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| 1 | Immune response,stress resistance and bacterial challenge in juvenile rainbow trouts Oncorhynchus mykiss fed diets containing chitosan-oligosaccharides显示文摘Effects of dietary supplementation of chitosan-oligosaccharides(COS)on the growth performance,immune response,stress resistance,and disease resistance of juvenile rainbow trout Oncorhynchus mykiss were studied.Four experimental diets containing 0,20,40,or 60 mg/kg COS(COS0,COS20,COS40,and COS60,respectively)were fed to juvenile rainbow trout(initial weight=5.2±0.3 g)for 8 weeks.By the end of the feeding trial,representative groups of fish from each dietary treatment were challenged with stressor(30 sec air exposure)and pathogen exposure(intraperitoneal injection with Aeromonas hydrophila).Results showed that supplementation of COS in diets did not affect production performance and body composition of rainbow trout.However,fish fed the COS40 diet demonstrated improved phagocytic activities,respiratory burst activities and decreased serum cortisol level.Additionally,survival following A.hydrophila challenge was significant higher among fish fed the COS-supplemented feeds,although there was no difference based on the level of supplementation.The present study suggests that COS can be used as an immuno-stimulant in rainbow trout feeds. | Lin LUO Xuefeng CAI Chuan HE Min XUE Xiufeng WU Haining CAO | 2009 | Current Zoology2009，55，6： | 22 |
| 2 | Multi-dimension apportionment of clean air “parade blue”phenomenon in Beijing显示文摘The mass concentration and major chemical components of fine particulate matter were measured before,during and after Beijing's massive parade commemorating 70th anniversary of the Chinese Victory in World War II on September 3,2015.Regional emission inventory,positive matrix factorization(PMF),observations from space and backward air mass trajectories were jointly applied to identify the major pollution sources and their temporal and spatial variations.The contributions of emissions variations and the meteorological conditions related to the'parade blue'phenomenon in Beijing and its surrounding areas were investigated in detail.The main cause of the decreased PM_(2.5)mass concentration was attributed to the absolute reduction in emissions of primary air pollutants.The chemical composition of PM_(2.5)varied significantly before,during and after the parade.Fugitive dust particles were well controlled,the secondary formation of PM_(2.5)was reduced along with the controlled gaseous precursors'emissions from vehicles and industrial sources during the temporary intensified control period.During the parade period,the SO_2and NO_2column concentrations in Beijing and the surrounding areas decreased sharply,indicating that the coordinated reduction in primary emissions from the surrounding areas of Beijing played an important role in lowering the ambient concentration of SO_2and NO_2and accordingly lowered PM_(2.5)and improved the regional air quality.A comparison of the temperature,humidity,and wind speed and direction during the same periods in 2014 and 2015 showed that the meteorological conditions positively influenced the achievement of'parade blue'. | Yifeng Xue Yong Wang Xuefeng Li Hezhong Tian Lei Nie Xiaoqing Wu Junrui Zhou Zhen Zhou | 2018 | Journal of Environmental Sciences2018，30，3： | 5 |
| 3 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 4 | High-frequency vibration analysis of thin plate based on wavelet-based FEM using B-spline wavelet on interval显示文摘The wavelet finite element existing methods(WFEMs)own higher calculation accuracy and efficiency for structure analysis.Unfortunately,the WFEMs are still limited in low-frequency domain on when type capturing dynamic characteristics plate of thin plate.to This paper this proposes limitation.The the wavelet multi-elements method based and C1 B-spline Kirchhoff are(C1BKP)element break up The validity,numerical stability convergence respectively and investigated systematically in numerical predicting modes study.the corresponding results show The that the calculation accuracy errors numerical rapidly stability are 0.4%very excellent when1000high-order plate natural frequency.maximum Besides,relative method can be for reduced to within the first of thin under simply supported.the is suitable predicting the dynamic characteristics of thin plate under various boundary conditions. | GENG Jia ZHANG XingWu CHEN XueFeng XUE XiaoFeng | 2017 | Science China(Technological Sciences)2017，60，5： | 4 |
| 5 | SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy显示文摘The global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused severe morbidity and mortality in humans.It is urgent to understand the function of viral genes.However,the function of open reading frame 10(ORF10),which is uniquely expressed by SARS-CoV-2,remains unclear.In this study,we showed that overexpression of ORF10 markedly suppressed the expression of type I interferon(IFN-I)genes and IFN-stimulated genes.Then,mitochondrial antiviral signaling protein(MAVS)was identified as the target via which ORF10 suppresses the IFN-I signaling pathway,and MAVS was found to be degraded through the ORF10-induced autophagy pathway.Furthermore,overexpression of ORF10 promoted the accumulation of LC3 in mitochondria and induced mitophagy.Mechanistically,ORF10 was translocated to mitochondria by interacting with the mitophagy receptor Nip3-like protein X(NIX)and induced mitophagy through its interaction with both NIX and LC3B.Moreover,knockdown of NIX expression blocked mitophagy activation,MAVS degradation,and IFN-I signaling pathway inhibition by ORF10.Consistent with our observations,in the context of SARS-CoV-2 infection,ORF10 inhibited MAVS expression and facilitated viral replication.In brief,our results reveal a novel mechanism by which SARS-CoV-2 inhibits the innate immune response;that is,ORF10 induces mitophagy-mediated MAVS degradation by binding to NIX. | Xingyu Li Peili Hou Wenqing Ma Xuefeng Wang Hongmei Wang Zhangping Yu Huasong Chang Tiecheng Wang Song Jin Xue Wang Wenqi Wang Yudong Zhao Yong Zhao Chunqing Xu Xiaomei Ma Yuwei Gao Hongbin He | 2022 | Cellular & Molecular Immunology2022，19，1： | 4 |
| 6 | Dynamic edge-based biomarker non-invasively predicts hepatocellular carcinoma with hepatitis B virus infection for individual patients based on blood testing显示文摘Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths in Asia and Africa. Developing effective and non-invasive biomarkers of HCC for individual patients remains an urgent task for early diagnosis and convenient monitoring. Analyzing the transcriptomic profiles of peripheral blood mononuclear cells from both healthy donors and patients with chronic HBV infection in different states (i.e. HBV carrier, chronic hepatitis B, cirrhosis, and HCC), we identified a set of 19 candidate genes according to our algorithm of dynamic network biomarkers. These genes can both characterize different stages during HCC progression and identify cirrhosis as the critical transition stage before carcinogenesis. The interaction effects (i.e. coexpressions) of candidate genes were used to build an accurate prediction model: the so-called edge-based biomarker. Considering the convenience and robustness of biomarkers in clinical applications, we performed functional analysis, validated candidate genes in other independent samples of our collected cohort, and finally selected COL5A1, HLA-DQB1, MMP2, and CDK4 to build edge panel as prediction models. We demonstrated that the edge panel had great performance in both diagnosis and prognosis in terms of precision and specificity for HCC, especially for patients with alpha-fetoprotein-negative HCC. Our study not only provides a novel edge-based biomarker for non-invasive and effective diagnosis of HBV-associated HCC to each individual patient but also introduces a new way to integrate the interaction terms of individual molecules for clinical diagnosis and prognosis from the network and dynamics perspectives. | Yiyu Lu Zhaoyuan Fang Meiyi Li Chen Qian Tao Zeng Lina Lu Qilong Chen Hui Zhang Qianmei Zhou Yan Sun Xuefeng Xue Yiyang Hu Luonan Chen Shibing Su | 2019 | Journal of Molecular Cell Biology2019，11，8： | 3 |
| 7 | Analysis of gas-solid flow and shaft-injected gas distribution in an oxygen blast furnace using a discrete element method and computational fluid dynamics coupled model显示文摘 | Zeshang Dong Jingsong Wang Haibin Zuo Xuefeng She Qingguo Xue | 2017 | Particuology2017，15，3： | 3 |
| 8 | Efficient transfer and expression of human clotting factor IX cDNA in neonatal hemophilia B mice mediated by VSV-G pseudotyped retrovi-rus显示文摘The feasibility of in vivo gene therapy for hemophilia B by VSV-G pseudotyped retroviral vector was introduced. The novel packaging cell line 293GPG was used to produce VSV-G/G1NaBAIX pseudotyped virus with the highest liters up to 8.5×108cfu .mL-1. In contrast to the conventional retrovirus, VSV-G pseudotyped virus was more resistant to inactivation by serum complements (P<0.001). Our results also demonstrated that VSV-G pseudotyped virus was more stable in neonatal mice serum than in adult mice serum (P<0.01). After intraperitoneal injection of different doses of virus, hFIX antigen was detected and lasted for more than 120 d, the highest level reached (72.5+6.1) ng- mL11. Moreover, the functional activity was improved to some extent in all hFIX-treated mice, the most remarkable improvement was observed in the mice treated with higher dose of virus whose clotting activity increased to (3.4±1.5)% and APTT (activated partial thromboplastin time) reduced to (43.2±7.2) s. The anti-hFIX antibody was | WANG Hongwei YE Chenbo CHEN Li WANG Xuefeng QIU Xinfang XUE Jinglun LU Daru | 2001 | Chinese Science Bulletin2001，46，18： | 2 |
| 9 | Experimental Study of H_(2)and/or N_(2)Addition Effects on CO/CO_(2)-Air Flames using a Combustion Diagnostic System显示文摘In this work,the effects of H_(2)(0–8 vol%)addition,N_(2)(0–8 vol%)addition,and H_(2)/N_(2)(4 vol%/4 vol%)addition in CO/CO_(2)gas flow on the flame structure,flame temperature,and CO_(2)concentration in flames were investigated.A combustion diagnostic system based on tunable diode laser absorption spectroscopy(TDLAS)was utilized to measure the flame temperature and CO_(2)concentration in flames simultaneously.This work simulated the combustion of converter gas(CO/CO_(2)/H_(2)/N_(2))in an industrial turbulent partly premixed burner.The results show that with the addition of H_(2)(0–8 vol%)in CO/CO_(2)flame and the addition of H_(2)(4 vol%)in CO/CO_(2)/N_(2)(4vol%)flame,the flame length is longer than that with the same volume addition of N_(2).The added reactions caused by the addition of H_(2)(4 vol%)in CO/CO_(2)flame and CO/CO_(2)/N_(2)(4 vol%)flame result in a larger high-temperature reaction zone.The enrichment of H_(2)(8 vol%)in CO/CO_(2)/H_(2)(4 vol%)flame,the dilution of N_(2)(0–8 vol%)in CO/CO_(2)flame,and the dilution of N_(2)(4 vol%)in CO/CO_(2)/H_(2)(4 vol%)flame make little difference on the high-temperature reaction zone.The promotion effects of H_(2)addition on CO_(2)formation are more prominent than the dilution effects of N_(2)addition on CO_(2)concentration in flames. | LIU Yu XUE Qingguo ZUO Haibin SHE Xuefeng WANG Jingsong | 2021 | Journal of Thermal Science2021，30，4： | 2 |
| 10 | Variations of monsoonal precipitation over the last 16,000 years in the eastern Nanling Mountains, South China显示文摘 | Wei Zhong Jibin Xue Yanming Zheng Qiaohong Ma Ying Cai Jun Ouyang Liubin Xu Shangzhe Zhou Xuefeng Yu | 2010 | Journal of Paleolimnology2010，，1： | 1 |
| 11 | Adjacent acid sites cooperatively catalyze fructose to 5-hydroxymethylfurfural in a new, facile pathway显示文摘To study the effect of adjacent hydroxyl to the active sites, several acid catalysts, i.e. substituted benzoic acids with adjacent carboxyl are employed in the fructose dehydration to 5-hydroxymethylfurfural(HMF).Experimental results reveal that Br?nsted acid sites with adjacent carboxyl present higher catalytic ability than isolated ones. Computational results suggest that the adjacent sites lead to co-interaction on fructose, corresponding more stable transition state and faster HMF formation rate. Based on the enhancement from the adjacent sites, a novel ordered mesoporous carbon(OMC) full of carboxyls in surface is prepared and turns out to be an effective solid catalyst for HMF production from fructose derived from biomass. | Xia Yu Yueying Chu Lei Zhang Hui Shi Mingjiang Xie Luming Peng Xuefeng Guo Wei Li Nianhua Xue Weiping Ding | 2020 | Journal of Energy Chemistry2020，29，8： | 1 |
| 12 | Science with the 2.5-meter Wide Field Survey Telescope(WFST)显示文摘The Wide Field Survey Telescope(WFST) is a dedicated photometric surveying facility being built jointly by University of Science and Technology of China(USTC) and the Purple Mountain Observatory(PMO). It is equipped with a 2.5-meter diameter primary mirror, an active optics system, and a mosaic CCD camera with 0.73 gigapixels on the primary focal plane for highquality image capture over a 6.5-square-degree field of view. The installation of WFST near the summit of Saishiteng mountain in the Lenghu region is scheduled in summer of 2023, and the operation is planned to start three months later. WFST will scan the northern sky in four optical bands(u, g, r and i) at cadences from hourly/daily in the deep high-cadence survey(DHS) program, to semi-weekly in the wide field survey(WFS) program. During a photometric night, a nominal 30 s exposure in the WFS program will reach a depth of 22.27, 23.32, 22.84, and 22.31(AB magnitudes) in these four bands, respectively, allowing for the detection of a tremendous amount of transients in the low-z universe and a systematic investigation of the variability of Galactic and extragalactic objects. In the DHS program, intranight 90 s exposures as deep as 23(u) and 24 mag(g), in combination with target of opportunity follow-ups, will provide a unique opportunity to explore energetic transients in demand for high sensitivities, including the electromagnetic counterparts of gravitational wave events, supernovae within a few hours of their explosions,tidal disruption events and fast, luminous optical transients even beyond redshift of unity. In addition, the final 6-year co-added images, anticipated to reach g■25.8 mag in WFS or 1.5 mags deeper in DHS, will be of fundamental importance to general Galactic and extragalactic science. The highly uniform legacy surveys of WFST will serve as an indispensable complement to those of the Vera C. Rubin Observatory's Legacy Survey of Space and Time(LSST) that monitors the southern sky. | Tinggui Wang Guilin Liu Zhenyi Cai Jinjun Geng Min Fang Haoning He Ji-an Jiang Ning Jiang Xu Kong Bin Li Ye Li Wentao Luo Zhizheng Pan Xuefeng Wu Ji Yang Jiming Yu Xianzhong Zheng Qingfeng Zhu Yi-Fu Cai Yuanyuan Chen Zhiwei Chen Zigao Dai Lulu Fan Yizhong Fan Wenjuan Fang Zhicheng He Lei Hu Maokai Hu Zhiping Jin Zhibo Jiang Guoliang Li Fan Li Xuzhi Li Runduo Liang Zheyu Lin Qingzhong Liu Wenhao Liu Zhengyan Liu Wei Liu Yao Liu Zheng Lou Han Qu Zhenfeng Sheng Jianchun Shi Yiping Shu Zhenbo Su Tianrui Sun Hongchi Wang Huiyuan Wang Jian Wang Junxian Wang Daming Wei Junjie Wei Yongquan Xue Jingzhi Yan Chao Yang Ye Yuan Yefei Yuan Hongxin Zhang Miaomiao Zhang Haibin Zhao Wen Zhao | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，10： | 1 |
| 13 | Preparation and Functional Design of Polyethyleneimine Reinforced Nanocellulose-based Aerogel显示文摘An aerogel electrode composed of conductive active materials based on nanocellulose aerogels can absorb more electrolytes,as well as enhance electron transport and ion diffusion channels.In the present study,aerogels with high strength were successfully prepared using 2,2,6,6-tetramethyl-1-piperidinyloxy free radical(TEMPO)-oxidized cellulose nanofibrils(CNF)as a raw material and polyethyleneimine(PEI)as a crosslinking agent.Simultaneously,functional electrode materials were prepared via self-assembly.Based on our findings,PEI can significantly improve the water and solvent solubility and enhance the wet strength and shape recovery ability of CNF aerogels.Meanwhile,the minimum density of the aerogel reached 0.0160 g/cm3,the maximum porosity was approximately 98.5%,and the maximum stress approximated 0.02 MPa.Furthermore,electrochemical tests revealed that after self-assembly of reduced graphene oxide(RGO)and polyaniline(PANI)solution,the mass specific capacitance of the functional composite aerogel was approximately 92 F/g and exhibited good chargedischarge performance. | Jiacheng Lin Tao Lin Xuefeng Yin Xue Cai Xiaoyao Wei Neng Zhang | 2022 | Paper And Biomaterials2022，7，1： | 1 |
| 14 | Understanding the enhancement of catalytic performance for olefin cracking: Hydrothermally stable acids in P/HZSM-5显示文摘 | Nianhua Xue Xiangke Chen Lei Nie Xuefeng Guo Weiping Ding Yi Chen Min Gu Zaiku Xie | 2007 | Journal of Catalysis2007，，1： | 1 |
| 15 | Adsorption of Cu^(2+)by Crosslinked Graft Copolymers of Starch显示文摘With the use of acrylic acid(AA)as a monomer,humic acid(HA)and starch as raw materials,potassium persulfate(KPS)as initiator,and N,Ndimethylacrylamide(MBA)as a cross-linking agent,AA/HA/Starch graft copolymer was prepared and characterized by SEM and FT-IR.The effects of temperature,adsorption time,adsorbent dosage,pH value and Cu^(2+)initial concentration of the solution on the adsorption performance of the crosslinked graft copolymer were also investigated.The results showed that the Cu^(2+)adsorption capacity of the AA/HA/Starch graft copolymer increased firstly and then decreased with increasing adsorbent dosage and the initial pH value of Cu^(2+)solution.With the increase of Cu^(2+)initial concentration and the extension of adsorption time,the adsorption amount of Cu^(2+)increased rapidly and then stabilized.And it decreased slightly with the increase of temperature.At pH value of 5.5,temperature of 298 K,adsorbent dosage of 50 mg,adsorption time of 125 min,and 100 mL Cu^(2+)solution with Cu^(2+)initial concentration of 100 mg/L,the Cu^(2+)adsorption capacity of the crosslinked graft copolymer was 238 mg/g.The adsorption of Cu^(2+)by the adsorbent followed the pseudo-second-order kinetic equation and Langmuir isothermal adsorption model,and the adsorption was attached to monolayer chemical adsorption.This study proved that AA/HA/Starch graft copolymer could be used as an efficient adsorbent for the removal of harmful and toxic metal cations such as Cu^(2+)from industrial wastewater. | Xue Cai Tao Lin Neng Zhang Xiaoyao Wei Xuefeng Yin | 2021 | Paper And Biomaterials2021，6，1： | 1 |
| 16 | Total dose irradiation and hot-carrier effects of sub-micro NMOSFETs显示文摘 | Cui Jiangwei Xue Yaoguo Yu Xuefeng | | 0，，01： | 1 |
| 17 | Carboxyl-functionalized Nanocellulose Reinforced Nanocomposite Proton Exchange Membrane显示文摘Nanocellulose(NCC) was prepared through the acid hydrolysis of microcellulose(MCC) and was reacted with maleic anliydride to obtain carboxyl-functionized nanocellulose(MA-NCCs). The presence of .OH and .SO3H on the surface of rod-like MA-NCC was confirmed by Fourier transfonn infrared spectrometry(FTIR). Sulfonated poly(aryl ether ether ketone ketone)(Ph-SPEEKK) was synthesized with bis(4-fluorophenyl-methanone) and 2-phenylhydroquinone as monomer. MA-NCC/Ph-SPEEKK nanocomposite membranes with different MA-NCCs content were prepared, and their properties were characterized. Compared with Ph-SPEEKK, MA-NCC/Ph-SPEEKK nanocomposite membrane showed better mechanical and thermal properties and higher proton conductivity. The proton conductivity of the composite membrane with 4%(mass fraction) MA-NCCs under 80℃ was 0.095 S/cm. And its tensile strength reached 30.3 MPa, which was 21.2% higher than that of Ph-SPEEKK pure polymer membrane. | YANG Xue WEI Yingcong CHU Xuefeng ZHAO Qi YAN Wenling DONG Chenjun LIU Baijun SUN Zhaoyan HU Wei ZHANG Niaona | 2019 | Chemical Research in Chinese Universities2019，35，4： | 0 |
| 18 | CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation显示文摘The G protein-coupled receptor ADGRE5(CD97)binds to various metabolites that play crucial regulatory roles in metabolism.However,its function in the antiviral innate immune response remains to be determined.In this study,we report that CD97 inhibits virus-induced type-I interferon(IFN-I)release and enhances RNA virus replication in cells and mice.CD97 was identified as a new negative regulator of the innate immune receptor RIG-I,and RIG-1 degradation led to the suppression of the IFN-I signaling pathway.Furthermore,overexpression of CD97 promoted the ubiquitination of RIG-I,resulting in its degradation,but did not impact its mRNA expression.Mechanistically,CD97 upregulates RNF125 expression to induce RNF125-mediated RIG-I degradation via K48-linked ubiquitination at Lys181 after RNA virus infection.Most importantly,CD97-deficient mice are more resistant than wild-type mice to RNA virus infection.We also found that sanguinarine-mediated inhibition of CD97 effectively blocks VSV and SARS-CoV-2 replication.These findings elucidate a previously unknown mechanism through which CD97 negatively regulates RIG-I in the antiviral innate immune response and provide a molecular basis for the development of new therapeutic strategies and the design of targeted antiviral agents. | Huasong Chang Peili Hou Xuefeng Wang Aibiao Xiang Hao Wu Wenjing Qi Rukun Yang Xue Wang Xingyu Li Wenqi He Guimin Zhao Weiyang Sun Tiecheng Wang Daniel Chang He Hongmei Wang Yuwei Gao Hongbin He | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 19 | Status of transjugular intrahepatic portosystemic shunt for portal hypertension in China:A national survey analysis显示文摘Aim:The transjugular intrahepatic portosystemic shunt(TIPS)procedure has been performed in China for 30 years,but our understanding of the status and difficulties associated with the use of TIPS for portal hypertension is incomplete.This study aims to investigate the current situation of the use of TIPS for portal hypertension,which should aid the development of TIPS in China.Methods:This study involved a questionnaire survey,initiated by the China Portal Hypertension Alliance(CHESS)to investigate the use of TIPS for portal hypertension in China.Questionnaires were released on the Internet between August 16,2022 and September 16,2022.Detailed information was collected from 545 hospitals contracted by the CHESS in China,which performed TIPS surgery in 2021.Results:The 545 hospitals covers the majority of hospitals in China that conduct TIPS intervention.In the survey,a total of 13,527 TIPS interventions were carried out with 94.1%(498/545)of them had a system of routine follow‐up after TIPS.The majority(42.6%[232/545])believed that the main indication of TIPS was the control of acute bleeding.Overall,48.1%(262/545)carried out early or pre‐emptive TIPS,53.0%(289/545)carried out TIPS for cavernous transformation of the portal vein,and 81.0%(441/545)chose routine embolization of collateral circulation during operation.Most used coils(97.0%[475/490])and biological glue(72.0%[353/490])as embolic materials,and 78.5%(428/545)routinely performed intraoperative portal pressure gradient measurements.When selecting TIPS stents,57.1%(311/545)chose viator‐specific stents,and 57.2%(312/545)chose conventional anticoagulation after TIPS.Conventional anticoagulation after TIPS is over a time interval of 3–6 months(55.4%[173/312]).The limitation of TIPS surgery is mainly its cost(72.3%[394/545])and insufficient understanding of the procedure by doctors in other related departments(77.4%[422/545]).Most of the hospital teams accept the use of domestic instruments in TIPS surgery(92.7%[505/545]).Conclusions:This survey shows that TIPS is an essential part of the treatment of portal hypertension in China.TIPS is widely used in Chinese patients with portal hypertension,and this survey presents a more comprehensive picture of the options and difficulties encountered in the implementation of TIPS.In the future,it is necessary to promote TIPS technology and further standardize surgical indications,routine operations,and instrument application. | Haibo Shao Xinwei Han Jianbo Zhao Junhui Sun Zhuting Fang Bin Xiong Xiaoli Zhu Weixin Ren Min Yuan Shiping Yu Meng Niu Weifu Lv Xueqiang Zhang Chunqing Zhang Lei Li Xuefeng Luo Yusheng Song Yilong Ma Tong Dang Hua Xiang Yun Jin Hui Xue Guiyun Jin Xiao Li Jiarui Li Shi Zhou Changlu Yu Song He Lei Yu Hongmei Zu Jun Ma Yanming Lei Ke Xu Xiaolong Qi | 2023 | Portal Hypertension & Cirrhosis2023，2，1： | 0 |
| 20 | Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet显示文摘Trimethylamine N-oxide(TMAO)is a risk factor of various chronic diseases,which was produced by metabolism from precursors to trimethylamine(TMA)in gut and the oxidation from TMA in liver.The TMA generation was influenced by diet,mainly due to the rich TMAO precursors in diet.However,it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO.Here,the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA,respectively,in mice fed with carbohydrates,proteins and fats in different proportion and sources.The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA,and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver.The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO,the risk factor for atherosclerosis,which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis. | Chengcheng Wang Xuefeng Duan Xiaoyue Li Jinyue Yang Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang | 2024 | Food Science and Human Wellness2024，13，2： | 0 |
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