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您的检索式：作者名="YINGZHE PIAO"
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| 1 | The concentration of CYFRA 21-1, NSE and CEA in cerebro-spinalfluid can be useful indicators for diagnosis of meningeal carcinomatosis oflung cancer显示文摘 | Peng Wang Yingzhe Piao Xiaohui Zhang Wenliang Li Xishan Hao | 2013 | Cancer Biomarkers2013，，2： | 1 |
| 2 | Microsurgical Treatment of Meningiomas Invading the Sagittal or Transverse Sinuses显示文摘OBJECTIVE To analyze our management strategy and results of treat- ing patients affected by meningiomas invading the sagittal or transverse sinuses. METHODS Review of data from 35 patients with pathologically con- firmed meningiomas(29 of the sagittal sinus and 6 of the transverse sinus) surgically treated between from July 1999 and June 2003, including clinical manifestations, mode of diagnosis and curative effect of microsurgery etc. For our surgical decision-making, meningiomas were classified into six types based on the degree of sinus involvement. RESULTS A Simpson's Grade I resection was achieved in 27 cases (77.1%), Grade II in 6 (17.1%) and Grade III in 2 (5.7%). No patients died after the operations. The recurrence rate in the study overall was 2.9%, with a follow-up period from 3 to 6 years. CONCLUSION Application of microsurgical techniques, protection of the sinus, avoidance of damages to the cerebral cortex, veins of the central sulcus, as well as other veins from the tumor, are the major factors for in- creasing the rate of total resection, reducing complications and improving the quality of life for the patients with meningiomas invading the sagittal or trans- verse sinuses. | PengWang Peng Li Chunhua She Yingzhe Piao Xiaoguang Wang Wenliang Li | 2007 | Chinese Journal of Clinical Oncology2007，4，4： | 0 |
| 3 | LSM12 facilitates the progression of colorectal cancer by activating the WNT/CTNNB1 signaling pathway显示文摘Aberrant activation of the WNT signaling pathway is a joint event in colorectal cancer(CRC),but the molecular mechanism is still unclear.Recently,RNA-splicing factor LSM12(like-Sm protein 12)is highly expressed in CRC tissues.This study aimed to verify whether LSM12 is involved in regulating CRC progression via regulating the WNT signaling pathway.Here,we found that LSM12 is highly expressed in CRC patient-derived tissues and cells.LSM12 is involved in the proliferation,invasion,and apoptosis of CRC cells,similar to the function of WNT signaling in CRC.Furthermore,protein interaction simulation and biochemical experiments proved that LSM12 directly binds to CTNNB1(also known asβ-Catenin)and regulates its protein stability to affect the CTTNB1-LEF1-TCF1 transcriptional complex formation and the associated WNT downstream signaling pathway.LSM12 depletion in CRC cells decreased the in vivo tumor growth through repression of cancer cell growth and acceleration of cancer cell apoptosis.Taken together,we suggest that the high expression of LSM12 is a novel factor leading to aberrant WNT signaling activation,and that strategies targeting this molecular mechanism may contribute to developing a new therapeutic method for CRC. | YAN ZHUANG CHUNLAN NING PENGFEI LIU YANPENG ZHAO YUE LI ZHENCHI MA LULING SHAN YINGZHE PIAO PENG ZHAO XUN JIN | 2022 | Oncology Research2022，30，6： | 0 |
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