4篇
您的检索式：作者名="YAO HeQuan"
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| 1 | A new approach to the bicyclo[3.3.1]nonane framework of huperzine A-like molecules via palladium-catalyzed intramolecular γ-arylation显示文摘In our synthetic studies toward huperzine A, a diastereoselective α′-alkylation of the α-amido-γ-methyl hexenone 4 was realized through a dianion intermediate which significantly enhanced the reactivity. Under the attempted Heck reaction conditions, an unexpected and unprecedented palladium-catalyzed intramolecular γ-arylation of 3 was observed, which generated 18 with bicyclo[3.3.1]nonane framework in satisfactory yield. | DING Rui LU YunYu YAO HeQuan SUN BingFeng LIN GuoQiang | 2012 | Science China Chemistry2012，55，6： | 2 |
| 2 | Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation显示文摘 | Dahong Li Shengtao Xu Hao Cai Lingling Pei Hengyuan Zhang Lei Wang Hequan Yao Xiaoming Wu Jieyun Jiang Yijun Sun Jinyi Xu | 2013 | European Journal of Medicinal Chemistry2013，，： | 1 |
| 3 | Site-Selective Palladium-Catalyzed 1,1-Arylamination of Terminal Alkenes显示文摘Many of the commonly used pharmaceuticals and biologically active natural products are nitrogencontaining compounds.Recently,the transitionmetal-catalyzed or the radical-mediated 1,2-carboamination of alkenes has been well explored to access amine scaffolds.However,synthetic strategies toward the 1,1-carboamination of alkenes are severely limited.Herein,we describe a method to achieve the 1,1-arylamination using readily available building blocks enabled by palladium catalysis.This sequential three step-Heck arylation,metal migration,followed by aza-1,6-Micheal addition process exhibits excellent chemo-and regioselectivity.To showcase the potential as a method for diversity-oriented drug discovery,the modification of numerous structurally complex bioactive molecules was also successfully performed. | Chunhua Han Libo Cai Dongquan Zhang Rui Pan Qiuyu Li Aijun Lin Hequan Yao | 2022 | CCS Chemistry2022，4，2： | 0 |
| 4 | Palladium-catalyzed asymmetric carbamoyl-carbonylation of alkenes显示文摘An unprecedented palladium-catalyzed asymmetric carbamoyl-carbonylation of tethered alkenes with CO and alcohols has been developed.This reaction provided an efficient route to access oxindoles andγ-lactams bearingβ-carbonyl substituted quaternary carbons in good yields with excellent chemo-,regio-and enantioselectivity.Gram-scale synthetic capability and facile transformations of the products to chiral spirooxindole and other functional molecules further illustrated the practicability of this reaction. | Ziwen Feng Qiuyu Li Long Chen Hequan Yao Aijun Lin | 2021 | Science China Chemistry2021，64，8： | 0 |
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