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| 1 | The hydrothermal karstification and its effect on Ordovician carbonate reservoir in Tazhong uplift of Tarim Basin, Northwest China显示文摘With a detailed study on petrology, mineralogy and geochemistry of some important Ordovician carbonate well core samples in Tazhong uplift of Tarim Basin, the distinguishing symbols of hydrothermal karstification are first put forward as the phenomena of rock hot depigmentation, hot cataclasm and the appearance of typical hydrothermal minerals such as fluorite, barite, pyrite, quartz and sphalerite. The main homogenization temperatures of primary fluid inclusions in fluorite are from 260 to 310℃, indicating the temperature of hydrothermal fluid. The fluid affected the dissolved rocks and showed typical geochemistry features with low contents of Na and Mg, and high contents of Fe, Mn and Si. The ratio of 3He/4He is 0.02Ra, indicating the fluid from the typical continental crust. The hydrothermal fluid karstification pattern may be described as follows: the hot fluid is from the Permian magma, containing dissolving ingredients of CO2 and H2S, and shifts along fault, ruptures and unconformity, and dissolves the surrounding carbonates while it flows. The mechanism of hydrothermal karstification is that the mixture of two or more fluids, which have different ion intensity and pH values, becomes a new unsaturated fluid to carbonates. The hydrothermal karstification is an important process to form hypo-dissolved pinholes in Ordovician carbonates of Tazhong uplift of Tarim Basin, and the forming of hydrothermal minerals also has favorable influence on carbonate reservoirs. | WU MaoBing WANG Yi ZHENG MengLin ZHANG WeiBiao LIU ChunYan | 2007 | Science China Earth Sciences2007，50，z2： | 7 |
| 2 | NUMERICAL SOLUTION OF FLUID-STRUCTURE INTERACTION IN LIQUID-FILLED PIPES BY METHOD OF CHARACTERISTICS显示文摘Fluid-structure interaction (FSI) is essentially a dynamic phenomenon and always exists in fluid-filled pipe system. The four-equation model, which has been proved to be effective to describe and predict the phenomenon of FSI due to friction coupling and Poisson coupling being taken into account, is utilized to describe the FSI of fluid-filled pipe system. Terse compatibility equations are educed by the method of characteristics (MOC) to describe the fluid-filled pipe system. To shorten computing time needed to get the solutions under the condition of keeping accuracy requirement, two steps are adopted, firstly the time step Δt and divided number of the straight pipe are optimized, sec-ondly the mesh spacing Δz close to boundary is subdivided in several submeshes automatically ac-cording to the speed gradient of fluid. The mathematical model and arithmetic are validated by com-parisons between simulation solutions of two straight pipe systems and experiment known from lit-erature. | YANG Chao YI Menglin | 2007 | Chinese Journal of Mechanical Engineering2007，20，3： | 5 |
| 3 | Signaling pathways in rheumatoid arthritis:implications for targeted therapy显示文摘Rheumatoid arthritis(RA)is an incurable systemic autoimmune disease.Disease progression leads to joint deformity and associated loss of function,which significantly impacts the quality of life for sufferers and adds to losses in the labor force.In the past few decades,RA has attracted increased attention from researchers,the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA,which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets.The current review intends to provide a comprehensive overview of RA,including a general introduction to the disease,historical events,epidemiology,risk factors,and pathological process,highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms,including genetic factors,epigenetic factors,summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA.therapeutic interventions including approved drugs,clinical drugs,pre-clinical drugs,and cutting-edge therapeutic technologies.These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future. | Qian Ding Wei Hu Ran Wang Qinyan Yang Menglin Zhu Meng Li Jianghong Cai Peter Rose Jianchun Mao Yi Zhun Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 4 | Basic Performance of the Composite Deck System Composed of Orthotropic Steel Deck and Ultrathin RPC Layer显示文摘 | Xudong Shao Dutao Yi Zhengyu Huang Hua Zhao Bin Chen Menglin Liu | 2013 | Journal of Bridge Engineering2013，，5： | 1 |
| 5 | STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway显示文摘Dear Editor,Rheumatoid arthritis(RA),which is the most common inflammatory arthritis disease,as well as a kind of most prevalent autoimmune disease,affects 1–3%population all over the world.1 Currently available treatments can reduce the disability rate of patients with RA to some extent,but they cannot completely block the inflammatory joint destruction and relieve the pain that comes with it.Our previous study found that Neuron Navigator 2(NAV2)increased significantly in RA and was regulated by transcription factor E2F1.2 However,it is still unclear why NAV2 is elevated at the genetic level in RA fibroblast-like synoviocytes(FLS).Additionally,RA’s exact pathological mechanisms and therapeutic targets are also not fully understood.Hence,an indepth study of the pathogenesis of RA is urgently needed. | Ran Wang Jianghong Cai Keyuan Chen Menglin Zhu Zhaoyi Li Hua Liu Tiantian Liu Jianchun Mao Qian Ding Yi Zhun Zhu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 6 | Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma显示文摘Background Metabolism reprogramming plays a vital role in glioblastoma(GBM)progression and recurrence by producing enough energy for highly proliferating tumor cells.In addition,metabolic reprogramming is crucial for tumor growth and immune-escape mechanisms.Epidermal growth factor receptor(EGFR)amplification and EGFR-vIII mutation are often detected in GBM cells,contributing to the malignant behavior.This study aimed to investigate the functional role of the EGFR pathway on fatty acid metabolism remodeling and energy generation.Methods Clinical GBM specimens were selected for single-cell RNA sequencing and untargeted metabolomics analysis.A metabolism-associated RTK-fatty acid-gene signature was constructed and verified.MK-2206 and MK-803 were utilized to block the RTK pathway and mevalonate pathway induced abnormal metabolism.Energy metabolism in GBM with activated EGFR pathway was monitored.The antitumor effect of Osimertinib and Atorvastatin assisted by temozolomide(TMZ)was analyzed by an intracranial tumor model in vivo.Results GBM with high EGFR expression had characteristics of lipid remodeling and maintaining high cholesterol levels,supported by the single-cell RNA sequencing and metabolomics of clinical GBM samples.Inhibition of the EGFR/AKT and mevalonate pathways could remodel energy metabolism by repressing the tricarboxylic acid cycle and modulating ATP production.Mechanistically,the EGFR/AKT pathway upregulated the expressions of acyl-CoA synthetase short-chain family member 3(ACSS3),acyl-CoA synthetase long-chain family member 3(ACSL3),and long-chain fatty acid elongation-related gene ELOVL fatty acid elongase 2(ELOVL2)in an NF-κB-dependent manner.Moreover,inhibition of the mevalonate pathway reduced the EGFR level on the cell membranes,thereby affecting the signal transduction of the EGFR/AKT pathway.Therefore,targeting the EGFR/AKT and mevalonate pathways enhanced the antitumor effect of TMZ in GBM cells and animal models.Conclusions Our findings not only uncovered the mechanism of metabolic reprogramming in EGFR-activated GBM but also provided a combinatorial therapeutic strategy for clinical GBM management. | Xiaoteng Cui Jixing Zhao Guanzhang Li Chao Yang Shixue Yang Qi Zhan Junhu Zhou Yunfei Wang Menglin Xiao Biao Hong Kaikai Yi Fei Tong Yanli Tan Hu Wang Qixue Wang Tao Jiang Chuan Fang Chunsheng Kang | 2023 | Cancer Communications2023，43，12： | 0 |
| 7 | Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection显示文摘Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic capacities.Methods: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular docking.Results: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory profile.Conclusion: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin. | Xiajing Xu Yongli Guo Menglin Chen Ning Li Yi Sun Shumeng Ren Jiao Xiao Dongmei Wang Xiaoqiu Liu Yingni Pan | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
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