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| 1 | Post-translational regulation of inflammasomes显示文摘在对微生物引起的感染的有免疫力的保护的 Inflammasomes 戏必需品角色。然而,过多的发炎在各种各样的人的疾病被含有,包括 autoinflammatory 症候群,糖尿病,多重硬化,心血管的混乱和 neurodegenerative 疾病。因此,当限制并行的织物损坏时, inflammasome 活动的精确规定为足够的有免疫力的保护是批评的。在这评论,我们集中于调整 NLRP3, NLRP1, NLRC4, AIM2 和 IFI16 inflammasomes 的激活的 translational 以后修正(PTM ) 的新兴的角色。我们预计 PTM 的这些类型将在另外的类型和更少的描绘得好的 inflammasomes 被识别。因为这些高度多样、万用的 PTM 响应感染和织物损坏塑造不同煽动性的回答,指向酶在这些包含了 PTM 将无疑在各种各样的 pathophysiological 条件下面为 inflammasome 活动的精确调整提供机会。 | Jie Yang Zhonghua Liu Tsan Sam Xiao | 2017 | Cellular & Molecular Immunology2017，14，1： | 15 |
| 2 | Serum Amyloid A Protein: A Potential Biomarker Correlated With Clinical Stage of Lung Cancer显示文摘Objective To identify serum diagnosis or progression biomarkers in patients with lung cancer using protein chip profiling analysis. Method Profiling analysis was performed on 450 sera collected from 213 patients with lung cancer, 19 with pneumonia, 16 with pulmonary tuberculosis, 65 with laryngeal carcinoma, 55 with laryngopharyngeal carcinoma patients, and 82 normal individuals. A new strategy was developed to identify the biomarkers on chip by trypsin pre-digestion. Results Profiling analysis demonstrated that an 11.6kDa protein was significantly elevated in lung cancer patients, compared with the control groups (P<0.001). The level and percentage of 11.6kDa protein progressively increased with the clinical stages I-IV and were also higher in patients with squamous cell carcinoma than in other subtypes. This biomarker could be decreased after operation or chemotherapy. On the other hand, 11.6kDa protein was also increased in 50% benign diseases of lung and 13% of other cancer controls. After trypsin pre-digestion, a set of new peptide biomarkers was noticed to appear only in the samples containing a 11.6kDa peak. Further identification showed that 2177Da was a fragment of serum amyloid A (SAA, MW 11.6kDa). Two of the new peaks, 1550Da and 1611Da, were defined from the same protein by database searching. This result was further confirmed by partial purification of 11.6kDa protein and MS analysis. Conclusion SAA is a useful biomarker to monitor the progression of lung cancer and can directly identify some biomarkers on chip. | DAN-HUI LIU XIAO-MIN WANG LI-JUAN ZHANG SONG-WEI DAI LI-YUN LIU JI-FU LIU SHAN-SHAN WU SHUAN-YING YANG SAM FU XUE-YUAN XIAO DA-CHENG HE | 2007 | Biomedical and Environmental Sciences2007，20，1： | 12 |
| 3 | The influence of pore structure on P-& S-wave velocities in complex carbonate reservoirs with secondary storage space显示文摘Secondary storage spaces with very complex geometries are well developed in Ordovician carbonate reservoirs in the Tarim Basin,which is taken as a study case in this paper.It is still not clear how the secondary storage space shape influences the P-& S-wave velocities (or elastic properties) in complex carbonate reservoirs.In this paper,three classical rock physics models (Wyllie timeaverage equation,Gassmann equation and the Kuster-Toks z model) are comparably analyzed for their construction principles and actual velocity prediction results,aiming at determining the most favourable rock physics model to consider the influence of secondary storage space shape.Then relationships between the P-& S-wave velocities in carbonate reservoirs and geometric shapes of secondary storage spaces are discussed from different aspects based on actual well data by employing the favourable rock physics model.To explain the influence of secondary storage space shape on V P-V S relationship,it is analyzed for the differences of S-wave velocities between derived from common empirical relationships (including Castagna's mud rock line and Greenberg-Castagna V P-V S relationship) and predicted by the rock physics model.We advocate that V P-V S relationship for complex carbonate reservoirs should be built for different storage space types.For the carbonate reservoirs in the Tarim Basin,the V P-V S relationships for fractured,fractured-cavernous,and fractured-hole-vuggy reservoirs are respectively built on the basis of velocity prediction and secondary storage space type determination.Through the discussion above,it is expected that the velocity prediction and the V P-V S relationships for complex carbonate reservoirs should fully consider the influence of secondary storage space shape,thus providing more reasonable constraints for prestack inversion,further building a foundation for realizing carbonate reservoir prediction and fluid prediction. | Wang Haiyang Sam Zandong Sun Yang Haijun Gao Hongliang Xiao Youjun Hu Hongru | 2011 | Petroleum Science2011，8，4： | 10 |
| 4 | Pre-stack inversion for caved carbonate reservoir prediction:A case study from Tarim Basin,China显示文摘The major storage space types in the carbonate reservoir in the Ordovician in the TZ45 area are secondary dissolution caves.For the prediction of caved carbonate reservoir,post-stack methods are commonly used in the oilfield at present since pre-stack inversion is always limited by poor seismic data quality and insufficient logging data.In this paper,based on amplitude preserved seismic data processing and rock-physics analysis,pre-stack inversion is employed to predict the caved carbonate reservoir in TZ45 area by seriously controlling the quality of inversion procedures.These procedures mainly include angle-gather conversion,partial stack,wavelet estimation,low-frequency model building and inversion residual analysis.The amplitude-preserved data processing method can achieve high quality data based on the principle that they are very consistent with the synthetics.Besides,the foundation of pre-stack inversion and reservoir prediction criterion can be established by the connection between reservoir property and seismic reflection through rock-physics analysis.Finally,the inversion result is consistent with drilling wells in most cases.It is concluded that integrated with amplitude-preserved processing and rock-physics,pre-stack inversion can be effectively applied in the caved carbonate reservoir prediction. | Zhang Yuanyin Sam Zandong Sun Yang Haijun Wang Haiyang HanJianfa Gao Hongliang Luo Chunshu Jing Bing | 2011 | Petroleum Science2011，8，4： | 9 |
| 5 | Guaranteed Cost Controller Design of Networked Control Systems with State Delay显示文摘这份报纸为联网的控制系统(NCS ) 的一个类涉及州反馈的保证费用控制器设计与州延期。NCS 的一个新模型在导致网络的延期的考虑下面被提供。为为 NCS 的一个保证费用控制器的存在的一个 suffcient 条件被一套线性矩阵不平等(LMI ) 介绍。一个方法,它能转变对非凸凸,被使用。因此,一个数字算法被建议获得更低的界限。通过一个例子的理论分析显示出方法的有效性。 | XIE Jin-Song FAN Bing-Quan Young Sam Lee YANG Jin | 2007 | 自动化学报2007，33，2： | 9 |
| 6 | A new method of formation evaluation for fractured and caved carbonate reservoirs:A case study from the Lundong area,Tarim Basin,China显示文摘The carbonate reservoirs in the Tarim Basin are characterized by low matrix-porosity,heterogeneity and anisotropy,which make it difficult to predict and evaluate these reservoirs.The reservoir formations in Lundong area experienced a series of diagenesis and tectonic evolution stages.And secondary storage spaces such as fractures and dissolution caves were developed while nearly all the primary pores have disappeared.Based on a summary of different types of storage spaces and their responses in conventional logs,FMI and full waveform sonic logs which are sensitive to different reservoirs,the comprehensive probability index (CPI) method is applied to evaluating the reservoirs and a standard of reservoir classification is established.By comparing the evaluation results with actual welllogging results,the method has proven to be practical for formation evaluation of carbonate reservoirs,especially for the fractured carbonate reservoirs.In reservoir fluid identification,the multivariate stepwise discriminant analysis (MSDA) method is introduced.Combining the CPI method and MSDA method,comprehensive formation evaluation has been performed for fractured and caved carbonate reservoirs in the Tarim Basin.Additionally,on the basis of secondary pore inversion results,another new method of formation evaluation is also proposed in the discussion part of this paper.Through detailed application result analysis,the method shows a promising capability for formation evaluation of complex carbonate reservoirs dominated by various secondary pores such as holes,caves,and cracks. | Yang Haijun Sam Zandong Sun Cai Lulu Xiao Youjun WangHaiyang Luo Chunshu Hu Hongru | 2011 | Petroleum Science2011，8，4： | 7 |
| 7 | Seismic attributes and integrated prediction of fractured and caved carbonate reservoirs in the Tarim Basin,China显示文摘The carbonate reservoirs in the Tarim Basin are characterized by anisotropy and strong heterogeneity.Combined with an integrated analysis of data from seismic,geology,and drilling results,a series of attributes which are suitable for fractured and caved carbonate reservoir prediction is discussed,including amplitude,coherence analysis,spectra decomposition,seismic absorption attenuation analysis and impedance inversion.Moreover,3-D optimization of these attributes is achieved by integration of multivariate discriminant analysis and principle component analysis,where the logging data are taken as training samples.Using the optimized results,the spatial distribution and configuration features of the caved reservoirs can be characterized in detail.This technique not only improves the understanding of the spatial distribution of current reservoirs but also provides a significant basis for the discovery and production of carbonate reservoirs in the Tarim Basin. | Liu Lifeng Sam Zandong Sun Yang Haijun Han Jianfa Gao Hongliang Jing Bing Zhu Xinghui | 2011 | Petroleum Science2011，8，4： | 6 |
| 8 | The application of amplitude-preserved processing and migration for carbonate reservoir prediction in the Tarim Basin,China显示文摘Conventional seismic exploration method based on post-stack data usually fails to identify the distribution of fractured and caved carbonate reservoirs in the Tarim Basin,so the rich pre-stack information should be applied to the prediction of carbonate reservoirs.Amplitude-preserved seismic data processing is the foundation.In this paper,according to the feature of desert seismic data (including weak reflection,fast attenuation of high frequency components,strong coherent noises,low S/N and resolution),a set of amplitude-preserved processing techniques is applied and a reasonable processing flow is formed to obtain the high quality data.After implementing a set of pre-stack amplitude-preserved processing,we test and define the kernel parameters of amplitude-preserved Kirchhoff PSTM (pre-stack time migration) and subsequent gathers processing,in order to obtain the amplitude-preserved gathers used to the isotropic pre-stack inversion for the identification of caved reservoirs.The AVO characteristics of obtained gathers fit well with the synthetic gathers from logging data,and it proves that the processing above is amplitudepreserved.The azimuthal processing techniques,including azimuth division and binning enlargement,are implemented for amplitude-preserved azimuthal gathers with the uniform fold.They can be used in the anisotropic inversion to detect effective fractures.The processing techniques and flows are applied to the field seismic data,and are proved available for providing the amplitude-preserved gathers for carbonate reservoir prediction in the Tarim Basin. | Sam Zandong Sun Yang Haijun Zhang Yuanyin Han Jianfa WangDan Sun Wenbo Jiang Shan | 2011 | Petroleum Science2011，8，4： | 6 |
| 9 | P-wave fracture prediction algorithm using pre-stack data with limited azimuth distribution:A case study in the TZ45 area,Tarim Basin,China显示文摘Fractured reservoirs always show anisotropic amplitude features,i.e.the reflection amplitude of seismic waves varies with offset and azimuth (AVOZ).A noise attenuation fracture inversion algorithm is presented for fracture detection based on P-wave AVOZ.The conventional inversion method always fails when applied to limited azimuth data because of the existence of noise.In our inversion algorithm,special attention is paid to suppressing the noise during inversion,to overcome the limitation of the conventional inversion method on limited azimuth data.Numerical models are employed to illustrate the effectiveness of the method.The inversion algorithm is then applied to Tazhong 45 area field data which is acquired under limited azimuth distribution.Compared with cores and fullbore formation microimage (FMI),the inverted results (fracture density and orientation) are reasonable,suggesting that the inversion algorithm is feasible for fracture prediction in the Tarim Basin. | Sam Zandong Sun Wang Zhaoming Yang Haijun Xiao Xi Wang Yueying Chen Lei Yang Pei | 2011 | Petroleum Science2011，8，4： | 5 |
| 10 | Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7显示文摘Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and headaches.Despite the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of inflammation.This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators.Our results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response. | Eun-Jin YANG Ji-Young MOON Min-Jin KIM Dong Sam KIM Chan-Shick KIM Wook Jae LEE Nam Ho LEE Chang-Gu HYUN | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，5： | 5 |
| 11 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 12 | Fractured reservoir modeling by discrete fracture network and seismic modeling in the Tarim Basin,China显示文摘Fractured reservoirs are an important target for oil and gas exploration in the Tarim Basin and the prediction of this type of reservoir is challenging.Due to the complicated fracture system in the Tarim Basin,the conventional AVO inversion method based on HTI theory to predict fracture development will result in some errors.Thus,an integrated research concept for fractured reservoir prediction is put forward in this paper.Seismic modeling plays a bridging role in this concept,and the establishment of an anisotropic fracture model by Discrete Fracture Network (DFN) is the key part.Because the fracture system in the Tarim Basin shows complex anisotropic characteristics,it is vital to build an effective anisotropic model.Based on geological,well logging and seismic data,an effective anisotropic model of complex fracture systems can be set up with the DFN method.The effective elastic coefficients,and the input data for seismic modeling can be calculated.Then seismic modeling based on this model is performed,and the seismic response characteristics are analyzed.The modeling results can be used in the following AVO inversion for fracture detection. | Sam Zandong Sun Zhou Xinyuan Yang Haijun Wang Yueying WangDi Liu Zhishui | 2011 | Petroleum Science2011，8，4： | 4 |
| 13 | Joint hard X-ray observations with ASO-S/HXI and SO/STIX显示文摘This paper discusses the potential of future joint hard X-ray solar flare observations between the Hard X-ray Imager(HXI)onboard the Advanced Space-based Solar Observatory(ASO-S)mission and the Spectrometer/Telescope for Imaging X-rays(STIX)on Solar Orbiter.The different viewing perspectives of the two telescopes relative to the Sun will allow us for the first time to systematically study non-thermal hard X-ray emissions stereoscopically.During the 4-years of the nominal mission of ASO-S,we expect to jointly observe about 160 flares above GOES M1 class to systematically study hard X-ray directivity.For about 16 partially limb-occulted STIX flares,we will have observations of the entire flare by HXI.Such observations will enable us to simultaneously study the all-important coronal hard X-ray sources,which are generally lost in the instrument’s individual imaging dynamic range,in combination with the chromospheric footpoint emissions.The two different detector systems used in the two telescopes make the relative calibration between the two instruments a key task that needs to be addressed before creditable science results can be published.If an accurate inter-calibration can be achieved using jointly observed flares on the disk,observations with HXI and STIX will provide new and essential key diagnostics for solar flare physics. | Sam Krucker Gordon JHurford Yang Su Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 3 |
| 14 | A study on the randomness measure of imageHashing显示文摘 | Guopu Zhu Jiwu Huang Sam Kwong Jianquan Yang | 2009 | IEEE Transcations on Information Forensics and Security2009，4，4： | 1 |
| 15 | D2 Lymphadenectomy with Surgical Ex Vivo Dissection into Node Stations for Gastric Adenocarcinoma Can Be Performed Safely in Western Patients and Ensures Optimal Staging显示文摘 | Benjamin Schmidt Kevin K. Chang Ugwuji N. Maduekwe Nicole Look-Hong David W. Rattner Gregory Y. Lauwers John T. Mullen Han-Kwang Yang Sam S. Yoon | 2013 | Annals of Surgical Oncology2013，，9： | 1 |
| 16 | Hilbert-Huang trans- form for analysis of heart rate variability in cardiac health 显示文摘 | Li Helong Kwong Sam Yang Lihua | 2011 | IEEE/ACM Transactions on Computational Biology and Bioin- formatics2011，8，6： | 1 |
| 17 | A data-constrained Computational Model for Morphology Structures显示文摘 | YANG Sam Tulloh A Cole I | 2007 | Journal of the Australasian Ceramic Society2007，42，2： | 1 |
| 18 | Microstrueture of a Paint Primer-a Data-constrained Modeling Analysis显示文摘 | YANG Sam GAO Daehao Muster T | 2010 | Materials Science Forum2010，654，1： | 1 |
| 19 | A Data-constrained 3D Model for Material Compositional Mierostruetures显示文摘 | YANG Sam Furman S Tulloh A | 2008 | Frontiers in Materials Science and Technology2008，32，1： | 1 |
| 20 | 采用高效体积排阻色谱技术研究油茶籽油在加热过程中极性化合物的形成及其组分分布(英文)显示文摘目的:测定加热过程中油茶籽油中极性化合物及其组分的变化,同时与其它常用油脂进行对比,评估油茶籽油作为煎炸用油的优势。创新点:首次在油茶籽油中采用制备型硅胶柱层析-高效体积排阻色谱技术,监测了极性化合物总量及其组分分布在加热过程中的变化规律,预估油茶籽油的使用寿命,为煎炸用油的选择提供科学理论依据。方法:取等量市售油茶籽油、橄榄油、大豆油和棕榈油,在180°C分别加热2、4、6、8和10小时并收集样品。实验结束后,首先利用制备型硅胶柱层析分离测定总极性化合物含量的变化,并采用高效体积排阻色谱技术对分离得到的极性化合物组分进行定量分析。结论:油茶籽油在加热过程中所形成的极性化合物总量(TPC)呈线性增加趋势,其形成速率显著低于橄榄油和大豆油(图1)。随着加热时间的延长,油茶籽油中的氧化甘油三酯(ox-TGM)、氧化甘油三酯二聚物(TGD)和氧化甘油三酯多聚物(TGO)的含量显著增加(P<0.05)。此外,ox-TGM和TGD在油茶籽油中的形成速率明显低于其在橄榄油和大豆油中的形成速率,然而这三种油脂之间的TGO含量的变化不存在显著差异(图4)。综上所述,油茶籽油可作为一种具有开发前景和健康食用价值的煎炸用油。 | Hong-xia FENG Rokayya SAM Lian-zhou JIANG Yang LI Wen-ming CAO | 2016 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2016，17，11： | 1 |
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