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| 1 | The design of HEPS global timing system显示文摘Purpose The high energy photon source(HEPS)is a 4th generation synchrotron light source under construction by the institute of high energy physics.The accelerator complex consists of a 500-MeV Linac,a full-energy synchrotron booster,a 6-GeV synchrotron storage ring(SR),and three e-beam transport lines for injection and extraction among accelerators.A global timing system(GTS)covers the timing needs for all accelerator,beamline,and experiment systems.The GTS is designed to coordinate the injection processes and various measurements and protections.Most systems require that the RMS jitter of the GTS signal is less than 30 ps,while the trigger jitters for the electron gun and SR injection and extraction kickers are less than 10 ps.Method The HEPS GTS is an event-based timing system based on MicroTCA.4 hardware architecture.The MicroTCA.4300 series products from the micro-research Finland Oy are implemented in the HEPS GTS system.Results and conclusions The RMS jitter,integrated from 1 Hz to 10 MHz,of the 166.6 MHz event clock is 5.489 ps.The RMS jitter of TTL outputs is less than 30 ps.This paper reports the design of the HEPS GTS,which satisfies all of the HEPS physics requirements for timing with preliminary test results shown. | Fang Liu Ge Lei Zhe Duan Cai Meng Chenyan Lu Yanhua Shao Xinpeng Ma Nan Gan Yuemei Peng Jianshe Cao Chungming Chu Yanfeng Sui Jingyi Li IHEP | 2021 | Radiation Detection Technology and Methods2021，5，3： | 1 |
| 2 | Design of a novel chimeric peptide via dual blockade of CD47/SIRPαand PD-1/PD-L1 for cancer immunotherapy显示文摘Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types,only a small subset of patients can benefit from PD-1/PD-L1 blockade.CD47 expressed on tumor cells protects them from phagocytosis through interaction with SIRPαon macrophages,while PD-L1 dampens T cell-mediated tumor killing.Therefore,dual targeting PD-L1 and CD47 may improve the efficacy of cancer immunotherapy.A chimeric peptide Pal-DMPOP was designed by conjugating the double mutation of CD47/SIRPαblocking peptide(DMP)with the truncation of PD-1/PD-L1 blocking peptide OPBP-1(8-12)and was modified by a palmitic acid tail.Pal-DMPOP can significantly enhance macrophage-mediated phagocytosis of tumor cells and activate primary T cells to secret IFN-γin vitro.Due to its superior hydrolysis-resistant activity as well as tumor tissue and lymph node targeting properties,Pal-DMPOP elicited stronger anti-tumor potency than Pal-DMP or OPBP-1(8-12)in immune-competent MC38 tumor-bearing mice.The in vivo anti-tumor activity was further validated in the colorectal CT26 tumor model.Furthermore,Pal-DMPOP mobilized macrophage and T-cell anti-tumor responses with minimal toxicity.Overall,the first bispecific CD47/SIRPαand PD-1/PD-L1 dual-blockade chimeric peptide was designed and exhibited synergistic anti-tumor efficacy via CD8^(+)T cell activation and macrophage-mediated immune response.The strategy could pave the way for designing effective therapeutic agents for cancer immunotherapy. | Zheng Hu Wanqiong Li Shaomeng Chen Danhong Chen Ran Xu Danlu Zheng Xin Yang Shuzhen Li Xiuman Zhou Xiaoshuang Niu Youmei Xiao Zhuoying He Huihao Li Juan Liu Xinghua Sui Yanfeng Gao | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 3 | Diabetes mellitus promoted lymph node metastasis in gastric cancer: a 15-year single-institution experience显示文摘Background: Previous studies have revealed that diabetes mellitus (DM) promotes disease progress of gastric cancer (GC). This study aimed to further investigating whether DM advanced lymph nodes (LNs) metastasis in GC.Methods: The clinicopathologic data of GC patients with >15 examined LN (ELN) between October 2004 and December 2019 from a prospectively maintained database were included. The observational outcomes included the number (N3b status) and anatomical distribution (N3 stations) of metastatic LN (MLN).Results: A total of 2142 eligible patients were included in the study between October 2004 and December 2019. N3 stations metastasis (26.8% in DMvs. 19.3% in non-DM,P = 0.026) and N3b status (18.8% in DMvs. 12.8% in non-DM,P = 0.039) were more advanced in the DM group, and multivariate logistic regression analyses confirmed that DM was an independent factor of developing N3 stations metastasis (odds ratio [OR] = 1.771,P= 0.011) and N3b status (OR= 1.752,P= 0.028). Also, multivariate analyses determined DM was independently associated with more MLN (β = 1.424,P = 0.047). The preponderance of N3 stations metastasis (DMvs. non-DM, T1-2: 2.2%vs. 4.9%, T3: 29.0%vs. 20.3%, T4a: 38.9%vs. 25.8%, T4b: 50.0%vs. 36.6%;ELN16-29: 8.6%vs. 10.4%, ELN30-44: 27.9%vs. 20.5%, ELN ≥ 45: 37.7%vs. 25.3%), N3b status (DMvs. non-DM, T1-2: 0%vs. 1.7%, T3: 16.1%vs. 5.1%, T4a: 27.8%vs. 19.1%, T4b: 44.0%vs. 28.0%;ELN16-29: 8.6%vs. 7.9%, ELN30-44: 18.0%vs. 11.8%, ELN ≥ 45: 26.4%vs. 17.3%), and the number of MLN (DMvs. non-DM, T1-2: 0.4vs. 1.1, T3: 8.6vs. 5.2, T4a: 9.7vs. 8.6, T4b: 17.0vs. 12.8;ELN16-29: 3.6vs. 4.6, ELN30-44: 5.8vs. 5.5, ELN ≥ 45: 12.0vs. 7.7) of DM group increased with the advancement of primary tumor depth stage and raising of ELN.Conclusions: DM was an independent risk factor for promoting LN metastasis. The preponderance of LN involvement in the DM group was aggravated with the advancement of tumor depth. | Xinhua Chen Yuehong Chen Tao Li Weiqi Liang Huilin Huang Hongtao Su Chuyang Sui Yanfeng Hu Hao Chen Tian Lin Tao Chen Liying Zhao Hao Liu Guoxin Li Jiang Yu | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 4 | Peptide drugs: a new direction in cancer immunotherapy显示文摘Cancer immunotherapy has emerged as a promising approach in cancer treatment and is considered a major advancement after surgical interventions, radiotherapy, chemotherapy, and targeted therapy. The clinical use of immunotherapeutic drugs, particularly antibody-based drugs that target immune checkpoints, has notably increased~1. | Xinghua Sui Xiaoshuang Niu Xiuman Zhou Yanfeng Gao | 2024 | Cancer Biology & Medicine2024，21，3： | 0 |
| 5 | Electro-mechanical offset measurements of beam position monitors显示文摘Purpose The absolute beam position measurement in the booster and storage ring of the high energy photon source(HEPS)requires the offset between the electrical and mechanical centers of the beam position monitor(BPM).Method Traditionally,an RF signal is sent to an antenna or stretched wire aligned with the vacuum chamber,and the signal at each electrode is measured.Conversely,a replacement method using a vector network analyzer,which was proposed by Lambertson,does not involve mechanical alignment and can be used for electrical offset determination.Results and conclusions The electro-mechanical offsets of booster BPMs of the HEPS were measured using the Lambertson method.The result shows good agreement with the stretched wire method within a 30μm error. | Jun He Yanfeng Sui Yong Li Yaoyao Du Linda Yu Junhui Yue Jianshe Cao Xujian Wang Zhe Duan Ouzheng Xiao | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
| 6 | Research and development of the longitudinal feedback system digital signal processing electronics in BEPCII显示文摘Background The current strategy to achieve high luminosity for high energy physics experiments is to store huge currents distributed in many bunches in circular machines such as BEPCII,so the longitudinal coupled bunch instabilities of the beam are inevitable.Purpose Therefore,a longitudinal feedback system is needed to suppress longitudinal oscillation.Otherwise,the beam energy spread will increase;the luminosity and the beam lifetime will decrease under a certain beam current.Methods For filter design of the feedback system,the time domain least square fitting(TDLSF)method is compared to the selective wave filter method;digital signal processing electronics based on commercial board have been developed and tested on BEPCII.Results The final result shows that the self-developed longitudinal feedback system can suppress the longitudinal beam oscillation at 750 mA beam current and meet the requirements of BEPCII;the restrain depth to the sidebands reaches to 40.8 dB. | Di Yin Junhui Yue Huizhou Ma Jianshe Cao Shujun Wei Cunbiao Hao Yanfeng Sui Jun He Jingxia Zhao Zhi Liu | 2021 | Radiation Detection Technology and Methods2021，5，2： | 0 |
| 7 | Development of BPM feedthroughs for the High Energy Photon Source显示文摘Purpose Based on the requirements of the High Energy Photon Source(HEPS),the key components for strip-type and button-type beam position monitors(BPMs)and feedthroughs are designed and manufactured.Method The mechanical structure of the feedthroughs is designed according to the Computer Simulation Technology(CST)simulation results.Resultsandconclusions Small batches of feedthroughs are manufactured,and the structure is optimized based on mechanical,vacuum,electromagnetic,and other characteristic test results.The performance improved significantly owing to optimization through batch product testing,and quality control-related information from several manufacturers is obtained,which provide a foundation for the development of BPMs for HEPS. | Yong Li Jun He Yanfeng Sui Anxin Wang Lin Wang Dechong Zhu Ying Zhao Di Yin Qiang Ye Shujun Wei Taoguang Xu Junhui Yue Jianshe Cao | 2022 | Radiation Detection Technology and Methods2022，6，4： | 0 |
| 8 | Automatic test system development for digital beam position monitor of HEPS and BEPCII显示文摘Purpose Hundreds of digital beam position monitor processors(DBPM)are required to be produced during the construction of projects such as High Energy Photon Source(HEPS)and the upgrade project of the Beijing Electron Positron Collider(BEPCII),which brings great challenges to the test work.In order to achieve accurate,fast,and complete mass production tests of DBPMs,an automatic test system(ATS)has been developed in this article.Methods According to the test items of DBPM,the standardized testing softwareflow is designed based on virtual instru-ment program control technology and experimental physics and industrial control system(EPICS),which realize automatic adjustment of test parameters and automatic acquisition of test result data.Results and conclusions The ATS can realize one-button testing of channel coefficients,channel linearity,attenuator linearity,beam current dependence(BCD)and sampling signal-to-noise ratio(SNR),and generate test reports.The total test time is less than 3 minutes,which is significantly more efficient compared to manual testing.More than 90 BEPCII DBPMs has been tested by this ATS in the lab.The test results proved that such a system could automatically recognize defective products and satisfy the requirements of mass testing. | Xuhui Tang Yaoyao Du Jianshe Cao Shujun Wei Zhi Liu Qiang Ye Huizhou Ma Jing Yang Guodong Gao Yukun Li Yanfeng Sui Junhui Yue | 2022 | Radiation Detection Technology and Methods2022，6，3： | 0 |
| 9 | Streak camera calibration for bunch length measurement at BEPC II显示文摘Purpose Streak camera is an important device for bunch length measurement.The errors introduced by streak camera should be considered in measurement.In order to accurately measure bunch length,some streak camera calibrations are studied at BEPC II.Methods In this context,the point spread function,caused by the optical system,is measured at focus mode with both deflec-tions disabled.In the same conditions,the influence of camera gain on measurement is studied.For the dual sweep mode of streak camera,a calibration method using electrical delays is applied to calibrate the beam size result.Results Firstly,a point spread function calibration 1.78 ps of streak camera optical system is obtained with focus mode.Secondly,studying the effect of camera gain on measurement,an optimal camera gain range from 506 to 662 is selected,in which the bunch length measurement error is within 0.5 ps.Thirdly,a dual sweep calibration factor 1.02 is obtained.Conclusions For BEPCII bunch length,there is a little difference before and after the streak camera calibrations.However,for the accurate measurement of ultra-short bunch length,the calibrations are of great significance. | Wan Zhang Dechong Zhu Yanfeng Sui Huizhou Ma Junhui Yue Jianshe Cao | 2021 | Radiation Detection Technology and Methods2021，5，3： | 0 |
| 10 | Design of RF front end of digital BPM for BEPCII显示文摘Purpose In order to update the BPM electronic in BEPCII,a high-performance digital BPM processor is designed,and the RF front-end electronic is the key part in the digital BPM processor system.Methods According to the BEPCII physical parameters andADCunder-sampling theorem,the low-noise and high-dynamicrange RF front-end electronic module is designed.This article will introduce filter,RF amplifier,isolation,system test,etc.Results and conclusions The experimental results showed that BPM position short-term resolution is better than 100 nm,and long-term resolution is better than 5μm.It is the first domestic BPM processor that runs stably in the storage ring accelerator for a long time.Meanwhile,the study can help us to establish a solid foundation for the next work of BPM electronics development. | Yaoyao Du Jing Yang Lin Wang Xiyang Huang Yufei Ma Xinger Zhang Huizhou Ma Qiang Ye Yanfeng Sui Shujun Wei Junhui Yue Jianshe Cao | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
| 11 | Design and simulation of cavity BPM for BEPCII显示文摘Background In the linac of Beijing Electron Positron Collider II(BEPCII),the resolution of existing BPMs is several hundred microns.But the requirement of transverse position resolution of BPM for future top-up injection needs to be more precise.Purpose This paper is mainly concerned about the design and simulation of the cavity beam position monitor(CBPM)for BEPCII linac and free electron laser(FEL).The requirement of beam transverse position resolution for linac is several microns,even a few nanometers for FEL.Methods When the beam bunch goes through the CBPM,it can excite different electromagnetic field modes in resonator.In these modes,TM_(110) is the most sensitive to beam transverse position offset.The design of CBPM is aim to analyze the relationship between TM_(110) and beam transverse position by CST Studio and Ansys HFSS.Conclusion In this research,we design a pair of rectangular slots for position cavity to revise the direction of electromagnetic field.The simulation result of theoretical resolution is able to reach 15 nm@1nC with the operating frequency 2500 MHz.It is obviously that CBPM has more excellent resolution than all of operating BPM in BEPCII.Meanwhile,the research of CBPM improves the application of beam detection technology in BEPCII and accumulates technology for future design of HEPS and FEL.The mechanical design of the prototype is being fabricated. | Jiashen Zhou Jianshe Cao Yanfeng Sui Junhui Yue Jun He | 2019 | Radiation Detection Technology and Methods2019，3，3： | 0 |
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