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| 1 | Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis显示文摘Many factors are considered to contribute to hepatitis B virus(HBV)-associated hepatocellular carcinoma(HCC),including products of HBV,HBV integration and mutation,and host susceptibility. HBV X protein(HBx) can interfere with several signaling pathways associated with cell proliferation and invasion,and HBx C-terminal truncation has been suggested to impact the development of HCC. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator,HBx can affect regulatory non-coding RNAs(nc RNAs),including micro RNAs and long nc RNAs. HBx is also involved in epigenetic modification and DNA repair. HBx interacts with various signal-transduction pathways,such as the p53,Wnt,and nuclear factor-κB pathways. We conclude that HBx hastens the development of hepatoma. | Ming Geng Xuan Xin Li-Quan Bi Lu-Ting Zhou Xiao-Hong Liu | 2015 | World Journal of Gastroenterology2015，21，38： | 24 |
| 2 | Carbon Monoxide Alleviates Salt-Induced Oxidative Damage in Wheat Seedling Leaves显示文摘一氧化碳(公司),在降级期间释放的一个副产品他我在动物的 byheme 氧 ases ( EC 1.14.99.3 ),被认为是涉及最近作为在调停起一个主要作用被报导了的许多生物事件的一个重要生理的送信人 orbioactive 分子对导致氧化剂的肺损害的 cytoprotection 。在现在的学习,我们首先在小麦幼苗叶子对导致盐的氧化损坏决定了外长的公司的保护的效果。当 COdonor 表明了叶绿素的重要颠倒,与 0.01 微 mol/L 血色素对待的小麦幼苗腐烂,弄干重量,并且浇导致的 by300 mmol/L NaCl 强调的损失。有趣地,类脂化合物的增加被 0.01 nmol/L 血色素处理每在 salt-treatedleaves 观察的氧化颠倒。时间功课分析证明 0.01 微 mol/L 血色素的申请提高了 guaiacol 过氧化物酶,超级氧化物 dismutase,在小麦幼苗叶子的 ascorbate peroxidaseand 过氧化氢酶活动使遭到了腌应力。因为 CO scavenger 血红素(1.2 mg/L ) 堵住了 CO 施主血色素的行动,这些效果为公司是特定的。然而, CO 施主(1.0 微 mol/L ) 的更高的集中没减轻干燥重量和强调盐的小麦幼苗的水损失。这些结果建议一个公司施主的底层的外长的申请可能对咸度毒性是有益的…… | Ben-Kai Huang Sheng Xu Wei Xuan Ming LI Ze-Yu Cao Kai-Li Liu Teng-Fang Ling Wen-Biao Shen | 2006 | Journal of Integrative Plant Biology2006，48，3： | 20 |
| 3 | Evaluation of the Prostate Imaging Reporting and Data System for Magnetic Resonance Imaging Diagnosis of Prostate Cancer in Patients with Prostate-specific Antigen 〈20 ng/ml显示文摘 | Xuan Wang Jian-Ye Wang Chun-Mei Li Ya-Qun Zhang Jian-Long Wang Ben Wan Wei Zhang Min Chen Sa-Ying Li Gang Wan Ming Liu | 2016 | Chinese Medical Journal2016，，12： | 13 |
| 4 | Machine learning in materials science显示文摘Traditional methods of discovering new materials,such as the empirical trial and error method and the density functional theory(DFT)-based method,are unable to keep pace with the development of materials science today due to their long development cycles,low efficiency,and high costs.Accordingly,due to its low computational cost and short development cycle,machine learning is coupled with powerful data processing and high prediction performance and is being widely used in material detection,material analysis,and material design.In this article,we discuss the basic operational procedures in analyzing material properties via machine learning,summarize recent applications of machine learning algorithms to several mature fields in materials science,and discuss the improvements that are required for wide-ranging application. | Jing Wei Xuan Chu Xiang-Yu Sun Kun Xu Hui-Xiong Deng Jigen Chen Zhongming Wei Ming Lei | 2019 | InfoMat2019，1，3： | 9 |
| 5 | Molecular characteristics and structure–activity relationships of food-derived bioactive peptides显示文摘Peptides are functional active fragments of proteins which can provide nutrients needed for human growth and development,and they also have unique physiological activity characteristics relative to proteins.Bioactive peptides contain a great deal of development potential.More specifically,food-derived bioactive peptides have the advantages of a wide variety of sources,unique structures,high efficiency and safety,so they have broad development prospects.This review provides an overview of the current advances regarding the preparation,functional characteristics,and structure–activity relationships of food-derived bioactive peptides.Moreover,the prospects for the future development and application of food-derived bioactive peptides are discussed.This review may provide a better understanding of foodderived bioactive peptides,and some constructive inspirations for further research and applications in the food industry. | YANG Fu-jia CHEN Xu HUANG Mu-chen YANG Qian CAI Xi-xi CHEN Xuan DU Ming HUANG Jian-lian WANG Shao-yun | 2021 | Journal of Integrative Agriculture2021，20，9： | 9 |
| 6 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 7 | Lung-protective Ventilation in Patients with Brain Injury: A Multicenter Cross-sectional Study and Questionnaire Survey in China显示文摘 | Xu-Ying Luo Ying-Hong Hu Xiang-Yuan Cao Yan Kang Li-Ping Liu Shou-Hong Wang Rong-Guo Yu Xiang-You Yu Xia Zhang Bao-Shan Li Zeng-Xiang Ma Yi-Bing Weng Heng Zhang De-Chang Chen Wei Chen Wen-Jin Chen Xiu-Mei Chen Bin Du Mei-Li Duan Jin Hu Yun-Feng Hoang Gui-Jun Jia Li-Hong Li Yu-Min Liang Bing-Yu Qin Xian-Dong Wang Jian Xiong Li-Mei Yan Zheng-Ping Yang Chen-Ming Dong Dong-Xin Wang Qing-Yuan Zhan Shuang-Lin FU Lin Zhao Qi-Bing Huang Ying-Guang Xie Xiao-Bo Huang Guo-Bin Zhang Wang-Bin Xu Yuan Xu YaLing Liu He-Ling Zhao Rong-Qing Sun Ming Sun Qing-Hong Cheng Xin Qu Xiao-Feng Yang Ming Xu Zhong-Hua Shi Han Chen Xuan He Yan-Lin Yang Guang-Qiang Chen Xiu-Mei Sun Jian-Xin Zhou | 2016 | Chinese Medical Journal2016，，14： | 6 |
| 8 | Correlation between the expression of thrombospondin-1 and neovascularization in mucoepidermoid carcinoma显示文摘背景研究人员最近证明了 thrombospondin-1 (TSP-1 ) 在调整 neovascularization 有重要功能。然而,它是否禁止或加速 neovascularization,仍然是争论的。我们在 mucoepidermoid 癌关于在 TSP-1 和 vascularization 之间的关联发现了很少报告。在这研究,在 mucoepidermoid 癌的 TSP-1 的分发和表示被调查。我们也分析了( 1 )在 TSP-1 和 microvessel 密度( MVD )的表示之间的关联作为 neovascularization 活动的指示物,并且( 2 )在 mucoepidermoid carcinoma.Method ( 1 )的下的 xenotransplanted 模型的 neovascularization 和肿瘤生长上的 TSP-1 的效果 TSP-1 和 MVD 的表示的地点和紧张被 streptavidin-peroxidase ( SP )的方法在外科以后在 mucoepidermoid 癌的 45 种情况中分析 immunohistochemistry ;并且(2 ) recombinant 人 thrombospondin-1 (rhTSP-1 ) 一个星期被注射两次因为在在下的 xenotransplanted 肿瘤的肿瘤附近的五个连续星期在裸体老鼠 mucoepidermoid 癌当模特儿。每个星期,肿瘤尺寸被测量,以便拉 mucoepidermoid 癌,和 MVD 的 xenotransplanted 肿瘤模特儿的生长曲线是 TSP-1 蛋白质的积极表示是的 measured.Results (1 )57.78%(26/45 ) 。为 TSP-1 的最积极的染色在癌症房间的细胞质被发现,当染色的一些发生在细胞外的矩阵时。在 mucoepidermoid 癌的 45 种情况中的吝啬的 MVD 是 58.17 獲映牯琠敨搠灥桴漠 ? 湩慶楳湯 ? 潦浲 ? 景朠潲瑷 ? 瀠瑡潨潬楧慣? 牧摡 ? 愠摮搠来敲 ?景搠晩敦敲瑮慩楴 吗? | YANG Sen WANG Xiao-yi GUO Li-juan TANG Xiu-fa GAO Qing-hong XUAN Ming ZHANG Qiang TAN Ke WEN Yu-ming WANG Chang-mei XU Rui-an CAO Yu-tang | 2008 | Chinese Medical Journal2008，，19： | 4 |
| 9 | Effectiveness of Using Mean Corpuscular Volume and Mean Corpuscular Hemoglobin for Beta-thalassemia Carrier Screening in the Guangdong Population of China显示文摘Beta(β)-thalassemia is one of the most common hemoglobinopathies worldwide,creating major public health problems and social burdens in many regions.Screening forβ-thalassemia carriers is crucial for controlling this condition.To investigate the?effectiveness?of?mean?corpuscular?volume?(MCV)and mean corpuscular hemoglobin(MCH)for screeningβ-thalassemia,retrospective data were analyzed for 6,779β-thalassemia carriers subjected to genetic testing following thalassemia screening in Guangdong province between January 2018 and December 2019. | GU Heng WANG Yong Xia DU Meng Xuan XU Shan Shan ZHOU Bing Yi LI Ming Zhen | 2021 | Biomedical and Environmental Sciences2021，34，8： | 4 |
| 10 | Effect of creatine phosphate sodium on miRNA378,miRNA378* and calumenin mRNA in adriamycin-injured cardiomyocytes显示文摘Objective: To investigate the effect of creatine phosphate sodium(sodium phosphocreatine) on miRNA378, miRNA378* and calumenin m RNA in adriamycin-injured suckling mouse myocardium. Methods: The suckling mouse myocardium of primary culture were randomly divided into control group, adriamycin group and treatment group. To identify the suckling mouse myocardium, Smooth muscle actin-α(α-SMA) was monitored by immunohistochemical method. Cardiac function was evaluated by transthoracic echocardiography. The mRNA change of miRNA378, miRNA378* and calumenin m RNA were detected by quantitative real-time PCR. The expression of calumenin and GRP78 were identified by western blot. Results: Mitochondrial damage and vacuolization were found in adriamycin-induced suckling mouse myocardium compared with control group, while creatine phosphate sodium could reduce this phenomenon. Compared with the control group, the mRNA of miRNA378, miRNA378* and calumenin in adriamycin group was reduced, while creatine phosphate sodium could increase this phenomenon. The expression of calumenin and GRP78 were decreased after adriamycin treatment in suckling mouse myocardiums, creatine phosphate sodium increased the expression of calumenin and GRP78. Conclusion: The results of this experiment might be closely related to the effects of that creatine phosphate sodium reduced the pathological mechanism of suckling mouse myocardium with myocarditis caused by adriamycin. | Miao YU Zhi-hui HE Li-ying XUAN Xiao-tong SHAN Jie LONG Jing-yi FENG Yu WANG Ming ZHAO | 2016 | 中国应用生理学杂志2016，32，6： | 4 |
| 11 | Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration显示文摘Mitotic inheritance of the DNA methylome is a challenging task for the maintenance of cell identity.Whether DNA methylation pattern in different genomic contexts can all be faithfully maintained is an open question.A replication-coupled DNA methylation maintenance model was proposed decades ago,but some observations suggest that a replication-uncoupled maintenance mechanism exists.However,the capacity and the underlying molecular events of replication-uncoupled maintenance are unclear.By measuring maintenance kinetics at the single-molecule level and assessing mutant cells with perturbation of various mechanisms,we found that the kinetics of replication-coupled maintenance are governed by the UHRF1–Ligase 1 and PCNA–DNMT1 interactions,whereas nucleosome occupancy and the interaction between UHRF1 and methylated H3K9 specifically regulate replication-uncoupled maintenance.Surprisingly,replication-uncoupled maintenance is sufficiently robust to largely restore the methylome when replication-coupled maintenance is severely impaired.However,solo-WCGW sites and other CpG sites displaying aging-and cancer-associated hypomethylation exhibit low maintenance efficiency,suggesting that although quite robust,mitotic inheritance of methylation is imperfect and that this imperfection may contribute to selective hypomethylation during aging and tumorigenesis. | Xuan Ming Zhuqiang Zhang Zhuoning Zou Cong Lv Qiang Dong Qixiang He Yangyang Yi Yingfeng Li Hailin Wang Bing Zhu | 2020 | Cell Research2020，30，11： | 4 |
| 12 | Cognitive magnetic resonance imaging-ultrasound fusion transperineal targeted biopsy combined with randomized biopsy in detection of prostate cancer显示文摘BACKGROUND Prostate cancer(PCa)is one of the most common cancers among men.Various strategies for targeted biopsy based on multiparametric magnetic resonance imaging(mp-MRI)have emerged,which may improve the accuracy of detecting clinically significant PCa in recent years.AIM To investigate the diagnostic efficiency of a template for cognitive MRIultrasound fusion transperineal targeted plus randomized biopsy in detecting PCa.METHODS Data from patients with an increasing prostate-specific antigen(PSA)level but less than 20 ng/mL and at least one lesion suspicious for PCa on MRI from December 2015 to June 2018 were retrospectively analyzed.All patients underwent cognitive fusion transperineal template-guided targeted biopsy followed by randomized biopsy outside the targeted area.A total of 127 patients with complete data were included in the final analysis.A multivariable logistic regression analysis was conducted,and a two-sided P<0.05 was considered statistically significant.RESULTS PCa was detected in 66 of 127 patients,and 56 cases presented clinically significant PCa.Cognitive fusion targeted biopsy alone detected 59/127 cases of PCa,specifically 52/59 cases with clinically significant PCa and 7/59 cases with clinically insignificant PCa.A randomized biopsy detected seven cases of PCa negative on targeted biopsy,and four cases had clinically significant PCa.PSA density(OR:1.008,95%CI:1.003-1.012,P=0.001;OR:1.006,95%CI:1.002-1.010,P=0.004)and Prostate Imaging-Reporting and Data System(PI-RADS)scores(both P<0.001)were independently associated with the results of cognitive fusion targeted biopsy combined with randomized biopsy and targeted biopsy alone.CONCLUSION This single-centered study proposed a feasible template for cognitive MRIultrasound fusion transperineal targeted plus randomized biopsy.Patients with higher PSAD and PI-RADS scores were more likely to be diagnosed with PCa. | Cheng Pang Miao Wang Hui-Min Hou Jian-Yong Liu Zhi-Peng Zhang Xuan Wang Ya-Qun Zhang Chun-Mei Li Wei Zhang Jian-Ye Wang Ming Liu | 2021 | World Journal of Clinical Cases2021，9，36： | 3 |
| 13 | Dexamethasone ameliorates severe pneumonia but slightly enhances viral replication in the lungs of SARS-CoV-2-infected Syrian hamsters显示文摘The pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 230 million cases and over four million deaths worldwide.Furthermore,multiple emerging SARS-CoV-2 variants have shown enhanced infectivity,transmissibility,pathogenicity and ability to escape neutralization by vaccine-induced humoral immunity[1].The antibody resistance of SARS-CoV-2 variants constitutes a challenge for current vaccines and therapeutic antibodies.No specific antiviral is currently available for coronavirus in humans[2].Although remdesivir was approved by the FDA for the treatment of SARS-CoV-2 infection,the therapeutic effect is limited,particularly for critical cases with severe pneumonia. | Lunzhi Yuan Ming Zhou Jian Ma Xuan Liu Peiwen Chen Huachen Zhu Qiyi Tang Tong Cheng Yi Guan Ningshao Xia | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 14 | Implementing the communication for development strategy to improve knowledge and coverage of measles vaccination in western Chinese immunization programs:a before-and-after evaluation显示文摘Background:Communication for Development(C4D)is a strategy promoted by the United Nations Children’s Fund to foster positive and measurable changes at the individual,family,community,social,and policy levels of society.In western China,C4D activities have previously been conducted as part of province-level immunization programs.In this study,we evaluated the association of C4D with changes in parental knowledge of immunization services,measles disease,and measles vaccine,and changes in their children’s measles vaccine coverage.Methods:From April 2013 to April 2014,C4D activities were implemented as part of provincial immunization programs in the Inner Mongolia,Guangxi,Chongqing,Guizhou,Tibet,Shaanxi,Gansu,Ningxia,and Qinghai provinces.We used a before-and-after study design and employed face-to-face interviews to assess changes in parental knowledge and vaccination coverage.Results:We surveyed 2107 households at baseline and 2070 households after 1 year of C4D activities.Following C4D,95%of caregivers were aware of the vaccination record check requirement for entry into kindergarten and primary school;80%of caregivers were aware that migrant children were eligible for free vaccination;more than 70%of caregivers knew that measles is a respiratory infectious disease;and 90%of caregivers knew the symptoms of measles.Caregivers’willingness to take their children to the clinic for vaccination increased from 51.3%at baseline to 67.4%in the post-C4D survey.Coverage of one-dose measles-containing vaccine(MCV)increased from 83.8%at baseline to 90.1%after C4D.One-dose MCV coverage was greater than 95%in the Guangxi,Shaanxi,and Gansu provinces.Two-dose MCV coverage increased from 68.5 to 77.6%.House-to-house communication was the most popular C4D activity among caregivers(91.6%favoring),followed by posters and educational talks(64.8 and 49.9%favoring).Conclusions:C4D is associated with increased caregiver knowledge about measles,increased willingness to seek immunization services for their children,and increased measles vaccination coverage.Tailored communication strategies based on insights gained from these analyses may be able to increase vaccination coverage in hard-to-reach areas.C4D should be considered for larger scale implementation in China. | Ming Lu Yao-Zhu Chu Wen-Zhou Yu Robert Scherpbier Yu-Qing Zhou Xu Zhu Qi-Ru Su Meng-Juan Duan Xuan Zhang Fu-Qiang Cui Hua-Qing Wang Yi-Biao Zhou Qing-Wu Jiang | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 15 | Integrating morphological spatial pattern analysis and the minimal cumulative resistance model to optimize urban ecological networks: a case study in Shenzhen City, China显示文摘Background:With the increasing fragmentation of landscape induced by rapid urbanization,the construction of ecological networks is of great signifcance to alleviate the degradation of urban habitats and protect natural envi‑ronments.However,there is considerable uncertainty when constructing ecological networks,especially the difer‑ent approaches to selecting ecological sources.We used the southern Chinese city of Shenzhen as a study area to construct and optimize ecological networks using a coupling approach.Ecological source areas were extracted using morphological spatial pattern analysis(MSPA)and the landscape index method.Ecological networks were con‑structed using the minimal cumulative resistance(MCR)model and the gravity model.Stepping stones and ecological fault points were added in corridors to optimize the ecological network.Results:Ten core areas with maximum importance patch values were extracted by the landscape index method as ecological source areas according to MSPA,after which corridors between ecological sources were constructed based on the MCR model.The constructed ecological networks were optimized using 35 stepping stones and 17 ecologi‑cal fault points.The optimized ecological networks included 11 important corridors,34 general corridors,and seven potential corridors.The results of corridor landscape-type analysis showed that a suitable ecological corridor is 60 to 200 m wide.Conclusions:Overall,our results imply that ecological source areas can be identifed virtually,and that ecological networks can be signifcantly optimized by combining MSPA and MCR models.These results provide a methodologi‑cal reference for constructing ecological networks,and they will be useful for urban planning and biodiversity protec‑tion in Shenzhen and other similar regions around the world. | Yang‑Yang Li Yu‑Zhe Zhang Zhi‑Yun Jiang Cheng‑Xuan Guo Ming‑Yue Zhao Zhi‑Guang Yang Ming‑Yan Guo Bing‑Yue Wu Quan‑Ling Chen | 2021 | Ecological Processes2021，10，1： | 3 |
| 16 | Overview of the Solar Polar Orbit Telescope Project for Space Weather Mission显示文摘The Solar Polar ORbit Telescope(SPORT) project for space weather mission has been under intensive scientific and engineering background studies since it was incorporated into the Chinese Space Science Strategic Pioneer Project in 2011.SPORT is designed to carry a suite of remote-sensing and in-situ instruments to observe Coronal Mass Ejections(CMEs),energetic particles,solar high-latitude magnetism,and the fast solar wind from a polar orbit around the Sun.The first extended view of the polar regions of the Sun and the ecliptic enabled by SPORT will provide a unique opportunity to study CME propagation through the inner heliosphere,and the solar high-latitude magnetism giving rise to eruptions and the fast solar wind.Coordinated observations between SPORT and other spaceborne/ground-based facilities within the International Living With a Star(ILWS) framework can significantly enhance scientific output.SPORT is now competing for official selection and implementation during China's 13 th Five-Year Plan period of 2016-2020. | XIONG Ming LIU Ying LIU Hao LI Baoquan ZHENG Jianhua ZHANG Cheng XIA Lidong ZHANG Hongxin RAO Wei CHEN Changya SUN Weiying WU Xia DENG Yuanyong HE Han JIANG Bo WANG Yuming WANG Chuanbing SHEN Chenglong ZHANG Haiying ZHANG Shenyi YANG Xuan SANG Peng WU Ji | 2016 | 空间科学学报2016，36，3： | 3 |
| 17 | On s-semipermutable Subgroups of Finite Groups显示文摘假定 G 是一个有限的组, H 是 G 的亚群。我们说 H 是在 G 的 s-semipermutable 如果为 G 与的任何 Sylow p 亚群 G p 的 H G p = G p H (p, |H|)= 1。我们在有限的组的结构上调查 s-semipermutable 亚群的影响。一些最近的结果被概括并且统一。关键词 s-semipermutable 亚群 - 概括恰当的亚群 - p-nilpotent 组 - 浸透的形成先生(2000 ) 题目分类 20D10 - 20D20 由中国(资助号码 10871210 ) 的国家自然科学基础支持了,广东省(资助号码 06023728 ) | Yang Ming LI Xuan Li HE Yan Ming WANG | 2010 | Acta Mathematica Sinica,English Series2010，26，11： | 3 |
| 18 | Performance of a serial-connection multi-chamber piezoelectric micropump显示文摘The concept and structure of serial-connection multi-chamber (SCMC) micropumps with cantilever valves is introduced. The SCMC micropump, which can be manufactured using conventional production techniques and materials, has a multi-layer circular planar structure. The border-upon piezoelectric actuators of a SCMC micropump work in anti-phase, as a result the pumping performance is similar to that of several single-chamber pumps running in series. The theoretical analysis shows that the pumping performance of a SCMC micropump depends not only on the characteristic and geometrical parameters of the piezoelectric actuators, but also on the number of pump chambers. Both flowrate and pressure of a SCMC pump can be enhanced to a certain extent. Four piezoelectric micropumps with different chambers were fabricated and tested. The testing results show that the enhancing extents of the flowrate and pressure of a SCMC piezoelectric micropump are different. The maximum flowrate and pressure of the four-chamber pump achieved are 2.5 times and 3.6 times those of the single-chamber pump achieved. | KAN Jun-wu XUAN Ming LIU Guo-jun YANG Zhi-gang WU Yi-hui | 2005 | 光学精密工程2005，13，5： | 3 |
| 19 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 20 | Effects of MCI-186 on intracellular calcium ion concentration and membrane fluidity of hippocampal neurons in a rat model of Alzheimer's disease显示文摘The present study observed the effects of MCI-186 on the intracellular calcium ion concentra-tion ([Ca2+]i) and membrane fluidity of hippocampal neurons in Alzheimer's disease (AD) model rats to validate the neuroprotective effects of MCI-186.Compared with normal and sham-operated rats,the escape latency was obviously prolonged,spanning platform times were obviously reduced,[Ca2+]i was increased,and microviscosity η value was increased in AD rats.MCI-186 at 0.5 mg/mL and 0.2 mg/mL obviously shortened escape latency,increased spanning platform times and decreased [Ca2+]i and microviscosity η values in AD rats at 7 and 17 days after induction of the model.The differences in the above-mentioned indices between normal and MCI-186-treated rats were statistically significant.MCI-186 at 0.2 mg/mL yielded better curative effects than 0.5 mg/mL MCI-186.These findings suggest that MCI-186 improves learning and memory abilities in AD rats by decreasing [Ca2+]i and increasing membrane fluidity of hippocampal neurons. | Ming Yu Lei Qin Zhao Wang Xiaohong Lu Ying Zhu Wenhui Leng Xuan Wang | 2011 | Neural Regeneration Research2011，6，29： | 2 |
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