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| 1 | Peripheral T-lymphocyte subpopulations in different clinical stages of chronic HBV infection correlate with HBV load显示文摘AIM: To characterize the peripheral T-cell subpopulation profiles and their correlation with hepatitis B virus (HBV) replication in different clinical stages of chronic HBV infection.METHODS: A total of 422 patients with chronic HBV infection were enrolled in this study. The patients were divided into three stages: immune-tolerant stage, immune active stage, and immune-inactive carrier stage. Composition of peripheral T-cell subpopulations was determined by flow cytometry. HBV markers were detected by enzyme-linked immunosorbent assay. SerumHBV DNA load was assessed by quantitative real-time polymerase chain reaction.RESULTS: CD8+ T-cells were significantly higher in patients at the immune-tolerant stage than in patients at the immune-active and -inactive carrier stages (36.87 ± 7.58 vs 34.37 ± 9.07, 36.87 ± 7.58 vs 28.09 ± 5.64, P < 0.001). The peripheral blood in patients at the immune-tolerant and immune active stages contained more CD8+ T-cells than CD4+ T-cells (36.87 ± 7.58 vs 30.23 ± 6.35, 34.37 ± 9.07 vs 30.92 ± 7.40, P < 0.01), whereas the peripheral blood in patients at the immune-inactive carrier stage and in normal controls contained less CD8+ T-cells than CD4+ T-cells (28.09 ± 5.64 vs 36.85 ± 6.06, 24.02 ± 4.35 vs 38.94 ± 3.39, P < 0.01). ANOVA linear trend test showed that CD8+ T-cells were signif icantly increased in patients with a high viral load (39.41 ± 7.36, 33.83 ± 7.50, 31.81 ± 5.95 and 26.89 ± 5.71, P < 0.001), while CD4+ T-cells were signif icantly increased in patients with a low HBV DNA load (37.45 ± 6.14, 33.33 ± 5.61, 31.58 ± 6.99 and 27.56 ± 5.49, P < 0.001). Multiple regression analysis displayed that log copies of HBV DNA still maintained its highly signif icant coefficients for T-cell subpopulations, and was the strongest predictors for variations in CD3+, CD4+ and CD8+ cells and CD4+/CD8+ ratio after adjustment for age at HBV-infection, maternal HBV-infection status, presence of hepatitis B e antigen and HBV mutation.CONCLUSION: Differences in peripheral T-cell subpopulation profi les can be found in different clinical stages of chronic HBV infection. T-cell impairment is signifi cantly associated with HBV load. | Jing You Lin Zhuang Yi-Feng Zhang Hong-Ying Chen Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Teerha Piratvisuth Edward McNeil Lan Yu Bao-Zhang Tang .lun-Hua Huang | 2009 | World Journal of Gastroenterology2009，15，27： | 39 |
| 2 | Effect of viral load on T-lymphocyte failure in patients with chronic hepatitis B显示文摘AIM: To investigate peripheral T-lymphocyte sub-population profile and its correlation with hepatitis B virus (HBV) replication in patients with chronic hepatitis B (CHB).METHODS: Distribution of T-lymphocyte subpopulations in peripheral blood was measured by flow cytometry in 206 CHB patients. HBV markers were detected with ELISA. Serum HBV DNA load was assessed with quantitative real-time polymerase chain reaction (PCR). The relationship between HBV replication and variation in peripheral T-cell subsets was analyzed.RESULTS: CHB patients had significantly decreased CD3+ and CD4+ cells and CD4+/CD8+ ratio, and increased CD8+ cells compared with uninfected controls (55.44 ± 12.39 vs 71.07 ± 4.76, 30.92 ± 7.48 vs 38.94 ± 3.39, 1.01 ± 0.49 vs 1.67 ± 0.33, and 34.39 ± 9.22 vs 24.02 ± 4.35; P < 0.001, respectively). Univariate analysis showed a similar pattern of these parameters was significantly associated with high viral load, presence of serum hepatitis B e antigen (HBeAg) expression, liver disease severity, history of maternal HBV infection, and young age at HBV infection, all with P < 0.01. There was a significant linear relationship between viral load and these parameters of T-lymphocyte subpopulations (linear trend test P < 0.001). There was a negative correlation between the levels of CD3+ and CD4+ cells and CD4+/CD8+ ratio and serum level of viral load in CHB patients (r = -0.68, -0.65 and -0.75, all P < 0.0001), and a positive correlation between CD8+ cells and viral load (r = 0.70, P < 0.0001). There was a significant decreasing trend in CD3+ and CD4+ cells and CD4+/CD8+ ratio with increasing severity of hepatocyte damage and decreasing age at HBV infection (linear trend test P < 0.01). In multiple regression (after adjustment for age at HBV infection, maternal HBV infection status and hepatocyte damage severity) log copies of HBV DNA maintained a highly significant predictive coefficient on T-lymphocyte subpopulations, and was the strongest predictor of variation in CD3+, CD4+, CD8+ cells and CD4+/CD8+ ratio. However, the effect of HBeAg was not significant.CONCLUSION: T-lymphocyte failure was signifi-cantly associated with viral replication level. The substantial linear dose-response relationship and strong independent predictive effect of viral load on T-lymphocyte subpopulations suggests the possibility of a causal relationship between them, and indicates the importance of viral load in the pathogenesis of T cell hyporesponsiveness in these patients. | Jing You Hutcha Sriplung Alan Geater Virasakdi Chongsuvivatwong Lin Zhuang Hong-Ying Chen Lan Yu Bao-Zhang Tang Jun-Hua Huang | 2008 | World Journal of Gastroenterology2008，14，7： | 30 |
| 3 | Dynamic Microwave-assisted Extraction of Flavonoids from Radix Scutellariae显示文摘Dynamic microwave-assisted extraction(DMAE) of flavonoids from Radix Scutellarie was described in this article. A TM010 microwave resonant cavity was used as the energy coupler. Several parameters of DMAE, including concentration, flow rate, volume of the extraction solvent, and irradiation power, were optimized. The extraction was performed under the optimum conditions for the extraction of total flavonoids. The total flavonoids were determined by UV-Vis spectrophotometry. The main bioactive components, including baicalin, baicalein, and wogonin, were determined by HPLC. The extraction yields of the flavonoids obtained by DMAE were compared with those obtained by pressurized microwave assisted extraction(PMAE), ultrasonic extraction(UE), soxhlet extraction(SE), and reflux extraction(RE), and these results indicate that DMAE is a good alternative method for the extraction of flavonoids from Radix Scutellarie. | YOU Jing-yan ZHANG Hua-rong DING Lan XIAO Ting-ting ZHANG Han-qi SONG Da-qian | 2007 | Chemical Research in Chinese Universities2007，23，2： | 12 |
| 4 | Efficacy of thymosin alpha-1 and interferon alpha in treatment of chronic viral hepatitis B:A randomized controlled study显示文摘AIM: To observe the efficiency and safety of thymosin-α1 treatment in patients with hepatitis B e antigen (HBeAg) and HBV DNA positive chronic hepatitis. METHODS: Sixty-two patients were randomly divided into groups A and B. The patients in group A received subcutaneous injection of 1.6 mg thymosin-α1, twice a week (T-α1 group) for six months, and the patients in group B received 5 MU interferon alpha (IFN-α) each day for fifteen days, then three times weekly (IFN-α group) for six months. The results between two groups treated with and the group untreated with IFN-α which was followed up for 12 mo (historical control group consisting of 30 patients) were compared, and three groups were comparable between each other (P > 0.05) at baseline (age, sex, clinical history, biochemical, and serological parameters). RESULTS: At the end of treatment, complete response, which was defined as alanine aminotransferase (ALT) normalization and HBV DNA and HBeAg loss, occurred in 9 of 29 (31.0%) patients in the T-α1 group and in 15 of 33 (45.5%) patients in the IFN-α group (c2 = 1.36, P >0.05). After a follow-up period of six months, a complete response was observed in 14 of 29 (48.3%) patients in the T-α1 group and in 9 of 33 (27.3%) patients in the IFN-α group (c2 = 2.93, P > 0.05). Compared with the results observed in the historical control (HC) group untreated with IFN-α which was followed up for 12 mo, the rate of complete response was significantly higher in IFN-α group at the end of therapy (1 of 30 vs 15 of 33, c2 = 14.72, P < 0.001) and in the T-α1 group at the end of follow-up (1 of 30 vs 14 of 29, c2 = 15.71, P < 0.001). In T-α1 and IFN-α treatment groups, the area under (the plasma concentration time) curve (AUC) of negative HBV DNA and HBeAg was 34%, 17%, 31% and 19% smaller than that in the HC group. By the end of the follow- up period, the proportions of ALT normalization and negative HBV DNA in the T-α1 group were significantly higher than those in the IFN-α and HC groups. The odds of ALT normalization and negative HBV DNA at the end of the follow-up was three-fold higher in the T-α1 group than in the IFN-α group. Unlike IFN-α, T-α1 was well tolerated by all patients, and no side effects appeared in T-α1 group.CONCLUSION: The results suggest that a 6-mo course of T-α1 therapy is effective and safe in patients with chronic hepatitis B. T-α1 is able to reduce HBV replication in patients with chronic hepatitis B. Furthermore, T-α1 is better tolerated than IFN-α and can gradually induce more sustained ALT normalization and HBV DNA and HBeAg loss. However, a response rate of 48.3% is still less ideal. A more effective therapeutic approach warrants further study. | Jing You Lin Zhuang Hong-Ying Cheng Shou-Ming Yan Lan Yu Jun-Hua Huang Bao-Zhang Tang Meng-Ling Huang Yong-Liang Ma Virasakdi Chongsuvivatwong Hutcha Sriplung Alan Geater Yan-Wei Qiao Rong-Xue Wu | 2006 | World Journal of Gastroenterology2006，12，41： | 8 |
| 5 | A new perylene diimide-based colorimetric and fluorescent sensor for selective detection of Cu^(2+) cation显示文摘A new perylene diimide (PDI) ligand (1) functionalized with a dipicolylethylenediamine (DPEN) moiety was synthesized and first used as a colorimetric and fluorometric dual-channel sensor to specifically detect the presence of Cu2+ over a wide range of other cations. The solution of 1 (10 μmol/L) upon ad-dition of Cu2+ displayed distinguishing pink color compared with other cations including K+,Ni2+,Ca2+,Mn2+,Na+,Sr2+,Zn2+,Co2+,Cd2+,Mg2+,Cr3+,Ag+,and Ba2+,indicating the sensitivity and selectivity of 1 to Cu2+. Thus,the advantage of this assay is that naked-eye detection of Cu2+ becomes possible. More-over,among these metal ions investigated,only Cu2+ quenched more than half fluorescent intensity of 1. The ESI-TOF spectrum of a mixture of 1 and CuCl2 in combination of the fluorescence titration spectra of 1 (10 μmol/L) upon addition of various amounts of Cu2+ revealed the formation of a 2︰1 metal-ligand complex through the metal coordination interaction. | YAN LiWei,YANG Li,LAN JingBo & YOU JingSong Key Laboratory of Green Chemistry and Technology of Ministry of Education,College of Chemistry,and State Key Laboratory of Biotherapy,West China Hospital,West China Medical School,Sichuan University,Chengdu 610064,China | 2009 | Science China Chemistry2009，52，4： | 6 |
| 6 | Design of Environmental Monitoring and Control System for Large-scale Pig House with Fermentation Bed显示文摘The design and assembly of environmental monitoring and control system for large-scale pig house with fermentation bed helped to solve the problem of environmental automatic control in piggery.The sensors would monitor the temperature,humidity,light,wind direction,wind speed,CO2,NH3and other parameters.On-line real-time data collection was achieved.The expert system was constructed to control the temperature in piggery below 30℃,to control the air and mattress humidities higher than 65%.Under the conditions of different season or different wind speed,even in day and night,the control actuators were different.The actuators included fanning wet curtain,lighting,micro spraying,spraying,propeller fan,electric aluminum alloy shutter and spraying systems on the roof.The actuators were integrated,and they control the piggery environment simultaneously.The system also designed the remote video monitor interface,parameter-monitoring curved interface and operation interface,which provided a good man-machine interface. | Bo LIU Huiyong ZHENG Yingzhi LIN Shengbing LIU Hongyi ZHENG Chunzhong YOU Huai SHI Jianglin LAN Zhaolong LI Jianyang TANG Qinlou HUANG | 2015 | Agricultural Science & Technology2015，16，2： | 6 |
| 7 | Geospatial Service Web:towards integrated cyberinfrastructure for GIScience显示文摘A geospatial cyberinfrastructure is needed to support advanced GIScience research and education activities.However,the heterogeneous and distributed nature of geospatial resources creates enormous obstacles for building a unified and interoperable geospatial cyberinfrastructure.In this paper,we propose the Geospatial Service Web(GSW)to underpin the development of a future geospatial cyberinfrastructure.The GSW excels over the traditional spatial data infrastructure by providing a highly intelligent geospatial middleware to integrate various geospatial resources through the Internet based on interoperable Web service technologies.The development of the GSW focuses on the establishment of a platform where data,information,and knowledge can be shared and exchanged in an interoperable manner.Theoretically,we describe the conceptual framework and research challenges for GSW,and then introduce our recent research toward building a GSW.A research agenda for building a GSW is also presented in the paper. | GONG Jianya WU Huayi ZHANG Tong GUI Zhipeng LI Zhenlong YOU Lan SHEN Shengyu ZHENG Jie GENG Jing QI Kunlun YANG Wenjing LI Zhenqiang YU Jingmin | 2012 | Geo-Spatial Information Science2012，15，2： | 5 |
| 8 | Predicting Cirrhosis Risk Based on the Level of Circulating Hepatitis B Viral Load显示文摘 | Uchenna H. Iloeje Hwai–I. Yang Jun Su Chin–Lan Jen San–Lin You Chien–Jen Chen | 2006 | Gastroenterology2006，，3： | 4 |
| 9 | Efficacy of water fraction from Dioscorea cirrhosa on oxidative stress and apoptosis in H9c2 cardiomyocytes induced by H2O2显示文摘OBJECTIVE:To investigate the efficacy of water fraction from Dioscorea cirrhosa(WF)on oxidative damage and apoptosis of cardiomyocytes induced by H2O2,and to study its mechanism.METHODS:Cell viability was measured by the MST assay kit.The content of malondialdehyde(MDA),release of lactate dehydrogenase(LDH)and activity of catalase(CAT)and superoxide dismutase(SOD)were detected by biochemical kit.The content of reactive oxygen species(ROS)was assessed by nonfluorescent probe 2′,7′-dichlorofluorescin diacetate(DCFH-DA).JC-1 was used to analyze the mitochondrial membrane potential(mtΔΨ)and Annexin-V-FITC/PI staining was applied to assess apoptosis of H9c2 by flow cytometry.Moreover,the expression of B-cell lymphoma-2(Bcl-2),Bcl-2-associated X(Bax),caspase-3,caspase-9,cleaved-caspase-3 and cleaved-caspase-9 proteins was determined by western blot analysis.RESULTS:WF increased cell viability and decreased LDH leakage in H9c2 cells exposed to H2O2.WF treatment decreased ROS and MDA level,enhanced SOD and CAT activities,improved mtΔΨand inhibited apoptosis.Western blot analysis demonstrated that the ratio of Bcl-2/Bax was increased and the expression cleaved-caspase-3,caspase-3,cleaved-caspase-9 and caspase-9 were decreased in group treated with WF.CONCLUSION:WF protects H9c2 myocardial cells on H2O2-induced oxidative stress and apoptosis by scavenging ROS,improving antioxidant capacity,protecting mitochondrial and regulating the proteins expression related to apoptosis. | LIU Chunhua PAN Jie WANG Aimin LAN Yanyu LI Yongjun LU Yuan SUN Jia WANG Yonglin LIU Ting LU Dingyan YOU Jingrui | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 4 |
| 10 | Application of Keyhole Microneurosurgery in China显示文摘 | Li-Gang Chen Shu-Da Chen Guang-Fu Huang Ying Huang De-Zhi Kang Qing Lan Gang Li Xin-Gang Li Zhi-Xiong Liu Song-Tao Qi Xin-Hua Tian Guo-Liang Wang Shuo Wang Xiang-Yu Wang Yong-Fei Wang Yun-Jie Wang Chao You Yan-Bing Yu Shu-Yuan Yue Dong Zhang Jian-Min Zhang Jian-Ning Zhang Jun-Ting Zhang Shi-Zhong Zhang Xian Zhang Ya-Zhuo Zhang Ji-Zong Zhao Wei-Guo Zhao Yuan-Li Zhao Ding-Biao Zhou Liang-Fu Zhou | 2017 | Chinese Medical Journal2017，，16： | 3 |
| 11 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 12 | Activation of Piezo1 contributes to matrix stiffness-induced angiogenesis in hepatocellular carcinoma显示文摘Background:Despite integrin being highlighted as a stiffness-sensor molecule in matrix stiffness-driven angiogenesis,other stiffness-sensor molecules and their mechanosensory pathways related to angiogenesis in hepatocellular carcinoma(HCC)remain obscure.Here,we explored the interplay between Piezo1 and integrinβ1 in the mechanosensory pathway and their effects on HCC angiogenesis to better understand matrix stiffness-induced angiogenesis.Methods:The role of Piezo1 in matrix stiffness-induced angiogenesis was investigated using orthotopic liver cancer SD rat models with high liver stiffness background,and its clinical significance was evaluated in human HCC tissues.Matrix stiffness-mediated Piezo1 upregulation and activation were assayed using an in vitro fibronectin(FN)-coated cell culture system with different stiffness,Western blotting and Ca^(2+)probe.The effects of shPiezo1-conditioned medium(CM)on angiogenesis were examined by tube formation assay,wound healing assay and angiogenesis array.The underlying mechanism by which Piezo1 participated in matrix stiffness-induced angiogenesis was analyzed by microRNA quantitative real-time polymerase chain reaction(qRT-PCR),matrix stiffness measurement,dual-luciferase reporter assay,ubiquitination assay and co-immunoprecipitation.Results:Increased matrix stiffness significantly upregulated Piezo1 expression at both cellular and tissue levels,and high expression of Piezo1 indicated an unfavorable prognosis.High matrix stiffness also noticeably enhanced the activation level of Piezo1,similar to its expression level.Piezo1 knockdown significantly suppressed tumor growth,angiogenesis,and lung metastasis of HCC rat models with high liver stiffness background.shPiezo1-CM from HCC cells attenuated tube formation and migration abilities of vascular endothelial cells remarkably,and analysis of differentially expressed pro-angiogenic factors revealed that Piezo1 promoted the expression and secretion of vascular endothelial growth factor(VEGF),CXC chemokine ligand 16(CXCL16)and insulin-like growth factor binding protein 2(IGFBP2).Matrix stiffness-caused Piezo1 upregulation/activation restrained hypoxia inducible factor-1α(HIF-1α)ubiquitination,subsequently enhanced the expression of downstream pro-angiogenic factors to accelerate HCC angiogenesis.Besides,collagen 1(COL1)-reinforced tissue stiffening resulted in more expression of Piezo1 via miR-625-5p.Conclusions:This study unravels a new mechanism by which the inte-grinβ1/Piezo1 activation/Ca2+influx/HIF-1αubiquitination/VEGF,CXCL16 and IGFBP2 pathway participates in matrix stiffness-driven HCC angiogenesis.Simultaneously,a positive feedback regulation loop as stiff matrix/integrinβ1/miR-625-5p/Piezo1 and COL1/stiffer matrix mediates matrix stiffness-caused Piezo1 upregulation. | Miao Li Xi Zhang Mimi Wang Yaohui Wang Jiali Qian Xiaoxia Xing Zhiming Wang Yang You Kun Guo Jie Chen Dongmei Gao Yan Zhao Lan Zhang Rongxin Chen Jiefeng Cui Zhenggang Ren | 2022 | Cancer Communications2022，42，11： | 3 |
| 13 | Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles显示文摘 | Mei‐Hsuan Lee Hwai‐I. Yang Jessica Liu Richard Batrla‐Utermann Chin‐Lan Jen Uchenna H. Iloeje Sheng‐Nan Lu San‐Lin You Li‐Yu Wang Chien‐Jen Chen | 2013 | Hepatology2013，，2： | 3 |
| 14 | Identification and Function of Acid-sensing Ion Channels in RAW 264.7 Macrophage Cells显示文摘 | Lan NI Peng FANG Zhuang-li HU Hai-yun ZHOU Jian-guo CHEN Fang WANG You JIN | 2018 | Current Medical Science2018，38，3： | 2 |
| 15 | Recovery of the alografted smalintestine functions显示文摘RecoveryofthealograftedsmalintestinefunctionsJIANGZhiWei,LIJieShou,LINin,LIYouSheng,LIUFangLan,SHENGXueQinandCHENGYong... | JIANG Zhi Wei, LI Jie Shou, LI Nin, LI You Sheng, LIU Fang Lan, SHENG Xue Qin and CHENG Yong Min Subject headings Nutritional support small intestine/transplantation small intestine/physiopathology | 1997 | World Journal of Gastroenterology1997，3，2： | 2 |
| 16 | A spatiotemporal data collection of viral cases for COVID-19 rapid response显示文摘Under the global health crisis of COVID-19,timely,and accurate epi-demic data are important for observation,monitoring,analyzing,modeling,predicting,and mitigating impacts.Viral case data can be jointly analyzed with relevant factors for various applications in the context of the pandemic.Current COVID-19 case data are scattered across a variety of data sources which may consist of low data quality accompanied by inconsistent data structures.To address this short-coming,a multi-scale spatiotemporal data product is proposed as a public repository platform,based on a spatiotemporal cube,and allows the integration of different data sources by adopting various data standards.Within the spatiotemporal cube,a comprehensive data processing workflow gathers disparate COVID-19 epidemic data-sets at the global,national,provincial/state,county,and city levels.This proposed framework is supported by an automatic update with a 2-h frequency and the crowdsourcing validation team to produce and update data on a daily time step.This rapid-response dataset allows the integration of other relevant socio-economic and environ-mental factors for spatiotemporal analysis.The data is available in Harvard Dataverse platform(http://gffzz9c54d31c51204187skowkufbwobwx6nfn.ffgz.tsg.suse.edu.cn/dataset.xhtml?persistentId=doi:10.7910/DVN/8HGECN)and GitHub open source repository(http://gffzz188fe103f8f1460askowkufbwobwx6nfn.ffgz.tsg.suse.edu.cn/stccenter/COVID-19-Data). | Dexuan Sha Yi Liu Qian Liu Yun Li Yifei Tian Fayez Beaini Cheng Zhong Tao Hu Zifu Wang Hai Lan You Zhou Zhiran Zhang Chaowei Yang | 2021 | Big Earth Data2021，5，1： | 2 |
| 17 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 18 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 19 | Tandem Biocatalysis by CotA-TJ102@UIO-66-NH2 and Novozym 435 for Highly Selective Transformation of HMF into FDCA显示文摘2,5-Furandicarboxylic acid (FDCA) is a potential biorenewable chemical for applications including plastics, polyamides, drugs, etc. The selective biosynthesis of FDCA from 5-hydroxymethylfurfural (HMF) by a speci c enzyme poses a great challenge. In this study, we reported an e cient strategy to produce FDCA from HMF by the tandem biocatalysis of laccase (CotA-TJ102@UIO-66-NH 2 ) and Novozym 435. For the rst step, a nanoparticle metal organic framework was synthesized as a carrier to immobilize CotA-TJ102@UIO-66-NH 2 , which was assigned for the production of 5-formyl-2-furancarboxylic acid (FFCA) and featured an enzyme loading of 255.54 mg/g, speci c activity of 135.90 U/mg, and solid loading ratio of 99.65%. Under optimal conditions, an ideal FFCA yield of 98.5% was achieved, and the CotA-TJ102@UIO-66-NH2 pre- sented a high recycling capacity after 10 cycles. For the second step, Novozym 435 was applied for the further conversion of FFCA into FDCA, presenting a high FDCA yield of 95.5% under the optimized conditions. Novozym 435 also exhibited a high recyclability after eight cycles. As a result, the tandem biocatalysis strategy provided a 94.2% FDCA yield from HMF, indicating its excellence as a method for FDCA production. | Xin Chang Chengyu Zhang Lan Gao Xiao Liu Shengping You Wei Qi Kang Wang Xin Guo Rongxin Su Han Lu Zhimin He | 2019 | Transactions of Tianjin University2019，25，5： | 2 |
| 20 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
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