stabilized state upon the completion of construction.In addition, compared to the double-side drift method and the Cross Diaphragm Method(CRD) method, the suspension method can obviously reduce the surface settlement and vault settlement. Moreover, the surface settlements and the axial force of tie rods were continuously monitored during the construction process at the trial tunnel block.These specific monitoring measurements are illustrated in comparison to numerical analysis results. The monitored results show great agreement with the numerical predictions, confirming the success of the project. This research can serve as a valuable practical reference for similar projects, offering insights and guidance for addressing ground surface settlements and enhancing construction safety in the domain of large cross-section tunneling. | Guoqing Cai Xinxiang Zou Qiang Zhang Rui Yang Tianchi Wu Jiguang Li | 2023 | High-Speed Railway2023，1，4： | 0 |
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