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| 1 | Short Texts Classification Through Reference Document Expansion显示文摘With the rapid development of information technology, short texts arising from socialized human interaction are gradually predominant in network information streams. Accelerating demands are requiring the industry to provide more effective classification of the brief texts.However, faced with short text documents, each of which contains only a few words, traditional document classification models run into difficulty. Aggressive documents expansion works remarkably well for many cases but suffers from the assumption of independent, identically distributed observations. We formalize a view of classification using Bayesian decision theory, treat each short text as observations from a probabilistic model, called a statistical language model, and encode classification preferences with a loss function defined by the language models and the external reference document. According to Vapnik's methods of Structural risk minimization(SRM), the optimal classification action is the one that minimizes the structural risk, which provides a result that allows one to trade off errors on the training sample against improved generalization performance. We conduct experiments by using several corpora of microblog-like data, and analyze the experimental results. With respect to established baselines,results of these experiments show that applying our proposed document expansion method produces better chance to achieve the improved classification performance. | YANG Zhen FAN Kefeng LAI Yingxu GAO Kaiming WANG Yong | 2014 | Chinese Journal of Electronics2014，23，2： | 11 |
| 2 | The resurgent landscape of xenotransplantation of pig organs in nonhuman primates显示文摘Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation.Genetically engineered pigs have been discussed as a potential alternative to allogeneic donor organs.Although xenotransplantation of pig-derived organs in nonhuman primates(NHPs)has shown sequential advances in recent years,there are still underlying problems that need to be completely addressed before clinical applications,including(i)acute humoral xenograft rejection;(ii)acute cellular rejection;(iii)dysregulation of coagulation and inflammation;(iv)physiological incompatibility;and(v)cross-species infection.Moreover,various genetic modifications to the pig donor need to be fully characterized,with the aim of identifying the ideal transgene combination for upcoming clinical trials.In addition,suitable pretransplant screening methods need to be confirmed for optimal donor-recipient matching,ensuring a good outcome from xenotransplantation.Herein,we summarize the understanding of organ xenotransplantation in pigs-to-NHPs and highlight the current status and recent progress in extending the survival time of pig xenografts and recipients.We also discuss practical strategies for overcoming the obstacles to xenotransplantation mentioned above to further advance transplantation of pig organs in the clinic. | Xuan Zhang Quancheng Wang Jingjun Zhao Xiao Li Wei Peng Zhaoxu Yang Zhibin Lin Long Yang Rui Ding Kaishan Tao Kefeng Dou | 2021 | Science China(Life Sciences)2021，64，5： | 10 |
| 3 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 4 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 5 | A Multifunctional Anti-Proton Electrolyte for High-Rate and Super-Stable Aqueous Zn-Vanadium Oxide Battery显示文摘Large volumetric expansion of cathode hosts and sluggish transport kinetics in the cathode–electrolyte interface,as well as dendrite growth and hydrogen evolution at Zn anode side are considered as the system problems that cause the electrochemical failure of aqueous Zn-vanadium oxide battery.In this work,a multifunctional anti-proton electrolyte was proposed to synchronously solve all those issues.Theoretical and experimental studies confirm that PEG 400 additive can regulate the Zn^(2+) solvation structure and inhibit the ionization of free water molecules of the electrolyte.Then,smaller lattice expansion of vanadium oxide hosts and less associated by-product formation can be realized by using such electrolyte.Besides,such electrolyte is also beneficial to guide the uniform Zn deposition and suppress the side reaction of hydrogen evolution.Owing to the integrated synergetic modifica-tion,a high-rate and ultrastable aqueous Zn-V_(2)O_(3)/C battery can be constructed,which can remain a specific capacity of 222.8 m Ah g^(-1)after 6000 cycles at 5 A g^(-1),and 121.8 m Ah g^(-1) even after 18,000 cycles at 20 A g^(-1),respectively.Such“all-in-one”solution based on the electrolyte design provides a new strategy for developing high-performance aqueous Zn-ion battery. | Yangwu Chen Dingtao Ma Kefeng Ouyang Ming Yang Sicheng Shen Yanyi Wang Hongwei Mi Lingna Sun Chuanxin He Peixin Zhang | 2022 | Nano-Micro Letters2022，14，9： | 3 |
| 6 | A Blockchain-Based Flexible Data Auditing Scheme for the Cloud Service显示文摘Nowdays, cloud storage technology has become a hot topic, and an increasing number of users are concerned with the security of their data in the cloud.Many auditing schemes on the cloud are proposed and the introduction of a third-party auditor to assist users in verifying the integrity of cloud data. As a centralized node, the third-party auditor has to communicate with all cloud users and cloud service providers, which becomes the bottleneck of the whole scheme. To solve this problem,we design a blockchain-based flexible cloud data auditing scheme. In our scheme, a decentralized auditing framework is proposed to eliminate the dependency on the thirdparty auditor, which increases the stability, security and performance of the whole scheme. Since the cloud service provider can automatically generates auditing proofs, our scheme can relieve the communication burdens of the cloud service provider. The proposed scheme also adapts the Merkle Hash tree to improve the verification performance.Security analysis and experiments show that the proposed scheme is secure and has better stability and verification efficiency. | FAN Kefeng LI Fei YU Haiyang YANG Zhen | 2021 | Chinese Journal of Electronics2021，30，6： | 3 |
| 7 | Efficacy of rigosertib, a small molecular RAS signaling disrupter for the treatment of KRAS-mutant colorectal cancer显示文摘Objective:Mutant KRAS,the principal isoform of RAS,plays a pivotal role in the oncogenesis of colorectal cancer by constitutively activating the RAF/MEK/ERK and PI3K/AKT pathways.Effective targeted therapies are urgently needed.We investigated whether rigosertib,a benzyl styryl sulfone RAS signaling disruptor,could selectively kill KRAS-mutant colorectal cancer cells.Methods:CCK-8 was used to determine the cell viability.Patient-derived tumor and cancer cell xenograft models were used to detect the inhibitory efficacy of rigosertib.Flow cytometry was used to evaluate the apoptosis and cell cycle progression.Apoptosis and cell cycle arrest markers were detected by Western blot.DCFH-DA was used to determine the reactive oxygen species.Immunohistochemistry staining and Western blot were performed to characterize RAS signaling markers in colorectal cancer tissues and cells.Results:Rigosertib(RGS)exhibited a cytotoxic effect against colorectal cancer cells,which was greater in KRAS-mutant cells.Furthermore,RGS induced mitotic arrest and oxidative stress-dependent apoptosis in KRAS-mutant DLD1 and HCT116 cells.Besides,RGS disrupted RAS signaling,and the inhibition of RAS/MEK/ERK was independent of cellular oxidative stress.Using patient-derived xenograft models,the response and tumor inhibition of RGS were significantly higher in the KRAS-mutant subgroup,while p-MEK,p-ERK,and p-AKT levels of RGS-treated tumors were significantly decreased.Finally,in a KRAS-mutant,chemotherapy-resistant patient-derived xenograft model,RGS showed a stronger therapeutic effect than the combination standard therapy involving fluoropyrimidine+oxaliplatin/irinotecan+bevacizumab.Conclusions:These data showed that targeting RAS signaling using RGS could be a therapeutic treatment for KRAS-mutant colorectal cancer patients. | Xinyi Zhou Qian Xiao Dongliang Fu Haochen Zhang Yang Tang Jinjie He Yeting Hu Xiangxing Kong Fei Teng Xiangrui Liu Ying Yuan Kefeng Ding | 2022 | Cancer Biology & Medicine2022，19，2： | 2 |
| 8 | Suggestions on the Effective Development of Shale Gas in China显示文摘Shale gas is a practical resource with great potential that could be economically explored and developed in the near future. It has been commercially developed in North America and other places. Featuring a vast distribution, a low abundance,unfavorable reservoir conditions, ultra-low permeability and a fast production decline, shale gas is more difficult to develop than conventional natural gas, as it needs advanced drilling and completion technology to develop. During the early stage of shale gas exploration and development, the United States offered enterprises necessary incentives such as tax reductions and exemptions and subsidies to achieve sustainable shale gas development and encourage technological progresses. By comparing the state of China's shale gas development with that of the US' in terms of geological conditions, production technology,market price, tax relief, subsidy periods and amount, this paper intends to put forward related suggestions for the effective development of shale gas according to the current status of development. | Cao Yan Yang Kefeng Jing Keyao Hu Yan | 2018 | China Oil & Gas2018，25，4： | 2 |
| 9 | Text Dimensionality Reduction with Mutual Information Preserving Mapping显示文摘With the explosion of information,it is becoming increasingly difficult to get what is really wanted.Dimensionality reduction is the first step in efficient processing of large data.Although dimensionality can be reduced in many ways,little work has been done to achieve dimensionality reduction without changing the inner semantic relationship among high dimension data.To remedy this problem,we introduced a manifold learning based method,named Mutual information preserving mapping(MIPM),to explore the low-dimensional,neighborhood and mutual information preserving embeddings of highdimensional inputs.Experimental results show that the proposed method is effective for the text dimensionality reduction task.The MIPM was used to develop a temporal summarization system for efficiently monitoring the information associated with an event over time.With respect to the established baselines,results of these experiments show that our method is effective in the temporal summarization. | YANG Zhen YAO Fei FAN Kefeng HUANG Jian | 2017 | Chinese Journal of Electronics2017，26，5： | 2 |
| 10 | Percentile-based Neighborhood Precipitation Verification and Its Application to a Landfalling Tropical Storm Case with Radar Data Assimilation显示文摘The traditional threat score based on fixed thresholds for precipitation verification is sensitive to intensity forecast bias.In this study, the neighborhood precipitation threat score is modified by defining the thresholds in terms of the percentiles of overall precipitation instead of fixed threshold values. The impact of intensity forecast bias on the calculated threat score is reduced. The method is tested with the forecasts of a tropical storm that re-intensified after making landfall and caused heavy flooding. The forecasts are produced with and without radar data assimilation. The forecast with assimilation of both radial velocity and reflectivity produce precipitation patterns that better match observations but have large positive intensity bias.When using fixed thresholds, the neighborhood threat scores fail to yield high scores for forecasts that have good pattern match with observations, due to large intensity bias. In contrast, the percentile-based neighborhood method yields the highest score for the forecast with the best pattern match and the smallest position error. The percentile-based method also yields scores that are more consistent with object-based verifications, which are less sensitive to intensity bias, demonstrating the potential value of percentile-based verification. | ZHU Kefeng YANG Yi Ming XUE | 2015 | Advances in Atmospheric Sciences2015，32，11： | 2 |
| 11 | Expert consensus on split-liver transplantation显示文摘With the dawn of organ donation after a citizen's death in China,the use of split-liver transplantation(SLT)can effectively increase the source of donor liver,reduce the waiting time for organ transplantation in patients,and particularly solve the problem of organ shortage in children.In recent years,many transplantation centers have been performing SLT to varying degrees and efficacy.At the current stage,the experiences of countries with advanced transplantation techniques should be used to establish an SLT consensus that is suitable for China to further increase the ratio and efficacy of SLT.In this paper,we combined expert experiences to generate an SLT expert consensus that included donor and donor liver evaluation,recipient selection criteria,donor and recipient matching,selection of splitting form and tools,blood vessels and bile ducts dissection and allocation,perioperative management of SLT,and organ allocation. | Operative Surgical Group,Branch of Surgery of Chinese Medical Association Transplantation Group,Branch of Surgery of Chinese Medical Association Guihua Chen Kefeng Dou Yang Yang Shuhong Yi Qing Yang | 2021 | Liver Research2021，5，1： | 2 |
| 12 | Prevalence of diabetes among men and women in China显示文摘 | Sunhu Yang Kefeng Dou Wenjie Song | 2010 | The New England Journal of Medicine2010，362，： | 1 |
| 13 | A two-dimensional spectrum for general bistatic SAR processing显示文摘 | YANG Kefeng HE Feng LIANG Diannong | 2010 | IEEE Geosci Remote Sens Lett2010，7，10： | 1 |
| 14 | Simultaneous increase in conductivity and Seebeck coefficient in a polyaniline/graphene nanosheets thermoelectric nanocomposite显示文摘 | Yong Du Shirley Z. Shen Weidong Yang Richard Donelson Kefeng Cai Philip S. Casey | 2011 | Synthetic Metals2011，，23： | 1 |
| 15 | Predictability and skill of convection-permitting ensemble forecast systems in predicting the record-breaking“21·7”extreme rainfall event in Henan Province,China显示文摘During 19–21 July 2021,an extreme rainfall event occurred in Henan Province,China,during which a recordbreaking maximum hourly rainfall of 201.9 mm was recorded in Zhengzhou at 09 UTC July 20.In this study,the predictability of this extreme rainfall event is investigated using two convection-permitting ensemble forecast systems(CEFSs):one initialized from NCEP GEFS(named CEFS_GEFS)and the other initialized from time-lagged ERA5 data(named CEFS_ERA).Both are able to reproduce the daily heavy rainfall along the Taihang Mountains,but most members have significant position biases for the extreme rainfall in Zhengzhou.For the hourly rainfall,a few members are able to capture the evolution and propagation of extreme rainfall.However,all ensemble members underestimate the extreme hourly rainfall and have position errors of a few tens to a few hundreds of kilometers.Such results suggest that the predictability of the extreme hourly rainfall at the accuracy of city scale in Zhengzhou is low,especially by deterministic forecasting models,and the occurrence of the extreme requires many favorable conditions to happen simultaneously.In terms of the Brier score,CEFS_GEFS performs better than CEFS_ERA.The latter lacks spread,especially in regions with scarce rain,resulting in less dispersion in precipitation distributions and larger probability forecast error.When a neighborhood is applied,the probability of precipitation(POP)is significantly increased over Zhengzhou.While the traditional POP shows almost no skill for hourly rainfall≥25 mm h-1,the neighborhood POP significantly improves the forecast skill score,for both daily and hourly rainfall,suggesting higher predictability when spatial error among the ensemble members is allowed. | Kefeng ZHU Chenyue ZHANG Ming XUE Nan YANG | 2022 | Science China Earth Sciences2022，65，10： | 1 |
| 16 | A two-dimensional spectrum for general bistatic SAR processing 显示文摘 | YANG Kefeng HE Feng LIANG Diannong | 2010 | IEEE Geosci Remote Sens Lett2010，7，10： | 1 |
| 17 | Prevalence of diabetes among men and women in China显示文摘 | Sunhu Yang Kefeng Dou Wenjie Song | 2010 | the New England Journal of Medicine2010，362，： | 1 |
| 18 | Towards better coordination of the supply chain 显示文摘 | Xu Kefeng Dong Yang Evers P T | 2001 | Transportation Research part E2001，37，2： | 1 |
| 19 | Altitudinal movements of Guizhou snub-nosed monkeys(Rhinopithecus brelichi)in Fanjingshan National Nature Reserve,China:implications for conservation management of a flagship species显示文摘 | Niu Kefeng Tan C L Yang Yeqin | | 0，，04： | 1 |
| 20 | Into the night:camera traps reveal nocturnal activity in a presumptive diurnal primate,Rhinopithecus brelichi显示文摘 | Tan C L Yang Yeqin Niu Kefeng | | 0，，01： | 1 |
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