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| 1 | Proteomics Associated with Virulence Differentiation of Curvularia lunata in Maize in China显示文摘蛋白质的一个维的电气泳动(1-DE ) ,蛋白质的 two-dimensionalelectrophoresis (2-DE ) 并且 cDNA 顺序克隆被用来学习 Curvularia lunata 的毒力区别[Cochliobolus lunatus ] 在中国从玉米(Zea maydis ) 孤立。从蛋白质的 1-DE 胶化侧面, 110 个可再现的乐队与六被分开 C 孤立。lunata CX-3, SD-6, C-152, C107-1, DD-60 和 W-18。68 个乐队(61.82%) 是多态的,建议在 isolates 之中的巨大的生物多样性。所有孤立组由 0.605 的系数价值由不同剧毒的类型组成因为实验被聚类进三。组织 1,由有高毒力的 CX-3, SD-6 和 C-152 组成比组显示了更多的蛋白质乐队第 2a 3,与低毒力由 C107-1 和 DD-60 组成。Proteomics 途径基于 2-DEtechniques 被使用识别在 CX-3 和 DD-60 与毒力区别联系的特定的蛋白质。423 个蛋白质点的一个总数被分开。从他们, 75 个特定的蛋白质点在 2-DE 胶化被显示。在他们之中, 28 个蛋白质点在 CX-3 是唯一的, 8 在两 2-DE 胶化上在 DD-60,和 39 个蛋白质点被显示出,但是在紧张不同地表示。包括三个唯一的蛋白质点和 17 差别的 Twentyprotein 点在 CX-3 表示了蛋白质点(超过 2 褶层 DD-60 ) 进一步与 MALDI-TOF MS/MS 被识别。结果显示大多数识别蛋白质被发现与毒力区别,新陈代谢,压力反应和信号转导被联系。他们之一作为 Brn1 蛋白质被识别,它被报导了在真菌与黑素生合成和毒力区别有关。与我们的以前的调查结果结合了,我们假设那 Brn1 蛋白质和它的调整产品可能涉及 C 的毒力区别。lunata。因而,我们克隆 Brn1cDNA 碎片并且在另外的真菌与碎片联盟。结果显示 Brn1 的 633-bpsequence 在 C 克隆。lunata 是高度与比较真菌逻辑的人。为在我们的情况中的 Brn1 的准确基因角色的进一步的工作是在进行之中的…… | Shufa Xu Jie Chen Lixing Liu Xiaofei Wang Xiuli Huang Yuhong Zhai | 2007 | Journal of Integrative Plant Biology2007，49，4： | 25 |
| 2 | Effects of Water-table Depth and Soil Moisture on Plant Biomass, Diversity, and Distribution at a Seasonally Flooded Wetland of Poyang Lake, China显示文摘Hydrological regime has been widely recognized as one of the major forces determining vegetation distribution in seasonally flooded wetland. Poyang Lake, the largest freshwater lake in China, has been encountering dramatic changes in hydrological conditions in last decade, which greatly influenced the wetland vegetations. To explore the relationships between hydrology and vegetation distribution, water-table depth, soil moisture, species composition, diversity and biomass were measured at a seasonally flooded wetland section at Wucheng National Nature Reserve. Three plant communities, Artemisia capillaris, Phragmites australis and Carex cinerascens communities, were examined which are zonally distributed from upland to lakeshore with decreasing elevation. Canonical correspondence analysis(CCA), spearmen correlation and logistic regression were adopted to analyze the relationships between vegetation characteristics and hydrological variables of water-table depth and soil moisture. Results show that significant hydrological gradient exist along the wetland transect. Water-table demonstrates a seasonal variation and is consistently deepest in A. capillaris community(ranging from –0.5 m above ground to +10.3 m below ground), intermediate in P. australis community(–2.6 m to +7.8 m) and shallowest in C. cinerascens community(–4.5 m to +6.1 m). Soil moisture is lowest and most variable in A. capillaris community, highest and least variable in P. australis community, and intermediate and moderate variable in C. cinerascens community. The CCA ordination indicated that variables of water-table depth and soil moisture are strongly related to community distribution, which explained 81.7% of the vegetation variations. Species diversity indices are significantly positively correlated with soil moisture and negatively correlated with moisture variability, while above- and belowground biomass are positively correlated with moisture. Above- and belowground biomass present Gaussian models along the gradient of average water-table depth in growing season, while species diversity indices show bimodal patterns. The optimal average water-table depths for above- and belowground biomass are 0.8 m and 0.5 m, respectively, and are 2.2 m and 2.4 m for species richness and Shannon-Wiener indices, respectively. Outcomes of this work improved the understandings of the relationship between hydrology and vegetation. | XU Xiuli ZHANG Qi TAN Zhiqiang LI Yunliang WANG Xiaolong | 2015 | Chinese Geographical Science2015，25，6： | 24 |
| 3 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 4 | An Arctic sea ice thickness variability revealed from satellite altimetric measurements显示文摘A modified algorithm taking into account the first year(FY) and multiyear(MY) ice densities is used to derive a sea ice thickness from freeboard measurements acquired by satellite altimetry ICESat(2003–2008). Estimates agree with various independent in situ measurements within 0.21 m. Both the fall and winter campaigns see a dramatic extent retreat of thicker MY ice that survives at least one summer melting season. There were strong seasonal and interannual variabilities with regard to the mean thickness. Seasonal increases of 0.53 m for FY the ice and 0.29 m for the MY ice between the autumn and the winter ICESat campaigns, roughly 4–5 month separation, were found. Interannually, the significant MY ice thickness declines over the consecutive four ICESat winter campaigns(2005–2008) leads to a pronounced thickness drop of 0.8 m in MY sea ice zones. No clear trend was identified from the averaged thickness of thinner, FY ice that emerges in autumn and winter and melts in summer. Uncertainty estimates for our calculated thickness, caused by the standard deviations of multiple input parameters including freeboard, ice density, snow density, snow depth, show large errors more than 0.5 m in thicker MY ice zones and relatively small standard deviations under 0.5 m elsewhere. Moreover, a sensitivity analysis is implemented to determine the separate impact on the thickness estimate in the dependence of an individual input variable as mentioned above. The results show systematic bias of the estimated ice thickness appears to be mainly caused by the variations of freeboard as well as the ice density whereas the snow density and depth brings about relatively insignificant errors. | BI Haibo HUANG Haijun SU Qiao YAN Liwen LIU Yanxia XU Xiuli | 2014 | Acta Oceanologica Sinica2014，33，11： | 8 |
| 5 | Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese显示文摘动脉粥样硬化是 atherothrombotic 击(ATS ) 的一个重要 pathophysiological 基础,并且发炎在动脉粥样硬化形成起一个重要作用。在这研究,在三关键发炎相关的基因的单个核苷酸的多型性(SNP ) , 5-lipoxygenase 激活蛋白质(ALOX5AP ) , phosphodiesterase 4D (PDE4D ) ,和 interleukin-1 (IL-1 ) ,被调查用北汉汉语与 ATS 一起决定他们的协会。六 -- 182 个 ATS 病人和 598 无关的控制被招募。Genotyping 被聚合酶链反应限制碎片长度多型性和帮助矩阵的激光解吸附作用电离 time-of-flight 质量执行 spectrometry 教材扩展。每 SNP 的遗传型和等位基因频率统计上被分析。 ATS 的风险被作出对有利的裁决 ALOX5AP SG13S114A/T AA 遗传型( P = 0.040 )并且等位基因( P = 0.033 ), PDE4D SNP83C/T TT 遗传型( P = 0.010 )并且 T 等位基因( P = 0.008 )并且 SNP219A/G GG 遗传型( P = 0.025 )并且 G 等位基因( P = 0.022 ),并且 IL-1-889C/T T 等位基因( P = 0.035 )。差别在调整以后仍然保持重要。ALOX5AP HapA haplotype 没与 ATS 一起被相关(P = 0.834 ) ,但是 GCGA 代表了在风险 haplotype (P = 0.008 ) 。而且,在 SNP219-220 的 PDE4D AA haplotype 可能是在风险 haplotype (P = 0.013 ) ,当 GA 可能是保护的 haplotype 时(P = 0.005 ) 。ALOX5AP (SG13S114A/T ) , PDE4D (SNP83C/T, 219A/G ) ,并且 IL-1 (-889C/T) SNP 用北汉汉语与 ATS 的增加的风险被联系。 | Jiuhan Zhao Xiaohong Wang Jialiang Xu Nan Li Xiuli Shang Zhiyi He Jun Yang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 8 |
| 6 | Umbilical cord-derived mesenchymal stem cells regulate thymic epithelial cell development and function in Foxn 1^-/- mice显示文摘 | Guangyang Liu Lihua Wang Tianxiang Pang Delin Zhu Yi Xu Hanyu Wang Xiuli Cong Yongjun Liu | 2014 | Cellular & Molecular Immunology2014，11，3： | 6 |
| 7 | Recent advances in nanomaterials for sonodynamic therapy显示文摘Sonodynamic therapy(SDT),as a novel non-invasive strategy for eliminating tumor,has the advantages of deeper tissue penetration,fewer side effects,and better patient compliance,compared with photodynamic therapy(PDT).In SDT,ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species(ROS),induce the collapse of vacuoles in solution,and bring about irreversible damage to cancer cells.In recent years,much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS.However,the traditional organic sonosensitizers,such as porphyrins,hypericin,and curcumins,suffer from complex synthesis,poor water solubility,and low tumor targeting efficacy which limit the benefits of SDT.In contrast,inorganic sonosensitizers show good in vivo stability,controllable physicochemical properties,ease of achieving multifunctionality,and high tumor targeting,which greatly expanded their application in SDT.In this review,we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers,and directly produce ROS under ultrasound.Moreover,the prospects of inorganic nanomaterials for SDT application are also discussed. | Ting Xu Shaojing Zhao Changwei Lin Xiuli Zheng Minhuan Lan | 2020 | Nano Research2020，13，11： | 5 |
| 8 | Seismic stability of jointed rock slopes under obliquely incident earthquake waves显示文摘Seismic stability of slopes has been traditionally analyzed with vertically propagated earthquake waves.However,for rock slopes,the earthquake waves might approach the outcrop still with a evidently oblique direction.To investigate the impact of obliquely incident earthquake excitations,the input method for SV and P waves with arbitrary incident angles is conducted,respectively,by adopting the equivalent nodal force method together with a viscous-spring boundary.Then,the input method is introduced within the framework of ABAQUS software and verified by a numerical example.Both SV and P waves input are considered herein for a 2 D jointed rock slope.For the jointed rock mass,the jointed material model in ABAQUS software is employed to simulate its behavior as a continuum.Results of the study show that the earthquake incident angles have significance on the seismic stability of jointed rock slopes.The larger the incident angle,the greater the risk of slope instability.Furthermore,the stability of the jointed rock slopes also is affected by wave types of earthquakes heavily.P waves induce weaker responses and SV waves are shown to be more critical. | Huang Jingqi Zhao Mi Xu Chengshun Du Xiuli Jin Liu Zhao Xu | 2018 | Earthquake Engineering and Engineering Vibration2018，17，3： | 4 |
| 9 | Analysis of Fluid Model Modulated by an M/PH/1 Working Vacation Queue显示文摘We propose a fluid model driven by the queue length process of a working vacation queue with PH service distribution, which can be applied to the Ad Hoc network with every data group. We obtain the stationary distribution of the queue length in driving process based on a quasi-birth-and-death process. Then, we analyze the fluid model, and derive the differential equations satisfied by the stationary joint distribution of the fluid queue based on the balance equation. Moreover, we obtain some performance indices, such as, the average throughput, server utilization and the mean buffer content. These indices are relevant to pack transmission in the network, and they can be obtained by using the Laplace Transform (LT) and the Laplace-Stieltjes Transform (LST). Finally, some numerical examples have been discussed with respect to the effect of several parameters on the system performance indices. | Xiuli Xu Huining Wang | 2019 | Journal of Systems Science and Systems Engineering2019，28，2： | 4 |
| 10 | Phase evolution, microstructure, electric properties of (Ba1–xBi0.67xNa0.33x)(Ti1–xBi0.33xSn0.67x)O3 ceramics显示文摘(Ba1–xBi0.67xNa0.33x)(Ti1–xBi0.33xSn0.67x)O3(abbreviated as BBNTBS,0.02≤x≤0.12)ceramics were fabricated via a traditional solid state reaction method.The phase transition of BBNTBS from tetragonal to pseudo cubic is demonstrated by XRD and Raman spectra.The BBNTBS(x=0.1)ceramics have decent properties with a highεr(~2250),smallΔε/ε25℃ values of±15%over a wide temperature range from–58 to 171℃,and low tanδ≤0.02 from 10 to 200℃.The basic mechanisms of conduction and relaxation processes in the high temperature region were thermal activation,and oxygen vacancies might be the ionic charge transport carriers.Meanwhile,BBNTBS(x=0.1)exhibited decent energy storage density(Jd=0.58 J/cm3)and excellent thermal stability(the variation of Jd is less than 3% in the temperature range of 25–120℃),which could be a potential candidate for high energy density capacitors. | Xiuli CHEN Xu LI Huanfu ZHOU Jie SUN Xiaoxia LI Xiao YAN Congcong SUN Junpeng SHI | 2019 | Journal of Advanced Ceramics2019，8，3： | 4 |
| 11 | Nonlinear Seismic Response of Rock Tunnels Crossing Inactive Fault under Obliquely Incident Seismic P Waves显示文摘The failure mechanism of tunnels crossing faults is a critical issue for tunnels located in seismically active regions. This study aims to investigate the nonlinear response of rock tunnels crossing inactive faults under obliquely incident seismic P waves. Based on the equivalent nodal force method together with the viscous-spring boundary, an incident method for the site, which contains fault and is subjected to obliquely incident seismic P waves, is developed first. Then, based on the proposed incident method, the nonlinear response and the failure process of the tunnel crossing inactive fault are numerically studied. The numerical results show that the failure mechanism of the tunnel crossing inactive fault can be attributed to the combined action of the seismic waves and its associated fault slippage. Finally, parameter studies are conducted to investigate the effects of the wave impedance ratio of the fault to the surrounding rock and the incident angle of P waves. By the parameter analysis, it can be concluded that:(1) with decreasing the wave impedance ratio of the fault to the surrounding rock, the seismic response of the tunnel increases significantly;(2) the seismic response of the tunnel increases first and then decreases with the increasing of the incident angle of P waves. This study offers the insight for further research on the seismic stability of tunnels crossing inactive faults. | Hongyun Jiao Xiuli Du Mi Zhao Jingqi Huang Xu Zhao Wenlong Ouyang | 2021 | Journal of Earth Science2021，32，5： | 3 |
| 12 | Effectiveness of tonifying-kidney and regulating-liver therapy on diminished ovarian reserve: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To evaluate the effectiveness of the Traditional Chinese Medicine tonifying-kidney and regulating-liver therapy on diminished ovarian reserve(DOR).METHODS: The literature was comprehensively searched up to August 2019 using four Chinese and three English electronic databases to extract randomized clinical trials(RCTs) comparing Traditional Chinese Medicine tonifying-kidney and regulating-liver prescriptions(combined with hormone therapy or not) with Western Medicine. Data quality evaluation was conducted using the Cochrane risk of bias tool. Meta-analysis was conducted using Revman 5.3 software with effect estimates presented as mean difference(MD), risk ratio(RR), and95% confidence interval(CI).RESULTS: A total of nine RCTs with 512 participants were extracted and eligible for Meta-analysis.There were no significant differences between Chinese medicine and Western Medicine on basal serum follicle-stimulating hormone(FSH) level(MD0.11, 95% CI-0.52 to 0.74, 392 participants, seven trials), anti-Müllerian hormone level(MD 0.48, 95%CI-0.62 to 1.58, 95 participants, two trials), and the FSH and luteinizing hormone ratio(MD 0.01,95% CI-0.95 to 0.96, 115 participants, two trials).Chinese medicine was more effective at improving Traditional Chinese Medicine symptom scores(TCMSS)(MD-2.39, 95% CI-3.83 to-0.94, 160 participants, three trials), effective rate of TCMSS(RR1.18, 95% CI 1.02 to 1.36, 160 participants, three trials), antral follicle count(AFC)(MD 0.55, 95% CI 0.05 to 1.04, 155 participants, three trials), and FSH levels at 3 months post-treatment(MD-4.77, 95% CI-6.09 to-3.45, 137 participants, two trials).CONCLUSION: Compared with Western Medicine,tonifying-kidney and regulating-liver therapy is more effective at relieving symptoms and improving AFC and FSH at 3 months post-treatment. | Liu Liuqing Liu Yanfeng Yang Ming Xu Guiqin Li Ruiqi Xu Xiuli Pan Xue Liang Jialing | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 13 | Early faults prediction of running state of electromechanical systems and reconfigurable integration of series safety monitoring systems显示文摘Fault prediction technology of running state of electromechanical systems is one of the key technologies that ensure safe and reliable operation of electromechanical equipment in health state. For multiple types of modern, high-end and key electromechanical equipment, this paper will describe the early faults prediction method for multi-type electromechanical systems, which is favorable for predicting early faults of complex electromechanical systems in non-stationary, nonlinear, variable working conditions and long-time running state; the paper shall introduce the reconfigurable integration technology of series safety monitoring systems based on which the integrated development platform of series safety monitoring systems is built. This platform can adapt to integrated R&D of series safety monitoring systems characterized by high technology, multiple species and low volume. With the help of this platform, series safety monitoring systems were developed, and the Remote Network Security Monitoring Center for Facility Groups was built. Experimental research and engineering applications show that: this new fault prediction method has realized the development trend features extraction of typical electromechanical systems, multi-information fusion, intelligent information decision-making and so on, improving the processing accuracy, relevance and applicability of information; new reconfigurable integration technologies have improved the integration level and R&D efficiency of series safety monitoring systems as well as expanded the scope of application; the series safety monitoring systems developed based on reconfigurable integration platform has already played an important role in many aspects including ensuring safety operation of equipment, stabilizing product quality, optimizing running state, saving energy consumption, reducing environmental pollution, improving working conditions, carrying out scientific maintenance, advancing equipment utilization, saving maintenance charge and enhancing the level of information management. | Xu Xiaoli Zuo Yunbo Chen Tao Liu Xiuli Chen Shanpeng | 2014 | 仪器仪表学报2014，35，S2： | 3 |
| 14 | A Multifunctional {P_(2)Mo_(5)}-based Hybrid Applying to Catalysis, Electrocatalysis and Dye Adsorption显示文摘As a common environmental pollutant, thioether can cause serious environmental pollution, so selective oxidation of thioether has become one of the current research hotspots. In this paper, an inorganic-organic hybrid based on a Standberg-type polyoxometalate, [Hbiz]_(5)[HP_(2)Mo_(5)O_(23)]·5H_(2)O(1)(biz=benzimidazole), was obtained by adjusting pH under hydrothermal conditions. The structure was characterized by infrared spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction. Compound 1 can be used as an excellent catalyst for the oxidation of thioanisole. The experimental results showed that thioanisole could be catalytically oxidized to methyl phenyl sulfoxide by compound 1 as a catalyst within 40 min. The conversion rate and selectivity reached 99%. Compound 1 had good cycling stability as a heterogeneous catalyst. In addition, the electrocatalytic reduction of H_(2)O_(2) and Cr_(2)O_(7)^(2−) for hybrid 1 was preliminarily investigated. In addition, the adsorption performance of hybrid 1 on cationic dye crystal violet and methylene blue was tested, and the adsorption efficiencies can reach 98.5% and 86.3%, respectively. | LIU Xiaodong WANG Xiangchen XU Na ZHANG Zhong LI Xiaohui LIU Guocheng WANG Xiuli | 2022 | Chemical Research in Chinese Universities2022，38，6： | 2 |
| 15 | Diurnal Variation of Soil CO2 Efflux and Its Optimal Measuring Time-window of Temperate Meadow Steppes in Western Songnen Plain, China显示文摘In order to study the diurnal variation of soil CO_2 efflux from temperate meadow steppes in Northeast China, and determine the best time for observation, a field experiment was conducted with a LI-6400 soil CO_2 flux system under five typical plant communities(Suaeda glauca(Sg), Chloris virgata(Cv), Puccinellia distans(Pd), Leymus chinensis(Lc) and Phragmites australis(Pa)) and an alkali-spot land(As) at the meadow steppe of western Songnen Plain. The results showed that the diurnal variation of soil CO_2 efflux exhibited a single peak curve in the growing season. Diurnal maximum soil respiration(Rs) often appeared between 11:00 and 13:00, while the minimum occurred at 21:00–23:00 or before dawn. Air temperature near the soil surface(Ta) and soil temperature at 10 cm depth(T10) exerted dominant control on the diurnal variations of soil respiration. The time-windows 7:00–9:00 could be used as the optimal measuring time to represent the daily mean soil CO_2 efflux at the Cv, Pd, Lc and Pa sites. The daily mean soil CO_2 efflux was close to the soil CO_2 efflux from 15:00 to 17:00 and the mean of 2 individual soil CO_2 efflux from 15:00 to 19:00 at the As and Sg sites, respectively. During nocturnal hours, negative soil CO_2 fluxes(CO_2 downwards into the soil) were frequently observed at the As and Sg sites, the magnitude of the negative CO_2 fluxes were 0.10–1.55 μmol/(m^2·s) and 0.10–0.69 μmol/(m^2·s)at the two sites. The results implied that alkaline soils could absorb CO_2 under natural condition, which might have significant implications to the global carbon budget accounting. | YU Xiuli LI Xiujun XU Linshu WANG Ming ZHANG Jitao JIANG Ming WANG Guodong | 2016 | Chinese Geographical Science2016，26，4： | 2 |
| 16 | High energy storage density and power density achieved simultaneously in NaNbO_(3)-based lead-free ceramics via antiferroelectricity enhancement显示文摘High-performance lead-free dielectric ceramics with simultaneously high energy storage density and power density are in high demanded for pulse power systems.To realize excellent energy-storage characteristics,a strategy to enhance antiferroelectricity and construct a local random field simultaneously was proposed in this study.Based on the above strategy,a series of(1-x)NaNbO_(3)-xBi(Ni_(1/2)Sn_(1/2))O3[xBNS,x=0.05,0.10,0.15,0.20,and 0.22]solid solutions were designed and fabricated.An ultrahigh energy storage density(Utotal)of 7.35 J/cm^(3),and recoverable energy density(Urec)of 5.00 J/cm^(3) were achieved in the 0.10BNS ceramics.In addition,an adequate stability of energy storage properties at a range of temperatures(20e140℃),frequencies(1e100 Hz),and fatigue test durations(1e1-10^(4) cycles)were realized in 0.10BNS ceramics.0.10BNS ceramics displayed a high current density of 1005 A/cm2,an ultrahigh power density of 100.5 MW/cm^(3,)and an ultrashort discharge time of 46.5 ns?This remarkable performance not only justified our strategy but also confirmed 0.10BNS ceramics as a promising candidate for energy storage. | Xiaoyan Dong Xu Li Xiuli Chen Hongyun Chen Congcong Sun Junpeng Shi Feihong Pang Huanfu Zhou | 2021 | Journal of Materiomics2021，7，3： | 2 |
| 17 | Evolution of H9N2 influenza viruses isolated in Shandong Province显示文摘Dear Editor,The low-pathogenic avian influenza subtype of the H9N2virus circulates in domestic poultry and wild birds throughout the world,causing severe morbidity and mortality in commercial chickens during coinfection with other pathogens,resulting in enormous losses.This kind of virus has been prevalent since the H9N2 virus was first identified | ZHANG Wei XU HuaiYing MENG Fang MA XiuLi LIU Xia HUANG DiHai QIN ZhuoMing LIU JinHua ZHAO Peng | 2015 | Science China(Life Sciences)2015，58，2： | 2 |
| 18 | Weak characteristic information extraction from early fault of wind turbine generator gearboxKeywords wind turbine generator gearbox, B-singular value decomposition, local mean decomposition, weak characteristic information extraction, early fault warning显示文摘 | Xiaoli XU Xiuli LIU | 2017 | Frontiers of Mechanical Engineering2017，12，3： | 2 |
| 19 | Dasatinib inhibits proliferation of liver cancer cells,but activation of Akt/mTOR compromises dasatinib as a cancer drug显示文摘Dasatinib is a multi-target protein tyrosine kinase inhibitor.Due to its potent inhibition of Src,Abl,the platelet-derived growth factor receptor(PDGFR)family kinases,and other oncogenic kinases,it has been investigated as a targeted therapy for a broad spectrum of cancer types.However,its efficacy has not been significantly extended beyond leukemia.The mechanism of resistance to dasatinib in a wide array of cancers is not clear.In the present study,we investigated the effect of dasatinib on hepatocellular carcinoma cell growth and explored the underlying mechanisms.Our results showed that dasatinib potently inhibited the proliferation of SNU-449 cells,but not that of other cell lines,such as SK-Hep-1,even though it inhibited the phosphorylation of Src on both negative and positive regulation sites in all these cells.Dasatinib activated the phosphoinositide-dependent protein kinase1(PDK1)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR)signaling pathway in SK-Hep-1 cells,but not in SNU-449 cells.Blocking the Akt/mTOR signaling pathway strongly promoted the efficacy of dasatinib in SK-Hep-1 cells.In SNU-449 cells,dasatinib promoted apoptosis and the cleavage of caspase-3 and caspase-7,induced cell cycle arrest in the G1 phase,and inhibited the expression of Cyclin-dependent kinase(CDK4)/6/CyclinD1 complex.These findings demonstrate that dasatinib exerts its anti-proliferative effect on hepatocellular cell proliferation by blocking the Src family kinases;however,it causes Akt activation,which compromises dasatinib as an anti-cancer drug. | Chang Liu Xiaoxia Zhu Yuqi Jia Fenqing Chi Keru Qin Jinhong Pei Chan Zhang Xiuli Mu Hongwei Zhang Xiushan Dong Jun Xu Baofeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 20 | Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes显示文摘Various biotin-modified liposomes incorporated with docetaxel(DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome(PDL), 0.5%(mol) biotin modified liposome(0.5 BDL), 1%(mol) biotin modified liposome(1 BDL) and 2%(mol) biotin modified liposome(2 BDL) were prepared using thin film dispersion method. The prepared liposomes were characterized by measuring encapsulation efficiency(EE), particle size, Zeta-potential, physical stability and drug release profiles in vitro. MTT assay was performed to elevate the cytotoxicity of liposomes on MCF-7 cells. In vivo evaluation was further performed to investigate the effect of biotin surface density on the pharmacokinetic profiles. All the prepared liposomes exhibited high encapsulation efficiency, small particle size, narrow particle distribution and sustained release profiles in vitro. In MTT assay, 0.5 BDL showed largest tumor cell toxicity, compared with DTX solution. All liposomes containing DTX showed prolonged blood circulation in vivo, and 0.5 BDL showed the longest circulation time among the biotin modified liposome. Surface modification of liposome had a negative impact on the circulation of liposomes in the blood, which needs to be considered when designing the ligand mediated targeting delivery systems. A proper amount of biotin liposome with 0.5% molar ratio is expected to produce the best anti-tumor effect. | Chun Chu Ping Xu Haoyue Zhao Qing Chen Dawei Chen Haiyang Hu Xiuli Zhao Mingxi Qiao | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 2 |
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