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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 3 | Long-Term Results after Placement of Aortic Bifurcation Self-Expanding Stents: 10 Year Mortality, Stent Restenosis, and Distal Disease Progression显示文摘 | J. Graeme Houston Raj Bhat Rose Ross Peter A. Stonebridge | 2007 | CardioVascular and Interventional Radiology2007，，1： | 2 |
| 4 | Signaling pathways in rheumatoid arthritis:implications for targeted therapy显示文摘Rheumatoid arthritis(RA)is an incurable systemic autoimmune disease.Disease progression leads to joint deformity and associated loss of function,which significantly impacts the quality of life for sufferers and adds to losses in the labor force.In the past few decades,RA has attracted increased attention from researchers,the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA,which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets.The current review intends to provide a comprehensive overview of RA,including a general introduction to the disease,historical events,epidemiology,risk factors,and pathological process,highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms,including genetic factors,epigenetic factors,summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA.therapeutic interventions including approved drugs,clinical drugs,pre-clinical drugs,and cutting-edge therapeutic technologies.These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future. | Qian Ding Wei Hu Ran Wang Qinyan Yang Menglin Zhu Meng Li Jianghong Cai Peter Rose Jianchun Mao Yi Zhun Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 5 | Pharmacokinetics of linagliptin in subjects with hepatic impairment显示文摘 | Ulrike Graefe‐Mody Peter Rose Silke Retlich Arne Ring Lisa Waldhauser Rodica Cinca Hans‐Juergen Woerle | 2012 | British Journal of Clinical Pharmacology2012，，1： | 2 |
| 6 | Redicting Business Failure: A Macroeconomic Perspective 显示文摘 | Rose Peter S Andrews Wesley T Giroux Gary A P | 1982 | Journal of Accounting Auditing and Finance1982，，1： | 1 |
| 7 | Blast wave propagation in city streets -an overview显示文摘 | Peter D Smith Timothy A Rose | 2006 | Structural Safety and Reliability2006，，8： | 1 |
| 8 | PERCEIVED SOCIAL SUPPORT MEDIATES ANXIETY AND DEPRESSIVE SYMPTOM CHANGES FOLLOWING PRIMARY CARE INTERVENTION显示文摘 | Halina J. Dour Joshua F. Wiley Peter Roy‐Byrne Murray B. Stein Greer Sullivan Cathy D. Sherbourne Alexander Bystritsky Raphael D. Rose Michelle G. Craske | 2014 | Depress Anxiety2014，，5： | 1 |
| 9 | X-ray imaging of 30 year old wine grape wood reveals cumulative impacts of rootstocks on scion secondary growth and Ravaz index显示文摘Annual rings from 30 year old vines in a California rootstock trial were measured to determine the effects of 15 different rootstocks on Chardonnay and Cabernet Sauvignon scions.Viticultural traits measuring vegetative growth,yield,berry quality,and nutrient uptake were collected at the beginning(1995 to 1999)and end(2017 to 2020)of the lifetime of a vineyard initially planted in 1991 and removed in 2021.X-ray Computed Tomography(CT)was used to measure ring widths in 103 vines.Ring width was modeled as a function of ring number using a negative exponential model.Early and late wood ring widths,cambium width,and scion trunk radius were correlated with 27 traits.Modeling of annual ring width shows that scions alter the width of the first rings but that rootstocks alter the decay of later rings,consistently shortening ring width throughout the lifetime of the vine.Ravaz index,juice pH,photosynthetic assimilation and transpiration rates,and instantaneous water use efficiency are correlated with scion trunk radius.Ultimately,our research indicates that rootstocks modulate secondary growth over years,altering physiology and agronomic traits.Rootstocks act in similar but distinct ways from climate to modulate ring width,which borrowing techniques from dendrochronology,can be used to monitor both genetic and environmental effects in woody perennial crop species. | ZoëMigicovsky Michelle Y.Quigley Joey Mullins Tahira Ali Joel F.Swift Anita Rose Agasaveeran Joseph D.Dougherty Brendan Michael Grant Ilayda Korkmaz Maneesh Reddy Malpeddi Emily L.McNichol Andrew W.Sharp Jackie L.Harris Danielle R.Hopkins Lindsay M.Jordan Misha T.Kwasniewski R.Keith Striegler Asia L.Dowtin Stephanie Stotts Peter Cousins Daniel H.Chitwood | 2023 | Horticulture Research2023，10，1： | 1 |
| 10 | Measurements of suspended sediment transport parameters in a tidal estuary显示文摘 | Rose Christopher P Peter D Thorne | 2001 | Cont Shelf Resh2001，，21： | 1 |
| 11 | Pharmacokinetics of linagliptin in subjects with hepatic impairment显示文摘 | Ulrike Graefe‐Mody Peter Rose Silke Retlich Arne Ring Lisa Waldhauser Rodica Cinca Hans‐Juergen Woerle | 2012 | British Journal of Clinical Pharmacology2012，，1： | 1 |
| 12 | Diversification of the Banking Firm显示文摘 | Rose Peter S | 1989 | The Financial Review1989，24，2： | 1 |
| 13 | An integrated anaerobic aerobic bioprocess for the remediation of chlorinated phenol- contaminated soil and groundwater显示文摘 | GEORGE A Ehlers PETER D Rose | 2006 | Water Environment Research2006，78，： | 1 |
| 14 | Development of New Reconstructive Techniques: Use of Integra in Combination with Fibrin Glue and Negative-Pressure Therapy for Reconstruction of Acute and Chronic Wounds显示文摘 | Marc G. Jeschke Christoph Rose Peter Angele Bernd Füchtmeier Michael N. Nerlich Ulrich Bolder | 2004 | Plastic and Reconstructive Surgery2004，，： | 1 |
| 15 | Filter and Broker: An Integrated Architecture for Information Mediation of Dynamic Sources 显示文摘 | Brigitte Grote Thomas Rose Gerhard Peter | | Journal of Organizational Computing and Electronic Commerce0，12，2： | 1 |
| 16 | Combined-Modality Therapy of Locally Advanced Cervical Cancer显示文摘 | Rose Peter G | 2003 | Journal of Clinical Oncology2003，21，10： | 1 |
| 17 | Taking a Calculated Risk显示文摘 | William Bailey Benoit Couet Fiona Lamb Graeme Simpson Peter Rose | 2000 | Oilfield Review Autumn2000，2035，： | 1 |
| 18 | The REMATCH trial: rationale, design, and end points显示文摘 | Eric A Rose Alan J Moskowitz Milton Packer Josephine A Sollano Deborah L Williams Anita R Tierney Daniel F Heitjan Paul Meier Deborah Davis Ascheim Ronald G Levitan Alan D Weinberg Lynne Warner Stevenson Peter A Shapiro Ronald M Lazar John T Watson Daniel | 1999 | The Annals of Thoracic Surgery1999，，3： | 1 |
| 19 | Autoimmune Hypophysitis显示文摘 | Patrizio Caturegli Craig Newschaffer Alessandro Olivi Martin G. Pomper Peter C. Burger Noel R. Rose | 2005 | Endocrine Reviews2005，，5： | 1 |
| 20 | The first demonstration of a microbial fuel cell as a viable power supply: Powering a meteorological buoy显示文摘 | Leonard M. Tender Sam A. Gray Ethan Groveman Daniel A. Lowy Peter Kauffman Julio Melhado Robert C. Tyce Darren Flynn Rose Petrecca Joe Dobarro | 2008 | Journal of Power Sources2008，，2： | 1 |
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