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| 1 | T1ρ/T2 mapping and histopathology of degenerative cartilage in advanced knee osteoarthritis显示文摘AIM To investigate whether normal thickness cartilage in osteoarthritic knees demonstrate depletion of proteoglycan or collagen content compared to healthy knees.METHODS Magnetic resonance(MR) images were acquired from5 subjects scheduled for total knee arthroplasty(TKA)(mean age 70 years) and 20 young healthy control subjects without knee pain(mean age 28.9 years). MR images of T1ρ mapping, T2 mapping, and fat suppressed proton-density weighted sequences were obtained.Following TKA each condyle was divided into 4 parts(distal medial, posterior medial, distal lateral, posterior lateral) for cartilage analysis. Twenty specimens(bone and cartilage blocks) were examined. For each joint,the degree and extent of cartilage destruction was determined using the Osteoarthritis Research Society International cartilage histopathology assessment system.In magnetic resonance imaging(MRI) analysis, 2 readers performed cartilage segmentation for T1ρ/T2 values and cartilage thickness measurement.RESULTS Eleven areas in MRI including normal or near normal cartilage thickness were selected. The corresponding histopathological sections demonstrated mild to moderate osteoarthritis(OA). There was no significant difference in cartilage thickness in MRI between control and advanced OA samples [medial distal condyle, P = 0.461;medial posterior condyle(MPC), P = 0.352; lateral distal condyle, P = 0.654; lateral posterior condyle, P = 0.550],suggesting arthritic specimens were morphologically similar to normal or early staged degenerative cartilage.Cartilage T2 and T1ρ values from the MPC were significantly higher among the patients with advanced OA(P= 0.043). For remaining condylar samples there was no statistical difference in T2 and T1ρ values between cases and controls but there was a trend towards higher values in advanced OA patients. CONCLUSION Though cartilage is morphologically normal or near normal, degenerative changes exist in advanced OA patients. These changes can be detected with T2 and T1ρ MRI techniques. | Benjamin S Kester Philip M Carpenter Hon J Yu Taiki Nozaki Yasuhito Kaneko Hiroshi Yoshioka Ran Schwarzkopf | 2017 | World Journal of Orthopedics2017，8，4： | 12 |
| 2 | Safety and efficacy of a new recombinant F Ⅷ formulated with sucrose (rF Ⅷ - FS) in patients with haemophilia A: a longterm, multicentre clinical study in Japan显示文摘 | Yoshioka A Shima M Fukutake K | 2001 | Haemophilia2001，7，3： | 1 |
| 3 | Rigid polyurethane foams from combined liquefaction mixtures of wood and starch 显示文摘 | Yao Y G Yoshioka M Shiraishi N | 1995 | Mokuzai Gakkaishi1995，41，7： | 1 |
| 4 | Influence of precipitated hydride on the fracture behavior of zircaloy fuel cladding tube显示文摘 | KURODA M YOSHIOKA K YAMANAKA S | 2000 | J Nucl Sci Technol2000，，37： | 1 |
| 5 | High performance amorphous-silicon thin film transistors prepared by catalytic chemical vapor deposition with high deposition rate 显示文摘 | Sakai M Tsutsumi T Yoshioka T | 2001 | Thin Solid Films2001，395，12： | 1 |
| 6 | Population dif- ferentiation in the Pacific white-sided dolphin Lageno- rhynchus obllquidens inferred from mitochondrial DNA and microsatellite analyses 显示文摘 | Hayano A Yoshioka M Tanaka M | 2004 | Zoological Science2004，21，9： | 1 |
| 7 | Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population显示文摘 | SaijoY Utsugi M Yoshioka E | 2009 | Environ Health Prev Med2009，14，3： | 1 |
| 8 | Effects of an interleukin-1 beta analogue[Lys-D-Pro-Thr],on incomplete cerebral ischemia-induced inhibition of long-term potentiation in rat hippocampal neurons in vivo显示文摘 | Yoshioka M hoh Y Mori K | | 0，，03： | 1 |
| 9 | Induction of a small heat shock protein and its functional roles in Nicotiana plants in the defense response against Ralstonia solanacearum显示文摘 | Maimbo M Ohnishi K Hikichi Y Yoshioka H Kiba A | | 0，，04： | 1 |
| 10 | Soluble Properties of Liquefied Biomass Prepared in Organic Solvents the Soluble Behavior of Liquefied Biomass in Various Diluents显示文摘 | YAO Y YOSHIOKA M SHIRAISHI N | 1994 | Moku- zai Gakkaishi1994，40，2： | 1 |
| 11 | Suppression of anchorage independent growth of human cancer cell lines by the TRIF52/periostin/OSF-2 gene显示文摘 | Yoshioka N Fuji S Shimakage M | 2002 | Exp Cell Res2002，279，1： | 1 |
| 12 | Water-absorbing polyurethane foams from liquefied starch 显示文摘 | Yao Y G Yoshioka M Shiraishi N | 1996 | Journal of Applied Polymer Science1996，60，7： | 1 |
| 13 | Pulmonary contusion causes long-term respiratory dysfunction with decreased functional residual capacity显示文摘 | Kishikawa M Yoshioka T Shimazu T | 1991 | J Trauma1991，31，9： | 1 |
| 14 | Functional delinea- tion and differentiation dynamics of human CD4+ T cells ex- pressing the FoxP3 transcription factor显示文摘 | Miyara M Yoshioka Y Kitoh A etal | 2009 | Immunity2009，30，： | 1 |
| 15 | Hydrodesulfurization activity of Co-Mo / Al2 O3 catalysts prepared with citric acid:Post-treatment of calcined catalysts with high Mo loading显示文摘 | Rinaldi N Yoshioka M Kubota T | 2010 | J Jpn Petrol Inst2010，53，5： | 1 |
| 16 | A case of segmental zoster paresis with enhanced anterior and posterior spinal Roots on MRI显示文摘 | Yoshioka M Kurita Y Hashimoto M | 2012 | J Neurol2012，259，3： | 1 |
| 17 | Water-absorbing polyurethane foams from liquefied starch显示文摘 | YOSHIOKA M NOBUO S | 1996 | J Appl Polym Sci1996，60，11： | 1 |
| 18 | A new combination chemotherapy with cis-diammine-glycolatinum (Nedaplatin) and 5-Fu for advanced esophageal cancers显示文摘 | Yoshioka T Gamoh M Shineha R | 1999 | Inter Med1999，38，11： | 1 |
| 19 | Relationship of Helicobacter pylori infection to arterial stiffness in Japanese subjects显示文摘 | Saijo Y Utsugi M Yoshioka E et a1 | 2005 | Hypertens Res2005，28，4： | 1 |
| 20 | Variable-precision Dominance-based Rough Set Approach and Attribute Re- duction显示文摘 | M Inuiguchi Y Yoshioka Y Kusunoki | 2009 | International Journal of Approximate Reasoning2009，50，： | 1 |
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