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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform显示文摘我们以前报导了人的 ACAT1 基因通过从染色体抄录的二不连续的 RNA 处理的 interchromosomal 生产妄想的 mRNA 1 和 7。妄想的 mRNA 把 AUG1397-1399 和 GGC1274-1276 用作翻译开始 codons 分别地,与在人的房间是确实地在场的后者生产正常 50-kDa ACAT1 和新奇酶地活跃的 56-kDa isoform,包括人的导出单核白血球的巨噬细胞。在这个工作,我们报导位于 GGC1274-1276 codon 的附近的 RNA 第二等的结构为 56-kDa isoform 的生产被要求。三预言的茎环(nt 1255-1268, 1286-1342 和 1355-1384 ) 的效果被 transfecting 表示 plasmids 个别地测试进包含的房间野类型,删除或变异的茎环序列连接了到一个部分 ACAT1 8 月开的读物框架(ORF ) 或到另外的基因的 ORF。表示模式被西方的污点分析监视。我们发现从染色体 7 的在上游的 stem-loop1255-1268 和从染色体 1 的下游的 stem-loop1286-1342 为 56-kDa isoform 的生产被需要,而从染色体 1 的最后 stem-loop1355-1384 是非必需的。用有一个稳定的发卡的 monocistronic 和 bicistronic 向量的实验的结果证明从 GGC1274-1276 codon 的那翻译开始被一个内部核糖体入口地点(怒火) 调停。进一步的实验表明从 GGC1274-1276 codon 的那翻译开始要求在上游的组成 AU 的 RNA 第二等的结构和下游地 GC 富有的结构。这个机械学的工作为人的 ACAT1 抄本的妄想的性质的生物意义提供进一步的支持。 | Jia Chen Xiao-Nan Zhao Li Yang Guang-Jing Hu Ming Lu Ying Xiong Xin-Ying Yang Catherine CY Chang Bao-Liang Song Ta-Yuan Chang Bo-Liang Li | 2008 | Cell Research2008，18，9： | 5 |
| 3 | Single oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate显示文摘 | Yang JL Wang LC Chang CY | 1999 | Environmental and molecular mutagenesis1999，33，： | 2 |
| 4 | The Jnk-1 and Jnk-2 protein kinases are required for regional specific apoptosis during early brain development显示文摘 | Kuan CY Yang DD Samanta Roy DR | 1999 | Neuron1999，22，3： | 1 |
| 5 | Prophylactic vertebroplasty may reduce the risk of adjacent intact vertebra from fatigue injury:an ex vivo biomechanical study显示文摘 | Chiang CK Wang YH Yang CY | 2009 | Spine (Phila Pa 1976)2009，34，： | 1 |
| 6 | Preparation of macroporous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives显示文摘 | Lin HR Kuo CJ Yang CY | 2002 | J Biomed Mater Res2002，63，3： | 1 |
| 7 | Pyogenic liver abscess in Taiwan: emphasis on gas-forming liver abscess in diabetics显示文摘 | Yang CC Chen CY Lin XZ | 1993 | Am J Gastroenterol1993，88，11： | 1 |
| 8 | Absence of excitotoxicity - induced apoptosis in the hippocampus of mice lacking the Jnk3 gene 显示文摘 | Yang DD Kuan CY Whitmarsh A J | 1997 | Nature1997，389，6653： | 1 |
| 9 | Singlet oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate 显示文摘 | YANG JL WANG LC CHANG CY | 1999 | Environ Mol Mutagen1999，33，3： | 1 |
| 10 | Effect of grape genotype and tissue type on callus growth and production of resve- ratrols and their piceids after UV-C irradiation显示文摘 | Liu W Liu CY Yang CX | 2010 | Food Chem2010，122，： | 1 |
| 11 | Determination of multi- residue for malachite green, gentian violet and their metabolites in aquatic products by high-performance liquid chromatography cou- pled with molecularly imprinted solid-phase extraction 显示文摘 | LONG CY MAI Z B YANG Y F | 2009 | Jour- nal of Chromatography A2009，1216，： | 1 |
| 12 | Early identification of lepto- spirosis as an ignored cause of muhiple organ dysfunction syndrome 显示文摘 | Yang HY Yen TH Lin CY | 2012 | Shock2012，38，1： | 1 |
| 13 | Absence of excitotoxicity- induced apoptosis in the hippocampus of mice lacking the Jnk3 gene显示文摘 | Yang DD Kuan CY Whitmarsh AJ | 1997 | Nature1997，389，： | 1 |
| 14 | Prenatal 2D ultrasonic diagnosis offetal complete atrioventricular block and bilateral hydrocelea withaccuhmaternal SSA显示文摘 | Chen CY Wu YC Yang ML | 2006 | Taiwan J Obstet Gyneco2006，45，1： | 1 |
| 15 | Mitogen -activated protein kinasephosphatase -1: a critical phosphatase manipulating mitogen -activated protein kinase signaling in cardiovascular disease(review)显示文摘 | Li CY Yang LC Guo K | 2015 | Int J Mol Med2015，35，4： | 1 |
| 16 | Effectiveness of na- tional evidence-based medicine competition in Taiwan显示文摘 | Weng YH Kuo KN Yang CY | 2013 | BMC Med Educ2013，13，7： | 1 |
| 17 | Cell apoptosis induced by deha-elemene in colorectal adenocarcinoma cells via a mitochondrial-mediated pathway 显示文摘 | Xie CY Yang W Li M | 2009 | Yakugaku Zasshi2009，129，： | 1 |
| 18 | Cutaneous manifestations of human immunodeficiency virus infection in Taiwan显示文摘 | Tzung TY Yang CY Chao SC el al | 2004 | Kaohsi-ung J Med Sci2004，20，5： | 1 |
| 19 | In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs显示文摘 | DONG Y YANG MM KWAN CY | 1997 | Life Sci1997，60，8： | 1 |
| 20 | Synthetic peroxisome pro- lifer-ator-activated receptor-y agonist, rosiglitazone increaseplasma levels of adionectin in type 2 diabetic patients 显示文摘 | Yang WS Jeng CY Jeng CY | 2002 | Diabetes Care2002，25，2： | 1 |
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