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| 1 | Chemical screen identifies a geroprotective role of quercetin in premature aging显示文摘Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders. | Lingling Geng Zunpeng Liu Weiqi Zhang Wei Li Zeming Wu Wei Wang Ruotong Ren Yao Su Peichang Wang Liang Sun Zhenyu Ju Piu Chan Moshi Song Jing Qu Guang-Hui Liu | 2019 | Protein & Cell2019，10，6： | 13 |
| 2 | Air pollution in mega cities in China显示文摘 | Chak K. Chan Xiaohong Yao | 2007 | Atmospheric Environment2007，，1： | 10 |
| 3 | Would integrated Western and traditional Chinese medicine have more benefits for stroke rehabilitation? A systematic review and meta-analysis显示文摘Background Stroke is a major cause of death or long-term disability worldwide.Many patients with stroke receive integrative therapy consisting of Western medicine(WM)and routine rehabilitation in conjunction with Chinese medicine(CM),such as acupuncture and Chinese herbal medicine.However,there is no available evidence on the effectiveness of the combined use of WM and CM interventions in stroke rehabilitation.Aims The purpose of this meta-analysis is to evaluate the results of all individual studies to assess the combined use of CM and WM in stroke rehabilitation compared with WM only.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed.MEDLINE,EMBASE,Cochrane and China National Knowledge Infrastructure(CNKI)were searched.The included outcomes were dependency,motor function,depression and swallowing function.Subgroup analysis was performed,and publication bias was assessed using funnel plots.Summary of review 58 studies and 6339 patients were included in the meta-analysis.Subgroup analysis revealed that combined therapy comprising both acupuncture and WM had a superior effect on improving dependency and swallowing function compared with standard WM therapy alone.Potential superiority of combined therapy comprising CM and WM in improving depression compared with standard WM therapy was also found.Conclusions Our results indicate that the combined use of CM and WM could be more efficacious in stroke rehabilitation compared with the use of WM therapy alone.However,most studies were short in duration(2 to 4 weeks)and prone to different types of biases,which prevents making any conclusion regarding the long-term effects and raises concerns regarding true efficacy in context of high likelihood of Hawthorn bias.So,more randomised controlled trials with more rigorous design and longer duration of treatment and follow-up need to be conducted to compare WM alone versus WM and CM combined. | Linda LD Zhong Ya Zheng Alexander Y Lau Norman Wong Liang Yao Xingyao Wu Tengteng Shao Zhenxing Lu Huijuan Li Chun Sum Yuen Jianwen Guo Suzanne Lo Janita Chau Kam Wa Chan Bacon Fung Leung Ng Zhaoxiang Bian Edwin Chau-leung Yu | 2022 | Stroke & Vascular Neurology2022，7，1： | 7 |
| 4 | One-step synthesis of fluorescent smart thermo- responsive copper clusters: A potential nanothermometer in living cells显示文摘与在生活房间探查的敏感温度一起,在生物学和医药诊断的温度测量是很重要的;然而,它仍然面对重要挑战。有吸引人的光性质的金属 nanoclusters (NC ) 可能正在答应候选人克服如此的挑战。这里,一出新奇一步舞合成方法被介绍准备高度荧光灯处于由把谷胱甘肽(GSH ) 用作减少的代理人和阻止同样形成的 NC 的聚集的保护的层的周围的条件的铜 NC (CuNCs ) 。结果的 CuNCs 与 2.3 nm 的一条平均直径,包含 13 原子和展览红荧光( 他们 = 610 nm ) 与高量收益(QY,多达 5.0%) 。有趣地, CuNCs 的荧光信号在意大利对在 1580 的范围的环境温度 reversibly 应答。学习题目经历了 ba 慀 ? 慀吗?? | Chan Wang Lin Ling Yagang Yao Qijun Song | 2015 | Nano Research2015，8，6： | 5 |
| 5 | Tuneable red,green,and blue single-mode lasing in heterogeneously coupled organic spherical microcavities显示文摘Tuneable microlasers that span the full visible spectrum,particularly red,green,and blue(RGB)colors,are of crucial importance for various optical devices.However,RGB microlasers usually operate in multimode because the mode selection strategy cannot be applied to the entire visible spectrum simultaneously,which has severely restricted their applications in on-chip optical processing and communication.Here,an approach for the generation of tuneable multicolor single-mode lasers in heterogeneously coupled microresonators composed of distinct spherical microcavities is proposed.With each microcavity serving as both a whispering-gallery-mode(WGM)resonator and a modulator for the other microcavities,a single-mode laser has been achieved.The colors of the single-mode lasers can be freely designed by changing the optical gain in coupled cavities owing to the flexibility of the organic materials.Benefiting from the excellent compatibility,distinct color-emissive microspheres can be integrated to form a heterogeneously coupled system,where tuneable RGB single-mode lasing is realized owing to the capability for optical coupling between multiple resonators.Our findings provide a comprehensive understanding of the lasing modulation that might lead to innovation in structure designs for photonic integration. | Yuxiang Du Chang-Ling Zou Chunhuan Zhang Kang Wang Chan Qiao Jiannian Yao Yong Sheng Zhao | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 6 | Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B显示文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status. | Calvin Q Pan Sing Chan Huy Trinh Alan Yao Ho Bae Lillian Lou | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 7 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 8 | Graphs Whose Critical Groups Have Larger Rank显示文摘图 G 的批评的组 C (G) 是跨越图的树的数字的精炼并且仔细与拉普拉斯算符矩阵被连接。让 r (G) 是发电机的最小的数字(即,等级) 组 C,(G) 和(G) 是 G 的独立周期的数字。在这份报纸,某禁止的导致的 subgraphs 为 r (G)= n 被给 3 并且有 r (G)=(G)= n 的所有图 3 被描绘。 | Yao Ping HOU Wai Chee SHIU Wai Hong CHAN | 2011 | Acta Mathematica Sinica,English Series2011，27，9： | 3 |
| 9 | Air pollution in mega cities in China显示文摘 | Chak K. Chan Xiaohong Yao | 2007 | Atmospheric Environment2007，，1： | 3 |
| 10 | Performance of BCC-CSM Models with Different Horizontal Resolutions in Simulating Extreme Climate Events in China显示文摘In this study,the performance of the Beijing Climate Center(BCC)Climate System Model version 1.1(BCCCSM1.1)(280-km resolution)and the BCC-CSM1.1 m(110-km resolution)in simulating extreme climate events over China in the last 40 years is compared.Both models capture the main spatial distribution features of heavy precipitation(R95T),the number of consecutive wet days(CWD),the annual count of days with precipitation≥1 mm(R1),the maximum consecutive 5-day precipitation(Rx5),and the numbers of frost days(FD)and summer days(SU).The BCC-CSM1.1 m has a better ability to simulate the detailed distribution of extreme climate events than the BCCCSM1.1,including R95T,CWD,R1,and the simple precipitation intensity index(SDII).However,the BCCCSM 1.1 m does not show an improvement in simulating the number of days with extreme precipitation(R90N),the number of consecutive dry days(CDD),the heat wave duration index(HWDI),the warm day frequency(TX90 P),and cold night frequency(TN10P).This indicates that the simulation of the R95T,CWD,R1,and SDII climate events is more sensitive to the resolution of the model.The improved BCC-CSM1.1 m is used to explore the projection of extreme climate change in China during the 21 st century under the RCP4.5(Representative Concentration Pathways)and RCP8.5 scenarios.The results show that extreme precipitation will increase dramatically over North and Southwest China in the late 21 st century.The CWD index will decrease on the Tibetan Plateau and in northeastern and central China and will increase in other parts of China;R1 will increase in northern China and decrease in southern China;Rx5 will increase dramatically in southern China;FD will decrease and SU will increase over China in the late 21 st century under both emission scenarios,with larger amplitudes in RCP8.5. | Linxiao WEI Xiaoge XIN Chan XIAO Yonghua LI Yao WU Hongyu TANG | 2019 | Journal of Meteorological Research2019，33，4： | 3 |
| 11 | Lack of Response in Severe Pneumocystis Pneumonia to Combined Caspofungin and Clindamycin Treatment: a Case Report显示文摘PNEUMOCYSTIS pneumonia (PCP) is among the most common opportunistic infections in patients with acquired immune deficiency syndrome (AIDS).Although trimethoprim-sulfamethoxazole (TMP-SMX) is the first line therapy for that condition given its efficacy,approximately one third of patients experienced dose-limiting toxicity.1 For cases of severe to moderate PCP,if TMP-SMX treatment fails or is contraindicated,primaquine combined with clindamycin or intravenous pentamidine is recommended as second line therapy.2 However,both primaquine and pentamidine are associated with severe adverse reactions and often unavailable at hospitals in China.3 As a result,other treatment options have been explored. | Yao Zhang Hua Zhang Jun Xu Chan Wu Xiao-jun Ma | 2011 | Chinese Medical Sciences Journal2011，26，4： | 3 |
| 12 | Gas sensing capabilities of TiO_(2) porous nanoceramics prepared through premature sintering显示文摘Pure and noble metal(Pt,Pd,and Au)doped TiO_(2)nanoceramics have been prepared from TiO_(2)nanoparticles through traditional pressing and sintering.For those samples sintered at 550℃,a typical premature sintering occurred,which led to the formation of a highly porous microstructure with a Brunauer-Emmett-Teller(BET)specific surface area of 23 m^(2)/g.At room temperature,only Pt-doped samples showed obvious response to hydrogen,with sensitivities as high as~500 for 1000 ppm H_(2)in N_(2);at 300℃,all samples showed obvious responses to CO,while the responses of noble metal doped samples were much higher than that of the undoped ones.The mechanism for the observed sensing capabilities has been discussed,in which the catalytic effect of Pt for hydrogen is believed responsible for the room-temperature hydrogen sensing capabilities,and the absence of glass frit as commonly used in commercial thick-film metal oxide gas sensors is related to the high sensitivities.It is proposed that much attention should be paid to metal oxide porous nanoceramics in developing gas sensors with high sensitivities and low working temperatures. | Yao XIONG Zilong TANG Yu WANG Yongming HU Haoshuang GU Yuanzhi LI Helen Lai Wah CHAN Wanping CHEN | 2015 | Journal of Advanced Ceramics2015，4，2： | 3 |
| 13 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 14 | Experimental investigation of regulated and unregulated emissions from a diesel engine fueled with Euro V diesel fuel and fumigation methanol显示文摘 | Z.H. Zhang C.S. Cheung T.L. Chan C.D. Yao | 2009 | Atmospheric Environment2009，，8： | 2 |
| 15 | CH_2,NH,and O heteroatom substitution effects on the electronic,optical,and charge transport properties of a 2,1,3-benzothiadiazole-based derivative:Insights from theory显示文摘A set of CH2-,NH-,and O-substituted 2,1,3-benzothiadiazole(BTD)-based derivatives have been investigated theoretically in order to explore their electronic,optical,and charge transport properties.The calculation results show that the electronic and optical properties of the pristine molecule can be easily tuned through changing the S substituent in the central aromatic ring.Based on the calculated maximum emission wavelength,we predict that CH2-,NH-,and O-substituted BTD-based derivatives could be used as red,green,and orange light-emitting materials,respectively.After CH2-,NH-or O-substitution,the oscillator strengths of the emission spectra are enhanced with respect to that of the pristine molecule,implying that these compounds have larger fluorescence intensity.Finally,it can be deduced that CH2-,NH-,and O-substituted BTD-based derivatives may act as hole transport materials in organic light-emitting diodes. | HU Bo YAO Chan WANG QingWei ZHANG Hao YU JianKang | 2012 | Science China Chemistry2012，55，7： | 2 |
| 16 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 17 | Characterization of edible bird’s nest by peptide fingerprinting with principal component analysis显示文摘OBJECTIVES:Proteins are the major component and play a key role in nutritious and therapeutic functions of edible bird’s nest(EBN);however,limited studies have been conducted on the protein due to difficulties in extraction,isolation as well as identification.This study aimed to provide comprehensive information for the quality evaluation of EBN peptides,which would be a valuable reference for further study on EBN proteins.METHODS:Here,we developed a quality control method using high performance liquid chromatography(HPLC)peptide fingerprints deriving from EBN being digested with simulated gastric fluid.The characteristic peptide peaks were collected and identified by LC-MS/MS.RESULTS:The characteristic peptide peaks,corresponding to the protein fragments of acidic mammalian chitinase-like,lysyl oxidase,and Mucin-5AC-like,were identified and quantified.Interestingly,the principal component analysis indicated that the fingerprints were able to discriminate colour of EBN(white/red)and production sites(cave/house)of White EBN on the same weight basis.As proposed by the model developed in this study,Muc-5AC-like and AMCaselike proteins were the markers with the highest discriminative power.CONCLUSIONS:The overall findings suggest that HPLC peptide fingerprints were able to clearly demonstrate peptide profile differences between genuine and adulterated EBN samples;and classify EBN samples by its color and production site.In addition,the protein identification results suggested that Muc-5AC-like protein was the major protein in EBN. | Chun-Fai Wong Gallant Kar-Lun Chan Ming-Lu Zhang Ping Yao Huang-Quan Lin Tina Ting-Xia Dong Geng Li Xiao-Ping Lai Karl Wah-Keung Tsim | 2017 | Food Quality and Safety2017，1，1： | 2 |
| 18 | Concentration and chemical composition of PM 2.5 in Shanghai for a 1-year period显示文摘 | Boming Ye Xueli Ji Haizhen Yang Xiaohong Yao Chak K Chan Steven H Cadle Tai Chan Patricia A Mulawa | 2002 | Atmospheric Environment2002，，4： | 2 |
| 19 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 20 | The water-soluble ionic composition of PM25 in Shanghai and Beijing,China显示文摘 | YAO X H CHAN C K FANG M | 2002 | Atmos Environ2002，36，26： | 1 |
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