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| 1 | 新疆望峰金矿成矿流体研究及其成因意义显示文摘新疆望峰金矿,产于中天山结晶基底中的韧性剪切带内。围岩蚀变和流体包裹体研究表明,成矿过程包括了3个阶段,从早到晚有石英黄铁矿阶段、多金属硫化物阶段和石英碳酸盐阶段,温度分别集中在360~520℃、240~360℃和120~240℃;矿化以第Ⅱ阶段为主。成矿流体的δ18O值变化于1.15‰~2.70‰之间,属于变质热液与大气降水热液的混合流体。包裹体成分表明成矿流体来源较浅,但有利于金矿化;CO2/H2O比值多大于0.026,也有利于成矿。而包裹体捕获压力表明成矿作用发生在5.6~1.2km深度范围,主要发生在1.9km左右;矿化过程与地壳抬升伸展的过程一致,自然亦与碰撞造山体制的矿化规律一致。因此,古生代末期的碰撞造山作用导致了望峰金矿的形成,冰达坂断裂两侧是寻找望峰式金矿的有利地带。石英红外光谱分析表明,CO2光密度(D2)及其与H2O光密度(D1)的比值(D2/D1)普遍较高,指示矿化较强;D2>0.55和D2/D10.26是该区富金样品的标志。 | Chen Yanjing 1) Li Xin 1) Jing Jun 2) Gao Xiuli 1) Chen Huayong 1) Wu Xidan 2) Wu Dehua 2) ( 1) Department of Geology, Peking University 2)Team 15 of Gold Headquarters, MMIC, Urumqi ) | 1998 | 地球学报(中国地质科学院院报)1998，19，2： | 18 |
| 2 | Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis显示文摘Microglia are considered to be potential antigen-presenting cells and have the ability to present antigen under pathological conditions. Nevertheless, whether and how microglia are involved in immune regulation are largely unknown. Here, we investigated the suppressive activity of microglia during experimental autoimmune encephalomyelitis(EAE) induced by myelin oligodendrocyte glycoprotein, with the goal of understanding their role in regulating the T cell reaction. Using flow cytometric analysis, we found that microglia were characterized by increased cell number and up-regulated programmed death ligand-1(PD-L1) at the peak phase of EAE. Meanwhile,both the CD^(4+)T cells and microglia that infiltrated the central nervous system expressed higher levels of PD1, the receptor for PD-L1, accompanied by a decline of Th1 cells.In an ex vivo co-culture system, microglia from EAE mice inhibited the proliferation of antigen-specific CD^(4+)T cells and the differentiation of Th1 cells, and this was significantly inhibited by PD-L1 blockade. Further,microglia suppressed Th1 cells via nitric oxide(NO), the production of which was dependent on PD-L1. Thus, these data suggest a scenario in which microglia are involved in the regulation of EAE by suppressing Th1-cell differentiation via the PD-L1-NO pathway. | Jingxia Hu Hao He Zhengang Yang Guangming Zhu Li Kang Xiuli Jing Hai Lu Wengang Song Bo Bai Hua Tang | 2016 | Neuroscience Bulletin2016，32，1： | 9 |
| 3 | Recent developments in intelligent biomedical polymers显示文摘Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes in environmental stimuli. Due to their unique 'intelligent' characteristics, stimuli-sensitive polymers have found a wide variety of applications in biomedical and nanotechnological fields. This review focuses on the recent developments in biomedical application of intelligent polymer systems, such as intelligent hydrogel systems, intelligent drug delivery systems and intelligent molecular recognition systems. Also, the possible future directions for the application of these intelligent polymer systems in the biomedical field are presented. | XIAO ChunSheng TIAN HuaYu ZHUANG XiuLi CHEN XueSi JING XiaBin | 2009 | Science China Chemistry2009，52，2： | 6 |
| 4 | Prussian blue nanoparticle-loaded microbubbles for photothermally enhanced gene delivery through ultrasound-targeted microbubble destruction显示文摘By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fabricated for photothermally enhanced gene transfection through ultrasound-targeted microbubble destruction. CS/PB NPs of(2.69 ± 0.49) nm could complex DNA effectively when the mass ratio was2:1. It was found that MBs@CS/PB/DNA could enhance ultrasound imaging greatly both in vitro and in vivo. In addition, MBs@CS/PB/DNA could be disrupted by applying a higher-intensity ultrasound irradiation to release CS/PB/DNA, which could effectively transform the nearinfrared(NIR) light into heat to assist the uptake of CS/PB/DNA by cells. With the aid of ultrasound irradiation and NIR light irradiation, the gene transfection efficiency was significantly enhanced to(43.08 ± 1.13) %, much higher than polyethylenimine. Moreover, MBs@CS/PB/DNA showed excellent biocompatibility, encouraging the further exploration of MBs@CS/PB/DNA to be a platform for combined ultrasound image, photothermal therapy, drug delivery, and gene therapy. | Xiaoda Li Xiuli Yue Jinrui Wang Xiaolong Liang Lijia Jing Li Lin Yongbo Yang Shanshan Feng Yajun Qian Zhifei Dai | 2016 | Science Bulletin2016，61，2： | 4 |
| 5 | Albumin-bound paclitaxel dimeric prodrug nanoparticles with tumor Qr redox heterogeneity-triggered drug release for synergistic photothermal/ chemotherapy显示文摘In spired by the clinically approved albumin based PTX formulatio n(Abraxa ne)and high-drug-loading dimeric prodrug tactics,herein we report a theranostic HAbraxane-likeH prodrug formulation,which is comprised of human serum albumin(HSA),a paclitaxel(PTX)dimer bridged with thioether liner(PTX2-S),and photosensitizer IR780 iodide.Nanoparticles(NPs)with PTX2-S and IR780 as the core and HSA as the stealth shell are formed.Compared with HSA-based PTX clinical formulation(Abraxane),the dimeric molecules not only constitute the bulk structure of the particles,but also act as crossi ng age nt,thus realizing drug loadi ng content in creasi ng from 6.6 wt.%to 48.7 wt.%with high loadi ng efficie ncy(>90%)and excellent stability in biological conditions.Importa ntly,the thioether lin kage dually resp onds to the tumor redox heteroge neity and the NPs gradually releases the pare nt drug PTX for chemotherapy.Mea nwhile,PTX2-S facilitates the en capsulatio n of IR780 iodide due to their π-π stacki ng interaction and IR780 iodide gen erates spatio-temporal hyperthermia un der light irradiation to kill cancer cells for photothermal therapy.The described craft integrates the biomimetic trait of HSA,high drug loading,tumor redox heterogeneity-initiated on-dema nd drug release,and combi nation therapy into one formulati on and the developed nan oparticles are promising for cancer treatment. | Qing Pei Xiuli Hu Xiaohua Zheng Rui Xia Shi Liu Zhigang Xie Xiabin Jing | 2019 | Nano Research2019，12，4： | 3 |
| 6 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 2 |
| 7 | Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine显示文摘 | Min Zheng Shi Liu Jing Li Dan Qu Haifeng Zhao Xingang Guan Xiuli Hu Zhigang Xie Xiabin Jing Zaicheng Sun | 2014 | Mater2014，，21： | 2 |
| 8 | Controlled release of urea encapsulated by starch-g-poly( l -lactide)显示文摘 | Li Chen Zhigang Xie Xiuli Zhuang Xuesi Chen Xiabin Jing | 2007 | Carbohydrate Polymers2007，，2： | 2 |
| 9 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 10 | Metal porphyrin/phenyltrimethylammonium tribromide: High efficient catalysts for coupling reaction of CO 2 and epoxides显示文摘 | Lili Jin Huanwang Jing Tao Chang Xiuli Bu Li Wang Zhongli Liu | 2006 | Journal of Molecular Catalysis A Chemical2006，，2： | 1 |
| 11 | An RBD virus-like particle vaccine for SARS-CoV-2 induces cross-variant antibody responses in mice and macaques显示文摘Dear Editor,Since early 2020,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has spread globally infecting over 500 million people and causing over 6 million deaths.The massive worldwide immunisation programmes and the arising clinical trial data present a unique opportunity to compare the vaccines and various delivery platforms(i.e.viral vector platform,mRNA platform and virus-like particle platform). | Yuanyuan Li Yanan Zhang Yu Zhou Yan Li Jiao Xu Yuanbao Ai Lei Xu Xiuli Xiao Bo Zhang Jing Jin | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 12 | p 显示文摘 | Yang Yanan Cai Jing Zhuang Xiuli | 2010 | Polymer2010，51，12： | 1 |
| 13 | pH-dependent self-assembly of amphiphilic poly( l -glutamic acid)-block-poly(lactic-co-glycolic acid) copolymers显示文摘 | Yanan Yang Jing Cai Xiuli Zhuang Zhaopei Guo Xiabin Jing Xuesi Chen | 2010 | Polymer2010，，12： | 1 |
| 14 | Fish species classification by color, texture and multi-class support vector machine using computer vision显示文摘 | Jing Hu Daoliang Li Qingling Duan Yueqi Han Guifen Chen Xiuli Si | 2012 | Computers and Electronics in Agriculture2012，，： | 1 |
| 15 | Synthesis and properties of thermoplastic poly (vinyl alcohol) - graft - lactic acid eopolymers显示文摘 | Jing Ding Sichong Chen Xiuli Wang | 2009 | Ind Eng Res2009，48，： | 1 |
| 16 | Selectively preparative purification of aristolochic acids and aristololactams from Aristolochia plants显示文摘 | Jing Zhang Yuansheng Xiao Jiatao Feng Sophia L. Wu Xingya Xue Xiuli Zhang Xinmiao Liang | | Journal of Pharmaceutical and Biomedical Analysis0，，： | 1 |
| 17 | Systematic screening and characterization of tertiary and quaternary alkaloids from corydalis yanhusuo W.T. Wang using ultra-performance liquid chromatography–quadrupole-time-of-flight mass spectrometry显示文摘 | Jing Zhang Yu Jin Jun Dong Yuansheng Xiao Jiatao Feng Xingya Xue Xiuli Zhang Xinmiao Liang | 2008 | Talanta2008，，： | 1 |
| 18 | Molecular characterization of the genome of duck enteritis virus显示文摘 | Yufeng Li Bing Huang Xiuli Ma Jing Wu Feng Li Wu Ai Minxun Song Hanchun Yang | 2009 | Virology2009，，2： | 1 |
| 19 | Optimizing distribution strategy for perishable foods using RFiD and sensor technologles显示文摘 | Jing Shi Zhang Jun Xiuli Qu | 2010 | Journal of Business & Industrial Marketing2010，25，8： | 1 |
| 20 | Macro-phenomenological high-strain-rate elastic fracture model for ice-impact simulations显示文摘The ice impact can cause a severe damage to an aircraft’s exposed structure,thus,requiring its prevention.The numerical simulation represents an effective method to overcome this challenge.The establishment of the ice material model is critical.However,ice is not a common structural material and exhibits an extremely complex material behavior.The material models of ice reported so far are not able to accurately simulate the ice behavior at high strain rates.This study proposes a novel high-precision macro-phenomenological elastic fracture model based on the brittle behavior of ice at high strain rates.The developed model has been compared with five reported models by using the smoothed particle hydrodynamics method so as to simulate the ice-impact process with respect to the impact speeds and ice shapes.The important metrics and phenomena(impact force history,deformation and fragmentation of the ice projectile and deflection of the target)were compared with the experimental data reported in the literature.The findings obtained from the developed model are observed to be most consistent with the experimental data,which demonstrates that the model represents the basic physics and phenomena governing the ice impact at high strain rates.The developed model includes a relatively fewer number of material parameters.Further,the used parameters have a clear physical meaning and can be directly obtained through experiments.Moreover,no adjustment of any material parameter is needed,and the consumption duration is also acceptable.These advantages indicate that the developed model is suitable for simulating the iceimpact process and can be applied for the anti-ice impact design in aviation. | Jiang FAN Qinghao YUAN Fulei JING Guangchen BAI Xiuli SHEN | 2023 | Chinese Journal of Aeronautics2023，36，3： | 0 |
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