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| 1 | Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma显示文摘Sulforaphane(SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy to cancer cells, which might impair the anti-tumor efficiency of SFN. However, the accurate function and mechanism of SFN inducing autophagy in cancers are still obscure, especially in esophageal squamous cell carcinoma(ESCC), one of malignancies with high incidence in North China. Here, we mainly explored the potential function of autophagy upon SFN treatment in ESCC and molecular mechanism. We demonstrated that SFN could inhibit cell proliferation and induce apoptosis by activating caspase pathway. Moreover, we found activation of NRF2 pathway by SFN was responsible for the induction of autophagy and also a disadvantage element to the anti-tumor effects of SFN on ESCC, indicating that SFN might induce protective autophagy in ESCC. We, therefore,investigated effects of autophagy inhibition on sensitivity of ESCC cells to SFN and found that chloroquine(CQ) could neutralize the activation of SFN on NRF2 and enhance the activation of SFN on caspase pathway, thus improved the anti-tumor efficiency of SFN on ESCC in vitro and in vivo. Our study provides a preclinical rationale for development of SFN and its analogs to the future treatment of ESCC. | Zhaoming Lu Yandan Ren Li Yang Ang Jia Yi Hu Yu Zhao Wuduo Zhao Bin Yu Wen Zhao Jianying Zhang Guiqin Hou | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 2 | Rod-shaped thiocyanate-induced abnormal band gap broadening in SCN^- doped CsPbBr3 perovskite nanocrystals显示文摘 | Yongbing Lou Yandan Niu Dongwen Yang Qiaoling Xu Yuhang Hu Ying Shen Jing Ming Jinxi Chen Lijun Zhang Yixin Zhao | 2018 | Nano Research2018，11，5： | 5 |
| 3 | Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors显示文摘CDK4/6 inhibitors are the standard treatment in advanced HR+/HER2-breast cancer patients.Nevertheless,the resistance to CDK4/6 inhibitors is inevitable and the strategies to overcome resistance are of great interest.Here,we show that the palbociclibresistant breast cancer cells expressed significantly higher levels of Cyclin D1 and CDK4 proteins because of upregulated protein synthesis.Silencing Cyclin D1 or CDK4 led to cell cycle arrest while silencing Cyclin E1 or CDK2 restored the sensitivity to palbociclib.Furthermore,PI3K/mTOR pathway was hyper-activated in palbociclib-resistant cells,leading to more phosphorylated 4E-BP1 and higher levels of Cyclin D1 and CDK4 translation.Targeting PI3K/mTOR pathway with a specific PI3Kαinhibitor(BYL719)or an mTOR inhibitor(everolimus)reduced the protein levels of Cyclin D1 and CDK4,and restored the sensitivity to palbociclib.The tumor samples expressed significantly higher levels of Cyclin D1,CDK4,p-AKT and p-4E-BP1 after progression on palbociclib treatment.In conclusion,our findings suggest that overexpressed Cyclin D1 and CDK4 proteins lead to the resistance to CDK4/6 inhibitor and PI3K/mTOR inhibitors are able to restore the sensitivity to CDK4/6 inhibitors,which provides the biomarker and rationale for the combinational use of CDK4/6 inhibitors and PI3K/mTOR inhibitors after CDK4/6 inhibitor resistance in breast cancer. | Zijie Cai Jingru Wang Yudong Li Qianfeng Shi Liang Jin Shunying Li Mengdi Zhu Qi Wang Lok Lam Wong Wang Yang Hongna Lai Chang Gong Yandan Yao Yujie Liu Jun Zhang Herui Yao Qiang Liu | 2023 | Science China(Life Sciences)2023，66，1： | 4 |
| 4 | Real-time 3-D space numerical shake prediction for earthquake early warning显示文摘In earthquake early warning systems, real-time shake prediction through wave propagation simulation is a promising approach. Compared with traditional methods, it does not suffer from the inaccurate estimation of source parameters. For computation efficiency, wave direction is assumed to propagate on the 2-D surface of the earth in these methods. In fact, since the seismic wave propagates in the 3-D sphere of the earth, the 2-D space modeling of wave direction results in inaccurate wave estimation. In this paper, we propose a 3-D space numerical shake prediction method, which simulates the wave propagation in3-D space using radiative transfer theory, and incorporate data assimilation technique to estimate the distribution of wave energy. 2011 Tohoku earthquake is studied as an example to show the validity of the proposed model. 2-D space model and 3-D space model are compared in this article, and the prediction results show that numerical shake prediction based on 3-D space model can estimate the real-time ground motion precisely, and overprediction is alleviated when using 3-D space model. | Tianyun Wang Xing Jin Yandan Huang Yongxiang Wei | 2017 | Earthquake Science2017，30，5： | 2 |
| 5 | Diurnal Circadian Lighting Accumulation Model:A Predictor of the Human Circadian Phase Shift Phenotype显示文摘Light is an important external factor that affects human circadian rhythms.This study aimed to explore the effects of different dimensions of diurnal light exposure on the physiological circadian phase shift(CPS)of the human body.A strict light exposure experiment with different timing schemes(8:00-12:00,13:00-17:00,18:00-22:00),durations(4 h,8 h)and effective circadian stimulus levels(circadian stimulus:0.35,0.55)was performed in an enclosed laboratory.Fourteen participants,including seven males and seven females,with a mean age of 24.29±2.43(mean±standard deviation),participated in this experiment and experienced all six lighting schemes.The results showed that both time factor(F_(3,40)=29.079,p<0.001,the power of the sample size=0.98)and circadian stimulus levels(T_(20)=−2.415,p=0.025,the power of sample size=0.76)sig-nificantly affect the CPS.On this basis,a diurnal circadian lighting accumulation(DCLA)-CPS model was proposed in the form of the Boltzmann function,and was validated by experimental data with high correlation(R^(2)=0.9320,RSS=0.1184),which provides strong support for rationally arranging the light level at different times of the day. | Dandan Hou Caixin Lin Yandan Lin | 2022 | Phenomics2022，2，1： | 1 |
| 6 | A GCG expansion (GCG) 11 in polyadenylate-binding protein nuclear 1 gene 2aused oculopharyngeal muscular dystrophy in a Chinese family 显示文摘 | Juan Ye Huina Zhang Yandan Zhou | 2011 | Molecular Vision2011，17，： | 1 |
| 7 | Decay resistance and dimensional stability improvement of wood by low melting point alloy heat treatment显示文摘Wood has no inherent natural resistance against agents of biodegradation. We evaluated the effects of metal bath heat treatment(MBHT) on decay resistance and dimensional stability of Chinese parasol(Firmiana simplex) and Chinese fir(Cunninghamia lanceolata) wood. A low melting point alloy was used as heating medium in the treatment of the wood samples at 150, 180, and 210 °C for2, 4, and 8 h. Heat-treated and control samples were exposed to brown rot fungus(Poria placenta) and white rot fungus(Coriolus versicolor) for decay resistance testing and anti-swelling efficiency(ASE). The improved decay resistance with increase temperatures with low mass losses of 7.3 and 7.3% for F. simplex, and 3.9 and 3.6% for C.lanceolata at 210 °C for 8 h against Coriolus versicolor and Poria placenta, respectively. ASE indicated that MBHT contributed to improved dimensional stability of both wood species after treatment. Scanning electron micrograph results indicate that metal bath-treated samples showed strong decay resistance. Therefore, our approach to thermally modify wood should be explored to overcome the energy utilization by using low melting point alloy for the heat treatment of wood. | Kufre Edet Okon Fengcai Lin Yandan Chen Biao Huang | 2018 | Journal of Forestry Research2018，29，6： | 1 |
| 8 | Tin-based metal bath heat treatment: an efficient and recyclable green approach for Pinus massoniana wood modification显示文摘Pinus massoniana L. was thermally treated with low melting point alloy as heating medium to investigate the strength properties changes. Contact angle, color and scanning electron microscopy were recorded to assess the effectiveness of the treatment. Samples were pre-treated in a micro-wave for 5 min followed by metal bath heat treatment at 150, 180, and 210 °C for 2, 4, and 8 h,respectively. Strength properties of metal bath treated wood were decreased with increase temperature and time.Density, modulus of rupture, impact bending, modulus of elasticity were reduced for all treatments. Maximum compressive strength slightly increased at 150 °C for 4 h followed by gradual reduction. The Janka hardness was reduced in the tangential and radial directions. Treatment of the wood at 210 °C for 8 h caused the wood to become brittle and rupture. The contact angle was considerably higher after thermal treatment. The color of the wood became darker with increasing temperature of thermal treatment. Micrographs of the heat-treated samples showed damage to the cell wall with increase in temperature. Metal bath heat treatment of wood was carried out successfully and some strength properties were reduced. | Kufre Edet Okon Fengcai Lin Yandan Chen Biao Huang | 2018 | Journal of Forestry Research2018，29，6： | 1 |
| 9 | Targeted delivery of PLKI-siRNA by SeFv suppresses Her2+ breast cancer growth and metastasis 显示文摘 | YAO Yandan SUN Tianmeng HUANG Songyin | 2012 | Sci Transl Med2012，4，130： | 1 |
| 10 | The effect of spectrum on visual field in road lighting显示文摘 | Lin Yandan Chen Wencheng Chen Dahua | 2004 | Building and Environ ment2004，39，： | 1 |
| 11 | CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3显示文摘 | Jingqi Chen Yandan Yao Chang Gong Fengyan Yu Shicheng Su Jianing Chen Bodu Liu Hui Deng Fengsong Wang Ling Lin Herui Yao Fengxi Su Karen S. Anderson Qiang Liu Mark E. Ewen Xuebiao Yao Erwei Song | 2011 | Cancer Cell2011，，4： | 1 |
| 12 | Recovery of walking function in stroke patients 显示文摘 | Hirofumi MD Yandaner | 1995 | Arch Phy Med Rehabil1995，76，1： | 1 |
| 13 | The combined modification of Ti and P to USY and its function in hydro- genation and ring opening reaction of tetralin显示文摘 | Wang Yandan Shen Baojian Hao Kun | 2012 | Catalysis Communications2012，25，： | 1 |
| 14 | Influence of combined alkaline treatment and Fe - Ti - loading modification on ZSM - 5 zeolite and its catalytic performance in light olefin production 显示文摘 | Hao Kun Shen Baojian Wang Yandan | 2012 | Journal of Industrial and Engineering Chemistry2012，18，5： | 1 |
| 15 | Application and comparison of derivatized cellulose and amylose chiral stationary phases for the separation of enantiomers of pharmaceutical compounds by high-performance liquid chromatography 显示文摘 | Tao W Yandan W C | 1999 | J Chromatogr A1999，855，2： | 1 |
| 16 | No Reference Image Sharpness Assessment Based on Global Color Difference Variation显示文摘Image quality assessment(IQA)model is designed to measure the image quality in consistent with subjective ratings by computational models.In this research,a valid no reference IQA(NR-IQA)model for color image sharpness assessment is proposed based on local color difference map in a color space.In the proposed model,the absolute color difference variation and relative color difference variation are combined to evaluate sharpness in YIQ color space(a color coordinate system for the development of the United States color television system).The difference between sharpest and blurriest spot of an image is represented by the absolute color difference variation,and relative color difference variation expresses the variation in the image content.Extensive experiments are performed on five publicly available benchmark synthetic blur databases and two real blur databases,and the results prove that the proposed model work better than the other state-of-the-art and latest NR-IQA models for the prediction accuracy on blurry images.Besides,the model maintains the lowest computational complexity. | Chenyang SHI Yandan LIN | 2024 | Chinese Journal of Electronics2024，33，1： | 1 |
| 17 | Effect of Phosphorus Modified USY on Coupled Hydrogenation and Ring Opening Performance of NiW/USY+Al2O3 Hydro-Upgrading Catalyst显示文摘 | Wang Yandan Shen Baojian Wang Liang | | 0，，01： | 1 |
| 18 | Influence of average molecular weight on antioxidant and functional properties of cartilage collagen hydrolysates from Sphyrna lewini , Dasyatis akjei and Raja porosa显示文摘 | Zhongrui Li Bin Wang Changfeng Chi Yandan Gong Hongyu Luo Guofang Ding | 2012 | Food Research International2012，，： | 1 |
| 19 | Weighted estimates for bilinear square functions with non-smooth kernels and commutators显示文摘Under weaker conditions on the kernel functions,we discuss the boundedness of bilinear square functions associated with non-smooth kernels on the product of weighted Lebesgue spaces.Moreover,we investigate the weighted boundedness of the commutators of bilinear square functions(with symbols which are BMO functions and their weighted version,respectively)on the product of Lebesgue spaces.As an application,we deduce the corresponding boundedness of bilinear Marcinkiewicz integrals and bilinear Littlewood-Paley^-functions. | Rui BU Zunwei FU Yandan ZHANG | 2020 | Frontiers of Mathematics in China2020，15，1： | 1 |
| 20 | Nanoparticles(NPs)-mediated systemic mRNA delivery to reverse trastuzumab resistance for effective breast cancer therapy显示文摘Monoclonal antibody-based therapy has achieved great success and is now one of the most crucial therapeutic modalities for cancer therapy.The first monoclonal antibody authorized for treating human epidermal growth receptor 2(HER2)-positive breast cancer is trastuzumab.However,resistance to trastuzumab therapy is frequently encountered and thus significantly restricts the therapeutic outcomes.To address this issue,tumor microenvironment(TME)pH-responsive nanoparticles(NPs)were herein developed for systemic mRNA delivery to reverse the trastuzumab resistance of breast cancer(BCa).This nanoplatform is comprised of a methoxyl-poly(ethylene glycol)-b-poly(lactic-co-glycolic acid)copolymer with a TME pH-liable linker(Meo-PEG-Dlinkm-PLGA)and an amphiphilic cationic lipid that can complex PTEN mRNA via electrostatic interaction.When the long-circulating mRNA-loaded NPs build up in the tumor after being delivered intravenously,they could be efficiently internalized by tumor cells due to the TME pH-triggered PEG detachment from the NP surface.With the intracellular mRNA release to up-regulate PTEN expression,the constantly activated PI3K/Akt signaling pathway could be blocked in the trastuzumab-resistant BCa cells,thereby resulting in the reversal of trastuzumab resistance and effectively suppress the development of BCa. | Zhihui Dong Zhuoshan Huang Senlin Li Ying Wang Yandan Yao Xianzhu Yang Xiaoding Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
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