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3篇 您的检索式：作者名="Yalan Deng"

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		题名	作者	年代	出处	被引量
	1	The vicK gene of Streptococcus mutans mediates its cariogenicity via exopolysaccharides metabolism显示文摘Streptococcus mutans(S.mutans)is generally regarded as a major contributor to dental caries because of its ability to synthesize extracellular polysaccharides(EPS)that aid in the formation of plaque biofilm.The VicRKX system of S.mutans plays an important role in biofilm formation.The aim of this study was to investigate the effects of vicK gene on specific characteristics of EPS in S.mutans biofilm.We constructed single-species biofilms formed by different mutants of vicK gene.Production and distribution of EPS were detected through atomic force microscopy,scanning electron microscopy and confocal laser scanning microscopy.Microcosmic structures of EPS were analyzed by gel permeation chromatography and gas chromatography-mass spectrometry.Cariogenicity of the vicK mutant was assessed in a specific pathogen-free rat model.Transcriptional levels of cariogenicityassociated genes were confirmed by quantitative real-time polymerase chain reaction.The results showed that deletion of vicK gene suppressed biofilm formation as well as EPS production,and EPS were synthesized mostly around the cells.Molecular weight and monosaccharide components underwent evident alterations.Biofilms formed in vivo were sparse and contributed a decreased degree of caries.Moreover,expressional levels of genes related to EPS synthesis were down-regulated,except for gtfB.Our report demonstrates that vicK gene enhances biofilm formation and subsequent caries development.And this may due to its regulations on EPS metabolism,like synthesis or microcosmic features of EPS.This study suggests that vicK gene and EPS can be considered as promising targets to modulate dental caries.	Yalan Deng Yingming Yang Bin Zhang Hong Chen Yangyu Lu Shirui Ren Lei Lei Tao Hu	2021	International Journal of Oral Science2021，13，4：	2
	2	Efficient enantioselective synthesis of CF_(2)Hcontaining dispiro[benzo[b]thiophene-oxindolepyrrolidine]s via organocatalytic cycloaddition显示文摘An efficient and practical organocatalytic asymmetric[3+2]cycloaddition of difluoromethylated ketoimines and methyleneindolinones catalyzed by a quinine-derived squaramide has been disclosed.Under mild conditions,a broad range of CF_(2)H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s bearing four adjacent chiral centers including two vicinal spiro quaternary stereocenters were obtained in high yields(up to 99%yield)with excellent diastereoselectivities(>20:1 dr,in all cases)and enantioselectivities(up to 99%ee).	Yabo Deng Yongzhen Li Yalan Wang Shuo Sun Sichao Ma Pengfei Jia Wenguang Li Kairong Wang Wenjin Yan	2022	Organic Chemistry Frontiers2022，9，1：	1
	3	X-ray ptychographic tomography reveals buried 3D structural defects in metal halide perovskites显示文摘Metal halide perovskites(MHPs)are an emerging class of semiconductors that have demonstrated their promise at various energy frontiers.Especially,perovskite-based solar cells(PSCs)are considered as a disruptive photovoltaic technology with their power conversion efficiency rapidly climbing to certified 25.7%[1].	Yalan Zhang Mingwei Hao Hua Zhou Junjing Deng Yuanyuan Zhou	2022	Journal of Energy Chemistry2022，31，10：	0

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