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| 1 | High-frequency enhanced response based on Sb_(2)Te_(3)topological insulators显示文摘Topological insulators represent a new quantum phase of matter with spin-polarized surface states that are protected from backscattering, exhibiting electronic responses to light, such as topological quantum phase transitions. However, the effects of high-frequency driving topological intrinsic systems have remained largely unexplored challenges experimentally for high-sensitivity terahertz detection. In this study, by integrating Sb2Te3 topological insulators with subwavelength metal antennas through micro-nano processing, a high-frequency terahertz detector with high sensitivity is proposed. The enhanced response originates from the asymmetric scattering of the surface electrons in the Sb_(2)Te_(3) flakes induced by the terahertz wave. The device displays room-temperature photodetection with a responsivity of 192 mA/W and equivalent noise power of less than 0.35 nW/Hz^(1/2) in the frequency range from 0.02 to 0.3 THz. These results pave the way for the exploitation of topological insulators for high-frequency operation in real-time imaging within long-wavelength optoelectronics. | SHI ZHANG CHAOFAN SHI WEIWEI TANG LIBO ZHANG LI HAN CHENGSEN YANG ZHENGYANG ZHANG JIAN WANG MIAO CAI GUANHAI LI CHANGLONG LIU LIN WANG XIAOSHUANG CHEN WEI LU | 2022 | Photonics Research2022，10，10： | 1 |
| 2 | Effect of hydration pretreatment on tunnel etching behaviour of aluminium foil显示文摘 | LIANG Libo HE Yedong SONG Hongzhou YANG Xiaofei CAI Xiaoyu XIONG Chuanyong LI Yingri | 2013 | Corrosion Science2013，70，： | 1 |
| 3 | Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration显示文摘Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally-invasive approach.Injectable calcium phosphate bone cement(CPC)has attracted broad attention for its bioactivity,as compared to non-degradable polymethyl methacrylate cement.However,its brittleness,poor anti-washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt weakness.Herein,we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid)(PLGA)nanofiber into CPC,with carboxymethyl cellulose(CMC)to offer good injectability as well as anti-wash-out capacity.Furthermore,the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements,where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ingrowth.Inter-estingly,the reinforced biodegradable cement afforded a sustainable provision of Ca^(2+)bioactive components,together with its porous structure,to improve synergistically new bone formation and osteo-integration in vivo by using a rat model of femur condyle defect.Further study on regenerative mechanisms indicated that the good minimally-invasive bone regeneration may come from the synergistic enhanced osteogenic effect of calcium ion enrichment and the improved revascularization capacity contributed from the porosity as well as the lactic acid released from PLGA nanofiber.These results indicate the injectable bone cement with high strength,anti-washout property and controllable biodegradability is a promising candidate for bone regeneration in a minimally-invasive approach. | Peihao Cai Shunyi Lu Jieqin Yu Lan Xiao Jiayi Wang Haifeng Liang Lei Huang Guanjie Han Mengxuan Bian Shihao Zhang Jian Zhang Changsheng Liu Libo Jiang Yulin Li | 2023 | Bioactive Materials2023，，3： | 1 |
| 4 | Site-Selective Palladium-Catalyzed 1,1-Arylamination of Terminal Alkenes显示文摘Many of the commonly used pharmaceuticals and biologically active natural products are nitrogencontaining compounds.Recently,the transitionmetal-catalyzed or the radical-mediated 1,2-carboamination of alkenes has been well explored to access amine scaffolds.However,synthetic strategies toward the 1,1-carboamination of alkenes are severely limited.Herein,we describe a method to achieve the 1,1-arylamination using readily available building blocks enabled by palladium catalysis.This sequential three step-Heck arylation,metal migration,followed by aza-1,6-Micheal addition process exhibits excellent chemo-and regioselectivity.To showcase the potential as a method for diversity-oriented drug discovery,the modification of numerous structurally complex bioactive molecules was also successfully performed. | Chunhua Han Libo Cai Dongquan Zhang Rui Pan Qiuyu Li Aijun Lin Hequan Yao | 2022 | CCS Chemistry2022，4，2： | 0 |
| 5 | Ecological health analysis of wetlands in the middle reaches of Yangtze River under changing environment显示文摘Changes in wetland ecosystems have a critical impact on the local ecology and species diversity.Different development scenarios and policies are key factors influencing their changes.Therefore,we studied changes of wetlands in the middle Yangtze River basin(MYRB)in 2001-2020,and a patch-generated land use simulation(PLUS)model and random forest(RF)method were applied to predict and analyze the changes under different scenarios in the MYRB in the future(i.e.2035-2095).The results indicated that:(1)The regions with high wetland proportions were concentrated in the central and eastern MYRB in 2001-2020,with a 1.5%decrease in overall wetland area;(2)The RF could simulate the future ecological quality with training and testing accuracies of 0.98 and 0.92,respectively;(3)Remote Sensing Ecological Index(RSEI)less than 0.5 in the central and eastern regions and 13.3%reduction in the northwest in the SSP245 scenario.In general,the study provides a basis for future regional studies of ecosystem quality and provides data to support wetland conservation and management. | Shengqing Zhang Xiaoyan Zhai Peng Yang Jun Xia Sheng Hu Libo Zhou Cai Fu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 6 | Protein phosphatase 6 (Pp6) is crucial for regulatory T cell function and stability in autoimmunity显示文摘Regulatory T(T_(reg))cells constitute a dynamic population that is critical in autoimmunity.T_(reg) cell therapies for autoimmune diseases are mainly focused on enhancing their suppressive activities.However,recent studies demonstrated that certain inflammatory conditions induce T_(reg) cell instability with diminished FoxP3 expression and convert them into pathogenic effector cells.Therefore,the identification of novel targets crucial to both T_(reg) cell function and plasticity is of vital importance to the development of therapeutic approaches in autoimmunity.In this study,we found that conditional Pp6 knockout(cKO)in T_(reg) cells led to spontaneous autoinflammation,immune cell activation,and diminished levels of FoxP3 in CD4^(+)T cells in mice.Loss of Pp6 in T_(reg) cells exacerbated two classical mouse models of T_(reg)-related autoinflammation.Mechanistically,Pp6 deficiency increased CpG motif methylation of the FoxP3 locus by dephosphorylating Dnmt1 and enhancing Akt phosphorylation at Ser473/Thr308,leading to impaired FoxP3 expression in T_(reg) cells.In summary,our study proposes Pp6 as a critical positive regulator of FoxP3 that acts by decreasing DNA methylation of the FoxP3 gene enhancer and inhibiting Akt signaling,thus maintaining T_(reg) cell stability and preventing autoimmune diseases. | Wei Cai Junxun Zhang Hong Zhou Xiangxiao Li Fangzhou Lou Yang Sun Zhenyao Xu Jing Bai Qianqian Yin Zhikai Wang Libo Sun Xiaojie Cai Sibei Tang Yue Wu Li Fan Hong Wang Honglin Wang Qun Li | 2022 | Genes & Diseases2022，9，2： | 0 |
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