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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 3 | Anti-HBV effect of TAT-HBV targeted ribonuclease显示文摘AIM: To prepare and purify TAT-HBV targeted ribonuclease fusion protein, evaluate its transduction activity and investigate its effect on HBV replication in 2.2.15 cells.METHODS: The prokaryotic expression vector pTAT containing TR gene was used in transforming E. coli BL21(DE3) LysS and TR was expressed with the induction of IPTG. The TAT-TR fusion protein was purified using Ni-NTA-agrose and PD-10 desalting columns, and analyzed by SDSPAGE. Transduction efficiency of TAT-TR was detected with immunofluorescence assay and the concentration of HBeAg in the supernatant of the 2.2.15 cells was determined via solid-phase radioimmunoassay (spRIA). MTT assay was used to detect the cytotoxicity of TAT-TR.RESULTS: The SDS-PAGE showed that the TAT-TR fusion protein was purified successfully, and the purity of TAT-TR was 90 %. The visualization of TAT-TR by immunofiuorescence assay indicated its high efficiency in transducing 2.2.15 cells.RIA result suggests that TAT-TR could inhibit the replication of HBV effectively, it didn′t affect cell growth and had no cytotoxicity.CONCLUSION: TAT-TR possesses a significant anti-HBV activity and the preparation of TAT-TR fusion protein has laid the foundation for the use of TR in the therapeutic trial of HBV infection. | Jin Ding Jun Liu Cai-Fang Xue Wei-Dong Gong Ying-Hui Li Ya Zhao Department of Etiology,Fourth Military Medical University,Xi’an 710032,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，7： | 12 |
| 4 | Brain iron overload following intracranial haemorrhage显示文摘Intracranial haemorrhages,including intracerebral haemorrhage(ICH),intraventricular haemorrhage(IVH)and subarachnoid haemorrhage(SAH),are leading causes of morbidity and mortality worldwide.In addition,haemorrhage contributes to tissue damage in traumatic brain injury(TBI).To date,efforts to treat the long-term consequences of cerebral haemorrhage have been unsatisfactory.Incident rates and mortality have not showed significant improvement in recent years.In terms of secondary damage following haemorrhage,it is becoming increasingly apparent that blood components are of integral importance,with haemoglobin-derived iron playing a major role.However,the damage caused by iron is complex and varied,and therefore,increased investigation into the mechanisms by which iron causes brain injury is required.As ICH,IVH,SAH and TBI are related,this review will discuss the role of iron in each,so that similarities in injury pathologies can be more easily identified.It summarises important components of normal brain iron homeostasis and analyses the existing evidence on iron-related brain injury mechanisms.It further discusses treatment options of particular promise. | Thomas Garton Richard F Keep Ya Hua Guohua Xi | 2016 | Stroke & Vascular Neurology2016，1，4： | 11 |
| 5 | Spatial Interpolation and Sample Size Optimization for Soil Copper(Cu) Investigation in Cropland Soil at County Scale Using Cokriging显示文摘Knowledge on spatial distribution and sampling size optimization of soil copper(Cu) could lay solid foundations for environmetal quality survey of agricultural soils at county scale.In this investigation,cokriging method was used to conduct the interpolation of Cu concentraiton in cropland soil in Shuangliu County,Sichuan Province,China.Based on the original 623 physicochmically measured soil samples,560,498,and 432 sub-samples were randomly selected as target variable and soil organic matter(SOM) of the whole original samples as auxiliary variable.Interpolation results using Cokriging under different sampling numbers were evaluated for their applicability in estimating the spatial distribution of soil Cu at county sacle.The results showed that the root mean square error(RMSE) produced by Cokriging decreased from 0.9 to 7.77%,correlation coefficient between the predicted values and the measured increased from 1.76 to 9.76% in comparison with the ordinary Kriging under the corresponding sample sizes.The prediction accuracy using Cokriging was still higher than original 623 data using ordinary Kriging even as sample size reduced 10%,and their interpolation maps were highly in agreement.Therefore,Cokriging was proven to be a more accurate and economic method which could provide more information and benefit for the studies on spatial distribution of soil pollutants at county scale. | PANG Su,LI Ting-xuan,WANG Yong-dong,YU Hai-ying and LI Xi College of Resource and Environmental Science,Sichuan Agricultural University,Ya’an 625014,P.R.China | 2009 | Agricultural Sciences in China2009，8，11： | 10 |
| 6 | Inflammasome activation in mouse inner ear in response to MCMV induced hearing loss显示文摘Objective: To identify presence of inflammasome activated in mouse cochlea with sensorineural hearing loss(SNHL) caused by cytomegalovirus(CMV) infection.Method: MCMV was injected into the right cerebral hemisphere in neonatal BALB/c mice at 2000 pfu virus titers. Auditory brainstem responses(ABRs) were tested to evaluate hearing at 21 days. Histopathological studies were conducted to confirm localizations of MCMV infected cells in the inner ear. Expression of inflammasome related factors was assessed by immunofluorescence, Quantitative real-time PCR and Western blotting.Results: In the mouse model of CMV induced SNHL, inflammasome related kinase Caspase-1 and downstream inflammatory factor IL-1b and IL-18 were found increased and activated after CMV infection in the cochlea. These factors could further up-regulate expression of IL-6 and TNFa. These inflammatory factors are neurotoxicity and may contribute to hearing impairment. Furthermore, we also detected significantly increased AIM2 protein that accumulated in the SGN of cochleae with CMV infection.Significance: We have shown that inflammasome as a novel inherent immunity mechanism may contribute to hearing impairment.Conclusion: Our data indicate that imflammasome assemble in mouse inner ear in response to CMV infection. We have revealed a novel pathology event in CMV induced SNHL involving activation of inflammasome in mouse cochlea. Additionally, we have shown that inflammasome may be a novel target for prevention and treatment of CMV related SNHL. | Xi Shi Yanfen Dong Ya Li ZenLu Zhao Huan Li Shiwei Qiu Yaohan Li Weiwei Guo Yuehua Qiao | 2015 | Journal of Otology2015，10，4： | 9 |
| 7 | Study of Static Adsorption Capacity of ACF for Xenon at 201 K显示文摘The static adsorption performances of a series of active carbon fiber(ACF)for xenon at 201 K were measured with a model ASAP2010M specific surface area and aperture distribution instrument by changing the working gas of instrument from N 2 to Xenon. Compared with grain active carbon(GAC): (1) the adsorption performance of Viscose based ACF(VACF) adsorbents is better than that of GAC; (2) owing to the difference of aperture distribution, the adsorption performance of ACF with different radicales is different under the same experiment conditions though the specific surface area is similar; (3) there is no definite relationship between adsorption performance and specific surface area; (4) the VACF A2 is the superior xenon adsorbent at the experimental temperature. | WANG Ya long ** , ZHANG Hai tao, WANG Xu hui, ZHANG Li xing, CHEN Li yun, XIE Jin chuan (Northwest Institute of Nuclear Technology, Xian 710024, P. R. China) | 2002 | Chemical Research in Chinese Universities2002，18，2： | 9 |
| 8 | UAV navigation in high dynamic environments:A deep reinforcement learning approach显示文摘Unmanned Aerial Vehicle(UAV) navigation is aimed at guiding a UAV to the desired destinations along a collision-free and efficient path without human interventions, and it plays a crucial role in autonomous missions in harsh environments. The recently emerging Deep Reinforcement Learning(DRL) methods have shown promise for addressing the UAV navigation problem,but most of these methods cannot converge due to the massive amounts of interactive data when a UAV is navigating in high dynamic environments, where there are numerous obstacles moving fast.In this work, we propose an improved DRL-based method to tackle these fundamental limitations.To be specific, we develop a distributed DRL framework to decompose the UAV navigation task into two simpler sub-tasks, each of which is solved through the designed Long Short-Term Memory(LSTM) based DRL network by using only part of the interactive data. Furthermore, a clipped DRL loss function is proposed to closely stack the two sub-solutions into one integral for the UAV navigation problem. Extensive simulation results are provided to corroborate the superiority of the proposed method in terms of the convergence and effectiveness compared with those of the state-of-the-art DRL methods. | Tong GUO Nan JIANG Biyue LI Xi ZHU Ya WANG Wenbo DU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 8 |
| 9 | Inhibition of HBV targeted ribonuclease enhanced by introduction of linker显示文摘AIM: To construct human eosinophil-derived neurotoxin (hEDN) and HBV core protein (HBVc) eukaryotic fusion expression vector with a linker (Gly4 Ser)3 between them to optimize the molecule folding, which will be used to inhibit HBV replication in vitro.METHODS: Previously constructed pcDNA3. 1(-)/TR was used as a template. Linker sequence was synthesized and annealed to form dslinker, and cloned into pcDNA3.1(-)/TR to produce plasmid pcDNA3.1(-)/HBc-linker. Then the hEDN fragment was PCR amplified and inserted into pcDNA3.1(-)/HBc-linker to form pcDNA3.1(-)/TNL in which the effector molecule and the target molecule were separated by a linker sequence. pcDNA3.1(-)/TNL expression was identified by indirect immunofluorescence staining. Radioimmunoassay was used to analyse anti-HBV activity of pcDNA3.1(-)/TNL.Meanwhile, metabolism of cells was evaluated by NTT colorimetry.RESULTS: hEDN and HBVc eukaryotic fusion expression vector with a linker (Gly4Ser)3 between them was successfully constructed. pcDNA3.1(-)/TNL was expressed in HepG2.2.15 cells efficiently. A significant decrease of HBsAg concentration from pcDNA3.1(-)/TNL transfectant was observed compared to pcDNA3. 1(-)/TR (P=0.036, P<0.05).MTT assay suggested that there were no significant differences between groups (P=0.08, P>0.05).CONCLUSION: Linker introduction enhances the inhibitory effect of HBV targeted ribonuclease significantly. | Wei-Dong Gong Jun Liu Jin Ding Ya Zhao Ying-Hui Li Cai-Fang Xue Department of Pathogenic Organisms,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China | 2003 | World Journal of Gastroenterology2003，9，7： | 6 |
| 10 | The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats显示文摘Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs [1] . However, few studies | BAI Ya Na MA Li WANG Qiu Ying PU Hong Quan ZHANG Xiao Pei WU Xi Jiang XUAN Xiao Qiang CHENG Ning | 2013 | Biomedical and Environmental Sciences2013，26，7： | 5 |
| 11 | Preparation of CS-CMC Bipolar Membrane and its Application in Electro-generated FeO_4^(2-)显示文摘CS-CMC bipolar membrane was prepared and the cross-section photograph of CS-CMC BM was observed by SEM. FT-IR spectrum indicated that CS-CMC BM contained -N=CRH2+ and -COO- functional groups. The charge density of -N=CRH2+ in CS membrane was about 14.13 mmol/g and the charge density of -COO- in CMC membrane was about 9.01 mmol/g. The electrochemistry properties of CS-CMC BM were also studied. CS-CMC BM not only can effectively stop FeO4 from diffusing into the cathode chamber, but also plays an important role in the supply of OH- consumed during the electro-generated FeO42- process. | Yu Xi REN Zhen CHEN Ri Yao CHEN Xi ZHEN Ya Ming GENG | 2006 | Chinese Chemical Letters2006，17，11： | 5 |
| 12 | Cells in G_2/M phase increased in human nasopharyngeal carcinoma cell line by EBV-LMP1 through activation of NF-кB and AP-1显示文摘Although previous studies showed that the principal oncoprotein encoded by Epstein-Barr virus, latent membrane protein 1 (LMP1), could induce the nasopharyngeal carcinoma cells in G2/M phase increased, littleis known about the target molecules and mechanisms. The present study demonstrated that LMP1 couldinduce the accumulation of p53 protein and upregulate its transactivity in a dose dependent manner, whichresulted in the decrease of the kinase activity of cdc2/cyclin B complex and inducing arrest at G2/M phasethrough the activation of NF-kB and AP-1 signaling pathways, and the effect of NF-kB was more obviousthan that of AP-1. This study provided some significant evidence for further elucidating the molecular mechanisms that LMP1 had effects on the surveillance mechanism of cell cycle and promoting the survivalof transformed cells and tumorigenesis. | LIN DENG,JING YANG,XIAO RONG ZHAO,XI YUN DENG,LIANG ZENG,HUAN HUA GU,MIN TANG,YA CAOCancer Research Institute,Xiangya School of Medicine,Central South University,Xiangya Road 88,Chang-sha,Hunan 410078,China | 2003 | Cell Research2003，13，3： | 5 |
| 13 | Spatial Pattern of Long-term Residence in the Urban Floating Population of China and its Influencing Factors显示文摘Exploring long-term residence among the urban floating population is crucial to understanding urban growth in China,particularly since the 2008 financial crisis.By using China Migrants Dynamic Survey data for 2012–2014,China Labor-force Dynamics Survey data for 2014–2016,and macroscale urban matched data,we analyzed the spatial pattern of long-term residential behavior in China’s urban floating population in 2012–2016 and developed an urban spatial utility equilibrium model containing‘macro’urban factors and‘micro’individual and household factors to explain the pattern.The results first revealed that long-term residence is defined as≥6 yr for the urban floating population in China.Second,members of this population are more likely to be long-term residents of the megacities in the three urban agglomerations in eastern China as well as of small and medium-sized cities in western and northeastern China,whereas short-term residence is more likely in cities in central China and near the three urban agglomerations.Third,urban population density and housing prices,both have a significant U-shaped effect,are main factors affecting the spatial pattern of long-term residence. | CHEN Le XI Meijun JIN Wanfu HU Ya | 2021 | Chinese Geographical Science2021，31，2： | 5 |
| 14 | Effects of Low Concentrations of Di-(2-ethylhexyl) and Mono-(2-ethylhexyl) Phthalate on Steroidogenesis Pathways and Apoptosis in the Murine Leydig Tumor Cell Line MLTC-1显示文摘这研究的目的是在 vitro 在一根鼠科的 Leydig 肿瘤房间线(MLTC-1 ) 在 steroidogenesis 上评估 DEHP 和 MEHP 的低集中的效果。流动 cytometry 分析的结果表明 apoptotic 房间的比例显著地在暴露以后被增加到 DEHP。所有三基因(P450scc, P450c17,并且 3 ? HSD ) 在学习下面显示出增加的表达式追随者暴露到 DEHP 或 MEHP,尽管一些不足道的禁止的效果出现了在 10 ? mol/L 处理组同样与控制相比。它也被发现那 DEHP 或 MEHP 在特别刺激了 INSL3 mRNA 和蛋白质 0.001 ? mol/L 处理组。睾丸激素分泌物在暴露以后被刺激到 DEHP 或 MEHP。在 MLTC-1 房间的 steroidogenic 酶和 INSL3 的改变可能在雄激素生产上涉及 DEHP/MEHP 的 biphasic 效果。 | CHEN Xi LIU Ya Nan ZHOU Qing Hong LENG Ling CHANG Ying TANG Nai Jun | 2013 | Biomedical and Environmental Sciences2013，26，12： | 4 |
| 15 | Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury显示文摘Objective:Our recent studies have shown that blood components,including haemoglobin and iron,contribute to hydrocephalus development and brain injury after intraventricular haemorrhage(IVH).The current study investigated the role of lipocalin 2(LCN2),a protein involved in iron handling,in the ventricular dilation and neuroinflammation caused by brain injury in a mouse model of IVH.Design:Female wild-type(WT)C57BL/6 mice and LCN2-deficient(LCN2^(−/−))mice had an intraventricular injection of haemoglobin,and control mice received an equivalent amount of saline.MRI was performed presurgery and postsurgery to measure ventricular volume and the brains were used for either immunohistochemistry or western blot.Results:Ventricular dilation was observed in WT mice at 24 h after haemoglobin(25 mg/mL,20µL)injection(12.5±2.4 vs 8.6±1.5 mm^(3) in the control,p<0.01).Western blotting showed that LCN2 was significantly upregulated in the periventricular area(p<0.01).LCN2 was mainly expressed in astrocytes,whereas the LCN2 receptor was detected in astrocytes,microglia/macrophages and neurons.Haemoglobin-induced ventricle dilation and glia activation were less in LCN2^(−/−)mice(p<0.01).Injection of high-dose haemoglobin(50 mg/mL)resulted in lower mortality in LCN2^(−/−)mice(27%vs 86%in WT;p<0.05).Conclusions:Intraventricular haemoglobin caused LCN2 upregulation and ventricular dilation.Haemoglobin resulted in lower mortality and less ventricular dilation in LCN2^(−/−)mice.These results suggest that LCN2 has a role in haemoglobin-induced brain injury and may be a therapeutic target for IVH. | Hajime Shishido Yasunori Toyota Ya Hua Richard F Keep Guohua Xi | 2016 | Stroke & Vascular Neurology2016，1，2： | 3 |
| 16 | Behavioral Tests After Intracerebral Hemorrhage in the Rat显示文摘 | Ya Hua Timothy Schallert Richard F. Keep Jimin Wu Julian T. Hoff Guohua Xi | 2002 | Stroke: Journal of the American Heart Association2002，，10： | 3 |
| 17 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 18 | The Deleterious or Beneficial Effects of Different Agents in Intracerebral Hemorrhage: Think Big, Think Small, or Is Hematoma Size Important?显示文摘 | Richard F. Keep Guohua Xi Ya Hua Julian T. Hoff | 2005 | Stroke2005，，7： | 3 |
| 19 | Experimental investigation of transient characteristics of mild surge and diffuser rotating stall in a centrifugal compressor with vaned diffuser显示文摘The centrifugal compressor is widely used for gas compression in various industrial fields such as aero-engine, gas turbine and turbocharger. However, the stable operating range is usually restricted by the occurrence of flow instability such as stall and surge. The paper experimentally examines the developing process of surge and stall occurring in a centrifugal compressor to advance the understanding on flow mechanism of flow instability. It is found that three types of pressure fluctuation can be observed at low flowrate region. At the critical point, the local stall firstly occurs in some specific diffuser passages and the enlarged local diffuser stall eventually induces the mild surge of compression system indicated by the sinusoidal pressure fluctuation. At lower mass flow rate, the diffuser stall cell begins to circumferentially propagate along the impeller rotating direction at 11% of rotor speed with the existence of mild surge. In comparative analysis of IGV pre-swirl angle on the occurrence of mild surge, the mild surge still occurs at the operating condition when the slope of the characteristic map of test stage is still obviously negative, in which the compression system is supposed to be stable in previous study. And a new suggested criterion for the prediction of mild surge is demonstrated that the occurrence of mild surge depends on the destabilization effect of downstream components about diffuser and volute. Combined with the experimental data, the streamwise distribution characteristic of diffuser stall can be used to develop the simplified model of lumped parameters for the analysis on the generation mechanism of the diffuser rotating stall. The quantitative investigation on the relation between the pressure-rise characteristic of subcomponents and the occurrence of mild surge and diffuser rotating stall not only advances the prediction of stability limit but also lays the theoretic foundation for controlling these unsteady behaviors to improve the operating range. | ZHAO Yang XI Guang ZOU HanSen SUN Ya Wei WANG ZhiHeng | 2020 | Science China(Technological Sciences)2020，63，7： | 2 |
| 20 | Vestibular-evoked myogenic potentials recorded from miniature pigs and rats显示文摘Objective:To report vestibular evoked myogenic potentials from different recording sites(neck extensor or masseter muscles) in miniature pigs and rats.Methods:Potentials were recorded using 1000 Hz tone bursts from the neck extensor muscle or masseter muscle in normal adult Bama miniature pigs and rats anesthetized with 3%pentobarbital sodium and Sumianxin Ⅱ.Results:At 80 dB SPL,the first positive wave(P wave) of VEMPs was recognizable in 58%of rats with a latency of 6.45±0.23 ms and an amplitude of 1.45±0.49 μV when recorded from the neck extensor muscle,and in 50%of rats with a latency of 6.38±0.34 ms and an amplitude of 1.57±0.35 μV when recorded from the masseter muscle.In miniature pigs,at the same stimulus intensity,P wave was recognizable in 58%of the animals with a latency of 7.65±0.64 ms and an amplitude of 1.66±0.34 μV when recorded from the neck extensor muscle,and in 50%of the animals with a latency of 7.65±0.64 ms and an amplitude of 0.31±0.28 μV when recorded from the masseter muscle.Conclusion:VEMP can be induced from both neck extensor and masseter muscles in the miniature pig and rat.For a given species,the site of recording affects P wave induction rate and amplitude but not latency.Consistency and repeatability analysis suggests that the masseter muscle is a better recording site in miniature pigs while the cervical extensor is a better recording site in rats.For a given recording site,both latency and amplitude of the P wave are slightly greater in miniature pigs than in rats. | Li Ya Zhang Yan Qiu Shi Wei Yuan Na Shi Xi Qiao Yuehua Shi-Ming Yang | 2016 | Journal of Otology2016，11，3： | 2 |
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